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1. 发明专利

JP2009247315A Method of detecting target nucleic acid 有权
标题翻译：检测目标核酸的方法
公开(公告)号：JP2009247315A
公开(公告)日：2009-10-29
申请号：JP2008102096
申请日：2008-04-10
申请人： National Agriculture & Food Research Organization , National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所 , 独立行政法人農業・食品産業技術総合研究機構
发明人： IWAURA SATOYOSHI , KAMEYAMA MAYUMI , SHIMIZU TOSHIMI
IPC分类号： C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for detecting a target nucleic acid (DNA or RNA) by observing an aqueous solution in which the target nucleic acid is dissolved, under a microscope.
SOLUTION: A nucleic acid of an examined object, a pair of probe designed based on the base sequence of the target nucleic acid, and a nucleotide lipid having nucleotide at molecular terminals of a bivalent or trivalent hydrocarbon chain, are dissolved in an aqueous solvent. As the target nucleic acids are present in the aqueous solution, they form complemental nucleic acid base pairs and thereby self-assemble to form fiber, so that the observation of their forms determines whether the target nucleic acid is present or not.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种通过在显微镜下观察其中溶解了目标核酸的水溶液来检测靶核酸（DNA或RNA）的方法。解决方案：将检测对象的核酸，基于靶核酸的碱基序列设计的一对探针和在二价或三价烃链的分子末端具有核苷酸的核苷酸脂溶于水溶剂。由于目标核酸存在于水溶液中，它们形成互补核酸碱基对，从而自组装形成纤维，使得观察其形式决定了靶核酸是否存在。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2010260011A Vesicle, and method for manufacturing the same 有权
标题翻译： VESICLE及其制造方法
公开(公告)号：JP2010260011A
公开(公告)日：2010-11-18
申请号：JP2009113707
申请日：2009-05-08
申请人： National Agriculture & Food Research Organization , National Institute Of Advanced Industrial Science & Technology , 独立行政法人産業技術総合研究所 , 独立行政法人農業・食品産業技術総合研究機構
发明人： IWAURA SATOYOSHI , KAMEYAMA MAYUMI , IIZAWA TOMOHIKO , NAMIKAWA HIROYUKI , SHIMIZU TOSHIMI
IPC分类号： B01J13/04
摘要： PROBLEM TO BE SOLVED: To provide a method for simply and stably forming a nanosized vesicle without requiring chemical or physical pretreatment, and the vesicle formed thereby. SOLUTION: The nanosized vesicle is formed by dispersing nucleotide lipid, wherein nucleotides are provided to both terminals of a hydrocarbon chain, in an aqueous solvent. This nucleotide lipid is represented by the formula R-X n (wherein n is 2 or 3; X is nucleotide; and R is a divalent or trivalent hydrocarbon chain and bonded to the hydrocarbon chain in the phosphoric acid part of nucleotide). If a water-soluble component or a water dispersible component is contained in the aqueous solvent, it can be taken in the vesicle. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种简单且稳定地形成纳米尺寸囊泡的方法，而不需要化学或物理预处理，并且由此形成囊泡。解决方案：通过在水性溶剂中分散核苷酸脂质形成纳米尺寸囊泡，其中核苷酸被提供给烃链的两个末端。该核苷酸脂质由式RX（s）表示，其中n为2或3; X为核苷酸; R为二价或三价烃链，并与磷酸部分的烃链结合核苷酸）。如果在水性溶剂中含有水溶性成分或水分散性成分，则可以将其吸收在囊泡中。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2009233825A Method for mass-producing metal-complexed organic nanotube 有权
标题翻译：用于生产金属复合有机纳米管的方法
公开(公告)号：JP2009233825A
公开(公告)日：2009-10-15
申请号：JP2008085969
申请日：2008-03-28
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： OGISO MAKI , ASAKAWA MASUMI , SHIMIZU TOSHIMI
IPC分类号： B82B3/00
CPC分类号： D01F6/68
摘要： PROBLEM TO BE SOLVED: To provide a method for drastically improving production efficiency in a method for producing a metal-complexed organic nanotube composed of a self-assembly of a peptide lipid.
SOLUTION: The method for producing a metal-complexed organic nanotube comprises a process of suspending the peptide lipid expressed by general formula: RCO(NH-CHR'-CO)
m OH (wherein, R represents a hydrocarbon group of carbon numbers 6-24, R' represents an amino acid side chain, and m represents an integer of 1-10) or H(NH-CHR'-CO)
m NHR (wherein, R represents a hydrocarbon group of carbon numbers 7-25, R' represents an amino acid side chain, and m represents an integer of 1-10) in an organic solvent, a process of mixing a metal salt solution into the suspension, a process of generating the metal-complexed organic nanotube by leaving the suspension at rest at room temperature, and a process of collecting the metal-complexed organic nanotube from the suspension and air-drying the nanotubes at room temperature or drying under reduced pressure at room temperature.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：解决的问题：提供一种在由肽脂质的自组装构成的金属络合的有机纳米管的制造方法中大幅提高生产效率的方法。解决方案：金属络合的有机纳米管的制造方法包括使由通式RCO（NH-CHR'-CO）表示的肽类脂质悬浮的方法，其中，R 表示碳原子数为6〜24的烃基，R'表示氨基酸侧链，m表示1-10的整数）或H（NH-CHR'-CO）其中，R表示碳数为7〜25的烃基，R'表示氨基酸侧链，m表示1-10的整数），将金属盐溶液混入悬浮液中的方法，通过将悬浮液在室温下静置而产生金属络合的有机纳米管的方法，以及从悬浮液中收集金属络合的有机纳米管并在室温下空气干燥纳米管或在室内减压干燥的方法温度。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2009136975A Organic nanotube encapsulating low molecular weight compound 审中-公开
标题翻译：有机纳米粒子包封低分子量化合物
公开(公告)号：JP2009136975A
公开(公告)日：2009-06-25
申请号：JP2007317092
申请日：2007-12-07
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： AOYANAGI SUSUMU , ASAKAWA MASUMI , OGISO MAKI , IIJIMA AYUKO , SHIMIZU TOSHIMI
IPC分类号： B82B1/00 , A61K9/00 , A61K47/40 , B01J20/24 , B82B3/00 , C09K3/00
摘要： PROBLEM TO BE SOLVED: To provide a method for encapsulating organic and inorganic materials in tubes of organic nanotubes that can be inexpensively and easily synthesized, without using an organic solvent, and a method for discharging the encapsulated material.
SOLUTION: A low molecular weight compound is encapsulated in inner pores of organic nanotubes by adding and stirring organic nanotubes formed by aggregating molecules of an amphiphilic compound to an aqueous solution in which the low molecular weight compound and cyclodextrin are coexistent. The organic nanotubes encapsulating the low molecular weight compound are mixed with water to discharge the low molecular weight compound encapsulated in the inner pores of the organic nanotubes.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种将有机和无机材料封装在有机纳米管的管中的方法，其可以廉价且容易地合成，而不使用有机溶剂，以及用于排出封装材料的方法。解决方案：通过加入并搅拌通过将两亲性化合物的分子聚集形成的有机纳米管与低分子量化合物和环糊精共存的水溶液，将低分子量化合物包封在有机纳米管的内孔中。将包封低分子量化合物的有机纳米管与水混合以排出包封在有机纳米管的内孔中的低分子化合物。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2005239632A Polymerizable bicephalic glycolipid, tube-shaped aggregate thereof and its polymer 审中-公开
标题翻译：聚乙二醇，聚乙二醇及其聚合物
公开(公告)号：JP2005239632A
公开(公告)日：2005-09-08
申请号：JP2004051222
申请日：2004-02-26
申请人： Japan Science & Technology Agency , National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所 , 独立行政法人科学技術振興機構
发明人： MASUDA MITSUTOSHI , KAMIYA MASAKO , SHIMIZU TOSHIMI , MASUBUCHI SAYURI , NAMIKAWA HIROYUKI
IPC分类号： C07H13/04 , B82B1/00 , B82B3/00 , C07H5/06
CPC分类号： B82Y30/00
摘要： PROBLEM TO BE SOLVED: To provide a new glycolipid capable of forming a tube-shaped aggregate stabilizable by polymerization; and to provide a fine fiber or tube-shaped aggregate thereof.
SOLUTION: The tube-shaped fiber stable over a long period is obtained by forming autoaggregate by using an asymmetrical polymerizable bicephalic glycolipid, and polymerizing the product. The polymerizable bicephalic glycolipid is represented by the general formula (wherein, G is a residue obtained by removing a reduced terminal hydroxy group of aldopyranose; X is a hydrogen atom, a hydroxy group, a carboxy group or an amino group; (a) and b are the same or different and each an integer of 0-20). The aggregate, and the hollow tube-shaped polymer obtained by polymerizing the aggregate are also provided.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供能够形成可通过聚合稳定的管状骨料的新糖脂; 并提供细纤维或管状聚集体。解决方案：长时间稳定的管状纤维通过使用不对称的可聚合双头脂糖形成自聚集体并使产物聚合而获得。可聚合双糖脂由通式表示（其中，G是通过除去醛糖吡喃糖的缩合的末端羟基得到的残基; X是氢原子，羟基，羧基或氨基;（a）和 b相同或不同，每个为0-20的整数）。还提供了聚集体和通过聚合聚集体获得的中空管状聚合物。版权所有（C）2005，JPO＆NCIPI

6. 发明专利

JP2004224717A N-glycoside-type glycolipid and hollow fiber-like organic nanotube comprising the same 有权
公开(公告)号：JP2004224717A
公开(公告)日：2004-08-12
申请号：JP2003013266
申请日：2003-01-22
申请人： Japan Science & Technology Agency , National Institute Of Advanced Industrial & Technology , 独立行政法人科学技術振興機構 , 独立行政法人産業技術総合研究所
发明人： KAMIYA MASAKO , SHIMIZU TOSHIMI , JOHN JONG HWA
IPC分类号： C07H13/06 , B82B1/00 , B82B3/00 , C07H5/04 , C07H5/06
CPC分类号： C07H13/06 , B82Y10/00 , B82Y30/00 , C07H5/06 , C07K9/001 , Y10S977/706 , Y10S977/742
摘要： PROBLEM TO BE SOLVED: To obtain a new hollow fiber-like organic nanotube and microtube which are simply produced in a short time and have wide use ranges.
SOLUTION: The N-glycoside-type glycolipid is represented by general formula (1): G-NHCO-R (G is a saccharide residue after removal of a hemiacetal-hydroxy group bonded to an anomer carbon atom of a saccharide; R is a 10-39C unsaturated hydrocarbon group). The hollow fiber-like organic nanotube is formed by dissolving the N-glycoside-type glycolipid in water, slowly cooling the solution, allowing the solution to stand at a room temperature to cause the self-integration of the molecule. The hollow fiber-like organic nanotube has 70-500 nm average outer diameter, 40-300 nm average inner diameter (average diameter of hollow) and about several hundred nm-several hundred μm length.
COPYRIGHT: (C)2004,JPO&NCIPI

7. 发明专利

JP2004123663A Spherical fine particle in which molecular orientation is uniformly arranged and method for producing the same 有权
公开(公告)号：JP2004123663A
公开(公告)日：2004-04-22
申请号：JP2002293533
申请日：2002-10-07
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： MATSUZAWA YOKO , MATSUMOTO MUTSUYOSHI , OGISO MAKI , SHIMIZU TOSHIMI
IPC分类号： A61L27/00 , A61K8/72 , C07K1/04 , C07K5/062 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide spherical fine particles, in which molecular orientation is uniformly arranged, composed of a compound represented by formula A and useful in a fine chemical field and electronic/information fields, or the like, as a functional material or a medical material, or the like and to provide a method for producing the fine particles. SOLUTION: The spherical fine particles in which the molecular orientation is uniformly arranged are composed of a compound represented by formula A (wherein X is an integer of 1-3; Y is an integer of 8-20; R is hydrogen or a 1-5C alkyl group). The spherical fine particles can be produced by immersing a base material having a hydrophilic property into an aqueous solution of a salt of the compound represented by formula A and depositing the fine particles under an acidic atmosphere. COPYRIGHT: (C)2004,JPO

8. 发明专利

JP2004083474A Compound prepared by bonding two molecules of crown ether derivative comprising crown ether derivative and secondary ammonium salt and its production method 有权
公开(公告)号：JP2004083474A
公开(公告)日：2004-03-18
申请号：JP2002246064
申请日：2002-08-27
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： ASAKAWA MASUMI , HIRAMOTO MAYUMI , SHIMIZU TOSHIMI
IPC分类号： C07D323/00
摘要： PROBLEM TO BE SOLVED: To provide a compound which has substituents capable of forming new noncovalent bonds and can be used in producing a noncovalently bonded polymer and a mechanically bonded polymer. SOLUTION: The compound prepared by bonding two molecules of a crown ether derivative is anyone represented by the formula. In the formula, Q is a substituent; and X is an arbitrary atomic or molecular anion. COPYRIGHT: (C)2004,JPO

9. 发明专利

JP2003055642A Hydrogelling agent 有权
标题翻译：加氢剂
公开(公告)号：JP2003055642A
公开(公告)日：2003-02-26
申请号：JP2001248636
申请日：2001-08-20
申请人： Japan Science & Technology Corp , National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所 , 科学技術振興事業団
发明人： SHIMIZU TOSHIMI , IWAURA SATOYOSHI , MASUDA MITSUTOSHI
IPC分类号： C09K3/00 , C07H19/10 , C07H21/04
CPC分类号： C07H19/10 , C07H21/04
摘要： PROBLEM TO BE SOLVED: To provide a gelling agent containing a biomaterial structuring component capable of expecting bioadaptability, capable of easy mass production, and capable of solidifying a large quantity of water or an aqueous solution with a minimal weight and a simple method.
SOLUTION: This hydrogel-forming agent is represented by the general formula: R-A
n [wherein n is 2 or 3, A represents the same or different nucleotide, R represents a hydrocarbon chain (which is divalent if n is 2, and trivalent if n is 3), and the hydrocarbon chain is bonded at the phosphate portion of the nucleotide].
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供含有能够预期生物适应性的生物材料结构组分的胶凝剂，其能够容易地批量生产，并且能够以最小的重量和简单的方法固化大量的水或水溶液。解决方案：该水凝胶形成剂由以下通式表示：R-An [其中n为2或3，A表示相同或不同的核苷酸，R表示烃链（如果n为2，则为二价），如果 n为3），烃链在核苷酸的磷酸部分键合。

10. 发明专利

JP2012127016A Method for producing hollow fiber-like organic nanotube in semi-wet system 审中-公开
标题翻译：在半湿润系统中生产中空纤维有机纳米管的方法
公开(公告)号：JP2012127016A
公开(公告)日：2012-07-05
申请号：JP2010277974
申请日：2010-12-14
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： OGISO MAKI , U RYEO-YEON , AOYANAGI SUSUMU , ASAKAWA MASUMI , SHIMIZU TOSHIMI
IPC分类号： D01F6/00
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an organic nanotube by creating a solid-solid configuration change from a plate-like to a nanotube-like shape in a semi-wet system, that is different from a conventional production method utilizing self assembling of organic molecules in a solution system or a solution-solid equilibrium system or a generally known production method utilizing a lipid phase transition temperature.SOLUTION: The hollow fiber-like organic nanotube is obtained by adding an alkali to a dry powder of a peptide lipid represented by the general formula RCO(NH-CHR'-CO)OH (in the formula, R represents a 6-24C hydrocarbon group, R' represents an amino acid side chain, and m represents an integer of 1-10) to wet and then adding an acid, or by adding an alkali to a dry powder of a peptide lipid represented by the general formula HCl H(NH-CHR'-CO)NHR (in the formula, R represents a 7-25C hydrocarbon group, R' represents an amino acid side chain, and m represents an integer of 1-10) to wet in order to create a configuration change in a wet substance.
摘要翻译：解决的问题：为了提供一种通过在半湿式系统中产生从板状至纳米管状形状的固相配置变化来制造有机纳米管的方法，这与常规生产不同在溶液系统或溶液 - 固体平衡系统中利用自组装有机分子的方法或利用脂质相转变温度的通常已知的生产方法。解决方案：通过向通式RCO（NH-CHR'-CO）表示的肽脂质的干粉中加入碱来获得中空纤维状有机纳米管， / SB> OH（式中，R表示6-24C烃基，R'表示氨基酸侧链，m表示1-10的整数），然后加入酸，或加入碱与通式为HCl H（NH-CHR'-CO）表示的肽脂质的干粉末（式中，R表示7-25C烃基），R'表示氨基酸侧链，m表示1-10的整数），以便产生湿物质中的构型变化。版权所有（C）2012，JPO＆INPIT

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