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1. 发明授权

US08934968B2 Neurostimulation and coronary artery disease treatment 有权
标题翻译：神经刺激和冠状动脉疾病治疗
公开(公告)号：US08934968B2
公开(公告)日：2015-01-13
申请号：US11779769
申请日：2007-07-18
申请人： Todd K. Whitehurst , James R. Thacker , James P. McGivern , Kelly H. McClure
发明人： Todd K. Whitehurst , James R. Thacker , James P. McGivern , Kelly H. McClure
IPC分类号： A61N1/362 , A61N1/36 , A61M5/142
CPC分类号： A61N1/36114 , A61M5/14276 , A61M2205/054 , A61M2205/3523 , A61M2205/8206 , A61M2230/06
摘要： A method for treating a patient may include treating coronary artery disease in combination with angina pectoris and/or the control of angina pain by delivering chemical and/or electrical stimulation pulses to the cardiac and/or nervous tissue of the patient in a coordinated manner. A system for treating a patient suffering from coronary artery disease and angina may include a stimulator that generates at least one pulse in accordance with prescribed parameters, a catheter, a lead, and/or a sensor.
摘要翻译：用于治疗患者的方法可以包括通过以协调的方式将化学和/或电刺激脉冲递送到患者的心脏和/或神经组织来治疗与心绞痛联合的冠状动脉疾病和/或控制心绞痛。用于治疗患有冠状动脉疾病和心绞痛的患者的系统可以包括根据规定参数产生至少一个脉冲的刺激器，导管，引线和/或传感器。

2. 发明授权

US08712547B2 Cavernous nerve stimulation via unidirectional propagation of action potentials 有权
标题翻译：通过动作电位的单向传播进行海绵体神经刺激
公开(公告)号：US08712547B2
公开(公告)日：2014-04-29
申请号：US13036278
申请日：2011-02-28
申请人： Todd K. Whitehurst , James P. McGivern , Rafael Carbunaru , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley
发明人： Todd K. Whitehurst , James P. McGivern , Rafael Carbunaru , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley
IPC分类号： A61N1/05 , A61N1/372
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/37205
摘要： An implantable stimulation device includes a device body; at least one set of partitioned electrodes disposed on a portion of the device body and configured and arranged for application of electrical stimulation to adjacent tissue; and insulating material separating the partitioned electrodes from each other. Each set of partitioned electrodes includes a plurality of partitioned electrodes disposed around a circumference of the device body. The implantable stimulation device can be configured and arranged so that each of the partitioned electrodes is independently programmable.
摘要翻译：可植入刺激装置包括装置主体; 至少一组分隔电极，其设置在所述装置主体的一部分上，并被配置和布置成用于对相邻组织施加电刺激; 以及将分隔电极彼此分离的绝缘材料。每组分隔电极包括围绕装置主体的圆周设置的多个分隔电极。可植入式刺激装置可以被配置和布置成使得每个分隔电极可独立编程。

3. 发明授权

US08515541B1 Methods and systems for treating post-stroke disorders 有权
标题翻译：治疗中风后疾病的方法和系统
公开(公告)号：US08515541B1
公开(公告)日：2013-08-20
申请号：US11317465
申请日：2005-12-22
申请人： Kristen N. Jaax , Todd K. Whitehurst , Rafael Carbunaru
发明人： Kristen N. Jaax , Todd K. Whitehurst , Rafael Carbunaru
IPC分类号： A61N1/36
CPC分类号： A61N1/0531 , A61N1/0539 , A61N1/36103 , A61N1/37205 , A61N1/3756
摘要： Methods of treating a post-stroke disorder include applying at least one stimulus to a stimulation site within a patient with an implanted stimulator in accordance with one or more stimulation parameters. The stimulation site may include, for example, at least one or more of a motor cortex, thalamus, cerebellum, basal ganglia, globus pallidus, and periaqueductal gray. Systems for treating a post-stroke disorder include an implantable stimulator configured to apply at least one stimulus to a stimulation site within a patient in accordance with one or more stimulation parameters. The stimulation site may include, for example, at least one or more of a motor cortex, thalamus, cerebellum, basal ganglia, globus pallidus, and periaqueductal gray.
摘要翻译：治疗中风后病症的方法包括根据一个或多个刺激参数，使用植入的刺激器将至少一种刺激施加到患者内的刺激部位。刺激部位可以包括例如运动皮层，丘脑，小脑，基底神经节，苍白球和周围导管灰色中的至少一个或多个。用于治疗中风后病症的系统包括可植入刺激器，其被配置为根据一个或多个刺激参数将至少一种刺激施加到患者内的刺激部位。刺激部位可以包括例如运动皮层，丘脑，小脑，基底神经节，苍白球和周围导管灰色中的至少一个或多个。

4. 发明授权

US08412334B2 Treatment of mood and/or anxiety disorders by electrical brain stimulation and/or drug infusion 有权
标题翻译：通过电脑刺激和/或药物输注治疗情绪和/或焦虑症
公开(公告)号：US08412334B2
公开(公告)日：2013-04-02
申请号：US13244066
申请日：2011-09-23
申请人： Todd K. Whitehurst , Kristen N. Jaax
发明人： Todd K. Whitehurst , Kristen N. Jaax
IPC分类号： A61N1/18
CPC分类号： A61N1/36096 , A61M5/172 , A61M5/1723 , A61N1/37205 , A61N1/3787
摘要： A system and method for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to treat mood and/or anxiety disorders uses an implantable system control unit (SCU), specifically an implantable signal/pulse generator (IPG) or microstimulator with one or more electrodes in the case of electrical stimulation, and an implantable pump with one or more catheters in the case of drug infusion. In cases requiring both electrical and drug stimulation, one or more SCUs are used. Alternatively and preferably, when needed, an SCU provides both electrical stimulation and one or more stimulating drugs. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译：用于将一种或多种刺激性药物引入和/或施加电刺激以治疗情绪和/或焦虑症的系统和方法使用可植入系统控制单元（SCU），特别是可植入信号/脉冲发生器（IPG）或微刺激器在电刺激的情况下具有一个或多个电极，以及在药物输注的情况下具有一个或多个导管的可植入泵。在需要电刺激和药物刺激的情况下，使用一个或多个SCU。或者，优选地，当需要时，SCU提供电刺激和一种或多种刺激性药物。在优选实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。

5. 发明授权

US08364278B2 Lead assembly for implantable microstimulator 有权
标题翻译：可植入微型激励器的导线组件
公开(公告)号：US08364278B2
公开(公告)日：2013-01-29
申请号：US10503281
申请日：2003-01-29
申请人： Anne M. Pianca , Todd K. Whitehurst , James P. McGivern
发明人： Anne M. Pianca , Todd K. Whitehurst , James P. McGivern
IPC分类号： A61N1/05
CPC分类号： H01R43/16 , A61N1/05 , H01R13/5224 , Y10T29/49204
摘要： A lead assembly for a small implantable medical device connects a remote electrode to a microdevice and inhibits fluid ingress into the connection. Microdevices may provide either or both tissue stimulation and sensing. Known microdevices include spaced apart electrodes on the outer surface of the microdevice. The lead assembly includes an insulated lead including a proximal end and a distal end, with at least one conductor therebetween; at least one electrode at the distal end of the lead and electrically connected to the at least one conductor, and a connector attached to the proximal end of the lead and adapted to be removably connectable to the microdevice. The connector includes at least one contact to electrically connect at least one device electrode on the microdevice to the at least one conductor. The lead assembly is configured to inhibit fluid ingress into the connector.
摘要翻译：用于小型可植入医疗装置的引导组件将远程电极连接到微型装置并且阻止流体进入连接。微器件可以提供组织刺激和感测之一或两者。已知的微器件在微器件的外表面上包括间隔开的电极。引线组件包括绝缘引线，其包括近端和远端，其间具有至少一个导体; 在所述引线的远端处的至少一个电极并且电连接到所述至少一个导体，以及连接到所述引线的近端并适于可移除地连接到所述微器件的连接器。所述连接器包括至少一个接触件，以将所述微器件上的至少一个器件电极电连接到所述至少一个导体。引线组件被配置为抑制流体进入连接器。

6. 发明授权

US08315704B2 Stimulation of a stimulation site within the neck or head 有权
标题翻译：刺激颈部或头部刺激部位
公开(公告)号：US08315704B2
公开(公告)日：2012-11-20
申请号：US12940862
申请日：2010-11-05
申请人： Kristen N. Jaax , Todd K. Whitehurst
发明人： Kristen N. Jaax , Todd K. Whitehurst
IPC分类号： A61N1/05
CPC分类号： A61N1/3787 , A61N1/0534 , A61N1/36071 , A61N1/37211 , A61N2001/0582
摘要： Methods of applying a stimulus to a stimulation site within the neck or head of a patient include implanting a distal portion of one or more leads adjacent to the stimulation site, forming a loop with a proximal portion of the one or more leads, and securing the distal and proximal portions of the one or more leads to one or more securing sites with one or more securing devices. The distal portion of the one or more leads includes a number of electrodes disposed thereon that are configured to deliver the stimulus to the stimulation site. Systems for applying a stimulus to a stimulation site within the neck or head of a patient include one or more leads having a number of electrodes disposed on a distal portion thereof and one or more securing devices configured to secure the one or more leads to one or more securing sites. The distal portion of the one or more leads is implanted adjacent to the stimulation site and the electrodes are configured to deliver the stimulus to the stimulation site. The proximal portion of the one or more leads is formed in a loop.
摘要翻译：将刺激施加到患者的颈部或头部内的刺激部位的方法包括将邻近刺激部位的一个或多个引线的远端部分植入，形成具有一个或多个引线的近端部分的环，一个或多个引线的远端和近端部分具有一个或多个固定装置的一个或多个固定位置。一个或多个引线的远端部分包括布置在其上的多个电极，其被配置为将刺激传递到刺激部位。将刺激施加到患者的颈部或头部内的刺激部位的系统包括一个或多个引线，其具有设置在其远端部分上的多个电极，以及一个或多个固定装置，其被配置成将一个或多个引线固定到一个或多个引线更多的安全网站。一个或多个引线的远端部分被邻近刺激部位植入，并且电极构造成将刺激递送到刺激部位。一个或多个引线的近端部分形成为环形。

7. 发明授权

US08313453B2 Burr hole sealing device for preventing brain shift 有权
标题翻译：用于防止脑移位的毛刺孔密封装置
公开(公告)号：US08313453B2
公开(公告)日：2012-11-20
申请号：US12549174
申请日：2009-08-27
申请人： Rafael Carbunaru , Todd K. Whitehurst , Andrew DiGiore , Kristen Jaax
发明人： Rafael Carbunaru , Todd K. Whitehurst , Andrew DiGiore , Kristen Jaax
IPC分类号： A61M5/00
CPC分类号： A61N1/0539 , A61B17/3415 , A61B90/14 , A61B2017/3419 , A61B2090/103 , A61M2039/025 , A61M2039/0276 , A61M2039/0282
摘要： A burr hole sealing device for preventing brain shift during a stimulation lead implantation procedure is provided. The device includes a suction cup ring and a self-sealing membrane positioned within the aperture of the ring. The sealing device is attached adjacent to a burr hole and over a dura layer that is exposed in the bottom of the burr hole. The stimulation lead is disposed through the burr hole, through the membrane, through the dura layer and into brain tissue. The membrane is configured to allow the lead to pass therethrough while maintaining a tight seal around the diameter of the lead, thereby hindering leakage of cerebrospinal fluid out of the cranial cavity and maintaining a substantially fixed intracranial pressure. In one embodiment, the sealing device includes a syringe for adding fluid to, or removing fluid from, the cranial cavity in response to a detected change in intracranial pressure.
摘要翻译：提供了一种用于在刺激引线植入程序期间防止脑移位的钻孔密封装置。该装置包括吸盘环和位于环的孔内的自密封膜。密封装置邻近毛刺孔并暴露在钻孔底部的硬脑膜层上。刺激引线通过毛刺孔穿过膜，穿过硬脑膜层并进入脑组织。膜被配置为允许引线通过，同时保持围绕铅直径的紧密密封，从而阻止脑脊液从脑腔中泄漏并保持基本上固定的颅内压。在一个实施例中，密封装置包括用于响应于检测到的颅内压变化而将流体添加到颅腔或从头颅腔移除流体的注射器。

8. 发明申请

US20120016336A1 TREATMENT OF MOOD AND/OR ANXIETY DISORDERS BY ELECTRICAL BRAIN STIMULATION AND/OR DRUG INFUSION 有权
标题翻译：通过电脑刺激和/或药物浸润治疗原发性和/或恶性疾病
公开(公告)号：US20120016336A1
公开(公告)日：2012-01-19
申请号：US13244066
申请日：2011-09-23
申请人： Todd K. Whitehurst , Kristen N. Jaax
发明人： Todd K. Whitehurst , Kristen N. Jaax
IPC分类号： A61M5/00 , A61N1/36
CPC分类号： A61N1/36096 , A61M5/172 , A61M5/1723 , A61N1/37205 , A61N1/3787
摘要： A system and method for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to treat mood and/or anxiety disorders uses an implantable system control unit (SCU), specifically an implantable signal/pulse generator (IPG) or microstimulator with one or more electrodes in the case of electrical stimulation, and an implantable pump with one or more catheters in the case of drug infusion. In cases requiring both electrical and drug stimulation, one or more SCUs are used. Alternatively and preferably, when needed, an SCU provides both electrical stimulation and one or more stimulating drugs. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译：用于将一种或多种刺激性药物引入和/或施加电刺激以治疗情绪和/或焦虑症的系统和方法使用可植入系统控制单元（SCU），特别是可植入信号/脉冲发生器（IPG）或微刺激器在电刺激的情况下具有一个或多个电极，以及在药物输注的情况下具有一个或多个导管的可植入泵。在需要电刺激和药物刺激的情况下，使用一个或多个SCU。或者，优选地，当需要时，SCU提供电刺激和一种或多种刺激性药物。在优选实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。

9. 发明授权

US08095219B2 Stimulation of the stomach in response to sensed parameters to treat obesity 有权
标题翻译：响应于感测参数来刺激胃以治疗肥胖
公开(公告)号：US08095219B2
公开(公告)日：2012-01-10
申请号：US12359138
申请日：2009-01-23
申请人： Philip H. J. Lee , Todd K. Whitehurst , Carla M. Woods
发明人： Philip H. J. Lee , Todd K. Whitehurst , Carla M. Woods
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61N1/05
摘要： A neurostimulation kit and a method of treating a patient are provided. The kit comprises a stimulation backing that includes a flat, electrically insulative, body having a pair of opposing first and second planar surfaces, and an electrode affixed to the first surface of the insulative body. The stimulation backing is implanted within a patient and affixed therein to place the electrode into contact with a tissue surface. The kit comprises a neurostimulator including a housing and stimulation circuitry contained within the housing. The neurostimulator is implanted within the patient by affixing the housing to the second surface of the insulative body, such that the stimulation circuitry is electrically coupled to the electrode.
摘要翻译：提供神经刺激试剂盒和治疗患者的方法。该套件包括刺激衬垫，其包括具有一对相对的第一和第二平坦表面的平坦的电绝缘体，以及固定到绝缘体的第一表面的电极。将刺激背衬植入患者体内并固定在其中以使电极与组织表面接触。该套件包括神经刺激器，其包括容纳在壳体内的壳体和刺激电路。神经刺激器通过将外壳固定到绝缘体的第二表面而植入患者体内，使得刺激电路电耦合到电极。

10. 发明授权

US08060209B2 Methods and systems of treating ischemia pain in visceral organs 有权
标题翻译：治疗内脏器官缺血性疼痛的方法和系统
公开(公告)号：US08060209B2
公开(公告)日：2011-11-15
申请号：US12359144
申请日：2009-01-23
申请人： Kristen N. Jaax , Todd K. Whitehurst , Andrew DiGiore
发明人： Kristen N. Jaax , Todd K. Whitehurst , Andrew DiGiore
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/05 , A61N1/0551 , A61N1/36007
摘要： Methods and systems of treating a patient with ischemia pain include providing a stimulator, configuring one or more stimulation parameters to treat ischemia pain in a visceral organ, programming the stimulator with the one or more stimulation parameters, generating a stimulus configured to treat ischemia pain with the stimulator in accordance with the one or more stimulation parameters, and applying the stimulus with the stimulator to one or more stimulation sites in accordance with the one or more stimulation parameters.
摘要翻译：治疗缺血性疼痛的患者的方法和系统包括提供刺激器，配置一个或多个刺激参数以治疗内脏器官中的缺血性疼痛，用所述一个或多个刺激参数编程所述刺激器，产生经配置以治疗缺血性疼痛的刺激所述刺激器根据所述一个或多个刺激参数，以及根据所述一个或多个刺激参数将刺激器刺激施加到一个或多个刺激部位。

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