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91. 发明申请

US20110002956A1 MUTANT HUMAN CD80 AND COMPOSITIONS FOR AND METHODS OF MAKING AND USING THE SAME 有权
标题翻译：突变人CD80及其组合物及其制备和使用方法
公开(公告)号：US20110002956A1
公开(公告)日：2011-01-06
申请号：US12211029
申请日：2008-11-10
申请人： David B. Weiner , Michael G. Agadjanyan , Rafick P. Sekaly , Mark Holterman
发明人： David B. Weiner , Michael G. Agadjanyan , Rafick P. Sekaly , Mark Holterman
IPC分类号： A61K39/12 , C07H21/04 , A61K38/02 , C07K14/705 , A61P31/12 , A61P37/06
CPC分类号： C07K14/70532 , A61K39/00
摘要： Improved vaccines and methods of using the same are disclosed Immunosuppressive compositions for treating individuals who have autoimmune diseases or transplants and methods of using the same are disclosed.
摘要翻译：公开了改进的疫苗和使用该疫苗的方法。公开了用于治疗患有自身免疫性疾病或移植物的个体的免疫抑制组合物及其使用方法。

92. 发明授权

US07598041B2 HIV-1 VPR interactions with mitochondrial apoptosis inducing factor and methods of using the same 失效
标题翻译： HIV-1 VPR与线粒体凋亡诱导因子的相互作用及其使用方法
公开(公告)号：US07598041B2
公开(公告)日：2009-10-06
申请号：US10478742
申请日：2002-05-28
申请人： David B. Weiner , Karuppiah Muthumani
发明人： David B. Weiner , Karuppiah Muthumani
IPC分类号： G01N33/53 , G01N33/567 , A61K38/00 , C12P21/08 , A61K49/00
CPC分类号： G01N33/56988 , G01N2333/163 , G01N2500/02
摘要： Assays to identify Vpr/AIF interaction and translocation inhibitors are disclosed.
摘要翻译：公开了鉴定Vpr / AIF相互作用和易位抑制剂的试验。

93. 发明申请

US20090104230A1 COMPOSITIONS AND METHODS OF USING CAPSID PROTEIN FROM FLAVIVIRUSES AND PESTIVIRUSES 审中-公开
标题翻译：使用蚜虫蛋白质和杀虫剂的组合物和方法
公开(公告)号：US20090104230A1
公开(公告)日：2009-04-23
申请号：US11972421
申请日：2008-01-10
申请人： David B. Weiner , Karuppiah Muthumani , Joo-Sung Yang
发明人： David B. Weiner , Karuppiah Muthumani , Joo-Sung Yang
IPC分类号： A61K39/00 , C12N5/06 , C12Q1/70 , A61K38/16 , A61K31/7088
CPC分类号： A61K38/162 , A61K48/00 , A61K2039/53 , C07K14/005 , C07K2319/02 , C12N2740/16222 , C12N2770/24122 , C12N2770/24322 , G01N33/56983 , G01N2469/20 , Y02A50/39 , Y02A50/394
摘要： This invention provides methods of inducing cell death with Flavivirus or Pestivirus capsid protein, such as West Nile virus (WNV) capsid protein, and functional fragments thereof. The invention also provides methods of treating patients suffering from diseases characterized by hyperproliferating cells by administering pharmaceutical compositions comprising WNV or other virus including Flavivirus or Pestivirus capsid or other protein or a nucleic acid molecule encoding the same. Methods of identifying compounds which have anti-viral and/or anti-WNV and/or anti-Flavivirus and/or anti-Pestivirus capsid or other protein activity are disclosed. The invention also provides vaccine compositions comprising capsid or other proteins, or fragments thereof, or nucleic acids encoding same, from WNV or other virus including Flavivirus or Pestivirus and a pharmaceutically acceptable carrier. The invention also provides diagnostic methods and kits for identifying individuals exposed to WNV or other viruses including Flavivirus or Pestivirus.
摘要翻译：本发明提供了用黄病毒或瘟病毒衣壳蛋白（例如西尼罗河病毒（WNV）衣壳蛋白）及其功能片段诱导细胞死亡的方法。本发明还提供了通过施用包含WNV或其它病毒（包括黄病毒或瘟病毒衣壳或其他蛋白质）的药物组合物或其编码的核酸分子来治疗患有特征在于过度增殖细胞的疾病的患者的方法。公开了鉴定具有抗病毒和/或抗WNV和/或抗黄病毒和/或抗瘟病毒衣壳或其它蛋白质活性的化合物的方法。本发明还提供包含衣壳或其它蛋白质或其片段，或编码其的核酸的疫苗组合物，来自WNV或其它病毒，包括黄病毒或瘟病毒和药学上可接受的载体。本发明还提供用于鉴定暴露于WNV或其它病毒（包括黄病毒或瘟病毒）的个体的诊断方法和试剂盒。

94. 发明授权

US07151172B1 Attenuated vif DNA immunization cassettes for genetic vaccines 有权
标题翻译：用于遗传疫苗的减毒vif DNA免疫盒
公开(公告)号：US07151172B1
公开(公告)日：2006-12-19
申请号：US09486625
申请日：1998-09-18
申请人： Velpandi Ayyavoo , Thanadavarayan Nagashunmugam , David B. Weiner
发明人： Velpandi Ayyavoo , Thanadavarayan Nagashunmugam , David B. Weiner
IPC分类号： C07H21/04 , C07K1/00 , C12N15/00 , C12N5/10 , C12P21/06 , A61K31/70
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K2317/00 , C12N2710/24143 , C12N2740/16322 , Y10S530/826
摘要： The present invention is directed to nucleic acid molecules encoding attenuated, non-functional virion infectivity factor (vif) proteins. The nucleic acid molecules of the invention are inserted into recombinant expression vectors and administered to mammals in order to induce a cellular and humoral immune response to the encoded protein product.
摘要翻译：本发明涉及编码减毒，非功能性病毒粒子感染因子（vif）蛋白的核酸分子。将本发明的核酸分子插入到重组表达载体中并施用于哺乳动物，以诱导编码的蛋白质产物的细胞和体液免疫应答。

95. 发明授权

US07001759B1 Compositions and methods for delivery of genetic material 有权
标题翻译：用于遗传物质传递的组合物和方法
公开(公告)号：US07001759B1
公开(公告)日：2006-02-21
申请号：US09359975
申请日：1999-07-23
申请人： David B. Weiner , William V. Williams , Bin Wang
发明人： David B. Weiner , William V. Williams , Bin Wang
IPC分类号： A61K31/167 , C12N15/63 , C12N15/87 , C07H21/04
CPC分类号： A61K39/21 , A61K39/00 , A61K39/0011 , A61K39/0225 , A61K39/12 , A61K39/29 , A61K39/292 , A61K2039/53 , A61K2039/55516 , C12N15/63 , C12N2730/10134 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , C12N2760/20134 , C12N2770/24234 , Y02A50/464 , Y02A90/26 , Y10S514/818
摘要： Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional, or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against pathogens are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
摘要翻译：公开了将遗传物质引入个体细胞的方法和用于实施其的组合物和试剂盒。所述方法包括使个体的细胞与多核苷酸功能增强子接触并向细胞施用不含逆转录病毒颗粒的核酸分子的步骤。核酸分子包含编码蛋白质的核苷酸序列，该蛋白质包含与病原体抗原或与过度增殖或自身免疫疾病相关的抗原的表位相同或基本相似的至少一个表位，涉及一种缺失的，非功能的或部分功能的基因或对个体产生治疗作用的蛋白质。公开了预防和治疗个体免受病原体的方法。公开了用于本发明的实践方法的药物组合物和试剂盒。

96. 发明授权

US06818627B1 Functional fragments of HIV-1 Vpr protein and methods of using the same 失效
标题翻译： HIV-1 Vpr蛋白的功能片段及其使用方法
公开(公告)号：US06818627B1
公开(公告)日：2004-11-16
申请号：US09485421
申请日：2000-10-05
申请人： Sundarasamy Mahalingam , Velpandi Ayyavoo , Mamata Patel , Thomas Kieber-Emmons , David B. Weiner
发明人： Sundarasamy Mahalingam , Velpandi Ayyavoo , Mamata Patel , Thomas Kieber-Emmons , David B. Weiner
IPC分类号： A61K4800
CPC分类号： C07K14/005 , A61K47/64 , A61K47/6901 , A61K48/00 , A61K2039/53 , C12N2740/16322 , G01N33/56988 , G01N2500/00
摘要： Conjugated compositions comprising a fragment of HIV-1 Vpr or a non-HIV-1 Vpr protein conjugated to a therapeutic compound and methods of using the same to deliver therapeutic compounds to a cell's nucleus or for the preparation of drug delivery particles are disclosed. Functional fragments of HIV-1 Vpr and functional non-HIV-1 Vpr proteins, and pharmaceutical compositions comprising the same are disclosed. Methods of inhibiting cell proliferation and methods of treating an individual who has a hyperproliferative disease are disclosed. Methods of identifying compounds that inhibit Vpr protein binding to the p6 domain of p55 or to p6 protein and kits for performing such methods are disclosed.
摘要翻译：公开了包含与治疗性化合物缀合的HIV-1Vpr片段或非HIV-1Vpr蛋白的片段的共轭组合物及其使用方法将治疗性化合物递送至细胞核或用于制备药物递送颗粒。公开了HIV-1Vpr和功能性非HIV-1 Vpr蛋白的功能片段和包含其的药物组合物。公开了抑制细胞增殖的方法和治疗具有过度增殖性疾病的个体的方法。公开了鉴定抑制Vpr蛋白与p55或p6蛋白的p6结构域结合的化合物的方法和用于进行这些方法的试剂盒。

97. 发明授权

US06468982B1 Genetic immunization 失效
标题翻译：遗传免疫
公开(公告)号：US06468982B1
公开(公告)日：2002-10-22
申请号：US08880576
申请日：1997-06-23
申请人： David B. Weiner , William V. Williams , Bin Wang
发明人： David B. Weiner , William V. Williams , Bin Wang
IPC分类号： A61K4800
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N15/87 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , Y02A50/464 , Y02A90/26 , Y10S435/975 , Y10S514/818
摘要： Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being, expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
摘要翻译：公开了个体对病原体感染的预防和治疗免疫的方法，与过度增殖细胞和自身免疫疾病相关的疾病。所述方法包括对个体的细胞施用包含编码蛋白质的核苷酸序列的核酸分子的步骤，所述核苷酸序列包含与病原体抗原的表位相同或基本上相似的至少一个表位，相关的过度增殖细胞蛋白质或与自身免疫疾病相关的蛋白质。在每种情况下，核苷酸序列可操作地连接到调节序列以使得能够在细胞中表达。核酸分子不含病毒颗粒，能够在所述细胞中表达。细胞可以与细胞刺激剂接触细胞。公开了预防和治疗个体免受HIV感染的方法。公开了用于本发明的实践方法的药物组合物和试剂盒。

98. 发明授权

US5837460A Methods of identifying biologically active receptor-binding peptides 失效
标题翻译：识别生物活性受体结合肽的方法
公开(公告)号：US5837460A
公开(公告)日：1998-11-17
申请号：US712212
申请日：1996-09-03
申请人： Joan M. Von Feldt , Thomas Kieber-Emmons , David B. Weiner , William V. Williams
发明人： Joan M. Von Feldt , Thomas Kieber-Emmons , David B. Weiner , William V. Williams
IPC分类号： C07K14/53 , C07K14/535 , C07K14/54 , C07K14/55 , C07K14/61 , C07K16/06 , C07K16/24 , G01N33/68 , G01N33/74 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/74 , C07K14/53 , C07K14/535 , C07K14/5403 , C07K14/5409 , C07K14/55 , C07K14/61 , C07K16/065 , C07K16/243 , G01N33/68 , G01N33/6863 , G01N33/6869 , C07K2317/34 , C07K2317/73 , G01N2333/535 , G01N2500/00 , Y10S435/965
摘要： A method of identifying peptides which mimic biologically active proteins is disclosed. The method comprises the steps of making a recombinant antibody library from genetic material obtained from an animal which has been immunized against antibodies that bind to the biological active protein to the mimicked. Recombinant antibodies are screened to identify antibodies which compete with the biological active protein. Peptides which comprise the recombinant antibody's CDR sequences are synthesized. Synthetic peptides which mimic GM-CSF are also disclosed.
摘要翻译：公开了鉴定模拟生物活性蛋白质的肽的方法。该方法包括以下步骤：从已经针对结合生物活性蛋白的抗体免疫的动物获得的遗传物质制备重组抗体文库。筛选重组抗体以鉴定与生物活性蛋白竞争的抗体。合成包含重组抗体的CDR序列的肽。还公开了模拟GM-CSF的合成肽。

99. 发明授权

US5830876A Genetic immunization 失效
标题翻译：遗传免疫
公开(公告)号：US5830876A
公开(公告)日：1998-11-03
申请号：US453349
申请日：1995-05-30
申请人： David B. Weiner , William V. Williams , Bin Wang
发明人： David B. Weiner , William V. Williams , Bin Wang
IPC分类号： A61K48/00 , A61K39/00 , A61K39/12 , A61K39/21 , C07K14/16 , C12N15/87 , A61K45/05 , A61K31/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C12N15/87 , A61K2039/53 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , Y10S435/975 , Y10S514/818
摘要： A method of immunizing an individual against pathogen is disclosed. Also disclosed is a method of treating an individual who has a hyperproliferative disease, or of treating an individual who is infected by a pathogen. Specifically, the individual is injected with bupivacaine along with DNA in an expressible form, the DNA encoding an antigen. The encoded antigen can be from a protein from the pathogen or from a protein associated with the hyperproliferative disease.
摘要翻译：公开了免疫个体对病原体的方法。还公开了治疗具有过度增殖性疾病的个体或治疗被病原体感染的个体的方法。具体地说，个体以可表达形式的DNA注射布比卡因，编码抗原的DNA。编码的抗原可以来自病原体的蛋白质或来自与过度增殖性疾病相关的蛋白质。

100. 发明授权

US5593972A Genetic immunization 失效
标题翻译：遗传免疫
公开(公告)号：US5593972A
公开(公告)日：1997-01-14
申请号：US125012
申请日：1993-09-21
申请人： David B. Weiner , William V. Williams , Bin Wang
发明人： David B. Weiner , William V. Williams , Bin Wang
IPC分类号： A61K48/00 , A61K39/00 , A61K39/12 , A61K39/21 , C07K14/16 , C12N15/87 , A61K45/05 , A61K31/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C12N15/87 , A61K2039/53 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , Y10S435/975 , Y10S514/818
摘要： Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
摘要翻译：公开了个体对病原体感染的预防和治疗免疫的方法，与过度增殖细胞和自身免疫疾病相关的疾病。所述方法包括对个体的细胞施用包含编码蛋白质的核苷酸序列的核酸分子的步骤，所述核苷酸序列包含与病原体抗原的表位相同或基本上相似的至少一个表位，相关的过度增殖细胞蛋白质或与自身免疫疾病相关的蛋白质。在每种情况下，核苷酸序列可操作地连接到调节序列以使得能够在细胞中表达。核酸分子不含病毒颗粒，能够在所述细胞中表达。细胞可以与细胞刺激剂接触细胞。公开了预防和治疗个体免受HIV感染的方法。公开了用于本发明的实践方法的药物组合物和试剂盒。

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