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1. 发明申请

US20070190667A1 Diagnostic testing process and apparatus 审中-公开
标题翻译：诊断测试过程和设备
公开(公告)号：US20070190667A1
公开(公告)日：2007-08-16
申请号：US11787523
申请日：2007-04-17
申请人： Robert Cole , Andrew Sloane , William Hunter
发明人： Robert Cole , Andrew Sloane , William Hunter
IPC分类号： G01N33/543
CPC分类号： B01L3/5023 , B01L2200/0642 , B01L2300/0825 , B01L2300/16 , B01L2400/0406 , B01L2400/0633 , G01N33/54306 , G01N33/54366 , Y02A50/58 , Y10S435/81 , Y10S435/973 , Y10S436/81
摘要： A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed, (typically for the presence of a particular protein), and a detection analyte (typically an antibody bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.
摘要翻译：公开了一种用于流过测定过程的方法和装置。该方法的特征在于“预孵育步骤”，其中待分析的样品（通常为特定蛋白质的存在）和检测分析物（通常为与胶体金或荧光标签结合的抗体）已知结合特定蛋白质的蛋白质可以结合在一起所需的时间段。该预孵育步骤在样品和检测分析物的混合物与结合到膜的捕获分析物接触之前发生。提供预孵育步骤具有提高测定的灵敏度并降低测定所需样品的体积的效果。公开了一种用于实施该方法的装置，其限定用于接收样品的预孵育室和具有由膜和第二膜限定的基底的检测分析物，捕获分析物与该第二膜结合。在一个版本中，预孵育室在一个位置上被支撑在第二膜上方，但是可以被推入与承载捕获分析物的膜接触，从而允许流体从孵育室通过捕获膜转移。在另一个版本中，孵育室底部的膜是疏水性的并且其下侧接触捕获膜，并且当将润湿剂施加到预孵育室的内容物时，发生流体转移。

2. 发明申请

US20050164404A1 Diagnostic testing process 有权
标题翻译：诊断测试过程
公开(公告)号：US20050164404A1
公开(公告)日：2005-07-28
申请号：US10497925
申请日：2002-12-12
申请人： David Marlborugh , Andrew Sloane , Robert Cole , William Hunter
发明人： David Marlborugh , Andrew Sloane , Robert Cole , William Hunter
IPC分类号： G01N33/52 , B01L3/00 , G01N33/48 , G01N33/543 , G01N33/545 , G01N33/553 , G01N33/558
CPC分类号： B01L3/5023 , B01L2200/0642 , B01L2300/0825 , B01L2300/16 , B01L2400/0406 , B01L2400/0633 , G01N33/54306 , G01N33/54366 , Y02A50/58 , Y10S435/81 , Y10S435/973 , Y10S436/807 , Y10S436/81
摘要： A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed (typically for the presence of a particular protein), and a detection analyte (typically one or more antibodies bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre-incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.
摘要翻译：公开了一种用于流过测定过程的方法和装置。该方法的特征在于“预孵育步骤”，其中待分析的样品（通常为特定蛋白质的存在）和检测分析物（通常为结合胶体金或荧光标记的一种或多种抗体）已知结合特定蛋白质可以结合在一起所需的时间段。此预孵育步骤在样品和检测分析物的混合物与结合到膜的捕获分析物接触之前发生。提供预孵育步骤具有提高测定的灵敏度并降低测定所需样品的体积的效果。公开了一种用于实施该方法的装置，其限定用于接收样品的预孵育室和具有由膜和第二膜限定的基底的检测分析物，捕获分析物与该第二膜结合。在一个版本中，预孵育室在一个位置上被支撑在第二膜上方，但是可以被推入与承载捕获分析物的膜接触，从而允许流体从孵育室通过捕获膜转移。在另一个版本中，孵育室底部的膜是疏水性的并且其下侧接触捕获膜，并且当将润湿剂施加到预孵育室的内容物时，发生流体转移。

3. 发明申请

US20050124077A1 Diagnostic testing process and apparatus 有权
标题翻译：诊断测试过程和设备
公开(公告)号：US20050124077A1
公开(公告)日：2005-06-09
申请号：US10487052
申请日：2002-08-20
申请人： Robert Cole , Andrew Sloane , William Hunter
发明人： Robert Cole , Andrew Sloane , William Hunter
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： B01L3/5023 , B01L2200/0642 , B01L2300/0825 , B01L2300/16 , B01L2400/0406 , B01L2400/0633 , G01N33/54306 , G01N33/54366 , Y02A50/58 , Y10S435/81 , Y10S435/973 , Y10S436/81
摘要： A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed, (typically for the presence of a particular protein), and a detection analyte (typically an antibody bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.
摘要翻译：公开了一种用于流过测定过程的方法和装置。该方法的特征在于“预孵育步骤”，其中待分析的样品（通常为特定蛋白质的存在）和检测分析物（通常为与胶体金或荧光标签结合的抗体）已知结合特定蛋白质的蛋白质可以结合在一起所需的时间段。该预孵育步骤在样品和检测分析物的混合物与结合到膜的捕获分析物接触之前发生。提供预孵育步骤具有提高测定的灵敏度并降低测定所需样品的体积的效果。公开了一种用于实施该方法的装置，其限定用于接收样品的预孵育室和具有由膜和第二膜限定的基底的检测分析物，捕获分析物与该第二膜结合。在一个版本中，预孵育室在一个位置上被支撑在第二膜上方，但是可以被推入与承载捕获分析物的膜接触，从而允许流体从孵育室通过捕获膜转移。在另一个版本中，孵育室底部的膜是疏水性的并且其下侧接触捕获膜，并且当将润湿剂施加到预孵育室的内容物时，发生流体转移。

4. 发明申请

US20050109478A1 Foundry mold handling system with multiple dump outputs and method 有权
标题翻译：铸造模具处理系统具有多个转储输出和方法
公开(公告)号：US20050109478A1
公开(公告)日：2005-05-26
申请号：US10976606
申请日：2004-10-29
申请人： William Hunter , William Hunter
发明人： William Hunter , William Hunter
IPC分类号： B22C5/16 , B22C9/02 , B22C11/02 , B22D2/00 , B22D33/02 , B22D46/00 , B22D47/02
CPC分类号： B22D2/00 , B22D46/00 , B22D47/02
摘要： A mold handling system for carrying and transporting sand molds comprises a mold handling conveyor with multiple mold exits to provide different outputs for the sand molds. The mold handling system may include flags which can be used to mark selected molds to segregate the sand molds into different groups. A control system responds to flag sensors and tracks the molds to selectively control output of sand molds through the mold exits. Methods of handling sand molds using a mold handling system are also disclosed.
摘要翻译：用于运输和运输砂模的模具处理系统包括具有多个模具出口的模具处理输送机，以为砂模提供不同的输出。模具处理系统可以包括可用于标记所选模具以将砂模分离成不同组的标记。控制系统响应标志传感器并跟踪模具以选择性地控制通过模具出口的砂模的输出。还公开了使用模具处理系统处理砂模的方法。

5. 发明申请

US20060042775A1 Automated clamping mechanism and mold flask incorporating same 有权
公开(公告)号：US20060042775A1
公开(公告)日：2006-03-02
申请号：US10935065
申请日：2004-08-31
申请人： William Hunter , William Hunter
发明人： William Hunter , William Hunter
IPC分类号： B22C21/08
CPC分类号： B22C21/08
摘要： A mold flask assembly is provided with a novel clamping mechanism for clamping a pattern plate in the mold flask assembly of an automated molding machine. The clamping mechanism comprises a first clamp abutment and a clamping head extending along an axis. The clamping head provides a second clamp abutment. The first and second clamp abutments engage each other in a clamped position. The first and second clamp abutments are spaced along the axis and angularly displaced in a released position. A combination rotary and linear actuator is operative to facilitate relative linear translation and rotation between the rod and the bushing to move between the clamped and released positions.

6. 发明申请

US20070062667A1 Automated clamping mechanism and mold flask incorporating same 有权
标题翻译：自动夹紧机构和装有相同模具的烧瓶
公开(公告)号：US20070062667A1
公开(公告)日：2007-03-22
申请号：US11601122
申请日：2006-11-17
申请人： William Hunter , William Hunter
发明人： William Hunter , William Hunter
IPC分类号： B22C21/08
CPC分类号： B22C21/08
摘要： A mold flask assembly is provided with a novel clamping mechanism for clamping a pattern plate in the mold flask assembly of an automated molding machine. The clamping mechanism comprises a first clamp abutment and a clamping head extending along an axis. The clamping head provides a second clamp abutment. The first and second clamp abutments engage each other in a clamped position. The first and second clamp abutments are spaced along the axis and angularly displaced in a released position. A combination rotary and linear actuator is operative to facilitate relative linear translation and rotation between the rod and the bushing to move between the clamped and released positions.
摘要翻译：模具烧瓶组件设置有用于将图案板夹紧在自动模塑机的模具烧瓶组件中的新型夹紧机构。夹紧机构包括沿轴线延伸的第一夹紧邻接件和夹紧头。夹头提供第二夹紧支座。第一和第二夹紧支座在夹紧位置彼此接合。第一和第二夹紧支座沿着轴线间隔开并且在释放位置上成角度地移位。组合的旋转和线性致动器可操作以促进杆和衬套之间的相对线性平移和旋转以在夹紧位置和释放位置之间移动。

7. 发明申请

US20080089952A1 Compositions and methods for coating medical implants 审中-公开
公开(公告)号：US20080089952A1
公开(公告)日：2008-04-17
申请号：US11888674
申请日：2007-07-31
申请人： William Hunter , David Gravett , Philip Toleikis , Richard Liggins , Troy Loss
发明人： William Hunter , David Gravett , Philip Toleikis , Richard Liggins , Troy Loss
IPC分类号： A61K31/17 , A61K31/35 , A61K31/44 , A61K33/24 , A61P43/00
CPC分类号： A61L29/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L2300/404 , A61L2300/416
摘要： Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant.

8. 发明申请

US20080009902A1 SUTURES AND FIBROSING AGENTS 审中-公开
标题翻译：衣服和弯曲剂
公开(公告)号：US20080009902A1
公开(公告)日：2008-01-10
申请号：US11669097
申请日：2007-01-30
申请人： William Hunter , Rui Avelar , David Gravett , Philip Toleikis , Arpita Maiti
发明人： William Hunter , Rui Avelar , David Gravett , Philip Toleikis , Arpita Maiti
IPC分类号： A61B17/04
CPC分类号： A61L17/005 , A61K9/0024 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61L31/16 , A61L2300/30 , A61L2300/40 , A61L2300/45 , Y10T29/49826
摘要： Sutures are used in combination with fibrosing agents to induce or stimulate fibrosis that between the sutures and the host tissues into which the sutures are inserted. Compositions and methods are described for use in lifting tissue, closing wound, and other applications.
摘要翻译：缝线与纤维化剂组合使用以诱导或刺激缝合线和插入缝线的主体组织之间的纤维化。描述组合物和方法用于提升组织，闭合伤口和其它应用。

9. 发明申请

US20070213393A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS UTILIZING PROTEIN OR POLYSACCHARIDE CONTAINING ANTI-MICROTUBULE AGENTS 审中-公开
标题翻译：用于处理含有抗微生物剂的蛋白质或多糖的炎症条件的组合物和方法
公开(公告)号：US20070213393A1
公开(公告)日：2007-09-13
申请号：US11687528
申请日：2007-03-16
申请人： William Hunter , David Gravett , Richard Liggins , Philip Toleikis
发明人： William Hunter , David Gravett , Richard Liggins , Philip Toleikis
IPC分类号： A61K31/337 , A61K31/165 , A61K47/36 , A61K47/42 , C07C233/01 , C07D305/14
CPC分类号： A61K9/5161 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/1075 , A61K9/127 , A61K9/14 , A61K9/5153 , A61K9/7007 , A61K31/165 , A61K31/337 , A61K31/717 , A61K31/721 , A61K31/728 , A61K38/36 , A61K38/38 , A61K38/39 , A61K47/36 , A61K47/38 , A61K47/42 , A61K2300/00
摘要： Disclosed herein are compositions and methods for treating a variety of inflammatory conditions (e.g., inflammatory arthritis, adhesions, tumor excision sites, and fibroproliferative diseases of the eye). For example, there is provided a composition comprising a protein or polysaccharide containing dispersed (e.g., in micelle or liposome form) anti-microtubule agent, which may be formulated for administration to a patient in need thereof.
摘要翻译：本文公开了用于治疗各种炎性病症（例如炎症性关节炎，粘连，肿瘤切除部位和眼睛的纤维增生性疾病）的组合物和方法。例如，提供了包含含有分散（例如胶束或脂质体形式）抗微管剂的蛋白质或多糖的组合物，其可以配制用于给予有需要的患者。

10. 发明申请

US20070198063A1 Electrical devices and anti-scarring drug combinations 审中-公开
标题翻译：电器和抗瘢痕组合药物
公开(公告)号：US20070198063A1
公开(公告)日：2007-08-23
申请号：US11542163
申请日：2006-10-03
申请人： William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
发明人： William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
IPC分类号： A61N1/18
CPC分类号： A61N1/372 , A61N1/0568 , A61N1/3605 , A61N1/37 , A61N1/375
摘要： Electrical devices (e.g., cardiac rhythm management and neurostimulation devices) for contact with tissue are used in combination with an anti-scarring drug combination or a composition that comprises an anti-scarring drug combination to inhibit scarring that may otherwise occur when the devices are implanted within an animal.
摘要翻译：与组织接触的电子装置（例如，心律管理和神经刺激装置）与抗瘢痕形成药物组合或包含抗瘢痕形成药物组合的组合物组合使用以抑制当装置植入时可能发生的瘢痕形成在动物体内

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