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91. 发明申请

US20110079289A1 MICROVALVE HAVING MAGNETIC WAX PLUG AND FLUX CONTROL METHOD USING MAGNETIC WAX 有权
标题翻译：具有磁性波纹管的微型光栅和使用磁性WAX的通量控制方法
公开(公告)号：US20110079289A1
公开(公告)日：2011-04-07
申请号：US12968752
申请日：2010-12-15
申请人： Kwang-wook OH , Kak NAMKOONG , Chin-sung PARK
发明人： Kwang-wook OH , Kak NAMKOONG , Chin-sung PARK
IPC分类号： F15D1/00
CPC分类号： F15C5/00 , F16K99/0001 , F16K99/0032 , F16K99/0044 , F16K99/0046 , F16K2099/0084 , F16K2099/0086 , F16K2099/0092 , Y10T137/0391 , Y10T137/2191 , Y10T137/2196 , Y10T137/2224 , Y10T137/4643
摘要： Provided is a microvalve having a magnetic wax plug which includes a micro fluidic structure having an inlet portion and an outlet portion, a magnetic wax plug provided at a predetermined section where the inlet portion and the outlet portion meet, existing in a solid state, melted at a temperature higher than a predetermined temperature, and reversibly moving along a magnetic field, so as to control flux of a fluid through the micro fluidic structure, a heating portion provided corresponding to the section and heating the magnetic wax plug to be melted, and a magnetic field application portion selectively applying a magnetic field to a position where the melted magnetic wax plug arrives.
摘要翻译：提供一种具有磁性蜡塞的微型阀，其包括具有入口部分和出口部分的微流体结构，设置在入口部分和出口部分相遇的预定部分处的固体状态的熔融蜡在高于预定温度的温度下，并且沿着磁场可逆地移动，以便控制通过微流体结构的流体的通量;对应于该部分设置的加热部分，并加热待熔化的磁性蜡塞;以及选择性地将磁场施加到熔融的磁性蜡塞到达的位置的磁场施加部。

92. 发明申请

US20110077388A1 METHOD AND APPARATUS FOR ISOLATING NUCLEIC ACIDS 有权
标题翻译：用于分离核酸的方法和装置
公开(公告)号：US20110077388A1
公开(公告)日：2011-03-31
申请号：US12852824
申请日：2010-08-09
申请人： Kyu-youn HWANG , Joon-ho KIM , Kak NAMKOONG
发明人： Kyu-youn HWANG , Joon-ho KIM , Kak NAMKOONG
IPC分类号： C07H1/06 , B01D15/26
CPC分类号： C12N15/1006 , B01D15/3866
摘要： A method and apparatus for efficiently isolating nucleic acids from a nucleic acid-containing sample.
摘要翻译：一种用于从含核酸样品有效分离核酸的方法和装置。

93. 发明授权

US07915013B2 Method and apparatus for amplifying nucleic acids 有权
标题翻译：扩增核酸的方法和装置
公开(公告)号：US07915013B2
公开(公告)日：2011-03-29
申请号：US12504213
申请日：2009-07-16
申请人： Yoon-kyoung Cho , Joon-ho Kim , Kak Namkoong , Geun-bae Lim , Jun-hong Min
发明人： Yoon-kyoung Cho , Joon-ho Kim , Kak Namkoong , Geun-bae Lim , Jun-hong Min
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： G01N35/08 , B01F5/0646 , B01F5/0647 , B01F5/0654 , B01F13/0071 , B01F2015/0221 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0086 , B01J2219/00873 , B01J2219/00891 , B01L3/5027 , B01L3/502715 , B01L2300/0809 , B01L2300/0861 , B01L2300/0883 , G01N2035/00366 , G01N2035/00514
摘要： An apparatus for amplifying nucleic acids. The apparatus includes a substrate, a reaction vessel formed inside of the substrate, at least one first inlet channel formed inside the substrate, connected to an end of the reaction vessel, and allowing introduction of a reactant aqueous solution containing reactants for nucleic acid amplification into the reaction vessel, a second inlet channel formed inside the substrate, connected to the end of the reaction vessel, and allowing introduction of a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction into the reaction vessel, and a heating unit installed on the substrate in such a way to thermally contact with the substrate and heating the substrate.
摘要翻译：扩增核酸的装置。该装置包括基板，形成在基板内部的反应容器，形成在基板内部的至少一个第一入口通道，与反应容器的端部连接，并且允许将含有用于核酸扩增的反应物的反应物水溶液引入到反应容器，形成在基板内部的第二入口通道，连接到反应容器的端部，并且允许引入与反应物水溶液相分离并且不参与扩增反应的流体进入反应容器，以及加热单元，其以与基板热接触并加热基板的方式安装在基板上。

94. 发明授权

US07790109B2 Micro-fluid reaction vessel, method for manufacturing the same, and micro-fluid reaction method using the vessel 有权
标题翻译：微流体反应容器，其制造方法和使用该容器的微流体反应方法
公开(公告)号：US07790109B2
公开(公告)日：2010-09-07
申请号：US11625877
申请日：2007-01-23
申请人： Su-hyeon Kim , Jin-tae Kim , Kak Namkoong , In-ho Lee , Chin-sung Park , Young-sun Lee
发明人： Su-hyeon Kim , Jin-tae Kim , Kak Namkoong , In-ho Lee , Chin-sung Park , Young-sun Lee
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , B01J10/00 , B01J10/02 , B01J12/00 , B01J12/02 , F15C1/04 , F15C3/00 , F15C1/06
CPC分类号： B01L3/502738 , B01L7/52 , B01L2200/0689 , B01L2300/0816 , B01L2300/0825 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , B29C33/3857 , B29C33/60 , Y10T137/218 , Y10T137/2202 , Y10T137/2224
摘要： A micro-fluid reaction vessel includes an upper plate formed of an elastomer, a lower plate adhered to the upper plate, a micro-chamber and a micro-channel formed on an inner surface of the upper plate facing the lower plate and an inlet hole and an outlet hole formed in the upper plate and through which a fluid flows into or out of, respectively. The micro-channel is constructed to be closed by pressure applied to the upper plate and elastically restored when the pressure is not applied. A micro fluid reaction method uses the micro fluid reaction vessel and a method of manufacturing forms the microfluid reaction vessel.
摘要翻译：微流体反应容器包括由弹性体形成的上板，粘附到上板的下板，形成在面向下板的上板的内表面上的微室和微通道，以及入口孔以及形成在上板中并且流体分别流入或流出的出口孔。微通道被构造为通过施加到上板的压力而关闭，并且当不施加压力时弹性恢复。微流体反应方法使用微流体反应容器和制造方法形成微流体反应容器。

95. 发明申请

US20100221728A1 METHOD FOR QUANTIFYING INITIAL CONCENTRATION OF NUCLEIC ACID FROM REAL-TIME NUCLEIC ACID AMPLIFICATION DATA 有权
标题翻译：从实时核酸扩增数据定量核酸的初步浓度的方法
公开(公告)号：US20100221728A1
公开(公告)日：2010-09-02
申请号：US12709774
申请日：2010-02-22
申请人： Kak Namkoong , Jin-tae Kim , Young-sun Lee , Young-a Kim
发明人： Kak Namkoong , Jin-tae Kim , Young-sun Lee , Young-a Kim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851
摘要： Provided is a method for quantifying an initial concentration of a nucleic acid from a real-time nucleic acid amplification data. Nucleic acid (DNA or RNA) extracted from organism or virus is amplified using an enzyme. Then, the initial concentration of the nucleic acid is found by calculating the characteristic amplification cycle number or the characteristic amplification time at which the fluorescence intensity of the nucleic acid subtracted by the background fluorescence intensity of the nucleic acid has half of its maximum value, or the characteristic amplification cycle number or the characteristic amplification time at which the amplification efficiency has the maximum or the minimum value, or the prior-to-amplification fluorescence intensity of the nucleic acid subtracted by the background fluorescence intensity of the nucleic acid. Accordingly, the initial concentration of the nucleic acid can be calculated without differentiation or integration.
摘要翻译：提供了从实时核酸扩增数据定量核酸的初始浓度的方法。使用酶扩增从生物或病毒提取的核酸（DNA或RNA）。然后，通过计算由核酸的背景荧光强度减去的核酸的荧光强度具有其最大值的一半的特征扩增循环数或特异性扩增时间来发现核酸的初始浓度，或扩增效率具有由核酸的背景荧光强度减去的核酸的最大值或最小值或以前的扩增荧光强度的特征扩增循环数或特征扩增时间。因此，可以在不分化或整合的情况下计算核酸的初始浓度。

96. 发明申请

US20100186839A1 MICROFLUIDIC VALVE UNIT FOR CONTROLLING FLOW OF FLUID AND METHOD OF FABRICATING THE SAME 有权
标题翻译：用于控制流体流动的微流控阀单元及其制造方法
公开(公告)号：US20100186839A1
公开(公告)日：2010-07-29
申请号：US12555173
申请日：2009-09-08
申请人： Kak NAMKOONG , Won-seok CHUNG , Joon-ho KIM , Kyu-youn HWANG , Hee-kyun LIM
发明人： Kak NAMKOONG , Won-seok CHUNG , Joon-ho KIM , Kyu-youn HWANG , Hee-kyun LIM
IPC分类号： F15C1/04
CPC分类号： F16K99/0001 , B01L3/502707 , B01L3/502738 , B01L2400/0406 , B01L2400/0677 , F16K99/0032 , F16K99/004 , F16K2099/008 , F16K2099/0084 , Y10T29/49405 , Y10T137/218 , Y10T137/2196 , Y10T137/2202
摘要： A microfluidic valve unit for controlling the flow of fluid flowing along a channel, and a method of fabricating the same are provided. The valve unit includes a channel formed in a platform; a valve filler which includes a phase transition material that is disposed in the channel in a solid state at room temperature to close the channel and is melted when energy is applied thereto; and at least one capillary channel which extends from a sidewall of the channel and into which the valve filler flows when the valve filler is melted, wherein the at least one capillary channel has a cross-sectional area which is less than a cross-sectional area of the channel.
摘要翻译：提供一种用于控制沿着通道流动的流体的流动的微流体阀单元及其制造方法。阀单元包括形成在平台中的通道; 阀填料，其包括相变过渡材料，所述相变材料在室温下以固态设置在通道中以封闭通道，并且当施加能量时熔化; 以及至少一个毛细通道，其从所述通道的侧壁延伸并且当所述阀填充物熔化时阀填充物流动到所述毛细通道中，其中所述至少一个毛细通道的横截面积小于横截面积的频道。

97. 发明申请

US20100130732A1 SYSTEM AND METHOD FOR PROCESSING TARGET MATERIAL 有权
标题翻译：用于处理目标材料的系统和方法
公开(公告)号：US20100130732A1
公开(公告)日：2010-05-27
申请号：US12415262
申请日：2009-03-31
申请人： Won Seok CHUNG , Kak NAMKOONG , JOONHO KIM , KYUYOUN HWANG , HEEKYUN LIM
发明人： Won Seok CHUNG , Kak NAMKOONG , JOONHO KIM , KYUYOUN HWANG , HEEKYUN LIM
IPC分类号： C07H21/00 , G05B21/00
CPC分类号： G01N33/53 , B01L3/502738 , B01L7/00 , B01L7/52 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1822 , B01L2300/1827 , B01L2400/0409 , B01L2400/0677 , G01N21/07 , G01N33/48 , G01N35/00029 , G01N2035/00099 , G01N2035/00148 , G01N2035/00158 , G01N2035/00495 , Y10T436/111666
摘要： A system for processing a target material includes; a cartridge which stores a material which reacts with the target material, and may include at least one chamber and at least one valve connected to the at least one chamber, a first module which may be loaded with the at least one cartridge and may rotate, a second module which may selectively open or close the at least one valve, a third module which may selectively control the temperature of the at least one chamber, and a control module which may control the first module, the second module and the third module.
摘要翻译：一种处理目标材料的系统包括：存储与所述目标材料反应的材料的盒，并且可以包括至少一个室和连接到所述至少一个室的至少一个阀;第一模块，其可装载有所述至少一个筒并且可以旋转，可以选择性地打开或关闭所述至少一个阀的第二模块，可选择性地控制所述至少一个室的温度的第三模块，以及可以控制所述第一模块，所述第二模块和所述第三模块的控制模块。

98. 发明申请

US20100021972A1 METHOD AND APPARATUS FOR AMPLIFYING NUCLEIC ACIDS 有权
标题翻译：用于放大核酸的方法和装置
公开(公告)号：US20100021972A1
公开(公告)日：2010-01-28
申请号：US12504271
申请日：2009-07-16
申请人： Yoon-kyoung Cho , Joon-ho Kim , Kak Namkoong , Geun-bae Lim , Jun-hong Min
发明人： Yoon-kyoung Cho , Joon-ho Kim , Kak Namkoong , Geun-bae Lim , Jun-hong Min
IPC分类号： C12P19/34
CPC分类号： G01N35/08 , B01F5/0646 , B01F5/0647 , B01F5/0654 , B01F13/0071 , B01F2015/0221 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0086 , B01J2219/00873 , B01J2219/00891 , B01L3/5027 , B01L3/502715 , B01L2300/0809 , B01L2300/0861 , B01L2300/0883 , G01N2035/00366 , G01N2035/00514
摘要： A method and apparatus for amplifying nucleic acids. The method includes introducing into a reaction vessel via different inlet channels a reactant aqueous solution containing reactants for nucleic acid amplification and a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction, creating a plurality of reactant aqueous solution droplets surrounded by the fluid by contacting the reactant aqueous solution with the fluid in the reaction vessel, and amplifying the nucleic acids in the reactant aqueous solution droplets. The apparatus includes a substrate, a reaction vessel formed inside of the substrate, at least one first inlet channel formed inside the substrate, connected to an end of the reaction vessel, and allowing introduction of a reactant aqueous solution containing reactants for nucleic acid amplification into the reaction vessel, a second inlet channel formed inside the substrate, connected to the end of the reaction vessel, and allowing introduction of a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction into the reaction vessel, and a heating unit installed on the substrate in such a way to thermally contact with the substrate and heating the substrate.
摘要翻译：用于扩增核酸的方法和装置。该方法包括通过不同的入口通道将含有用于核酸扩增的反应物的反应物水溶液和与反应物水溶液相分离并且不参与扩增反应的流体引入反应容器，形成多个反应物水溶液通过使反应物水溶液与反应容器中的流体接触，并且扩增反应物水溶液液滴中的核酸，由流体包围的液滴。该装置包括基板，形成在基板内部的反应容器，形成在基板内部的至少一个第一入口通道，与反应容器的端部连接，并且允许将含有用于核酸扩增的反应物的反应物水溶液引入到反应容器，形成在基板内部的第二入口通道，连接到反应容器的端部，并且允许引入与反应物水溶液相分离并且不参与扩增反应的流体进入反应容器，以及加热单元，其以与基板热接触并加热基板的方式安装在基板上。

99. 发明授权

US07579151B2 Isolation and purification method of biomolecules using hydrogel 有权
标题翻译：使用水凝胶分离和纯化生物分子的方法
公开(公告)号：US07579151B2
公开(公告)日：2009-08-25
申请号：US11191221
申请日：2005-07-27
申请人： Young-sun Lee , Jung-im Han , Hyo-yeon Lee , Kak Namkoong , Kwang-wook Oh
发明人： Young-sun Lee , Jung-im Han , Hyo-yeon Lee , Kak Namkoong , Kwang-wook Oh
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12N15/1006
摘要： Provided is a method of isolating and purifying biomolecules using a hydrogel, the method including: bring a sample containing charged biomolecules into contact with a hydrogel to bind the biomolecules to the hydrogel; washing the hydrogel bound with the biomolecules; and eluting the bound biomolecules using an elution solvent. According to the method, the use of a hydrogel with a large surface area reduces the isolation time of biomolecules to 5 min or less, an external device such as an electromagnet is not required, and small-sized systems or LOC can be easily implemented due to applicability to microsystems through a polymer patterning technique.
摘要翻译：提供了使用水凝胶分离和纯化生物分子的方法，该方法包括：使含有带电生物分子的样品与水凝胶接触以将生物分子结合至水凝胶; 洗涤与生物分子结合的水凝胶; 并使用洗脱溶剂洗脱结合的生物分子。根据该方法，使用具有大表面积的水凝胶将生物分子的隔离时间减少到5分钟以下，不需要诸如电磁体的外部装置，并且可以容易地实现小尺寸系统或LOC 通过聚合物图案化技术适用于微系统。

100. 发明申请

US20090071542A1 MICROVALVE HAVING MAGNETIC WAX PLUG AND FLUX CONTROL METHOD USING MAGNETIC WAX 有权
标题翻译：具有磁性波纹管的微型光栅和使用磁性WAX的通量控制方法
公开(公告)号：US20090071542A1
公开(公告)日：2009-03-19
申请号：US12277780
申请日：2008-11-25
申请人： Kwang-wook OH , Kak NAMKOONG , Chin-sung PARK
发明人： Kwang-wook OH , Kak NAMKOONG , Chin-sung PARK
IPC分类号： F17D1/16
CPC分类号： F15C5/00 , F16K99/0001 , F16K99/0032 , F16K99/0044 , F16K99/0046 , F16K2099/0084 , F16K2099/0086 , F16K2099/0092 , Y10T137/0391 , Y10T137/2191 , Y10T137/2196 , Y10T137/2224 , Y10T137/4643
摘要： Provided is a microvalve having a magnetic wax plug which includes a micro fluidic structure having an inlet portion and an outlet portion, a magnetic wax plug provided at a predetermined section where the inlet portion and the outlet portion meet, existing in a solid state, melted at a temperature higher than a predetermined temperature, and reversibly moving along a magnetic field, so as to control flux of a fluid through the micro fluidic structure, a heating portion provided corresponding to the section and heating the magnetic wax plug to be melted, and a magnetic field application portion selectively applying a magnetic field to a position where the melted magnetic wax plug arrives.
摘要翻译：提供一种具有磁性蜡塞的微型阀，其包括具有入口部分和出口部分的微流体结构，设置在入口部分和出口部分相遇的预定部分处的固体状态的熔融蜡在高于预定温度的温度下，并且沿着磁场可逆地移动，以便控制通过微流体结构的流体的通量;对应于该部分设置的加热部分，并加热待熔化的磁性蜡塞;以及选择性地将磁场施加到熔融的磁性蜡塞到达的位置的磁场施加部。

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