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91. 发明申请

WO2006022800A2 SURFACE-MODIFIED SINGLE-WALLED CARBON NANOTUBES AND METHODS OF DETECTING A CHEMICAL COMPOUND USING SAME 审中-公开
标题翻译：表面改性的单壁碳纳米管和使用该化合物检测化学化合物的方法
公开(公告)号：WO2006022800A2
公开(公告)日：2006-03-02
申请号：PCT/US2004043242
申请日：2004-12-21
申请人： UNIV ARKANSAS , ZHAO WEI , SONG CHULHO
发明人： ZHAO WEI , SONG CHULHO
IPC分类号： D01F9/12 , C12M1/34
CPC分类号： B82Y30/00 , B82Y15/00 , C12Q1/005 , C12Q1/006 , D06M10/02 , D06M10/08 , D06M2101/40 , Y10T436/143333 , Y10T436/193333 , Y10T436/206664
摘要： A method for surface modification of single walled carbon nanotubes. In one embodiment, the method includes the steps of providing a detergent solution, adding a plurality of single walled carbon nanotubes into the detergent solution, performing a first sonication to disperse the single walled carbon nanotubes in the detergent solution, and performing a second sonication after the first sonication to make detergent encased single walled carbon nanotubes. At least one of the plurality of single walled carbon nanotubes is at least partially wrapped by one or more detergent molecules to make it a detergent encased single walled carbon nanotube. In one embodiment, the detergent comprises SDS, PSS or a combination of them.
摘要翻译：单壁碳纳米管的表面改性方法。在一个实施方案中，该方法包括以下步骤：提供洗涤剂溶液，将多个单壁碳纳米管加入到洗涤剂溶液中，进行第一超声处理以将单壁碳纳米管分散在洗涤剂溶液中，并在第第一次超声处理使洗涤剂包裹单壁碳纳米管。多个单壁碳纳米管中的至少一个至少部分被一个或多个洗涤剂分子包裹以使其成为洗涤剂包裹的单壁碳纳米管。在一个实施方案中，洗涤剂包括SDS，PSS或它们的组合。

92. 发明申请

WO2004012662A3 IMPROVED TREATMENT OF CANCER WITH GLUTAMINE 审中-公开
标题翻译：改善用谷氨酰胺治疗癌症
公开(公告)号：WO2004012662A3
公开(公告)日：2005-09-29
申请号：PCT/US0323987
申请日：2003-07-31
申请人： AESGEN INC , KLIMBERG V SUZANNE , PETIT ROBERT G II , SHINAL EDWARD C , UNIV ARKANSAS
发明人： KLIMBERG V SUZANNE , PETIT ROBERT G II , SHINAL EDWARD C
IPC分类号： A61K9/00 , A61K31/198 , A61K31/70 , A61K38/00 , A61K45/06 , A61K47/26 , A61K47/00
CPC分类号： A61K9/0095 , A61K9/0014 , A61K31/198 , A61K31/70 , A61K45/06 , A61K47/26 , A61K2300/00
摘要： Provided are methods of treating cancer, and/or the side effects of cancer therapy, involving the administration of glutamine, optionally in combination with a carbohydrate carrier that enhances the absorption of glutamine.
摘要翻译：提供了治疗癌症和/或癌症治疗的副作用的方法，涉及施用谷氨酰胺，任选地与增强谷氨酰胺吸收的碳水化合物载体组合。

93. 发明申请

WO2005025403A2 ULTRASOUND APPARATUS AND METHOD FOR AUGMENTED CLOT LYSIS 审中-公开
标题翻译：超声波装置和方法
公开(公告)号：WO2005025403A2
公开(公告)日：2005-03-24
申请号：PCT/US2004028934
申请日：2004-09-03
申请人： UNIV ARKANSAS , CULP WILLIAM C , WILSON JAMES D
发明人： CULP WILLIAM C , WILSON JAMES D
IPC分类号： A61B20060101 , A61B8/00 , A61B17/22 , A61N7/00 , A61N7/02 , A61B
CPC分类号： A61B17/22004 , A61B2017/22008 , A61B2017/22027 , A61B2017/22084 , A61B2017/22089 , A61N7/02 , A61N2007/0073 , A61N2007/0078 , A61N2007/0095
摘要： An apparatus and method for using ultrasound augmented with microbubbles, thrombolytic drugs or other agents for clot lysis wherein at least one ultrasound transducer (20) generates a plurality of acoustic signals and time, amplitude, phase and frequency modulation of the signals to provide more uniform power delivery with fewer gaps in the ultrasound field. Interference patterns from one or multiple transducers (12, 13, 14, 16, 20) are constantly shifted in position. A phased array (30) of transducers (31) may generate a directed beam that is swept over an area or directed to a specific location. In another embodiment, an array of transducers (12, 13, 14, 16, 20, 30) may generate ultrasound at a number of slightly varying frequencies to produce an interference pattern that sweeps in and out through the targeted tissue. A single array may be used to produce both effects simultaneously or separately.
摘要翻译：一种用于使用扩张微泡，溶栓药物或其他用于凝块溶解的试剂的超声波的装置和方法，其中至少一个超声换能器（20）产生多个声信号以及信号的时间，幅度，相位和频率调制以提供更均匀功率输送在超声波领域具有较少的间隙。来自一个或多个换能器（12,13,14,16,20）的干涉图案在位置上不断移动。换能器（31）的相控阵列（30）可以产生扫过区域或定向到特定位置的定向波束。在另一个实施例中，换能器阵列（12,13,14,16,20,30）可产生多个稍微变化的频率的超声波，以产生扫描穿过目标组织的干涉图案。可以使用单个阵列来同时或分开地产生两种效应。

94. 发明申请

WO03002058A9 BONE ANABOLIC COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：骨质疏松化合物及其使用方法
公开(公告)号：WO03002058A9
公开(公告)日：2004-07-08
申请号：PCT/US0218544
申请日：2002-06-10
申请人： ANABONIX INC , UNIV ARKANSAS
发明人： MANOLAGAS STAVROS C , KATZENELLENBOGEN JOHN A
IPC分类号： A61K45/00 , A61K31/045 , A61K31/047 , A61K31/05 , A61K31/16 , A61K31/166 , A61K31/381 , A61K31/415 , A61K31/44 , A61K31/444 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/56 , A61K31/565 , A61K31/568 , A61K31/569 , A61P3/06 , A61P3/14 , A61P5/16 , A61P5/18 , A61P9/08 , A61P9/10 , A61P15/10 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/18 , A61P29/00 , A61P35/00 , A61P35/04 , A61K31/38 , A61K31/50
CPC分类号： A61K31/505 , A61K31/045 , A61K31/047 , A61K31/05 , A61K31/16 , A61K31/166 , A61K31/381 , A61K31/415 , A61K31/44 , A61K31/444 , A61K31/445 , A61K31/501 , A61K31/506 , A61K31/565 , A61K31/568 , A61K31/569
摘要： A variety of bone anabolic compounds are useful for maintaining and/or increasing bone mass, density, and/or strength in mammals. Preferred compounds enhance bone anabolic activity while minimizing or eliminating undesirable feminizing or masculinizing effects.
摘要翻译：各种骨合成代谢化合物可用于维持和/或增加哺乳动物的骨量，密度和/或强度。优选的化合物增强骨合成代谢活性，同时最小化或消除不需要的女性化或男性化效应。

95. 发明申请

WO2004011181A3 METHOD AND APPARATUS FOR REMOVING MINUTE PARTICLE(S) FROM A SURFACE 审中-公开
标题翻译：用于从表面去除一分钟颗粒的方法和设备
公开(公告)号：WO2004011181A3
公开(公告)日：2004-05-13
申请号：PCT/US0319878
申请日：2003-07-25
申请人： UNIV ARKANSAS , ALLEN SUSAN DAVIS , KUDRYASHOV SERGEY I
发明人： ALLEN SUSAN DAVIS , KUDRYASHOV SERGEY I
IPC分类号： B08B7/00 , B08B7/04 , B23K20060101
CPC分类号： B08B7/0035 , B08B7/0042
摘要： Methods and apparatus for removing minute particle(s) from a substrate. The methods include arranging an energy transfer medium having a predetermined thickness under and around one or more particle(s) to be removed, and irradiating the energy transfer medium and/or the surface of the substrate with pulsed energy, wherein the predetermined thickness of the energy transfer medium is selected so that viscous and other drag forces within the energy transfer medium are sufficient to cause the one or more particle(s) to be removed from the surface of the substrate. The apparatus include a tailored energy transfer medium application unit configured to control application of an energy transfer medium onto the surface of a substrate, and a tailored energy source that irradiates the energy transfer medium and/or the substrate with a tailored energy pulse or pulses, wherein the energy transfer medium application unit controls application of the energy transfer medium in accordance with a dimension of at least one of the particle(s).
摘要翻译：从基材上去除微小颗粒的方法和设备。该方法包括将具有预定厚度的能量传递介质布置在待移除的一个或多个颗粒之下和周围，并且利用脉冲能量照射能量传输介质和/或衬底的表面，其中预定厚度的能量传递介质被选择为使得能量传递介质内的粘滞力和其他拖曳力足以使得一个或多个颗粒从基底的表面移除。该设备包括定制的能量传递介质施加单元和定制的能量源，该能量转移介质施加单元被配置为控制将能量传递介质施加到衬底的表面上，该能量源用定制的能量脉冲照射能量传递介质和/或衬底，其中所述能量传递介质施加单元根据所述一个或多个颗粒中的至少一个的尺寸来控制所述能量传递介质的施加。

96. 发明申请

WO03057619A8 APPARATUS AND METHOD FOR NANOSCALE AND MICROSCALE MECHANICAL MACHINING AND PROCESSING 审中-公开
标题翻译：纳米和微晶机械加工与加工的装置与方法
公开(公告)号：WO03057619A8
公开(公告)日：2004-05-13
申请号：PCT/US0300096
申请日：2003-01-02
申请人： UNIV ARKANSAS , MALSHE AJAY P , O'NEAL CHAD
发明人： MALSHE AJAY P , O'NEAL CHAD
IPC分类号： B23C1/00 , B23P13/04 , B81B5/00 , B81C1/00
CPC分类号： B81C99/002 , B81B5/00 , B81B2201/034 , B81C2201/0129 , Y10T29/49996 , Y10T408/03 , Y10T409/303808 , Y10T409/304256
摘要： A microscale device provides for a nanoscale machining. A tool, similar to probes used in atomic force microscopy is attached to a micro-load gear and is powered by a micromotor. This very small tool allows a variety of nanostructures to be fabricated on a variety of substrates.
摘要翻译：微型器件提供纳米尺度加工。类似于原子力显微镜中使用的探针的工具连接到微负载齿轮，并由微电机供电。这种非常小的工具允许在各种基底上制造各种纳米结构。

97. 发明申请

WO02101076A2 METHODS FOR TARGETED EXPRESSION OF THERAPEUTIC NUCLEIC ACID 审中-公开
标题翻译：用于靶向治疗性核酸表达的方法
公开(公告)号：WO02101076A2
公开(公告)日：2002-12-19
申请号：PCT/US0218650
申请日：2002-06-13
申请人： EASTERN VIRGINIA MED SCHOOL , UNIV ARKANSAS , INCELL CORP LLC , DRAKE RICHARD R , GUPTA SAURABH K , MERCER KELLY E , MCMASTERS ROBYN , MOYER MARY PAT
发明人： DRAKE RICHARD R , GUPTA SAURABH K , MERCER KELLY E , MCMASTERS ROBYN , MOYER MARY PAT
IPC分类号： C12N15/09 , A61K31/07 , A61K31/19 , A61K31/21 , A61K31/704 , A61K31/7105 , A61K35/74 , A61K35/76 , A61K38/00 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C12N5/10 , C12N15/85 , C12Q
CPC分类号： C12N15/85 , C12N2830/008 , C12N2830/85
摘要： Expression vectors that include a pre-selected therapeutic nucleic acid operably linked to a tumor specific or cell type-speci fic promoter and a Tcf-4 beta -catenin enhancer are provided. The therapeutic nucleic acid preferably includes a gene encoding a therapeutic protein for treatment of, for example, cancer. Methods for targeted expression of therapeutic nucleic acid, and methods for treating cancer, utilizing the expression vectors described herein, are also provided. Host cells are also provided that have been transformed with the expression vectors described herein.
摘要翻译：提供了包含与肿瘤特异性或细胞型特异性启动子和Tcf-4β-连接蛋白增强子可操作地连接的预先选择的治疗性核酸的表达载体。治疗性核酸优选包含编码用于治疗例如癌症的治疗性蛋白质的基因。还提供了利用本文所述的表达载体靶向表达治疗性核酸的方法和治疗癌症的方法。还提供已经用本文所述的表达载体转化的宿主细胞。

98. 发明申请

WO02064188A3 INFRARED ASSISTED MONITORING OF A CATHETER 审中-公开
标题翻译：红外辅助监测导管
公开(公告)号：WO02064188A3
公开(公告)日：2002-11-14
申请号：PCT/US0200410
申请日：2002-01-03
申请人： UNIV ARKANSAS
发明人： WANER MILTON , FERGUSON SCOTT L , FINK LOUIS M , ZHAROV VLADIMIR P
IPC分类号： A61B5/06 , A61M25/095 , A61B5/05
CPC分类号： A61B5/0059 , A61B5/064 , A61M25/0017 , A61M25/0082 , A61M25/01
摘要： An apparatus for the placement and monitoring of the position of an intraluminal indwelling catheter (10) using an infrared (IR) signal encoded in the catheter (10) and the detection of the IR signal by an IR optical detector (50). The IR signal may be encoded into the catheter (10) by IR emitted from the catheter or IR reflected from the catheter. In the first category, the catheter (10) is illuminated by IR radiation emitted from the distal end of the catheter, either by fiber optics (31) or by a micro-diode (80). In the second category, the catheter (10) is marked with regions of varying optical properties to form a pattern (60) that is easily visualized and distinctive from nearby anatomical structures. One embodiment has a helical pattern in either one or more solid bands or a series of helically arranged dots. Other embodiments employ a pair of criss-crossing helical bands or zebra stripes. In addition to IR radiation, other electromagnetic radiation, including visible light, may be used. An alternative embodiment for an IV catheter includes a partially opaque flash chamber (13) having a backing (90) with optical properties that contrast with that of blood to allow the detector (50) to image the blood filling the chamber (13) and verify a successful insertion.
摘要翻译：一种用于使用导管（10）中编码的红外（IR）信号和通过IR光学检测器（50）检测IR信号来放置和监测管腔内留置导管（10）的位置的设备。可以通过从导管发射的IR或从导管反射的IR将IR信号编码到导管（10）中。在第一类中，导管（10）通过光导纤维（31）或微型二极管（80）被从导管的远端发射的IR辐射照射。在第二类中，导管（10）标记有不同光学性质的区域以形成容易可视化并且与附近解剖结构不同的图案（60）。一个实施例在一个或多个实心带或一系列螺旋排列的点中具有螺旋图案。其他实施例采用一对纵横交叉的螺旋带或斑马条纹。除了红外辐射之外，可以使用其他电磁辐射，包括可见光。静脉导管的替代实施例包括具有背衬（90）的部分不透明闪蒸腔室（13），背衬（90）具有与血液的光学特性相反的光学特性以允许检测器（50）对填充腔室（13）的血液进行成像并验证插入成功。

99. 发明申请

WO0187306A8 COMPOSITIONS AND METHODS FOR THE TREATMENT OF COLORECTAL CANCER 审中-公开
标题翻译：用于治疗彩色癌的组合物和方法
公开(公告)号：WO0187306A8
公开(公告)日：2002-10-03
申请号：PCT/US0115326
申请日：2001-05-10
申请人： CELGENE CORP , UNIV ARKANSAS
发明人： GOVINDARAJAN RANGASWAMY , ZEITLIN ANDREW
IPC分类号： A61K31/445 , A61K31/454 , A61K31/47 , A61K31/4745 , A61K31/724 , A61P35/00 , A61P35/04 , A61P43/00
CPC分类号： A61K31/47 , A61K31/445 , A61K31/454 , A61K31/4745 , A61K31/724 , A61K2300/00

100. 发明申请

WO0140264A9 PEPTIDE ANTIGENS 审中-公开
标题翻译：肽抗原
公开(公告)号：WO0140264A9
公开(公告)日：2002-05-30
申请号：PCT/US0033124
申请日：2000-12-06
申请人： PANACEA PHARM LLC , UNIV ARKANSAS , SINAI SCHOOL MEDICINE
发明人： BANNON GARY A , BURKS WESLEY A , CAPLAN MICHAEL J , SAMPSON HUGH , SOSIN HOWARD
IPC分类号： A01K67/027 , A61K38/11 , A61K39/00 , A61K39/35 , A61K39/36 , A61K39/38 , C07K14/415 , A01K67/02 , C07K7/08 , G01N33/68
CPC分类号： C07K14/415 , A01K67/027 , A61K38/00 , A61K39/00 , A61K39/35 , A61K39/36 , A61K39/38 , A61K2039/53
摘要： The present invention provides compositions and methods for reducing the severity and/or number of allergic symptoms in individuals sensitive to one or more antigens. In general, the inventive compositions comprise fragments of antigens and are characterized by a reduced ability to bind to anti-antigen IgE. Preferred compositions comprise overlapping fragments that together represent substantially all of the structural features of the relevant antigen except that one or more IgE binding sites may be omitted. Particularly preferred compositions comprise fragments of anaphylactic antigens, especially food antigens such as peanut antigens or shellfish antigens.
摘要翻译：本发明提供用于降低对一种或多种抗原敏感的个体的过敏症状的严重性和/或数量的组合物和方法。通常，本发明的组合物包含抗原片段，其特征在于与抗原IgE结合的能力降低。优选的组合物包含重叠的片段，其一起代表相关抗原的基本上所有的结构特征，除了可以省略一个或多个IgE结合位点。特别优选的组合物包含过敏抗原的片段，特别是食品抗原如花生抗原或贝类抗原。

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