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1. 发明申请

WO0140264A9 PEPTIDE ANTIGENS 审中-公开
标题翻译：肽抗原
公开(公告)号：WO0140264A9
公开(公告)日：2002-05-30
申请号：PCT/US0033124
申请日：2000-12-06
申请人： PANACEA PHARM LLC , UNIV ARKANSAS , SINAI SCHOOL MEDICINE
发明人： BANNON GARY A , BURKS WESLEY A , CAPLAN MICHAEL J , SAMPSON HUGH , SOSIN HOWARD
IPC分类号： A01K67/027 , A61K38/11 , A61K39/00 , A61K39/35 , A61K39/36 , A61K39/38 , C07K14/415 , A01K67/02 , C07K7/08 , G01N33/68
CPC分类号： C07K14/415 , A01K67/027 , A61K38/00 , A61K39/00 , A61K39/35 , A61K39/36 , A61K39/38 , A61K2039/53
摘要： The present invention provides compositions and methods for reducing the severity and/or number of allergic symptoms in individuals sensitive to one or more antigens. In general, the inventive compositions comprise fragments of antigens and are characterized by a reduced ability to bind to anti-antigen IgE. Preferred compositions comprise overlapping fragments that together represent substantially all of the structural features of the relevant antigen except that one or more IgE binding sites may be omitted. Particularly preferred compositions comprise fragments of anaphylactic antigens, especially food antigens such as peanut antigens or shellfish antigens.
摘要翻译：本发明提供用于降低对一种或多种抗原敏感的个体的过敏症状的严重性和/或数量的组合物和方法。通常，本发明的组合物包含抗原片段，其特征在于与抗原IgE结合的能力降低。优选的组合物包含重叠的片段，其一起代表相关抗原的基本上所有的结构特征，除了可以省略一个或多个IgE结合位点。特别优选的组合物包含过敏抗原的片段，特别是食品抗原如花生抗原或贝类抗原。

2. 发明申请

WO0140264A2 PEPTIDE ANTIGENS 审中-公开
标题翻译：肽抗原
公开(公告)号：WO0140264A2
公开(公告)日：2001-06-07
申请号：PCT/US0033124
申请日：2000-12-06
申请人： PANACEA PHARM LLC , UNIV ARKANSAS , SINAI SCHOOL MEDICINE
发明人： BANNON GARY A , BURKS WESLEY A , CAPLAN MICHAEL J , SAMPSON HUGH , SOSIN HOWARD
IPC分类号： A01K67/027 , A61K38/11 , A61K39/00 , A61K39/35 , A61K39/36 , A61K39/38 , C07K14/415 , C07K7/00
CPC分类号： C07K14/415 , A01K67/027 , A61K38/00 , A61K39/00 , A61K39/35 , A61K39/36 , A61K39/38 , A61K2039/53
摘要： The present invention provides compositions and methods for reducing the severity and/or number of allergic symptoms in individuals sensitive to one or more antigens. In general, the inventive compositions comprise fragments of antigens and are characterized by a reduced ability to bind to anti-antigen IgE. Preferred compositions comprise overlapping fragments that together represent substantially all of the structural features of the relevant antigen except that one or more IgE binding sites may be omitted. Particularly preferred compositions comprise fragments of anaphylactic antigens, especially food antigens such as peanut antigens or shellfish antigens.
摘要翻译：本发明提供用于降低对一种或多种抗原敏感的个体的过敏症状的严重性和/或数量的组合物和方法。通常，本发明的组合物包含抗原片段，其特征在于与抗原IgE结合的能力降低。优选的组合物包含重叠的片段，其一起代表相关抗原的基本上所有的结构特征，除了可以省略一个或多个IgE结合位点。特别优选的组合物包含过敏抗原的片段，特别是食品抗原如花生抗原或贝类抗原。

3. 发明专利

AU1951201A Peptide antigens 未知
公开(公告)号：AU1951201A
公开(公告)日：2001-06-12
申请号：AU1951201
申请日：2000-12-06
申请人： PANACEA PHARM LLC , UNIV ARKANSAS , SINAI SCHOOL MEDICINE
发明人： BANNON GARY A , BURKS WESLEY A JR , CAPLAN MICHAEL J , SAMPSON HUGH , SOSIN HOWARD
IPC分类号： A01K67/027 , A61K38/095 , A61K39/00 , A61K39/35 , A61K39/36 , A61K39/38 , C07K14/415 , C07K7/00
摘要： IgE-blocking agents and methods of their use have been developed for desensitizing an individual to an antigen. These IgE-blocking agents work by blocking the antigen-binding site of the IgE molecules and thereby preventing the antigen from binding. These agents typically have up to one IgE binding site present per molecule so as prevent any cross-linking of IgE which could lead to an allergic reaction. Methods of using these novel IgE blocking agents include administering the agents to alleviate or prevent allergic reactions as well as administering the agents to decrease the risk of allergic reactions during immunotherapy or "rush" immunotherapy. Compositions and kits comprising these IgE binding agents are also provided.

4. 发明申请

WO0054803A3 IMMUNOSTIMULATORY NUCLEIC ACIDS AND ANTIGENS 审中-公开
标题翻译：免疫细胞核酸和抗原
公开(公告)号：WO0054803A3
公开(公告)日：2001-01-11
申请号：PCT/US0007213
申请日：2000-03-16
申请人： PANACEA PHARM LLC
发明人： SOSIN HOWARD B , CAPLAN MICHAEL J
IPC分类号： A61K39/35 , A61K39/38 , A61K39/39 , A61P37/04 , A61P37/08
CPC分类号： A61K39/38 , A61K39/35 , A61K39/39 , A61K2039/55561
摘要： The present invention provides methods and compositions for modulating an individual's immune response to antigens. It is an aspect of the present invention that allergic responses to antigens, which in some cases lead to asthma and even anaphylaxis, can be treated or prevented by administering compositions having immunostimulatory oligonucleotides having unmethylated CpG sequences. It is another aspect of the present invention that allergies to antigens, especially one that result in asthma and anaphylaxis, can be treated or prevented by administering compositions containing immunostimulatory oligonucleotides having unmethylated CpG dinucleotide sequences and further comprising antigen(s), fragments of the antigen, mixtures of fragments of the antigen, antigens modified to reduce Th2-type immune responses, and fragments of the antigen modified to reduce Th2-type immune responses. Cellular systems for studying immunostimulation by CpG containing nucleic acids include in vivo, in vitro or ex vivo systems.
摘要翻译：本发明提供了调节个体对抗原的免疫应答的方法和组合物。本发明的一个方面是通过施用具有具有非甲基化CpG序列的免疫刺激性寡核苷酸的组合物来治疗或预防对某些情况下导致哮喘甚至过敏反应的抗原的过敏反应。本发明的另一方面是通过施用含有具有非甲基化CpG二核苷酸序列的免疫刺激性寡核苷酸的组合物，并且进一步包含抗原，抗原片段，可以治疗或预防抗原，特别是导致哮喘和过敏反应的抗原，抗原片段的混合物，被修饰以减少Th2型免疫应答的抗原，以及被修饰以减少Th2型免疫应答的抗原片段。用于研究含有CpG的核酸的免疫刺激的细胞系统包括体内，体外或离体系统。

5. 发明申请

WO03049717A2 CONDUCTANCE OF IMPROPERLY FOLDED PROTEINS THROUGH THE SECRETORY PATHWAY AND RELATED METHODS FOR TREATING DISEASE 审中-公开
标题翻译：通过秘密路径导致的不正确折叠蛋白质的导管及相关治疗疾病的方法
公开(公告)号：WO03049717A2
公开(公告)日：2003-06-19
申请号：PCT/US0232801
申请日：2002-10-15
申请人： PANACEA PHARM LLC , CAPLAN MICHAEL J , EGAN MARIE E
发明人： CAPLAN MICHAEL J , EGAN MARIE E
IPC分类号： A61K9/00 , A61K9/20 , A61K31/00 , A61K31/02 , A61K31/122 , A61K31/343 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/407 , A61K31/47 , A61K31/713 , A61K38/16 , A61P5/48 , A61P7/00 , A61P11/00 , A61P13/00 , A61P31/12 , A61P35/00 , A61P43/00 , C12Q1/48 , G01N33/50 , A61K9/12 , A61K48/00
CPC分类号： A61K9/0078 , A61K9/0031 , A61K9/0053 , A61K9/0073 , A61K9/2013 , A61K9/2022 , A61K31/00 , A61K31/02 , A61K31/122 , A61K31/343 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/407 , A61K31/47 , A61K31/55 , A61K31/713 , C12Q1/48 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5076 , G01N33/6872 , G01N2333/91102
摘要： This invention provides the methodology and agents for treating any disease or clinical condition which is at least partly the result of endoplasmic reticulum-associated retention of proteins. Thus, the methods and agents of the present invention provide for the release of normally retained proteins from the endoplasmic reticulum. The present invention is particularly useful for treating any disease or clinical condition which is at least partly the result of endoplasmic reticulum-associated retention or degradation of mis-assembled or mis-folded proteins.
摘要翻译：本发明提供用于治疗任何疾病或临床病症的方法和试剂，其至少部分是蛋白质内质网相关保留的结果。因此，本发明的方法和试剂提供从内质网释放正常保留的蛋白质。本发明特别可用于治疗至少部分由内质网相关的残留或错误组合或错误折叠的蛋白质降解的结果的疾病或临床病症。

6. 发明专利

AU3933500A Methods for skewing the balance between th1 and th2 immune responses 未知
公开(公告)号：AU3933500A
公开(公告)日：2000-11-14
申请号：AU3933500
申请日：2000-04-07
申请人： PANACEA PHARM LLC
发明人： BOTTOMLY H KIM , CAPLAN MICHAEL J , SOSIN HOWARD B
IPC分类号： A61K39/00 , A61K39/35 , A61P37/00 , A61K35/00 , A61K38/19 , A61K35/14 , A61K39/02 , A61K38/17 , A61K31/70 , A61K39/085 , A61K39/106 , A61K48/00 , A61K9/48 , C07K19/00 , C12N15/62
摘要： The present invention provides compositions and methods for regulating immune system reactions by biasing T cell responses away from Th1 or Th2 responses in a pre-determined manner. Control is effected at the stage of antigen/APC encounter and/or at the stage of APC/T cell encounter. In preferred embodiments, a Th1 or Th2 response is inhibited through induction of the alternative response. The inventive methods and reagents are particularly useful for the management of autoimmune disorders, allergy, and asthma.

8. 发明专利

AU3760100A Immunostimulatory nucleic acids and antigens 未知
公开(公告)号：AU3760100A
公开(公告)日：2000-10-04
申请号：AU3760100
申请日：2000-03-16
申请人： PANACEA PHARM LLC
发明人： SOSIN HOWARD B , CAPLAN MICHAEL J
IPC分类号： A61K39/35 , A61K39/38 , A61K39/39 , A61P37/04 , A61P37/08

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