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1. 发明授权

US07763580B2 Methods for treating conditions associated with the accumulation of excess extracellular matrix 有权
标题翻译：治疗与过量细胞外基质积累有关的病症的方法
公开(公告)号：US07763580B2
公开(公告)日：2010-07-27
申请号：US10952361
申请日：2004-09-27
申请人： Nancy A. Noble , Wayne A. Border
发明人： Nancy A. Noble , Wayne A. Border
IPC分类号： A61K38/14 , A61K38/55 , A61K31/4164 , A61K31/401 , C12Q1/68
CPC分类号： A61K38/488 , A61K31/401 , A61K31/4178 , A61K31/573 , A61K38/14 , A61K38/49 , A61K38/556 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/2803 , C07K2317/76 , A61K2300/00
摘要： The present invention is methods and compositions for reducing and preventing the excess accumulation of extracellular matrix in a tissue and/or organ or at a wound site using a combination of agents that inhibit TGFβ, or using agents that inhibit TGFβ in combination with agents that degrade excess accumulated extracellular matrix, or at least one agent that degrades excess accumulated extracellular matrix. The compositions and methods of the invention are used to treat conditions such as fibrotic diseases and scarring that result from excess accumulation of extracellular matrix, impairing tissue or organ function or skin appearance in a subject.
摘要翻译：本发明是减少和预防组织和/或器官或伤口部位的细胞外基质过量积累的方法和组合物，其使用抑制TGFβb的试剂的组合;或使用抑制TGFβb的试剂; 与降解过量积累的细胞外基质的试剂组合，或至少一种降解过量积累的细胞外基质的试剂。本发明的组合物和方法用于治疗由受试者的细胞外基质的过量积累，损伤组织或器官功能或皮肤外观而导致的纤维化疾病和瘢痕形成等疾病。

2. 发明授权

US06509314B1 Methods of preventing or reducing scarring with decorin or biglycan 失效
标题翻译：用核心蛋白聚糖或双糖缩蛋白聚糖预防或减少瘢痕形成的方法
公开(公告)号：US06509314B1
公开(公告)日：2003-01-21
申请号：US08259335
申请日：1994-06-13
申请人： Erkki I. Ruoslahti , Wayne A. Border
发明人： Erkki I. Ruoslahti , Wayne A. Border
IPC分类号： A01N6100
CPC分类号： C07K14/4725 , A61K38/04 , A61K38/1858 , A61K38/39 , C07K14/4703 , C07K14/475 , C07K14/495 , C07K14/78 , C07K16/22 , C07K2319/00
摘要： The present invention relates to methods of preventing or reducing scarring in a wound area by administering decorin or biglycan to the wound.
摘要翻译：本发明涉及通过向伤口施用核心蛋白聚糖或双糖链蛋白聚糖来预防或减少伤口区域中的瘢痕形成的方法。

3. 发明授权

US5824655A Anti-transforming growth factor-.beta. gene therapy 失效
标题翻译：抗转化生长因子-β基因治疗
公开(公告)号：US5824655A
公开(公告)日：1998-10-20
申请号：US389887
申请日：1995-02-15
申请人： Wayne A. Border
发明人： Wayne A. Border
IPC分类号： C12N15/09 , A61K31/70 , A61K35/23 , A61K35/34 , A61K35/36 , A61K35/42 , A61K38/00 , A61K38/17 , A61K38/22 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/16 , A61P3/06 , A61P9/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P43/00 , C07K14/47 , C07K14/71 , C07K16/28 , C12N15/12 , C12P21/02 , A01N43/04
CPC分类号： C07K14/4725 , A61K38/177 , C07K14/71 , C07K16/2863 , A61K38/00 , A61K48/00
摘要： The present invention provides methods for reducing a pathology in a subject characterized by a deleterious accumulation of TGF-.beta.-induced extracellular matrix in a tissue by introducing a nucleic acid encoding a TGF.beta.-specific inhibitory agent or active fragment thereof into a cell in the subject. In one embodiment, the nucleic acid encoding the TGF-.beta. specific inhibitory agent is introduced into a cell in vivo by injection, for example, in skeletal muscle. In another embodiment, the nucleic acid encoding the TGF-.beta. specific inhibitory agent is transfected into a cell ex vivo to obtain a cell expressing the agent, and the cell is then administered into the subject to be treated. TGF-.beta. specific inhibitory agents of the present invention include, but are not limited to, members of the decoring family of proteoglycans such as decorin, biglycan, fibromodulin and lumican or an antibody specific for TGF-.beta.. Pathologies that can be reduced by the present invention include various fibrotic diseases and conditions.
摘要翻译：本发明提供了减少受试者病理学的方法，其特征在于通过将编码TGFβ特异性抑制剂或其活性片段的核酸引入组织中的TGF-β诱导的细胞外基质的有害积累进入细胞中学科。在一个实施方案中，编码TGF-β特异性抑制剂的核酸通过注射在体内被引入体内，例如在骨骼肌中。在另一个实施方案中，将编码TGF-β特异性抑制剂的核酸转染入体外的细胞以获得表达该试剂的细胞，然后将细胞施用于待治疗的受试者。本发明的TGF-β特异性抑制剂包括但不限于蛋白多糖装饰家族如核心蛋白聚糖，双糖链蛋白聚糖，纤维调节蛋白和lumican或TGF-β特异性抗体的成员。通过本发明可以减少的病理学包括各种纤维化疾病和病症。

4. 发明授权

US07214375B1 Methods of decreasing the accumulation of extracellular matrix associated with glomerulonephritis with anti-TGF-β-specific antibodies 失效
标题翻译：用抗TGF-β特异性抗体降低与肾小球肾炎相关的细胞外基质积累的方法
公开(公告)号：US07214375B1
公开(公告)日：2007-05-08
申请号：US08349479
申请日：1994-12-02
申请人： Wayne A. Border , Erkki I. Ruoslahti
发明人： Wayne A. Border , Erkki I. Ruoslahti
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/22 , A61K2039/505
摘要： The present invention provides a method for treating or arresting the progress of pathologies characterized by an accumulation of extracellular matrix components by providing an agent to suppress the activity of transforming growth factor β (TGF-β) a peptide growth factor which is anabolic and leads to fibrosis and angiogenesis. In one embodiment, such agent is anti-TGF-β antibody. Pathologies which can be so treated include, but are not limited to, glomerulonephritis, adult respiratory distress syndrome and cirrhosis of the liver. The invention further provides a method for the diagnosis of pathologies, or incipient pathologies, which are characterized by the accumulation of extracellular matrix components in tissues by determining the levels of TGF-β in the tissues, a high level being indicative of such pathologies.
摘要翻译：本发明提供了一种通过提供抑制转化生长因子β（TGF-β）的活性的药剂来治疗或阻止细胞外基质成分积累的病态的方法，所述肽生长因子是合成代谢并导致纤维化和血管生成。在一个实施方案中，这种试剂是抗TGF-β抗体。可以如此治疗的病理包括但不限于肾小球性肾炎，成人呼吸窘迫综合征和肝硬化。本发明还提供了用于诊断病理学或初期病理学的方法，其特征在于通过测定组织中TGF-β的水平，组织中的细胞外基质组分的积累指示这种病理学的高水平。

5. 发明授权

US06906026B1 Methods for treating conditions associated with the accumulation of excess extracellular matrix 有权
公开(公告)号：US06906026B1
公开(公告)日：2005-06-14
申请号：US09869820
申请日：2000-07-05
申请人： Nancy A. Noble , Wayne A. Border
发明人： Nancy A. Noble , Wayne A. Border
IPC分类号： A61K31/401 , A61K31/4178 , A61K38/14 , A61K38/49 , A61K38/55 , A61K45/06 , A61K48/00 , A61K38/00 , A61K39/395
CPC分类号： A61K31/573 , A61K31/401 , A61K31/4178 , A61K38/49 , A61K38/556 , A61K45/06 , A61K2300/00
摘要： The present invention is methods and compositions for reducing and preventing the excess accumulation of extracellular matrix in a tissue and/or organ or at a wound site using a combination of agents that inhibit TGFβ, or using agents that inhibit TGFβ in combination with agents that degrade excess accumulated extracellular matrix. The compositions and methods of the invention are used to treat conditions such as fibrotic diseases and scarring that result from excess accumulation of extracellular matrix, impairing tissue or organ function or skin appearance in a subject.

6. 发明授权

US06316258B1 Methods for preventing and treating fibrotic diseases resulting from accumulation of excess extracellular matrix induced by TGF&bgr; using renin inhibitors 有权
标题翻译：用于使用肾素抑制剂预防和治疗由TGFbeta诱导的过量细胞外基质累积引起的纤维化疾病的方法
公开(公告)号：US06316258B1
公开(公告)日：2001-11-13
申请号：US09211916
申请日：1998-12-15
申请人： Nancy A. Noble , Wayne A. Border
发明人： Nancy A. Noble , Wayne A. Border
IPC分类号： G01N3350
CPC分类号： C12N15/1136 , A61K31/401 , A61K38/1709 , A61K38/179 , A61K38/553 , A61K38/556 , A61K39/395 , A61K45/06 , C07K16/22 , C07K16/40 , C12N15/1137 , C12N15/1138 , A61K2300/00
摘要： The present invention is methods for inhibiting the renin-induced production of TGF&bgr; using a renin inhibitory agent to reduce excess accumulation of extracellular matrix in tissue in a subject, and to the use of renin inhibitory agents and additional TGF&bgr; inhibitory agents to reduce TGF&bgr; production to treat and prevent fibrotic diseases.
摘要翻译：本发明是使用肾素抑制剂抑制肾素诱导的TGFbeta产生的方法，以减少受试者组织中细胞外基质过量积累的方法，以及使用肾素抑制剂和另外的TGFbeta抑制剂来减少TGFbeta产生治疗和预防纤维化疾病。

7. 发明授权

US07713924B2 Methods for treating conditions associated with the accumulation of excess extracellular matrix 有权
标题翻译：治疗与过量细胞外基质积累有关的病症的方法
公开(公告)号：US07713924B2
公开(公告)日：2010-05-11
申请号：US10887378
申请日：2004-07-08
申请人： Nancy A. Noble , Wayne A. Border , Daniel A. Lawrence
发明人： Nancy A. Noble , Wayne A. Border , Daniel A. Lawrence
IPC分类号： A61K38/14 , A61K38/55 , A61K31/401 , C12Q1/68
CPC分类号： A61K31/573 , A61K31/401 , A61K31/4178 , A61K38/49 , A61K38/556 , A61K45/06 , A61K2300/00
摘要： The present invention is methods and compositions for reducing and preventing the excess accumulation of extracellular matrix in a tissue and/or organ or at a wound site using a combination of agents that inhibit TGFβ, or using agents that inhibit TGFβ in combination with agents that degrade excess accumulated extracellular matrix. The compositions and methods of the invention are used to treat conditions such as fibrotic diseases and scarring that result from excess accumulation of extracellular matrix, impairing tissue or organ function or skin appearance in a subject.
摘要翻译：本发明是减少和预防组织和/或器官或伤口部位的细胞外基质过量积累的方法和组合物，其使用抑制TGFβb的试剂的组合;或使用抑制TGFβb的试剂; 与降解过量积累的细胞外基质的试剂组合。本发明的组合物和方法用于治疗由受试者的细胞外基质的过量积累，损伤组织或器官功能或皮肤外观而导致的纤维化疾病和瘢痕形成等疾病。

8. 发明申请

US20080175848A1 Methods for treating conditions associated with the accumulation of excess extracellular matrix 审中-公开
标题翻译：治疗与过量细胞外基质积累有关的病症的方法
公开(公告)号：US20080175848A1
公开(公告)日：2008-07-24
申请号：US11981283
申请日：2007-10-30
申请人： Nancy A. Noble , Wayne A. Border
发明人： Nancy A. Noble , Wayne A. Border
IPC分类号： A61K48/00 , A61K31/473 , A61K31/403 , A61K31/401 , A61K39/395
CPC分类号： A61K38/488 , A61K31/401 , A61K31/4178 , A61K31/573 , A61K38/14 , A61K38/49 , A61K38/556 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/2803 , C07K2317/76 , A61K2300/00
摘要： The present invention is methods and compositions for reducing and preventing the excess accumulation of extracellular matrix in a tissue and/or organ or at a wound site using a combination of agents that inhibit TGFβ, or using agents that inhibit TGFβ in combination with agents that degrade excess accumulated extracellular matrix, or at least one agent that degrades excess accumulated extracellular matrix. The compositions and methods of the invention are used to treat conditions such as fibrotic diseases and scarring that result from excess accumulation of extracellular matrix, impairing tissue or organ function or skin appearance in a subject.
摘要翻译：本发明是使用抑制TGFbeta的药剂的组合或使用抑制TGFbeta与降解药物组合的试剂来减少和预防组织和/或器官或伤口部位的细胞外基质过量积累的方法和组合物过量积累的细胞外基质，或至少一种降解过量积累的细胞外基质的试剂。本发明的组合物和方法用于治疗由受试者的细胞外基质的过量积累，损伤组织或器官功能或皮肤外观而导致的纤维化疾病和瘢痕形成等疾病。

9. 发明授权

US5726149A Treatment of glomerulonephritis with decorin 失效
标题翻译：用核心蛋白聚糖治疗肾小球肾炎
公开(公告)号：US5726149A
公开(公告)日：1998-03-10
申请号：US645339
申请日：1991-01-22
申请人： Erkki I. Ruoslahti , Yu Yamaguchi , Wayne A. Border
发明人： Erkki I. Ruoslahti , Yu Yamaguchi , Wayne A. Border
IPC分类号： C12N15/09 , A61K38/00 , A61P9/10 , A61P13/02 , A61P13/12 , A61P15/00 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07K1/22 , C07K14/00 , C07K14/47 , C07K14/50 , C12N5/00 , C12N5/02 , C12N5/06 , C12N5/10 , C12N15/12 , C12P21/00 , C12P21/02 , C12R1/91 , A61K38/02 , A61K38/16 , A61K38/39
CPC分类号： C07K14/4725 , A61K38/00 , C07K2319/00
摘要： A method of treating of glomerulonephritis in a patient by administering decorin.
摘要翻译：通过管理核心蛋白聚糖治疗患者的肾小球肾炎的方法。

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