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1. 发明授权

US5629291A Methods of modulating fibronectin extracellular matrix assembly 失效
标题翻译：调节纤连蛋白细胞外基质组装的方法
公开(公告)号：US5629291A
公开(公告)日：1997-05-13
申请号：US340812
申请日：1994-11-17
申请人： Erkki I. Ruoslahti , Alex Morla
发明人： Erkki I. Ruoslahti , Alex Morla
IPC分类号： A61K38/00 , C07K14/78 , A61K38/17 , C12N5/02
CPC分类号： C07K14/78 , A61K38/00
摘要： The present invention provides fibronectin self-assembly sites. The invention provides a set of polypeptides derived from the first type III repeat of fibronectin which contain a fibronectin-fibronectin binding site. These polypeptides have been used to obtain a second set of polypeptides derived from the C-terminal type I repeats which contain a second fibronectin-fibronectin binding site which interacts with the first type III repeat of fibronectin. These polypeptides are capable of inhibiting fibronectin matrix assembly by interfering with fibronectin-fibronectin binding. These polypeptides are also capable of enhancing fibronectin matrix assembly and inducing disulfide cross-linking of fibronectin molecules in vitro. In addition, these polypeptides are capable of inhibiting migration of tumor cells. The polypeptides of the present invention have a number of related uses as well.
摘要翻译：本发明提供纤连蛋白自组装位点。本发明提供一组衍生自含有纤连蛋白 - 纤连蛋白结合位点的纤连蛋白的第一III型重复序列的多肽。已经使用这些多肽获得源自C末端I型重复序列的第二组多肽，其含有与纤连蛋白的第一III型重复相互作用的第二纤连蛋白 - 纤连蛋白结合位点。这些多肽能够通过干扰纤连蛋白 - 纤连蛋白结合来抑制纤连蛋白基质组装。这些多肽还能够体外增强纤连蛋白基质的组装和诱导纤连蛋白分子的二硫键交联。此外，这些多肽能够抑制肿瘤细胞的迁移。本发明的多肽也具有许多相关用途。

2. 发明授权

US5837813A Fibronectin Type III polypeptides 失效
标题翻译：纤连蛋白III型多肽
公开(公告)号：US5837813A
公开(公告)日：1998-11-17
申请号：US460421
申请日：1995-06-01
申请人： Erkki I. Ruoslahti , Alex Morla
发明人： Erkki I. Ruoslahti , Alex Morla
IPC分类号： A61K38/00 , C07K14/78 , A61K38/39
CPC分类号： C07K14/78 , A61K38/00
摘要： The present invention provides fibronectin self-assembly sites. The invention provides a set of polypeptides derived from the first type III repeat of fibronectin which contain a fibronectin-fibronectin binding site. These polypeptides have been used to obtain a second set of polypeptides derived from the C-terminal type I repeats which contain a second fibronectin-fibronectin binding site which interacts with the first type III repeat of fibronectin. These polypeptides are capable of inhibiting fibronectin matrix assembly by interfering with fibronectin-fibronectin binding. These polypeptides are also capable of enhancing fibronectin matrix assembly and inducing disulfide cross-linking of fibronectin molecules in vitro. In addition, these polypeptides are capable of inhibiting migration of tumor cells. The polypeptides of the present invention have a number of related uses as well.
摘要翻译：本发明提供纤连蛋白自组装位点。本发明提供一组衍生自含有纤连蛋白 - 纤连蛋白结合位点的纤连蛋白的第一III型重复序列的多肽。已经使用这些多肽获得源自C末端I型重复序列的第二组多肽，其含有与纤连蛋白的第一III型重复相互作用的第二纤连蛋白 - 纤连蛋白结合位点。这些多肽能够通过干扰纤连蛋白 - 纤连蛋白结合来抑制纤连蛋白基质组装。这些多肽还能够体外增强纤连蛋白基质的组装和诱导纤连蛋白分子的二硫键交联。此外，这些多肽能够抑制肿瘤细胞的迁移。本发明的多肽也具有许多相关用途。

3. 发明授权

US5747452A Method of modulating tumor cell migration using fibronectin type III peptides 失效
标题翻译：使用纤连蛋白III型肽调节肿瘤细胞迁移的方法
公开(公告)号：US5747452A
公开(公告)日：1998-05-05
申请号：US459064
申请日：1995-06-01
申请人： Erkki I. Ruoslahti , Alex Morla
发明人： Erkki I. Ruoslahti , Alex Morla
IPC分类号： A61K38/00 , C07K14/78 , A61K38/39
CPC分类号： C07K14/78 , A61K38/00
摘要： The present invention provides fibronectin self-assembly sites. The invention provides a set of polypeptides derived from the first type III repeat of fibronectin which contain a fibronectin-fibronectin binding site. These polypeptides have been used to obtain a second set of polypeptides derived from the C-terminal type I repeats which contain a second fibronectin-fibronectin binding site which interacts with the first type III repeat of fibronectin. These polypeptides are capable of inhibiting fibronectin matrix assembly by interfering with fibronectin-fibronectin binding. These polypeptides are also capable of enhancing fibronectin matrix assembly and inducing disulfide cross-linking of fibronectin molecules in vitro. In addition, these polypeptides are capable of inhibiting migration of tumor cells. The polypeptides of the present invention have a number of related uses as well.
摘要翻译：本发明提供纤连蛋白自组装位点。本发明提供一组衍生自含有纤连蛋白 - 纤连蛋白结合位点的纤连蛋白的第一III型重复序列的多肽。已经使用这些多肽获得源自C末端I型重复序列的第二组多肽，其含有与纤连蛋白的第一III型重复相互作用的第二纤连蛋白 - 纤连蛋白结合位点。这些多肽能够通过干扰纤连蛋白 - 纤连蛋白结合来抑制纤连蛋白基质组装。这些多肽还能够体外增强纤连蛋白基质的组装和诱导纤连蛋白分子的二硫键交联。此外，这些多肽能够抑制肿瘤细胞的迁移。本发明的多肽也具有许多相关用途。

4. 发明授权

US5453489A Polypeptide fragments of fibronectin which can modulate extracellular matrix assembly 失效
标题翻译：纤连蛋白的多肽片段可以调节细胞外基质组装
公开(公告)号：US5453489A
公开(公告)日：1995-09-26
申请号：US829462
申请日：1992-01-31
申请人： Erkki I. Ruoslahti , Alex Morla
发明人： Erkki I. Ruoslahti , Alex Morla
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , A61P43/00 , C07K14/78 , C12N15/12 , C12P21/02 , C12R1/01 , C07K14/00
CPC分类号： C07K14/78 , A61K38/00
摘要： In accordance with the present invention, there is provided a novel synthetic polypeptide derived from the first type III repeat of fibronectin. The synthetic polypeptide of the invention encompasses a fibronectin-fibronectin binding site, and is capable of inhibiting fibronectin matrix assembly. In contrast to previously identified fibronectin fragments that block fibronectin matrix assembly by blocking an initial event in matrix assembly (i.e., fibronectin binding to cells), the invention polypeptide appears to inhibit an intermediate step in matrix assembly, i.e., fibronectin self-association prior to the disulfide cross-linking that stabilizes the fibronectin matrix.
摘要翻译：根据本发明，提供了衍生自纤连蛋白的第一III型重复序列的新型合成多肽。本发明的合成多肽包括纤连蛋白 - 纤连蛋白结合位点，并能够抑制纤连蛋白基质组装。与通过阻断基质组装中的初始事件（即，纤连蛋白与细胞结合）来阻断纤连蛋白基质组装的先前鉴定的纤连蛋白片段相反，本发明多肽似乎抑制基质组装中的中间步骤，即纤连蛋白自身结合之前二硫键交联使纤连蛋白基质稳定。

5. 发明授权

US07030213B2 Conformationally stabilized cell adhesion peptides 失效
公开(公告)号：US07030213B2
公开(公告)日：2006-04-18
申请号：US09892071
申请日：2001-06-26
申请人： Michael D. Pierschbacher , Erkki I. Ruoslahti
发明人： Michael D. Pierschbacher , Erkki I. Ruoslahti
IPC分类号： A61K38/00
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K7/50 , C07K7/64 , C07K14/47 , C07K14/78
摘要： Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.

6. 发明授权

US5827821A Conformationally stabilized cell adhesion peptides 失效
公开(公告)号：US5827821A
公开(公告)日：1998-10-27
申请号：US914643
申请日：1992-07-16
申请人： Michael D. Pierschbacher , Erkki I. Ruoslahti
发明人： Michael D. Pierschbacher , Erkki I. Ruoslahti
IPC分类号： A61K38/00 , C07K14/47 , C07K14/78
CPC分类号： C07K7/06 , C07K14/47 , C07K14/78 , C07K7/08 , C07K7/50 , C07K7/64 , A61K38/00
摘要： Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.

7. 发明授权

US5695997A Tetrapeptide 失效
标题翻译：四肽
公开(公告)号：US5695997A
公开(公告)日：1997-12-09
申请号：US459641
申请日：1995-06-02
申请人： Erkki I. Ruoslahti , Michael D. Pierschbacher
发明人： Erkki I. Ruoslahti , Michael D. Pierschbacher
IPC分类号： A61K38/07 , A61K38/08 , A61L27/22 , C07K14/78 , C12N5/02 , C07K4/00 , C07K5/10 , C07K14/00
CPC分类号： A61K38/07 , A61K38/08 , A61L27/227 , C07K14/78
摘要： The peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, or other amino acid, having the same cell-attachment activity as fibronectin and the peptide X-Arg-Gly-Asp-Ser-Y, wherein X and Y, having said activity are disclosed.
摘要翻译：肽X-Arg-Gly-Asp-RY，其中X是H或至少一个氨基酸，Y是OH或至少一个氨基酸，R是选自Thr或Cys的氨基酸或其它氨基酸，其具有具有与纤连蛋白相同的细胞附着活性和肽X-Arg-Gly-Asp-Ser-Y，其中X和Y具有所述活性。

8. 发明授权

US5583103A Inhibition of transforming growth factor beta activity 失效
标题翻译：抑制转化生长因子β活性
公开(公告)号：US5583103A
公开(公告)日：1996-12-10
申请号：US212311
申请日：1994-03-14
申请人： Erkki I. Ruoslahti , Yu Yamaguchi
发明人： Erkki I. Ruoslahti , Yu Yamaguchi
IPC分类号： A61K38/00 , C07K14/47 , A61K38/19 , C07K14/495
CPC分类号： C07K14/4703 , C07K14/4725 , A61K38/00 , C07K2319/00
摘要： The present invention provides a method of inhibiting an activity of TGF.beta. comprising contacting the TGF.beta. with a purified decorin. In a specific embodiment, the present invention relates to the ability of decorin, a 40,000 dalton protein that usually carries a glycosaminoglycan chain, to bind TGF.beta.. The invention also provides a novel cell regulatory factor designated MRF. Also provided are methods of identifying, detecting and purifying cell regulatory factors and proteins which bind and affect the activity of cell regulatory factors.
摘要翻译：本发明提供了抑制TGFβ活性的方法，包括使TGFβ与纯化的核心蛋白聚糖接触。在一个具体实施方案中，本发明涉及核心蛋白聚糖，一种通常携带糖胺聚糖链的40,000道尔顿蛋白结合TGFβ的能力。本发明还提供了称为MRF的新型细胞调节因子。还提供鉴定，检测和纯化结合并影响细胞调节因子活性的细胞调节因子和蛋白质的方法。

9. 发明授权

US5169930A Fibronectin receptor 失效
标题翻译：纤维蛋白受体
公开(公告)号：US5169930A
公开(公告)日：1992-12-08
申请号：US461349
申请日：1990-01-05
申请人： Erkki I. Ruoslahti , Guido Tarone , Filippo G. Giancotti , Bruce E. Vogel
发明人： Erkki I. Ruoslahti , Guido Tarone , Filippo G. Giancotti , Bruce E. Vogel
IPC分类号： C07K14/435 , A61K38/00 , C07K1/16 , C07K1/22 , C07K14/705 , C07K16/00 , C07K16/28 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/53
CPC分类号： C07K14/7055 , A61K38/00
摘要： The present invention provides a substantially pure integrin-type receptor characterized in that it consists of an .alpha..sub.v and a .beta..sub.1 subunit. The .alpha..sub.v .beta..sub.1 integrin binds to fibronectin and GRGDSPK but does not bind to vitronectin. The .alpha..sub.v .beta..sub.1 integrin can be used to determine the presence of a .alpha..sub.v .beta..sub.1 ligand and to develop adhesion peptides specific for the various integrins. The presence of the .alpha..sub.v .beta..sub.1 integrin can be used to assess ability of cells to adhere to fibronectin.
摘要翻译：本发明提供了基本上纯的整联蛋白型受体，其特征在于其由αv和β1亚单位组成。 αvβ1整联蛋白与纤连蛋白和GRGDSPK结合，但不结合玻连蛋白。 αvβ1整联蛋白可用于确定αvβ1配体的存在并开发针对各种整合素特异的粘附肽。 αvβ1整联蛋白的存在可用于评估细胞粘附纤连蛋白的能力。

10. 发明授权

US4391749A Method for the purification of collagens 失效
标题翻译：胶原蛋白纯化方法
公开(公告)号：US4391749A
公开(公告)日：1983-07-05
申请号：US313326
申请日：1981-10-19
申请人： Eva S. Engvall , Erkki I. Ruoslahti
发明人： Eva S. Engvall , Erkki I. Ruoslahti
IPC分类号： B01D15/08 , C07K14/78 , A61K35/16 , C07G7/00 , C08H1/06 , C09H1/00
CPC分类号： G01N30/482 , B01D15/3804 , C07K14/78 , B01J2220/54
摘要： Collagen affinity matrices are prepared, useful for separating collagenous substances from other high molecular weight proteinaceous substances. Fibronectin is fragmentated chemically or by enzymatic digestion, etc. Fragments of fibronectin, which retain the collagen-binding site but are severed from other binding sites of intact fibronectin, are selected and coupled to solid support material.
摘要翻译：制备胶原亲和基质，用于从其他高分子量蛋白质物质中分离胶原物质。纤连蛋白被化学碎片化或通过酶促消化等。纤维连接蛋白的片段保留了胶原结合位点，但是从完整纤连蛋白的其他结合位点切断，并与固体支持材料偶联。

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