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1. 发明申请

WO2010002819A1 STACKED-ELECTRODE PEPTIDE-FRAGMENTATION DEVICE 审中-公开
标题翻译：堆叠电极肽分解装置
公开(公告)号：WO2010002819A1
公开(公告)日：2010-01-07
申请号：PCT/US2009/049133
申请日：2009-06-30
申请人： WATERS TECHNOLOGIES CORPORATION , LI, Guo-Zhong , JARRELL, Joseph, A.
发明人： LI, Guo-Zhong , JARRELL, Joseph, A.
IPC分类号： H01J49/00
CPC分类号： H01J49/0072 , H01J49/065
摘要： A chemical processing apparatus includes a fragmentation device that includes a linear set of stacked electrodes and a voltage control module that forms DC potential wells of opposite polarity for mutual confinement of opposite polarity ions. A method of protein analysis includes confining positive peptide ions and negatively charged reagent anions in, respectively, first and second DC potential wells in a fragmentation device, mixing the ions, in the fragmentation device, and analyzing ion fragments formed in the mixture.
摘要翻译：一种化学处理设备包括一个包括线性堆叠电极组的分段装置和形成相反极性的直流电势阱的电压控制模块，用于相互限制相反极性的离子。蛋白质分析的方法包括将分离的分离装置中的第一和第二DC势阱中的正肽离子和带负电荷的试剂阴离子限制在裂解装置中，并分析混合物中形成的离子碎片。

2. 发明申请

WO2009146345A1 TECHNIQUES FOR PERFORMING RETENTION-TIME MATCHING OF PRECURSOR AND PRODUCT IONS AND FOR CONSTRUCTING PRECURSOR AND PRODUCT ION SPECTRA 审中-公开
标题翻译：用于执行前体和产品离子的保持时间匹配以及用于构建前体和产物离子光谱的技术
公开(公告)号：WO2009146345A1
公开(公告)日：2009-12-03
申请号：PCT/US2009/045373
申请日：2009-05-28
申请人： WATERS TECHNOLOGIES CORPORATION , GORENSTEIN, Marc, V. , STAPELS, Marths, Degen , GEROMANOS, Scott , GOLICK, Daniel , SILVA, Jeffrey, C. , LI, Guo-Zhong
发明人： GORENSTEIN, Marc, V. , STAPELS, Marths, Degen , GEROMANOS, Scott , GOLICK, Daniel , SILVA, Jeffrey, C. , LI, Guo-Zhong
IPC分类号： C12Q1/02
CPC分类号： H01J49/0045 , G01N30/7233 , G01N30/8675 , G06F19/703 , H01J49/0036
摘要： Techniques are described for matching a precursor ion with one or more related product ions, including providing a plurality of input data sets obtained from a plurality of injections, each of the plurality of input data sets including a same precursor ion and one or more product ions, normalizing the plurality of input data sets in accordance with a single retention time for the precursor ion, for each of the plurality of input data sets, determining which product ions are within a predetermined retention time window with respect to the single retention time for the precursor ion, and if a product ion is within the predetermined retention time window in at least one of the plurality of input data sets, determining that the product ion is related to the precursor ion having the single retention time
摘要翻译：描述了用于将前体离子与一个或多个相关产物离子匹配的技术，包括提供从多个注射获得的多个输入数据集，所述多个输入数据集中的每一个包括相同的前体离子和一个或多个产物离子对于多个输入数据集合中的每一个，根据用于前体离子的单个保留时间，对多个输入数据集进行归一化，确定哪个产品离子相对于单个保留时间在预定保留时间窗内前体离子，并且如果产物离子在多个输入数据集中的至少一个中的预定保留时间窗内，则确定产物离子与具有单个保留时间的前体离子相关

3. 发明申请

WO2007140327A2 ION DETECTION AND PARAMETER ESTIMATION FOR N-DIMENSIONAL DATA 审中-公开
标题翻译：用于N维数据的离子检测和参数估计
公开(公告)号：WO2007140327A2
公开(公告)日：2007-12-06
申请号：PCT/US2007069784
申请日：2007-05-25
申请人： WATERS INVESTMENTS LTD , GORENSTEIN MARC V , LI GUO-ZHONG
发明人： GORENSTEIN MARC V , LI GUO-ZHONG
IPC分类号： G06F19/00
CPC分类号： H01J49/26 , G06F19/703 , G06F19/707 , G06K9/00496 , G06K9/00523 , H01J49/0036 , H01J49/02
摘要： Methods and apparatus for LC/IMS/MS analysis involve obtaining noisy raw data from a sample, convolving the data with an artifact-reducing filter, and locating, in retention-time, ion mobility, and mass-to-charge-ratio dimensions, one or more ion peaks of the convolved data.
摘要翻译：用于LC / IMS / MS分析的方法和装置包括从样品中获取有噪声的原始数据，使用伪影减少滤波器卷积该数据，以及在保留时间内定位离子迁移率和质量对电荷比的尺寸，卷积数据的一个或多个离子峰。

4. 发明申请

WO2006133109A1 METHODS AND APPARATUS FOR FRACTIONATION-BASED CHEMICAL ANALYSES 审中-公开
标题翻译：用于基于分解的化学分析的方法和装置
公开(公告)号：WO2006133109A1
公开(公告)日：2006-12-14
申请号：PCT/US2006/021771
申请日：2006-06-05
申请人： WATERS INVESTMENTS LIMITED , GORENSTEIN, Marc, V. , GEROMANOS, Scott, J. , SILVA, Jeffrey, Cruz , LI, Guo-Zhong
发明人： GORENSTEIN, Marc, V. , GEROMANOS, Scott, J. , SILVA, Jeffrey, Cruz , LI, Guo-Zhong
IPC分类号： G01N33/00
CPC分类号： H01J49/04 , C12Q1/37 , G01N27/62 , G01N30/72 , G01N30/7233 , G01N30/8665 , G01N30/8675 , G01N30/8679 , G01N33/6848 , G01N2030/042 , G01N2030/067
摘要： A method (100) for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each includes potions of two polypeptides though in different concentration ratios, digesting and performing LC/MS on each of the sample portions (110, and associating precursor ions observed via LC/MS with their corresponding polypeptide in response to LC/MS provided intensity data (170). A set of precursor ions that has substantially similar intensity ratios in both sample portions is determined to be associated with the same polypeptide.
摘要翻译：用于分析化学品的方法（100）包括将复杂样品分馏成至少两个样品部分，每个样品部分各自包含不同浓度比的两种多肽，在每个样品部分（110和缔合前体）上消化并进行LC / MS 通过LC / MS与其对应的多肽响应于LC / MS观察到的离子提供强度数据（170）。确定两组样品部分中具有基本上相似的强度比的一组前体离子与相同的多肽相关。

5. 发明申请

WO2005114930A3 METHOD AND APPARATUS FOR IDENTIFYING PROTEINS IN MIXTURES 审中-公开
标题翻译：用于鉴定混合蛋白的方法和装置
公开(公告)号：WO2005114930A3
公开(公告)日：2006-03-23
申请号：PCT/US2005017742
申请日：2005-05-20
申请人： WATERS INVESTMENTS LTD , GEROMANOS SCOTT J , GORENSTEIN MARC VICTOR , SILVA JEFFREY CRUZ , LI GUO-ZHONG
发明人： GEROMANOS SCOTT J , GORENSTEIN MARC VICTOR , SILVA JEFFREY CRUZ , LI GUO-ZHONG
IPC分类号： G01N33/68 , H04L13/18 , H01J49/00
CPC分类号： G06F19/16 , G01N33/6848 , G01N2030/8831 , H01J49/0036 , H01J49/0431 , H01J49/426 , G01N30/7233
摘要： A system and method for mass analysis where a sample (102) is separated in a liquid chromatograph (104), and subsequently analyzed in a mass spectrometer (112).
摘要翻译：一种用于质量分析的系统和方法，其中样品（102）在液相色谱仪（104）中分离，随后在质谱仪（112）中进行分析。

6. 发明申请

WO2006132994A3 SYSTEM AND METHOD FOR ABSOLUTE QUANTITATION OF PROTEINS USING LC/MS 审中-公开
公开(公告)号：WO2006132994A3
公开(公告)日：2006-12-14
申请号：PCT/US2006/021517
申请日：2006-06-02
申请人： WATERS INVESTMENTS LIMITED , GEROMANOS, Scott , SILVA, Jeffrey, Cruz , VISSERS, Hans , LI, Guo-zhong
发明人： GEROMANOS, Scott , SILVA, Jeffrey, Cruz , VISSERS, Hans , LI, Guo-zhong
IPC分类号： G06F19/00
摘要： Absolute quantitation of protein in a saηiple is provided by comparing a sum or average of the N highest ionization intensities observed for peptides of a particular protein along with a calibration standard. The calibration standard can be in the form of a table generated by prior protein peptide analysis performed using one or more pre-determined proteins. The comparison is used to determine a corresponding absolute quantity of protein based on the observed sum or average of ionization intensities. A simple conversion factor can be applied to the calibration standard value to determine the absolute quantity of protein in the sample.

7. 发明申请

WO2005114930A2 METHOD AND APPARATUS FOR IDENTIFYING PROTEINS IN MIXTURES 审中-公开
标题翻译：用于鉴定混合蛋白的方法和装置
公开(公告)号：WO2005114930A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/017742
申请日：2005-05-20
申请人： WATERS INVESTMENT LIMITED , GEROMANOS, Scott, J. , GORENSTEIN, Marc, Victor , SILVA, Jeffrey, Cruz , LI, Guo-Zhong
发明人： GEROMANOS, Scott, J. , GORENSTEIN, Marc, Victor , SILVA, Jeffrey, Cruz , LI, Guo-Zhong
IPC分类号： H04L13/18
CPC分类号： G06F19/16 , G01N33/6848 , G01N2030/8831 , H01J49/0036 , H01J49/0431 , H01J49/426 , G01N30/7233
摘要： Protein identification in a complex sample begins by selecting a database having proteins likely to be in the sample. In-silico digestion is performed on the proteins in the database to produce peptides. A target peptide is selected from the produced peptides. The masses of the Y- and B-ion fragments of the target peptide are determined. Thus, a list of masses is assembled. This list contains the Y-ions, B-ions as well as the unique mass associated with the unfragmented precursor itself. These masses are used to search previously obtained low- and high-energy AMRTs obtained from LC/MS analysis of the complex sample for any and all of the masses on the list. Any mass observed in the data within a detection threshold are considered a hit. If enough hits accumulate in a given retention time, the target peptide is identified as being in the sample. Peptides in the data base can detect peptides in the sample provided there is sufficient sequence overlap. Because sequence identity is not required, modified peptides can be found in the sample. The list of peptides identified in the complex sample can be used to identify the proteins present in the sample, track the chromatographic retention times of peptides between samples, and quantitate the peptides and proteins present in complex samples.
摘要翻译：复杂样品中的蛋白质鉴定开始于选择具有可能在样品中的蛋白质的数据库。对数据库中的蛋白质进行计算机内消化以产生肽。靶肽选自产生的肽。确定靶肽的Y和B离子片段的质量。因此，组合了一个质量清单。该列表包含Y离子，B离子以及与未分解前体本身相关联的独特质量。这些质量用于搜索从列表中的任何和所有质量的复杂样本的LC / MS分析中获得的先前获得的低能量和高能量AMRT。在检测阈值内的数据中观察到的任何质量都被认为是命中。如果足够的命中在给定的保留时间内积累，则目标肽被鉴定为在样品中。数据库中的肽可以检测样品中的肽，只要有足够的序列重叠。因为不需要序列同一性，所以可以在样品中找到修饰的肽。在复杂样品中鉴定的肽列表可用于鉴定样品中存在的蛋白质，跟踪样品间肽的色谱保留时间，并定量复杂样品中存在的肽和蛋白质。

8. 发明申请

WO2011085287A1 APPARATUS AND METHODS FOR CONTROLLING THE COMPOSITION OF FLUIDS IN A FLUID STREAM 审中-公开
标题翻译：控制流体中流体组成的装置和方法
公开(公告)号：WO2011085287A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020633
申请日：2011-01-10
申请人： WATERS TECHNOLOGIES CORPORATION , LI, Guo-Zhong , JOUDREY, Kurt , RYSZARD, Feldman , HEDEN, John , JACKSON, Michael, R. , ANGELOSANTO, John
发明人： LI, Guo-Zhong , JOUDREY, Kurt , RYSZARD, Feldman , HEDEN, John , JACKSON, Michael, R. , ANGELOSANTO, John
IPC分类号： B29B7/00 , B29B7/76 , B67D5/60
CPC分类号： B01F15/0404 , B01D15/166 , G01N30/34 , G01N2030/347 , G05D11/138
摘要： Embodiments of the present invention are directed to a devices and methods for forming a desired mixture of two or more fluids in a conduit. The devices and methods feature control means having error monitoring means and in response to an error event the control means organizes the packet-group of command signals to form at least one first error packet group. The error event occurs during the period of time in which the at least one error packet-group is received by a selectable valve. The at least one error packet-group comprising an order or timing of first command signals and second command signals to minimize deviation from the desired mixture in the flow of mixture-packets forming the desired mixture of two or more fluids in a conduit during the error event.
摘要翻译：本发明的实施例涉及用于在导管中形成两种或多种流体的期望混合物的装置和方法。所述设备和方法具有控制装置，其具有错误监视装置，并且响应于错误事件，控制装置组织命令信号的分组组以形成至少一个第一错误分组组。错误事件发生在由可选择的阀接收至少一个错误分组组的时间段期间。所述至少一个错误分组组包括第一命令信号和第二命令信号的顺序或定时，以最小化在错误期间形成管道中的两个或更多个流体的期望混合物的混合物分组流中与期望混合物的偏差事件。

9. 发明申请

WO2007140327A3 ION DETECTION AND PARAMETER ESTIMATION FOR N-DIMENSIONAL DATA 审中-公开
公开(公告)号：WO2007140327A3
公开(公告)日：2007-12-06
申请号：PCT/US2007/069784
申请日：2007-05-25
申请人： WATERS INVESTMENTS LIMITED , GORENSTEIN, Marc, V. , LI, Guo-zhong
发明人： GORENSTEIN, Marc, V. , LI, Guo-zhong
IPC分类号： B01D59/44
摘要： Methods and apparatus for LC/IMS/MS analysis involve obtaining noisy raw data from a sample, convolving the data with an artifact-reducing filter, and locating, in retention-time, ion mobility, and mass-to-charge-ratio dimensions, one or more ion peaks of the convolved data.

10. 发明申请

WO2007140251A2 APPARATUS AND METHOD FOR PERFORMING MASS SPECTROSCOPY 审中-公开
标题翻译：用于执行质谱分析的装置和方法
公开(公告)号：WO2007140251A2
公开(公告)日：2007-12-06
申请号：PCT/US2007069657
申请日：2007-05-24
申请人： WATERS INVESTMENTS LTD , GEROMANOS SCOTT J , LI GUO-ZHONG , SILVA JEFFREY C , GORENSTEIN MARC V , VISSERS HANS
发明人： GEROMANOS SCOTT J , LI GUO-ZHONG , SILVA JEFFREY C , GORENSTEIN MARC V , VISSERS HANS
IPC分类号： G06F19/00
CPC分类号： G06F19/18 , H01J49/0036
摘要： Embodiments of the present invention are directed to apparatus and methods for performing mass spectrometry. Data pair information is subjected to an ion audit process in which data pair information that relates to scored compounds is subtracted from the data pair information. The depleted information more readily reveals data pair information for compounds present with smaller signals.
摘要翻译：本发明的实施例涉及用于进行质谱分析的装置和方法。对数据对信息进行离散审核处理，其中从数据对信息中减去与刻痕化合物相关的数据对信息。耗尽的信息更容易地显示出具有较小信号的化合物的数据对信息。

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