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1. 发明授权

US07702385B2 Electrode contact configurations for an implantable stimulator 有权
标题翻译：可植入刺激器的电极接触配置
公开(公告)号：US07702385B2
公开(公告)日：2010-04-20
申请号：US11280582
申请日：2005-11-16
申请人： Michael A. Moffitt , Rafael Carbunaru , Todd K. Whitehurst , Alfred E. Mann
发明人： Michael A. Moffitt , Rafael Carbunaru , Todd K. Whitehurst , Alfred E. Mann
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/37205 , A61N1/3756
摘要： An exemplary implantable stimulator includes at least one electrode contact array and at least one additional electrode contact. Both the electrode contact array and the additional electrode contact are disposed on an external surface of the stimulator. The electrode contact array includes multiple electrode contacts that are configured to have a first polarity. The additional electrode is configured to have a second polarity. One or more of the electrode contacts disposed on the stimulator are configured to deliver monopolar stimulation and/or multipolar stimulation. Exemplary methods of stimulating a stimulation site within a patient include providing at least one electrode contact array and at least one additional electrode contact. Both the electrode contact array and the additional electrode contact are disposed on an external surface of the stimulator. The electrode contact array includes multiple electrode contacts that are configured to have a first polarity. The additional electrode is configured to have a second polarity. The method further includes applying an electrical stimulation current to the stimulation site via one or more of the electrode contacts that are disposed on the stimulator.
摘要翻译：示例性可植入刺激器包括至少一个电极接触阵列和至少一个附加电极接触。电极接触阵列和附加电极接触都设置在刺激器的外表面上。电极接触阵列包括被配置为具有第一极性的多个电极接触。附加电极被配置为具有第二极性。设置在刺激器上的一个或多个电极接触器被配置成传递单极刺激和/或多极刺激。刺激患者内的刺激部位的示例性方法包括提供至少一个电极接触阵列和至少一个另外的电极接触。电极接触阵列和附加电极接触都设置在刺激器的外表面上。电极接触阵列包括被配置为具有第一极性的多个电极接触。附加电极被配置为具有第二极性。该方法还包括经由设置在刺激器上的一个或多个电极接触件向刺激部位施加电刺激电流。

2. 发明授权

US08626297B2 Apparatus and methods for charging an implanted medical device power source 有权
标题翻译：用于对植入式医疗装置电源充电的装置和方法
公开(公告)号：US08626297B2
公开(公告)日：2014-01-07
申请号：US12233810
申请日：2008-09-19
申请人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
发明人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , H02J7/025 , H02J7/047 , H02J50/10
摘要： Apparatus and methods for charging an implanted medical device.
摘要翻译：用于对植入的医疗装置充电的装置和方法。

3. 发明申请

US20090082835A1 Apparatus and Methods For Charging An Implanted Medical Device Power Source 有权
标题翻译：一种植入式医疗器械电源充电装置及方法
公开(公告)号：US20090082835A1
公开(公告)日：2009-03-26
申请号：US12233810
申请日：2008-09-19
申请人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
发明人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
IPC分类号： A61N1/00
CPC分类号： A61N1/3787 , H02J7/025 , H02J7/047 , H02J50/10
摘要： Apparatus and methods for charging an implanted medical device.
摘要翻译：用于对植入的医疗装置充电的装置和方法。

4. 发明授权

US09327069B2 Methods and systems for treating a medical condition by promoting neural remodeling within the brain 有权
公开(公告)号：US09327069B2
公开(公告)日：2016-05-03
申请号：US11393565
申请日：2006-03-29
申请人： Allison M. Foster , Rafael Carbunaru , Kristen N. Jaax , Todd K. Whitehurst
发明人： Allison M. Foster , Rafael Carbunaru , Kristen N. Jaax , Todd K. Whitehurst
IPC分类号： A61N1/05 , A61M5/142 , A61N1/36 , A61N1/372
CPC分类号： A61M5/14276 , A61M2210/0693 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/3605 , A61N1/36082 , A61N1/37205
摘要： Methods of treating a medical condition include applying at least one stimulus to a stimulation site within the brain of a patient with an implanted stimulator in accordance with one or more stimulation parameters. The at least one stimulus is configured to promote neural remodeling within the brain of the patient. Systems for treating a medical condition include an implantable stimulator configured to apply at least one stimulus to a stimulation site within the brain of a patient in accordance with one or more stimulation parameters. The at least one stimulus is configured to promote neural remodeling within the brain of the patient.

5. 发明授权

US09095713B2 Methods and systems for treating autism by decreasing neural activity within the brain 有权
标题翻译：通过减少脑内的神经活动来治疗自闭症的方法和系统
公开(公告)号：US09095713B2
公开(公告)日：2015-08-04
申请号：US11478827
申请日：2006-06-30
申请人： Allison M. Foster , Todd K. Whitehurst , Rafael Carbunaru , Derrick Sung
发明人： Allison M. Foster , Todd K. Whitehurst , Rafael Carbunaru , Derrick Sung
IPC分类号： A61B5/0402 , A61N1/36 , A61M5/142 , A61N1/05
CPC分类号： A61N1/36082 , A61M5/14276 , A61M2210/0693 , A61N1/0531 , A61N1/0534
摘要： Methods of treating autism include applying at least one stimulus to a stimulation site within the brain of a patient with an implanted stimulator in accordance with one or more stimulation parameters. The stimulus is configured to decrease neural activity within at least a portion of the brain to treat autism. Systems for treating autism include a stimulator configured to apply at least one stimulus to a stimulation site within the brain of a patient in accordance with one or more stimulation parameters. The stimulus is configured to decrease neural activity within at least a portion of the brain to treat autism.
摘要翻译：治疗自闭症的方法包括根据一个或多个刺激参数用植入的刺激器将至少一种刺激施加到患者脑内的刺激部位。刺激被配置为减少至少一部分脑内的神经活动以治疗自闭症。用于治疗自闭症的系统包括刺激器，其被配置为根据一个或多个刺激参数将至少一个刺激应用于患者脑内的刺激部位。刺激被配置为减少至少一部分脑内的神经活动以治疗自闭症。

6. 发明授权

US08548604B2 Implantable microstimulators and methods for unidirectional propagation of action potentials 失效
标题翻译：可植入的微型激励器和动作电位单向传播的方法
公开(公告)号：US08548604B2
公开(公告)日：2013-10-01
申请号：US12960722
申请日：2010-12-06
申请人： Todd K. Whitehurst , Rafael Carbunaru , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley , Janusz A. Kuzma
发明人： Todd K. Whitehurst , Rafael Carbunaru , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley , Janusz A. Kuzma
IPC分类号： A61N1/05
CPC分类号： A61N1/37252 , A61N1/05 , A61N1/0556 , A61N1/36071 , A61N1/37205 , A61N1/37217 , A61N1/37288
摘要： Miniature implantable stimulators (i.e., microstimulators) are capable of producing unidirectionally propagating action potentials (UPAPs). The methods and configurations described may, for instance, arrest action potentials traveling in one direction, arrest action potentials of small diameters nerve fibers, arrest action potentials of large diameter nerve fibers. These methods and systems may limit side effects of bidirectional and/or less targeted stimulation.
摘要翻译：微型植入式刺激器（即微型刺激器）能够产生单向传播动作电位（UPAP）。所描述的方法和结构可以例如阻止在一个方向上行进的动作电位，阻止小直径神经纤维的动作电位，阻止大直径神经纤维的动作电位。这些方法和系统可以限制双向和/或较少靶向刺激的副作用。

7. 发明授权

US08423157B2 Electrode contact configurations for cuff leads 有权
标题翻译：袖带导线的电极触点配置
公开(公告)号：US08423157B2
公开(公告)日：2013-04-16
申请号：US13114898
申请日：2011-05-24
申请人： Michael Adam Moffitt , Rafael Carbunaru , Kristen N. Jaax , Todd K. Whitehurst
发明人： Michael Adam Moffitt , Rafael Carbunaru , Kristen N. Jaax , Todd K. Whitehurst
IPC分类号： A61N1/05 , A61N1/18 , A61N1/04
CPC分类号： A61N1/0556 , A61N1/0558
摘要： A stimulation system is disclosed that may include a stimulator unit coupled to electrode contacts on a cuff. In one embodiment, the cuff may be placed at least partially around a nerve. The stimulation system may include at least two electrode contacts disposed on the cuff such that a distance between the at least two electrode contacts various along a length of the electrode contacts. In another embodiment, a plurality of electrode contacts are disposed on the cuff such that distances between at least one electrode contact within the plurality of electrode contacts and each electrode contact immediately adjacent to the at least one electrode contact are different. The stimulator unit may also be implantable.
摘要翻译：公开了一种刺激系统，其可以包括耦合到袖带上的电极接触件的刺激器单元。在一个实施例中，袖带可以至少部分地放置在神经周围。刺激系统可以包括布置在袖带上的至少两个电极触点，使得至少两个电极触点之间的距离沿着电极触点的长度不同。在另一个实施例中，多个电极触点设置在袖带上，使得多个电极触点内的至少一个电极触点与紧邻至少一个电极触点的每个电极接触之间的距离是不同的。刺激器单元也可以是可植入的。

8. 发明授权

US08401654B1 Methods and systems for treating one or more effects of deafferentation 有权
标题翻译：用于处理一种或多种传递效应的方法和系统
公开(公告)号：US08401654B1
公开(公告)日：2013-03-19
申请号：US11479487
申请日：2006-06-30
申请人： Allison M. Foster , Rafael Carbunaru , Todd K. Whitehurst , Kristen N. Jaax
发明人： Allison M. Foster , Rafael Carbunaru , Todd K. Whitehurst , Kristen N. Jaax
IPC分类号： A61N1/00
CPC分类号： A61N1/36103 , A61M5/14276 , A61M2210/0693 , A61N1/0529 , A61N1/0551 , A61N1/36082 , A61N1/36139 , A61N1/36171 , A61N1/37205 , A61N1/37288
摘要： Methods of treating one or more effects of deafferentation within a patient include applying at least one stimulus to a stimulation site within the patient with an implanted stimulator in accordance with one or more stimulation parameters. The at least one stimulus is configured to treat one or more effects of deafferentation. Systems for treating one or more effects of deafferentation within a patient include a stimulator configured to apply at least one stimulus to a stimulation site within the patient in accordance with one or more stimulation parameters. The at least one stimulus is configured to treat one or more effects of deafferentation.
摘要翻译：治疗患者中一种或多种传入影响的方法包括根据一个或多个刺激参数，使用植入的刺激器将至少一种刺激应用于患者内的刺激部位。所述至少一个刺激被配置为处理一种或多种传递的影响。用于治疗患者内一种或多种传入影响的系统包括：刺激器，其构造成根据一个或多个刺激参数将至少一种刺激施加到患者内的刺激部位。所述至少一个刺激被配置为处理一种或多种传递的影响。

9. 发明授权

US08364280B2 Engagement tool for implantable medical devices 有权
标题翻译：可植入医疗器械的接合工具
公开(公告)号：US08364280B2
公开(公告)日：2013-01-29
申请号：US12506890
申请日：2009-07-21
申请人： Goran N. Marnfeldt , Rafael Carbunaru , Kelly H. McClure , Matthew I. Haller , Tom Xiaohai He , Todd K. Whitehurst , Meredith L. Anderson , James C. Makous , Kristen N. Jaax , Peter K. Johnson
发明人： Goran N. Marnfeldt , Rafael Carbunaru , Kelly H. McClure , Matthew I. Haller , Tom Xiaohai He , Todd K. Whitehurst , Meredith L. Anderson , James C. Makous , Kristen N. Jaax , Peter K. Johnson
IPC分类号： A61N1/00
CPC分类号： A61B17/3417 , A61B17/221 , A61B17/32056 , A61B17/3468 , A61B90/30 , A61B2017/00358 , A61B2017/22035 , A61B2017/2215 , A61B2017/320044 , A61N1/05 , A61N1/08
摘要： Systems for adjusting a position of an implanted medical device within a patient include an engagement tool configured to couple to the implanted medical device. The engagement tool adjusts the position of the medical device when coupled to the implanted medical device. Methods of adjusting a position of an implanted medical device within a patient include locating the implanted medical device, coupling an engagement tool to the medical device, and adjusting a position of the engagement tool to adjust the position of the medical device.
摘要翻译：用于调整患者内植入的医疗装置的位置的系统包括被配置为耦合到植入的医疗装置的接合工具。接合工具当耦合到植入的医疗装置时调节医疗装置的位置。调整患者内的植入医疗装置的位置的方法包括定位植入的医疗装置，将接合工具联接到医疗装置，以及调整接合工具的位置以调整医疗装置的位置。

10. 发明授权

US08352035B2 Connector assemblies for implantable stimulators 有权
公开(公告)号：US08352035B2
公开(公告)日：2013-01-08
申请号：US12262789
申请日：2008-10-31
申请人： Brett Schleicher , Rafael Carbunaru , Todd K. Whitehurst , Kristen N. Jaax , Greg Baldwin , Andrew DiGiore
发明人： Brett Schleicher , Rafael Carbunaru , Todd K. Whitehurst , Kristen N. Jaax , Greg Baldwin , Andrew DiGiore
IPC分类号： A61N1/00
CPC分类号： A61N1/3754 , A61N1/37205 , A61N1/37235 , A61N1/375 , A61N1/3752 , A61N1/3787
摘要： Exemplary systems include a stimulator configured to be implanted within a patient, the stimulator having a body defined by at least one side surface disposed in between distal and proximal end surfaces, and a connector assembly configured to be coupled to the stimulator and extend parallel to the at least one side surface of the stimulator. The connector assembly is further configured to facilitate removable coupling of a lead having one or more electrodes disposed thereon to the stimulator.

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