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1. 发明授权

US6067463A Method and apparatus for non-invasively measuring the amount of glucose in blood 有权
标题翻译：用于非侵入性测量血液中葡萄糖量的方法和装置
公开(公告)号：US6067463A
公开(公告)日：2000-05-23
申请号：US225430
申请日：1999-01-05
申请人： Tzyy-Wen Jeng , Shu-Jen Yeh , John M. Lindberg , Joseph Larry Pezzaniti , Omar S. Khalil , Gary M. Oosta , Charles F. Hanna , Arnold F. Stalder , Ete Z. Szuts
发明人： Tzyy-Wen Jeng , Shu-Jen Yeh , John M. Lindberg , Joseph Larry Pezzaniti , Omar S. Khalil , Gary M. Oosta , Charles F. Hanna , Arnold F. Stalder , Ete Z. Szuts
IPC分类号： G01N21/35 , A61B5/00 , A61B5/145 , A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532
摘要： A method and apparatus for measuring the concentration of an analyte of interest, e.g. glucose, in blood non-invasively, i.e., without penetrating the skin or obtaining a biological sample from the body of a patient. The method and apparatus uses a plurality of measurement channels with appropriate wavelengths of interest to control variations of signal and to separate the contribution of the analyte of interest from those of interfering compounds. The method and apparatus of this invention can also be adapted to allow a portion of a body part to be engorged with blood to bring about greater accuracy in optical measurements. In the method of this invention, at least two similar, but not identical, measurements are made concurrently. For example, at least two measurements can be made with similar, but not identical, wavelengths of electromagnetic radiation. The two wavelengths should not be overlapping to allow maximum non-identity. By making measurements concurrently, each measurement channel in the system experiences variations as they occur substantially simultaneously in all channels. By selecting one of the channels as a reference channel and by normalizing the optical measurements of the other channels to this reference channel, the variations common to all channels are eliminated. Removing these common variations from the optical measurements by normalization, such as by calculating ratios of the measurement of each of the measuring channels to that of the reference channel, will allow the actual changes of the signal for a specific analyte of interest to be measured.
摘要翻译：用于测量所关注的分析物的浓度的方法和装置，例如，葡萄糖在血液中非侵入性地，即不渗透皮肤或从患者的身体获得生物样品。该方法和装置使用具有适当的感兴趣波长的多个测量通道来控制信号的变化并分离感兴趣分析物对干扰化合物的贡献。本发明的方法和装置还可以适于允许身体部分的一部分被血液吸收以在光学测量中带来更高的精度。在本发明的方法中，同时进行至少两个相似但不相同的测量。例如，可以用类似但不相同的电磁辐射波长进行至少两次测量。两个波长不应重叠，以允许最大的非身份。通过同时进行测量，系统中的每个测量通道在所有通道中基本上同时发生变化。通过选择一个通道作为参考通道，并将其他通道的光学测量标准化到该参考通道，可以消除所有通道共用的变化。通过归一化从光学测量中去除这些常见的变化，例如通过计算每个测量通道的测量与参考通道的测量的比率，将允许测量特定分析物的信号的实际变化。

2. 发明授权

US06365109B1 Reagentless analysis of biological samples 有权
标题翻译：对生物样品进行无谓分析
公开(公告)号：US06365109B1
公开(公告)日：2002-04-02
申请号：US09407397
申请日：1999-09-28
申请人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
发明人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
IPC分类号： G01N110
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译：用于确定生物样品例如尿液的至少一种分析物（例如尿素）的至少一个参数例如浓度的装置和方法。特别适用于本发明的装置和方法的生物样品是尿液。通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。为了获得其他分析物（如尿素，肌酐，葡萄糖，酮和蛋白质）的浓度值，可以使用红外光吸收光谱。本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

3. 发明授权

US06773922B2 Reagentless analysis of biological samples 有权
标题翻译：对生物样品进行无谓分析
公开(公告)号：US06773922B2
公开(公告)日：2004-08-10
申请号：US10191148
申请日：2002-07-09
申请人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
发明人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
IPC分类号： G01N2141
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译：用于确定生物样品例如尿液的至少一种分析物（例如尿素）的至少一个参数例如浓度的装置和方法。特别适用于本发明的装置和方法的生物样品是尿液。通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。为了获得其他分析物（如尿素，肌酐，葡萄糖，酮和蛋白质）的浓度值，可以使用红外光吸收光谱。本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

4. 发明授权

US07303922B2 Reagentless analysis of biological samples by applying mathematical algorithms to smoothed spectra 有权
标题翻译：通过应用数学算法平滑光谱对生物样品进行无谓分析
公开(公告)号：US07303922B2
公开(公告)日：2007-12-04
申请号：US10829777
申请日：2004-04-22
申请人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
发明人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
IPC分类号： G01N21/00
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译：用于确定至少一个参数的装置和方法，至少一种分析物的浓度，例如，例如生物样品的尿素，例如，例如尿。特别适用于本发明的装置和方法的生物样品是尿液。通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。为了获得尿素，肌酐，葡萄糖，酮和蛋白质等其他分析物的浓度值，可以使用红外光吸收光谱。本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

5. 发明授权

US6087182A Reagentless analysis of biological samples 有权
标题翻译：对生物样品进行无谓分析
公开(公告)号：US6087182A
公开(公告)日：2000-07-11
申请号：US141483
申请日：1998-08-27
申请人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
发明人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
IPC分类号： G01N21/64 , G01N21/05 , G01N21/27 , G01N21/33 , G01N21/35 , G01N21/41 , G01N21/65 , G01N33/483 , G01N33/493 , G01N21/25
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e.g, urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译：用于确定至少一个参数的装置和方法，至少一种分析物的浓度，例如，例如尿素，例如尿液。特别适用于本发明的装置和方法的生物样品是尿液。通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。为了获得尿素，肌酐，葡萄糖，酮和蛋白质等其他分析物的浓度值，可以使用红外光吸收光谱。本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

6. 发明授权

US06426045B1 Reagentless analysis of biological samples 有权
标题翻译：对生物样品进行无谓分析
公开(公告)号：US06426045B1
公开(公告)日：2002-07-30
申请号：US09407716
申请日：1999-09-28
申请人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
发明人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
IPC分类号： G01N2141
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译：用于确定至少一个参数的装置和方法，至少一种分析物的浓度，例如，例如生物样品的尿素，例如，例如尿。特别适用于本发明的装置和方法的生物样品是尿液。通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。为了获得尿素，肌酐，葡萄糖，酮和蛋白质等其他分析物的浓度值，可以使用红外光吸收光谱。本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

7. 发明授权

US5064541A Devices and methods for the collection of a predetermined volume of plasma or serum 失效
标题翻译：用于收集预定体积的血浆或血清的装置和方法
公开(公告)号：US5064541A
公开(公告)日：1991-11-12
申请号：US499864
申请日：1990-03-27
申请人： Tzyy-Wen Jeng , Kristin D. Elmore , Gary M. Oosta , Terry A. Pry
发明人： Tzyy-Wen Jeng , Kristin D. Elmore , Gary M. Oosta , Terry A. Pry
IPC分类号： B01D39/00 , B01D39/16 , B01D39/18 , B01D39/20 , B01L3/00 , G01N33/49 , G01N33/52 , G01N33/53
CPC分类号： B01L3/508 , B01D39/00 , B01D39/163 , B01D39/1661 , B01D39/18 , B01D39/201 , B01D39/2034 , B01D39/2075 , B01L3/5023 , G01N33/491 , G01N33/526 , G01N33/5302 , B01L2200/12 , B01L2300/0681 , B01L2300/0825 , B01L2300/087 , B01L2400/0406 , Y10T436/25375
摘要： A device and method for permitting the separation of plasma or serum from whole blood. The device comprises a matrix of hydrophilic sintered porous material to which at least one red blood cell agglutinating agent has been applied. According to a first method of using the device, a sample of whole blood is applied to a first end of the matrix and the red blood cells within the sample come in contact with the agglutinating agents present in the matrix. The blood cells agglutinate, and are entrapped in the interstices of the matrix, while substantially blood-cell-free serum or plasma accumulates near the outlet of the device. A filter means in liquid receiving relationship with the matrix functions to wick the serum of plasma from the matrix.According to an alternative aspect of the invention, a filter means in liquid receiving relationship with the outlet of the matrix functions to retain any blood cells which pass through the matrix as the filter means wicks the plasma or serum from the matrix. Additional agglutinating agents may be incorporated within the filter means to facilitate retention of blood cells which pass through the matrix.Another aspect of the present invention involves a device for the measurement of a serum or plasma sample, utilizing a matrix of sintered porous material, such as sintered glass, sintered steel, sintered ceramics, sintered plastics, and equivalents thereof. The matrix is characterized by a reproducible fluid uptake capacity proportional to the fixed dimensions of said matrix, a minimal reactivity with plasma or serum components, and a hydrophilic internal surface which enables the matrix to collect and retain a predetermined volume of sample for analysis.
摘要翻译：允许血浆或血清从全血分离的装置和方法。该装置包括已经施加至少一种红细胞凝集剂的亲水性烧结多孔材料的基质。根据使用该装置的第一种方法，将全血样品施加到基质的第一端，并且样品内的红细胞与存在于基质中的凝集剂接触。血细胞凝集，并被截留在基质的空隙中，而基本上无血细胞的血清或血浆聚集在装置的出口附近。与基质液体接收关系的过滤装置用于从基质中吸收血浆的血清。根据本发明的另一方面，与基质的出口液体接收关系的过滤器装置用于保持通过基质的任何血细胞，因为过滤器装置将血浆或血清从基质中吸出。可以在过滤器装置内并入额外的凝集剂以促进通过基质的血细胞的保留。本发明的另一方面涉及一种利用烧结多孔材料如烧结玻璃，烧结钢，烧结陶瓷，烧结塑料及其等同物的基质来测量血清或血浆样品的装置。该基质的特征在于与所述基质的固定尺寸成比例的可再现的流体吸收能力，与血浆或血清组分的最小反应性，以及亲水性内表面，其使基质收集并保留预定体积的样品用于分析。

8. 发明授权

US4933092A Methods and devices for the separation of plasma or serum from whole blood 失效
标题翻译：用于从全血中分离血浆或血清的方法和装置
公开(公告)号：US4933092A
公开(公告)日：1990-06-12
申请号：US335064
申请日：1989-04-07
申请人： Diane L. Aunet , Gradimir G. Gerogevich , Tzyy-Wen Jeng , Gary M. Oosta , Neal A. Siegel
发明人： Diane L. Aunet , Gradimir G. Gerogevich , Tzyy-Wen Jeng , Gary M. Oosta , Neal A. Siegel
IPC分类号： B01D39/00 , B01D39/16 , B01D39/18 , B01D39/20 , B01L3/00 , B01L3/14 , G01N33/49 , G01N33/52
CPC分类号： B01L3/50825 , B01D39/00 , B01D39/163 , B01D39/1661 , B01D39/18 , B01D39/201 , B01D39/2034 , B01D39/2075 , B01L3/5023 , G01N33/491 , G01N33/526 , B01L2300/046 , B01L2300/0681 , B01L2300/087 , B01L2400/0406 , Y10T436/25375
摘要： A device and method for permitting the separation of plasma or serum from whole blood. The device comprises a matrix of hydrophilic sintered porous material to which at least one red blood cell agglutinating agent has been applied. According to a first method of using the device, a sample of whole blood is applied to a first end of the matrix and the red blood cells within the sample come in contact with the agglutinating agents present in the matrix. The blood cells agglutinate, and are entrapped in the interstices of the matrix, while substantially blood-cell-free serum or plasma accumulates near the outlet of the device. A filter means in liquid receiving relationship with the matrix functions to wick the serum or plasma from the matrix.According to an alternative aspect of the invention, a filter means in liquid receiving relationship with the outlet of the matrix functions to retain any blood cells which pass through the matrix is the filter means wicks the plasma or serum from the matrix. Additional agglutinating agents may be incorporated within the filter means to facilitate retention of blood cells which pass through the matrix.
摘要翻译：允许血浆或血清从全血分离的装置和方法。该装置包括已经施加至少一种红细胞凝集剂的亲水性烧结多孔材料的基质。根据使用该装置的第一种方法，将全血样品施加到基质的第一端，并且样品内的红细胞与存在于基质中的凝集剂接触。血细胞凝集，并被截留在基质的空隙中，而基本上无血细胞的血清或血浆聚集在装置的出口附近。与基质液体接收关系的过滤装置用于从基质中吸收血清或血浆。根据本发明的另一方面，与基质的出口液体接收关系的过滤装置用于保持通过基质的任何血细胞，过滤装置将血浆或血清从基质中吸出。可以在过滤器装置内并入额外的凝集剂以促进通过基质的血细胞的保留。

9. 发明授权

US6070093A Multiplex sensor and method of use 失效
标题翻译：多路传感器和使用方法
公开(公告)号：US6070093A
公开(公告)日：2000-05-30
申请号：US982839
申请日：1997-12-02
申请人： Gary M. Oosta , Tayy-Wen Jeng , John M. Lindberg , Michael L. McGlashen , Joseph L. Pezzaniti
发明人： Gary M. Oosta , Tayy-Wen Jeng , John M. Lindberg , Michael L. McGlashen , Joseph L. Pezzaniti
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , G01N21/21 , G01N33/487
CPC分类号： A61B5/1455 , A61B5/0095 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14558 , G01N21/21
摘要： A multiplex sensor and a method of use that provides enhanced selectivity and sensitivity. In this method, one or more parameters of the sample are measured by means of multiple spectroscopic techniques, and the interferences from physiological and spectral variables are reduced or eliminated. In one embodiment of the present invention comprises a multiplex sensor and a method of use that provides enhanced selectivity and sensitivity. One or more parameters of the sample are measured by means of at least two different spectroscopic techniques, wherein the at least two different spectroscopic techniques are selected from the group consisting of:(a) infrared absorbance(b) scattering(c) emission(d) polarization, and(e) photoacoustics.
摘要翻译：一种复用传感器和使用方法，其提供增强的选择性和灵敏度。在该方法中，通过多种光谱技术测量样品的一个或多个参数，减少或消除了生理和光谱变量的干扰。在本发明的一个实施例中，包括提供增强的选择性和灵敏度的多路复用传感器和使用方法。通过至少两种不同的光谱技术测量样品的一个或多个参数，其中所述至少两种不同的光谱技术选自：（a）红外吸收（b）散射（c）发射（d ）极化，（e）光声。

10. 发明授权

US06567678B1 Multiplex sensor and method of use 有权
标题翻译：多路传感器和使用方法
公开(公告)号：US06567678B1
公开(公告)日：2003-05-20
申请号：US09571095
申请日：2000-05-15
申请人： Gary M. Oosta , Tayy-Wen Jeng , John M. Lindberg , Michael L. McGlashen , Joseph L. Pezzaniti
发明人： Gary M. Oosta , Tayy-Wen Jeng , John M. Lindberg , Michael L. McGlashen , Joseph L. Pezzaniti
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/0095 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14558 , G01N21/21
摘要： A method for using a multiplex sensor that provides enhanced selectivity and sensitivity. In this method, one or more parameters of a sample are measured by means of multiple spectroscopic techniques, and interferences from physiological and spectral variables are reduced or eliminated. One or more parameters of the sample are measured by means of at least two spectroscopic techniques, wherein the at least two different spectroscopic techniques are selected from the group consisting of: (a) infrared absorbance (b) scattering (c) emission (d) polarization, and (e) photoacoustics.
摘要翻译：一种使用提供增强的选择性和灵敏度的多路传感器的方法。在该方法中，通过多个光谱技术测量样品的一个或多个参数，减少或消除来自生理和光谱变量的干扰。通过至少两种光谱技术测量样品的一个或多个参数，其中所述至少两种不同的光谱技术选自：（a）红外吸收（b）散射（c）发射（d）极化，（e）光声。

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