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1. 发明授权

US07214375B1 Methods of decreasing the accumulation of extracellular matrix associated with glomerulonephritis with anti-TGF-β-specific antibodies 失效
标题翻译：用抗TGF-β特异性抗体降低与肾小球肾炎相关的细胞外基质积累的方法
公开(公告)号：US07214375B1
公开(公告)日：2007-05-08
申请号：US08349479
申请日：1994-12-02
申请人： Wayne A. Border , Erkki I. Ruoslahti
发明人： Wayne A. Border , Erkki I. Ruoslahti
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/22 , A61K2039/505
摘要： The present invention provides a method for treating or arresting the progress of pathologies characterized by an accumulation of extracellular matrix components by providing an agent to suppress the activity of transforming growth factor β (TGF-β) a peptide growth factor which is anabolic and leads to fibrosis and angiogenesis. In one embodiment, such agent is anti-TGF-β antibody. Pathologies which can be so treated include, but are not limited to, glomerulonephritis, adult respiratory distress syndrome and cirrhosis of the liver. The invention further provides a method for the diagnosis of pathologies, or incipient pathologies, which are characterized by the accumulation of extracellular matrix components in tissues by determining the levels of TGF-β in the tissues, a high level being indicative of such pathologies.
摘要翻译：本发明提供了一种通过提供抑制转化生长因子β（TGF-β）的活性的药剂来治疗或阻止细胞外基质成分积累的病态的方法，所述肽生长因子是合成代谢并导致纤维化和血管生成。在一个实施方案中，这种试剂是抗TGF-β抗体。可以如此治疗的病理包括但不限于肾小球性肾炎，成人呼吸窘迫综合征和肝硬化。本发明还提供了用于诊断病理学或初期病理学的方法，其特征在于通过测定组织中TGF-β的水平，组织中的细胞外基质组分的积累指示这种病理学的高水平。

2. 发明授权

US5726149A Treatment of glomerulonephritis with decorin 失效
标题翻译：用核心蛋白聚糖治疗肾小球肾炎
公开(公告)号：US5726149A
公开(公告)日：1998-03-10
申请号：US645339
申请日：1991-01-22
申请人： Erkki I. Ruoslahti , Yu Yamaguchi , Wayne A. Border
发明人： Erkki I. Ruoslahti , Yu Yamaguchi , Wayne A. Border
IPC分类号： C12N15/09 , A61K38/00 , A61P9/10 , A61P13/02 , A61P13/12 , A61P15/00 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07K1/22 , C07K14/00 , C07K14/47 , C07K14/50 , C12N5/00 , C12N5/02 , C12N5/06 , C12N5/10 , C12N15/12 , C12P21/00 , C12P21/02 , C12R1/91 , A61K38/02 , A61K38/16 , A61K38/39
CPC分类号： C07K14/4725 , A61K38/00 , C07K2319/00
摘要： A method of treating of glomerulonephritis in a patient by administering decorin.
摘要翻译：通过管理核心蛋白聚糖治疗患者的肾小球肾炎的方法。

3. 发明授权

US06509314B1 Methods of preventing or reducing scarring with decorin or biglycan 失效
标题翻译：用核心蛋白聚糖或双糖缩蛋白聚糖预防或减少瘢痕形成的方法
公开(公告)号：US06509314B1
公开(公告)日：2003-01-21
申请号：US08259335
申请日：1994-06-13
申请人： Erkki I. Ruoslahti , Wayne A. Border
发明人： Erkki I. Ruoslahti , Wayne A. Border
IPC分类号： A01N6100
CPC分类号： C07K14/4725 , A61K38/04 , A61K38/1858 , A61K38/39 , C07K14/4703 , C07K14/475 , C07K14/495 , C07K14/78 , C07K16/22 , C07K2319/00
摘要： The present invention relates to methods of preventing or reducing scarring in a wound area by administering decorin or biglycan to the wound.
摘要翻译：本发明涉及通过向伤口施用核心蛋白聚糖或双糖链蛋白聚糖来预防或减少伤口区域中的瘢痕形成的方法。

4. 发明授权

US07030213B2 Conformationally stabilized cell adhesion peptides 失效
公开(公告)号：US07030213B2
公开(公告)日：2006-04-18
申请号：US09892071
申请日：2001-06-26
申请人： Michael D. Pierschbacher , Erkki I. Ruoslahti
发明人： Michael D. Pierschbacher , Erkki I. Ruoslahti
IPC分类号： A61K38/00
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K7/50 , C07K7/64 , C07K14/47 , C07K14/78
摘要： Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.

5. 发明授权

US5837813A Fibronectin Type III polypeptides 失效
标题翻译：纤连蛋白III型多肽
公开(公告)号：US5837813A
公开(公告)日：1998-11-17
申请号：US460421
申请日：1995-06-01
申请人： Erkki I. Ruoslahti , Alex Morla
发明人： Erkki I. Ruoslahti , Alex Morla
IPC分类号： A61K38/00 , C07K14/78 , A61K38/39
CPC分类号： C07K14/78 , A61K38/00
摘要： The present invention provides fibronectin self-assembly sites. The invention provides a set of polypeptides derived from the first type III repeat of fibronectin which contain a fibronectin-fibronectin binding site. These polypeptides have been used to obtain a second set of polypeptides derived from the C-terminal type I repeats which contain a second fibronectin-fibronectin binding site which interacts with the first type III repeat of fibronectin. These polypeptides are capable of inhibiting fibronectin matrix assembly by interfering with fibronectin-fibronectin binding. These polypeptides are also capable of enhancing fibronectin matrix assembly and inducing disulfide cross-linking of fibronectin molecules in vitro. In addition, these polypeptides are capable of inhibiting migration of tumor cells. The polypeptides of the present invention have a number of related uses as well.
摘要翻译：本发明提供纤连蛋白自组装位点。本发明提供一组衍生自含有纤连蛋白 - 纤连蛋白结合位点的纤连蛋白的第一III型重复序列的多肽。已经使用这些多肽获得源自C末端I型重复序列的第二组多肽，其含有与纤连蛋白的第一III型重复相互作用的第二纤连蛋白 - 纤连蛋白结合位点。这些多肽能够通过干扰纤连蛋白 - 纤连蛋白结合来抑制纤连蛋白基质组装。这些多肽还能够体外增强纤连蛋白基质的组装和诱导纤连蛋白分子的二硫键交联。此外，这些多肽能够抑制肿瘤细胞的迁移。本发明的多肽也具有许多相关用途。

6. 发明授权

US5827821A Conformationally stabilized cell adhesion peptides 失效
公开(公告)号：US5827821A
公开(公告)日：1998-10-27
申请号：US914643
申请日：1992-07-16
申请人： Michael D. Pierschbacher , Erkki I. Ruoslahti
发明人： Michael D. Pierschbacher , Erkki I. Ruoslahti
IPC分类号： A61K38/00 , C07K14/47 , C07K14/78
CPC分类号： C07K7/06 , C07K14/47 , C07K14/78 , C07K7/08 , C07K7/50 , C07K7/64 , A61K38/00
摘要： Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.

7. 发明授权

US5695997A Tetrapeptide 失效
标题翻译：四肽
公开(公告)号：US5695997A
公开(公告)日：1997-12-09
申请号：US459641
申请日：1995-06-02
申请人： Erkki I. Ruoslahti , Michael D. Pierschbacher
发明人： Erkki I. Ruoslahti , Michael D. Pierschbacher
IPC分类号： A61K38/07 , A61K38/08 , A61L27/22 , C07K14/78 , C12N5/02 , C07K4/00 , C07K5/10 , C07K14/00
CPC分类号： A61K38/07 , A61K38/08 , A61L27/227 , C07K14/78
摘要： The peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, or other amino acid, having the same cell-attachment activity as fibronectin and the peptide X-Arg-Gly-Asp-Ser-Y, wherein X and Y, having said activity are disclosed.
摘要翻译：肽X-Arg-Gly-Asp-RY，其中X是H或至少一个氨基酸，Y是OH或至少一个氨基酸，R是选自Thr或Cys的氨基酸或其它氨基酸，其具有具有与纤连蛋白相同的细胞附着活性和肽X-Arg-Gly-Asp-Ser-Y，其中X和Y具有所述活性。

8. 发明授权

US5583103A Inhibition of transforming growth factor beta activity 失效
标题翻译：抑制转化生长因子β活性
公开(公告)号：US5583103A
公开(公告)日：1996-12-10
申请号：US212311
申请日：1994-03-14
申请人： Erkki I. Ruoslahti , Yu Yamaguchi
发明人： Erkki I. Ruoslahti , Yu Yamaguchi
IPC分类号： A61K38/00 , C07K14/47 , A61K38/19 , C07K14/495
CPC分类号： C07K14/4703 , C07K14/4725 , A61K38/00 , C07K2319/00
摘要： The present invention provides a method of inhibiting an activity of TGF.beta. comprising contacting the TGF.beta. with a purified decorin. In a specific embodiment, the present invention relates to the ability of decorin, a 40,000 dalton protein that usually carries a glycosaminoglycan chain, to bind TGF.beta.. The invention also provides a novel cell regulatory factor designated MRF. Also provided are methods of identifying, detecting and purifying cell regulatory factors and proteins which bind and affect the activity of cell regulatory factors.
摘要翻译：本发明提供了抑制TGFβ活性的方法，包括使TGFβ与纯化的核心蛋白聚糖接触。在一个具体实施方案中，本发明涉及核心蛋白聚糖，一种通常携带糖胺聚糖链的40,000道尔顿蛋白结合TGFβ的能力。本发明还提供了称为MRF的新型细胞调节因子。还提供鉴定，检测和纯化结合并影响细胞调节因子活性的细胞调节因子和蛋白质的方法。

9. 发明授权

US5169930A Fibronectin receptor 失效
标题翻译：纤维蛋白受体
公开(公告)号：US5169930A
公开(公告)日：1992-12-08
申请号：US461349
申请日：1990-01-05
申请人： Erkki I. Ruoslahti , Guido Tarone , Filippo G. Giancotti , Bruce E. Vogel
发明人： Erkki I. Ruoslahti , Guido Tarone , Filippo G. Giancotti , Bruce E. Vogel
IPC分类号： C07K14/435 , A61K38/00 , C07K1/16 , C07K1/22 , C07K14/705 , C07K16/00 , C07K16/28 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/53
CPC分类号： C07K14/7055 , A61K38/00
摘要： The present invention provides a substantially pure integrin-type receptor characterized in that it consists of an .alpha..sub.v and a .beta..sub.1 subunit. The .alpha..sub.v .beta..sub.1 integrin binds to fibronectin and GRGDSPK but does not bind to vitronectin. The .alpha..sub.v .beta..sub.1 integrin can be used to determine the presence of a .alpha..sub.v .beta..sub.1 ligand and to develop adhesion peptides specific for the various integrins. The presence of the .alpha..sub.v .beta..sub.1 integrin can be used to assess ability of cells to adhere to fibronectin.
摘要翻译：本发明提供了基本上纯的整联蛋白型受体，其特征在于其由αv和β1亚单位组成。 αvβ1整联蛋白与纤连蛋白和GRGDSPK结合，但不结合玻连蛋白。 αvβ1整联蛋白可用于确定αvβ1配体的存在并开发针对各种整合素特异的粘附肽。 αvβ1整联蛋白的存在可用于评估细胞粘附纤连蛋白的能力。

10. 发明授权

US4391749A Method for the purification of collagens 失效
标题翻译：胶原蛋白纯化方法
公开(公告)号：US4391749A
公开(公告)日：1983-07-05
申请号：US313326
申请日：1981-10-19
申请人： Eva S. Engvall , Erkki I. Ruoslahti
发明人： Eva S. Engvall , Erkki I. Ruoslahti
IPC分类号： B01D15/08 , C07K14/78 , A61K35/16 , C07G7/00 , C08H1/06 , C09H1/00
CPC分类号： G01N30/482 , B01D15/3804 , C07K14/78 , B01J2220/54
摘要： Collagen affinity matrices are prepared, useful for separating collagenous substances from other high molecular weight proteinaceous substances. Fibronectin is fragmentated chemically or by enzymatic digestion, etc. Fragments of fibronectin, which retain the collagen-binding site but are severed from other binding sites of intact fibronectin, are selected and coupled to solid support material.
摘要翻译：制备胶原亲和基质，用于从其他高分子量蛋白质物质中分离胶原物质。纤连蛋白被化学碎片化或通过酶促消化等。纤维连接蛋白的片段保留了胶原结合位点，但是从完整纤连蛋白的其他结合位点切断，并与固体支持材料偶联。

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