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91. 发明申请

WO2006124724A2 VISUALIZATION OF CHEMICAL-ANALYSIS DATA 审中-公开
标题翻译：化学分析数据的可视化
公开(公告)号：WO2006124724A2
公开(公告)日：2006-11-23
申请号：PCT/US2006018637
申请日：2006-05-12
申请人： WATERS INVESTMENTS LTD , DECORRAL JOSE LUIS
发明人： DECORRAL JOSE LUIS
IPC分类号： G06F7/00
CPC分类号： G01N30/8651 , G01N30/7233 , G06T11/206 , G06T15/00 , H01J49/0036 , Y10T436/11
摘要： A method includes compressing chemical-analysis data points with no loss of information, generating, from the stored data points, nested data arrays, storing the nested data arrays in a video memory, rendering an image from the nested data arrays, and displaying the rendered image. A chemical-analysis instrument includes a chromatography module, a mass-spectrometry module that receives an eluent from the chromatography module, a computer unit that receives data points from the chromatography and mass-spectrometry modules, and a monitor for displaying rendered images.
摘要翻译：一种方法包括在不损失信息的情况下压缩化学分析数据点，从存储的数据点生成嵌套数据阵列，将嵌套数据阵列存储在视频存储器中，从嵌套数据阵列渲染图像，并显示渲染图片。化学分析仪器包括色谱模块，从色谱模块接收洗脱液的质谱模块，从色谱和质谱模块接收数据点的计算机单元，以及显示渲染图像的监视器。

92. 发明申请

WO2006019376A8 A TUBE JOINT AND A METHOD OF BONDING TUBES 审中-公开
标题翻译：一个管接头和一个接合管的方法
公开(公告)号：WO2006019376A8
公开(公告)日：2006-06-29
申请号：PCT/US2004022927
申请日：2004-07-16
申请人： WATERS INVESTMENTS LTD , DOURDEVILLE THEODORE , DELLAROVERE DENNIS
发明人： DOURDEVILLE THEODORE , DELLAROVERE DENNIS
IPC分类号： B23B31/00
CPC分类号： F16L47/03 , B29C66/1142 , B29C66/5221 , F16L47/02
摘要： The invention is a method of bonding a first fluid conduit (14) to one or more other fluid conduits (12) or elements such as an electrode (92) or heating element. The method comprises positioning a first fluid conduit (14) substantially in contact with the other fluid conduits or elements (12) wherein a bond region (16) is created. The bond region is wetted with a liquefied thermoplastic polymer (34) which is then subsequently cooled forming a substantially fluid tight bond between the first fluid conduit (14) and the other fluid conduits or elements (14).
摘要翻译：本发明是一种将第一流体导管（14）结合到一个或多个其他流体导管（12）或诸如电极（92）或加热元件的元件的方法。该方法包括将第一流体导管（14）定位成基本上与形成结合区域（16）的其他流体导管或元件（12）接触。结合区域用液化热塑性聚合物（34）润湿，随后冷却，在第一流体导管（14）和其他流体导管或元件（14）之间形成基本上流体密封的结合。

93. 发明申请

WO2006024001A2 GASKET AND SEAL APPARATUS 审中-公开
标题翻译：垫圈和密封装置
公开(公告)号：WO2006024001A2
公开(公告)日：2006-03-02
申请号：PCT/US2005030199
申请日：2005-08-24
申请人： WATERS INVESTMENTS LTD , LUONGO JOSEPH A , MURPHY CHARLES , FRISWELL DAVID , MOELLER MARK , KIRBY PETER
发明人： LUONGO JOSEPH A , MURPHY CHARLES , FRISWELL DAVID , MOELLER MARK , KIRBY PETER
CPC分类号： F16L15/04 , F16K27/02 , Y10T137/0491
摘要： Embodiments of the present invention feature devices and methods for holding fluids at high pressures. One embodiment of the present invention features a fluid containing conveying device for receiving and discharging fluids. The device comprises a housing having a chamber for containing a fluid. The housing has a first gasket receiving surface for receiving a gasket. A gasket formed of a deformable material and having a first abutment surface and second abutment surface. The first abutment surface received on the first gasket receiving surface and the second abutment surface for receiving a chamber closing piece. The chamber closing piece having a second gasket receiving surface, the chamber closing piece for closing the chamber. At least one of the first gasket receiving surface of the housing and the second gasket receiving surface of the chamber closing piece having a retaining grove, having at least one edge. Compression means for compressing the gasket, deforming the material such that the gasket is pressed into retaining groove and gripped by the edge of the cavity to prevent gasket movement.
摘要翻译：本发明的实施例的特征在于在高压下保持流体的装置和方法。本发明的一个实施例的特征在于用于接收和排出流体的含流体输送装置。该装置包括具有用于容纳流体的室的壳体。壳体具有用于接收垫圈的第一垫片接收表面。由可变形材料形成并具有第一邻接表面和第二邻接表面的垫圈。接收在第一垫片接收表面上的第一邻接表面和用于接收室闭合件的第二邻接表面。所述腔室封闭件具有第二垫片接收表面，所述腔室封闭件用于封闭所述腔室。壳体的第一垫片接收表面和腔室封闭件的第二垫片接收表面中的至少一个具有保留槽，其具有至少一个边缘。用于压缩垫圈的压缩装置，使材料变形，使得垫圈被压入保持槽并被空腔的边缘夹持以防止垫圈移动。

94. 发明申请

WO2005084337A3 A SELF-SETTING HIGH PRESSURE FITTING 审中-公开
标题翻译：自设高压配件
公开(公告)号：WO2005084337A3
公开(公告)日：2006-01-12
申请号：PCT/US2005006755
申请日：2005-03-02
申请人： WATERS INVESTMENTS LTD , KEENE RUSSELL
发明人： KEENE RUSSELL
IPC分类号： F16L25/00 , F16L35/00
CPC分类号： F16L15/009 , G01N30/6026
摘要： A coupling element (1) comprising a male sealing element (5) is disclosed herein. The male sealing element comprises a first end (7), second end (9), and a longitudinal axis extending between the first and second end. The coupling element is housed within a nut (3). In one aspect, the male sealing element has a generally cylindrical shape. Also, the male sealing element defines a fluid passageway therethrough for the transmission of fluid. The male sealing element is secured to a ferrule (13) which is located within a cavity of the nut. The first end of the male sealing element defines a conical sealing surface. In one aspect, the male conical sealing surface (17) mates with a female sealing element (23) which has a receptacle that is defined by a nearly complementary conical geometry. In this aspect, the male conical sealing surface has a mismatched angle when compared to the complementary conical female sealing element. The coupling element also has a biasing element (19) disposed between a retaining ring and the ferrule located within the nut cavity. This biasing element facilitates a fluid-tight, metal to metal (or metal to plastic, or plastic to plastic) seal between the male sealing element and female sealing element.
摘要翻译：本文公开了包括阳密封元件（5）的联接元件（1）。阳密封元件包括第一端（7），第二端（9）和在第一端和第二端之间延伸的纵向轴线。联接元件容纳在螺母（3）内。在一个方面，阳密封元件具有大致圆柱形形状。此外，阳密封元件限定了通过其的流体通道用于流体的传输。阳密封元件固定到位于螺母的腔内的套圈（13）。阳密封元件的第一端限定锥形密封表面。在一个方面，阳锥形密封表面（17）与阴密封元件（23）配合，阴密封元件（23）具有由几乎互补的圆锥形几何形状限定的容座。在这个方面，与互补锥形阴密封元件相比，阳锥形密封表面具有不匹配的角度。联接元件还具有设置在保持环和位于螺母腔内的套圈之间的偏置元件（19）。该偏置元件有助于在阳密封元件和阴密封元件之间的流体密封的金属对金属（或金属对塑料或塑料到塑料）的密封。

95. 发明申请

WO2004092707A3 AROMATIC PHOSPHONIUM SALTS AND THEIR USE AS LABELING REAGENTS MASS SPECTROMETRY ANALYSIS 审中-公开
标题翻译：芳香族磷酸盐钠盐及其作为标签试剂的大分子量分析
公开(公告)号：WO2004092707A3
公开(公告)日：2006-01-05
申请号：PCT/US2004011426
申请日：2004-04-14
申请人： WATERS INVESTMENTS LTD , GEBLER JOHN C , LEE PETER J J , CHEN WEIBIN
发明人： GEBLER JOHN C , LEE PETER J J , CHEN WEIBIN
IPC分类号： C07F9/54 , G01N20060101 , G01N33/68 , G01N24/00 , G01N33/00
CPC分类号： G01N33/6848 , C07F9/5407 , C07F9/5442 , G01N33/6842 , G01N2458/15 , H01J49/164 , Y10T436/24
摘要： This invention relates to methods and reagents for the assay, detection, quantification, location, or analysis of each of a plurality of substances of interest ("analytes") in a sample in which each substance is labeled with a cationic triarylphosphonium group. The present invention also provides MALDI mass spectrometry techniques in which the analysis of samples containing low molecule weight analytes is not obscured by matrix components. The invention also provides labeling reagents for use in labeling analytes prior to MS analysis in which the labeled analytes have a molecular weight above the useful detection threshold of MALDI techniques. In some aspects, the invention provides methods of quantitative MS analysis of components of a sample. Methods of the present invention include sensitive techniques for desorption/ionization of molecules at the picomole, femtomole, and attomole amounts. Another benefit of the present invention is that measurement of m/Z values is not complicated by the low-mass interference that a matrix normally offers, and therefore the invention provides methods of MALDI MS analysis of low molecular weight samples as well as mixtures of high and low molecular weight samples.
摘要翻译：本发明涉及用于将每种物质用阳离子三芳基鏻基团标记的样品中的多种感兴趣物质（“分析物”）中的每一种的测定，检测，定量，定位或分析的方法和试剂。本发明还提供MALDI质谱技术，其中含有低分子量分析物的样品的分析不被基质组分遮蔽。本发明还提供用于在MS分析之前标记分析物的标记试剂，其中标记的分析物的分子量高于MALDI技术的有用检测阈值。在一些方面，本发明提供了样品组分的定量MS分析方法。本发明的方法包括在吡索莫斯，飞甲和阿托莫尔量下解吸/电离分子的敏感技术。本发明的另一个好处是，通过基质通常提供的低质量干扰，m / Z值的测量并不复杂，因此本发明提供了低分子量样品的MALDI MS分析方法以及高分子量混合物和低分子量样品。

96. 发明申请

WO2005079261A2 SYSTEM AND METHOD FOR TRACKING AND QUATITATING CHEMICAL ENTITES 审中-公开
标题翻译：跟踪和查询化学实验的系统和方法
公开(公告)号：WO2005079261A2
公开(公告)日：2005-09-01
申请号：PCT/US2005004176
申请日：2005-02-11
申请人： WATERS INVESTMENTS LTD , GORENSTEIN MARC V , LI GUO-ZHONG
发明人： GORENSTEIN MARC V , LI GUO-ZHONG
IPC分类号： G01N30/72 , G01N30/86
CPC分类号： G01N30/8665 , G01N30/7233 , G01N30/8679 , G01N30/8693 , H01J49/0036
摘要： In complex separations, more than one entity may have the same molecular weight, to within the ability of instrument to distinguish. Accurate mass measurements are used in light of the previously unknown regularities in retention time to determine a retention time map. The retention time map allows a reference retention time to be assigned to each entity in a separation. The reference retention times, together with accurate mass measurements, can then be used to track and to compare entities between separations.
摘要翻译：在复杂分离中，多于一个实体可能具有相同的分子量，在仪器区分的能力范围内。根据以前未知的保留时间的规律，使用精确的质量测量来确定保留时间图。保留时间图允许在分离中将参考保留时间分配给每个实体。参考保留时间以及准确的质量测量可以用于跟踪和比较分离之间的实体。

97. 发明申请

WO2004111607A3 WIDE RANGE DYNAMIC RHEOMETER 审中-公开
标题翻译：宽范围动态温度计
公开(公告)号：WO2004111607A3
公开(公告)日：2005-06-23
申请号：PCT/US2004017880
申请日：2004-06-09
申请人： WATERS INVESTMENTS LTD
发明人： GARRITANO RONALD F , BERTING JOHN P , MODE PAUL G
IPC分类号： G01N11/14 , G01N11/00
CPC分类号： G01N11/14 , G01N2011/0013 , G01N2011/002
摘要： A rheometer (10) includes a holder assembly (14) for coupling a test specimen (50) to a motor assembly (20) to effect rotational strain in the test specimen (50) while enabling the determination of axial displacement effected by the test specimen normal to the direction of the rotational strain, the holder assembly (14) having a first member (34) coupled to the test specimen (50), a second member (16) coupled to the motor assembly (20), and a suspension arrangement (14) coupling the first member (34) with the second member (16) for simultaneous maximum resistance to relative rotational displacement between the first and second members and minimum resistance to relative axial displacement between the first and second members. Information pertaining to the axial displacement, and to the temperature of the test specimen, is obtained through measuring circuits (128, 132) which include sensors (120, 150, 160) placed in moving component parts of the rheometer.
摘要翻译：流变仪（10）包括用于将测试样品（50）耦合到马达组件（20）以在试样（50）中实现旋转应变的保持器组件（14），同时能够确定试样的轴向位移与所述旋转应变的方向垂直，所述保持器组件（14）具有联接到所述测试样本（50）的第一构件（34），联接到所述马达组件（20）的第二构件（16）（14）将所述第一构件（34）与所述第二构件（16）联接以同时最大阻力抵抗所述第一构件和所述第二构件之间的相对旋转位移，并且对所述第一构件和所述第二构件之间的相对轴向位移具有最小阻力。通过测量电路（128,132）获得关于轴向位移和测试样本的温度的信息，该测量电路包括放置在流变仪的移动部件中的传感器（120,150,160）。

98. 发明申请

WO2004071615A3 POLYMERIC SOLID SUPPORTS FOR CHROMATOGRAPHY NANOCOLUMNS 审中-公开
标题翻译：用于色谱纳米微粒的聚合物固体载体
公开(公告)号：WO2004071615A3
公开(公告)日：2004-11-18
申请号：PCT/US2004003484
申请日：2004-02-06
申请人： WATERS INVESTMENTS LTD , GRANGER JENNIFER H , PLUMB ROBERT
发明人： GRANGER JENNIFER H , PLUMB ROBERT
IPC分类号： B01D20060101 , B01J19/00 , B01J20/28 , G01N30/60
CPC分类号： B01J19/0093 , B01J20/28026 , B01J20/28057 , B01J20/28069 , B01J20/28083 , B01J20/281 , B01J20/282 , B01J20/283 , B01J20/284 , B01J20/285 , B01J20/286 , B01J2220/54 , B01J2220/84 , G01N30/603 , G01N30/6095 , Y10T436/255
摘要： Nanocolumn chromatography devices useful, e.g., in CEC and nanoLC are disclosed. An exemplary chromatography device of the invention includes a nanocolumn, e.g., a capillary, packed with a particulate stationary phase material and a solid support. The solid support, or in situ frit, is adjacent to and integral with the stationary phase material. An in situ frit of the invention may be a mixture of the stationary phase material and a polymeric network of cross-linked poly(diorganosiloxane), e.g., poly(dimethylsiloxane), which may optionally be sintered. The invention also provides methods of making and using such devices.
摘要翻译：公开了可用于例如CEC和纳米LC的纳柱色谱装置。本发明的示例性色谱装置包括纳米柱，例如毛细管，填充有颗粒状固定相材料和固体支持物。固体载体或原位玻璃料与固定相材料相邻并与之成为一体。本发明的原位玻璃料可以是固定相材料和交联聚（二有机硅氧烷）（例如聚（二甲基硅氧烷））的聚合物网络的混合物，其可任选烧结。本发明还提供了制造和使用这种装置的方法。

99. 发明申请

WO2004025153A3 FREEZE-THAW VALVE LIMITING CRYOGENIC USAGE 审中-公开
标题翻译：冷冻阀限制冷冻使用
公开(公告)号：WO2004025153A3
公开(公告)日：2004-08-19
申请号：PCT/US0328910
申请日：2003-09-15
申请人： WATERS INVESTMENTS LTD , GERHARDT GEOFF C , DOURDEVILLE THEODORE
发明人： GERHARDT GEOFF C , DOURDEVILLE THEODORE
IPC分类号： G01N1/28 , F16K13/10 , F16K31/00 , G01N37/00 , F25D3/00 , F17D1/16
CPC分类号： F16K13/10 , F16K31/002 , Y10T137/0391 , Y10T137/2196 , Y10T137/4643 , Y10T137/6579
摘要： Methods and devices for the management of cryogenic agents within analytical systems using freeze thaw valving having an expansion chamber (101) that limits the flow of the cryogenic agent. The expansion chamber (101) is fitted with an expansion nozzle (106) through which a cryogen flows and a porous frit (105) that allows the cryogen to be exhausted. The porous frit (105) initially allows a rapid flow of cryogen into the expansion chamber (101) . This rapid flow lowers the temperature of the expansion chamber (101) causing fluid contents within a freeze thaw segment (103) to freeze. As the cryogen expands into the expansion chamber (101) and turns into a solid, the porous frit (105) is occluded causing the rapid flow to be restricted. The restriction of the cryogen flow by the occlusion of the porous frit (105) allows the freeze thaw valve to use significantly less cryogen. Sublimation of the cryogen trapped within the porous frit (105) provides sufficient cooling to maintain the valve in its closed position.
摘要翻译：使用具有限制低温剂流动的膨胀室（101）的冻融阀在分析系统内管理低温剂的方法和装置。膨胀室（101）配有膨胀喷嘴（106），冷却剂流过该喷嘴（106）和允许冷冻剂排出的多孔玻璃料（105）。多孔玻璃料（105）最初允许冷冻剂快速流入膨胀室（101）。这种快速流动降低了膨胀室（101）的温度，导致冻融段（103）内的液体内容物冻结。随着冷冻剂膨胀到膨胀室（101）并变成固体，多孔玻璃料（105）被封闭，导致快速流动受到限制。通过堵塞多孔玻璃料（105）对冷冻剂流的限制允许冻融阀使用明显较少的冷冻剂。捕集在多孔玻璃料（105）内的冷冻剂的升华提供足够的冷却以将阀保持在其关闭位置。

100. 发明申请

WO03044526A9 PARALLEL CONCENTRATION, DESALTING AND DEPOSITION ONTO MALDI TARGETS 审中-公开
标题翻译：对MALDI目标的平行浓缩，脱盐和沉积
公开(公告)号：WO03044526A9
公开(公告)日：2004-06-03
申请号：PCT/US0236950
申请日：2002-11-18
申请人： WATERS INVESTMENTS LTD , KAROL ROBERT , FINCH JEFFREY , WALL DANIEL
发明人： KAROL ROBERT , FINCH JEFFREY , WALL DANIEL
IPC分类号： G01N30/02 , G01N30/08 , G01N30/32 , G01N30/46 , G01N30/72 , G01N30/84 , G01N30/88 , H01J49/00 , H01J49/04 , H01J49/16 , G01N33/50
CPC分类号： G01N30/466 , G01N30/468 , G01N30/724 , G01N30/84 , G01N2030/027 , G01N2030/324 , G01N2030/8417 , H01J49/00 , H01J49/0418 , H01J49/165
摘要： A method and apparatus the parallel processing of samples comprising a first chromatography column (115) and a second chromatography column (117), ans a multi port switching valve (111) being in fluid communication to said first and second chromatography columns. A solvent delivery system, a sample injector (113), and a nebulizer all being in fluid communication with the said multi port switching valve. A programmable control module controlling said solvent delievry system, said sample injector, said multi port switching valve, and said nebulizer whereby multiple samples are parallel processed by said first and second chromatography columns and deposited onto MALDI targets in a retrievable pattern.
摘要翻译：包含第一色谱柱（115）和第二色谱柱（117）的样品的并行处理的方法和装置，以及与所述第一和第二色谱柱流体连通的多孔切换阀（111）。溶剂输送系统，样品注射器（113）和与所述多端口切换阀流体连通的喷雾器。控制所述溶剂脱蜡系统，所述样品注射器，所述多孔切换阀和所述雾化器的可编程控制模块，由此由所述第一和第二色谱柱并行处理多个样品并以可回收图案沉积到MALDI靶上。

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