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1. 发明申请

US20050250786A1 PNA monomer and precursor 有权
标题翻译： PNA单体和前体
公开(公告)号：US20050250786A1
公开(公告)日：2005-11-10
申请号：US11183025
申请日：2005-07-15
申请人： Sung Kim , Hyunil Lee , Jong Lim , Hoon Choi , Jae Jeon , Sahn Ahn , Sung Lee , Won Yoon
发明人： Sung Kim , Hyunil Lee , Jong Lim , Hoon Choi , Jae Jeon , Sahn Ahn , Sung Lee , Won Yoon
IPC分类号： C12N15/09 , A61K31/513 , A61K31/52 , C07D277/80 , C07D405/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D473/02 , C07D473/18 , C07D473/32 , C07D473/34 , C07D43/14
CPC分类号： C07D417/04 , C07B2200/11 , C07D277/80 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrite, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.
摘要翻译：本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：其中E为氮或C-R' ; J为硫或氧; R'，R 1，R 2，R 3，R 4独立地为H，卤素，烷基，硝基，亚硝酸根，烷氧基，卤代烷基，卤代烷氧基，苯基或卤代苯基，R 5为H或保护或未保护的天然或非天然α- 氨基酸; 并且B是天然或非天然核碱基，其中当所述核碱基具有环外氨基功能时，所述功能受到在硫醇存在下对酸不稳定但对弱至中碱稳定的保护基保护。

2. 发明申请

US20060008835A1 PNA monomer and precursor 有权
公开(公告)号：US20060008835A1
公开(公告)日：2006-01-12
申请号：US11182672
申请日：2005-07-15
申请人： Sung Kim , Hyunil Lee , Jong Lim , Hoon Choi , Jae Jeon , Sang Ahn , Sung Lee , Won Yoon
发明人： Sung Kim , Hyunil Lee , Jong Lim , Hoon Choi , Jae Jeon , Sang Ahn , Sung Lee , Won Yoon
IPC分类号： C12Q1/68 , C07D473/14
CPC分类号： C07D417/04 , C07B2200/11 , C07D277/80 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

3. 发明申请

US20050250785A1 PNA monomer and precursor 有权
公开(公告)号：US20050250785A1
公开(公告)日：2005-11-10
申请号：US11182977
申请日：2005-07-15
申请人： Sung Kim , Hyunil Lee , Jong Lim , Hoon Choi , Jae Jeon , Sang Ahn , Sung Lee , Won Yoon
发明人： Sung Kim , Hyunil Lee , Jong Lim , Hoon Choi , Jae Jeon , Sang Ahn , Sung Lee , Won Yoon
IPC分类号： C12N15/09 , A61K31/513 , A61K31/52 , C07D277/80 , C07D405/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D473/02 , C07D473/18 , C07D473/32 , C07D473/34 , A61K31/506
CPC分类号： C07D417/04 , C07B2200/11 , C07D277/80 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

4. 发明申请

US20060030709A1 PNA monomer and precursor 有权
公开(公告)号：US20060030709A1
公开(公告)日：2006-02-09
申请号：US11182935
申请日：2005-07-15
申请人： Sung Kim , Hyunil Lee , Jong Lim , Hoon Choi , Jae Jeon , Sang Ahn , Sung Lee , Won Yoon
发明人： Sung Kim , Hyunil Lee , Jong Lim , Hoon Choi , Jae Jeon , Sang Ahn , Sung Lee , Won Yoon
IPC分类号： A61K31/522 , C07D473/12 , C07D473/14 , C07D405/14
CPC分类号： C07D417/04 , C07B2200/11 , C07D277/80 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

5. 发明申请

US20060003374A1 Method of making PNA oligomers 有权
标题翻译：制备PNA低聚物的方法
公开(公告)号：US20060003374A1
公开(公告)日：2006-01-05
申请号：US11182936
申请日：2005-07-15
申请人： Sung Kim , Hyunil Lee , Jong Lim , Hoon Choi , Jae Jeon , Sang Ahn , Sung Lee , Won Yoon
发明人： Sung Kim , Hyunil Lee , Jong Lim , Hoon Choi , Jae Jeon , Sang Ahn , Sung Lee , Won Yoon
IPC分类号： C12Q1/68 , C07D473/02 , C07D473/14 , C07D43/14
CPC分类号： C07D417/04 , C07B2200/11 , C07D277/80 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.
摘要翻译：本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：其中E为氮或C-R' ; J为硫或氧; R'，R 1，R 2，R 3，R 4独立地是H，卤素，烷基，硝基，腈，烷氧基，卤代烷基，卤代烷氧基，苯基或卤代苯基，R 5是H或被保护或未被保护的天然或非天然α- 氨基酸; 并且B是天然或非天然核碱基，其中当所述核碱基具有环外氨基功能时，所述功能受到在硫醇存在下对酸不稳定但对弱至中碱稳定的保护基保护。

6. 发明申请

US20050283005A1 PNA monomer and precursor 有权
公开(公告)号：US20050283005A1
公开(公告)日：2005-12-22
申请号：US11183034
申请日：2005-07-15
申请人： Sung Kim , Hyunil Lee , Jong Lim , Hoon Choi , Jae Jeon , Sang Ahn , Sung Lee , Won Yoon
发明人： Sung Kim , Hyunil Lee , Jong Lim , Hoon Choi , Jae Jeon , Sang Ahn , Sung Lee , Won Yoon
IPC分类号： C12N15/09 , A61K31/513 , A61K31/52 , C07D277/80 , C07D405/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D473/02 , C07D473/18 , C07D473/32 , C07D473/34
CPC分类号： C07D417/04 , C07B2200/11 , C07D277/80 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

7. 发明申请

US20050020810A1 Peptides which target tumor and endothelial cells, compositions and uses thereof 审中-公开
标题翻译：靶向肿瘤和内皮细胞的肽，组合物和用途
公开(公告)号：US20050020810A1
公开(公告)日：2005-01-27
申请号：US10722843
申请日：2003-11-25
申请人： Robert Ternansky , Amy Allan , Patricia Gladstone , Won Yoon , Graham Parry , Fernando Donate , Andrew Mazar
发明人： Robert Ternansky , Amy Allan , Patricia Gladstone , Won Yoon , Graham Parry , Fernando Donate , Andrew Mazar
IPC分类号： A61K38/00 , A61K38/08 , A61K38/10 , A61K47/48 , C07K7/06 , C07K7/08
CPC分类号： C07K7/06 , A61K38/00 , A61K47/62
摘要： The present invention relates generally to peptide analogs of Ac—PHSCN—NH2 which target tumor and endothelial cells and have anti-tumor, anti-angiogenic and anti-metasastic activity, methods of making these peptides, compositions thereof and methods of using these peptides and pharmaceutical compositions thereof to treat, prevent and detect diseases characterized by tumor growth, metastasis and angiogenesis. The peptide analogs may serve, inter alia, as carriers of radioactivity, PET-active compounds, toxins, fluorescent molecules and PEG molecules.
摘要翻译：本发明一般涉及靶向肿瘤和内皮细胞并具有抗肿瘤，抗血管生成和抗代谢活性的Ac-PHSCN-NH2的肽类似物，制备这些肽的方法，其组合物和使用这些肽的方法和用于治疗，预防和检测以肿瘤生长，转移和血管发生为特征的疾病的药物组合物。肽类似物尤其可以用作放射性载体，PET活性化合物，毒素，荧光分子和PEG分子。

8. 发明申请

US20100228963A1 METHODS OF PLACING ADVERTISMENTS, INTERSTITIALS AND TOOLBARS IN A WEB BROWSER 审中-公开
标题翻译：在网络浏览器中放置广告，互动和工具栏的方法
公开(公告)号：US20100228963A1
公开(公告)日：2010-09-09
申请号：US12530403
申请日：2008-03-07
申请人： Hisham Kassab , Saad Mneimneh , Won Yoon
发明人： Hisham Kassab , Saad Mneimneh , Won Yoon
IPC分类号： G06F15/16 , H04L9/00
CPC分类号： G06Q30/02
摘要： The present invention provides methods and systems that can render INE content to a web browser. Various methods and approaches are disclosed that when implemented would enable an INE to place some of INE's contents in a web browser of a user. The INE content can be in the form of a tool bar or interstitial content. The invention can provide one or more of the following advantages: a) provide an opportunity for INE to conduct e-commerce, b) enable an INE to develop alternate revenue generation model, and c) enable an INE or it's related entities to participate in e-commerce and advertising.
摘要翻译：本发明提供了可以向网络浏览器呈现INE内容的方法和系统。公开了各种方法和方法，其被实现将使INE能够将一些INE的内容放置在用户的网络浏览器中。 INE内容可以是工具栏或插页式内容的形式。本发明可以提供一个或多个以下优点：a）为INE提供电子商务的机会，b）使INE能够开发替代收入生成模型，以及c）使INE或其相关实体能够参与电子商务和广告。

9. 发明申请

US20070163275A1 Supercooling apparatus and control method thereof 失效
标题翻译：过冷却装置及其控制方法
公开(公告)号：US20070163275A1
公开(公告)日：2007-07-19
申请号：US11482047
申请日：2006-07-07
申请人： Joo Ha , Jae Lee , Kyung Hahm , Hye Lee , Jeong Kim , Young Shin , Chank Lim , Won Yoon , Jung Lim , Yong Kim
发明人： Joo Ha , Jae Lee , Kyung Hahm , Hye Lee , Jeong Kim , Young Shin , Chank Lim , Won Yoon , Jung Lim , Yong Kim
IPC分类号： F25C1/00 , F25D17/04 , F25C1/22 , B67D5/62
CPC分类号： F25D31/007 , A23G9/045 , A23G9/228 , F25D29/00 , F25D2700/08
摘要： A supercooling apparatus and a control method thereof. The method controls the supercooling apparatus having a storage compartment defined therein, and includes confirming beverages in the storage compartment, obtaining a proper supercooling temperature of each beverage, and controlling the storage compartment to have the proper supercooling temperature.
摘要翻译：过冷却装置及其控制方法。该方法控制具有限定在其中的储藏室的过冷却装置，并且包括确认储藏室中的饮料，获得每种饮料的适当的过冷却温度，并且控制储藏室具有适当的过冷却温度。

10. 发明申请

US20060164358A1 Plasma display and driving method thereof 失效
标题翻译：等离子体显示及其驱动方法
公开(公告)号：US20060164358A1
公开(公告)日：2006-07-27
申请号：US11319731
申请日：2005-12-29
申请人： Won Yoon , Yang Lee , Won Kim , Jang Cho
发明人： Won Yoon , Yang Lee , Won Kim , Jang Cho
IPC分类号： G09G3/36
CPC分类号： G09G3/2965 , G09G3/2942 , G09G2310/066 , G09G2360/16
摘要： A plasma display panel for adaptively reducing load effect and improving luminescence efficiency and discharge efficiency, and a driving method thereof. A plasma display panel includes a capacitive load; a source capacitor; a sustain voltage source to generate a sustain voltage; a first inductor formed on a first current path where a current flows from the capacitive load to the source capacitor; a second inductor formed on a second current path where a current flows from the source capacitor to the capacitive load; a switch configuration and switch control circuit that controls the switching operations of the switch configuration such that at least two discharges may occur during one sustain pulse cycle.
摘要翻译：一种用于自适应地降低负载效应并提高发光效率和放电效率的等离子体显示面板及其驱动方法。等离子体显示面板包括容性负载; 源电容器; 维持电压源，产生维持电压; 形成在电流从电容性负载流向源电容器的第一电流路径上的第一电感器; 形成在第二电流路径上的第二电感器，其中电流从源电容器流向电容性负载; 开关配置和开关控制电路，其控制开关配置的开关操作，使得在一个维持脉冲周期期间可能发生至少两次放电。

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