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    • 1. 发明申请
    • Compounds for the treatment of metabolic disorders
    • 用于治疗代谢紊乱的化合物
    • US20070105955A1
    • 2007-05-10
    • US10553936
    • 2004-04-20
    • Kirvin HodgeShalini SharmaRobert KaufmanAlbert LeeReid von Borstel
    • Kirvin HodgeShalini SharmaRobert KaufmanAlbert LeeReid von Borstel
    • A61K31/235C07C69/76
    • C07C69/734A61K31/235
    • Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; m is 2 or 3; q is 0 or 1; t is 0 or 1; R2 is alkyl having from 1 to 3 carbon atoms; R3 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula I by a ring carbon; and R1 is hydrogen or alkyl having 1 or 2 carbon atoms. Alternatively, when R1 is hydrogen, the biologically active agent can be a pharmaceutically acceptable salt of the compound of Formula (I).
    • 公开了可用于治疗诸如胰岛素抵抗综合征,糖尿病,高脂血症,脂肪肝疾病,恶病质,肥胖症,动脉粥样硬化和动脉硬化的各种代谢疾病的药剂。 式(I)其中n为1或2; m为2或3; q为0或1; t为0或1; R 2是具有1至3个碳原子的烷基; R 3是氢,卤素,具有1至3个碳原子的烷基或具有1至3个碳原子的烷氧基; A是未取代的或被1或2个选自:卤素,具有1或2个碳原子的烷基,全氟甲基,具有1或2个碳原子的烷氧基和全氟甲氧基取代的苯基; 或具有3至6个环碳原子的环烷基,其中环烷基是未取代的或一个或两个环碳独立地被甲基或乙基单取代; 或具有1或2个选自N,S和O的环杂原子的5或6元杂芳环,杂芳环通过环碳与式I化合物的其余部分共价结合; R 1是氢或具有1或2个碳原子的烷基。 或者,当R 1是氢时,生物活性剂可以是式(I)化合物的药学上可接受的盐。
    • 2. 发明申请
    • COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
    • 用于治疗代谢性疾病的化合物
    • US20080015254A1
    • 2008-01-17
    • US11841489
    • 2007-08-20
    • Kirvin HodgeShalini SharmaAlbert LeeReid von Borstel
    • Kirvin HodgeShalini SharmaAlbert LeeReid von Borstel
    • A61K31/192
    • C07C69/734A61K31/192A61K31/24C07C59/68C07C65/24C07C69/76C07C69/92
    • Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. wherein n is 1 or 2; m is 0, 1, 2, 4, or 5; q is 0 or 1; t is 0 or 1; R2 is alkyl having from 1 to 3 carbon atoms; R3 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula I by a ring carbon; and R1 is hydrogen or alkyl having 1 or 2 carbon atoms. Alternatively, when R1 is hydrogen, the biologically active agent can be a pharmaceutically acceptable salt of the compound of Formula I.
    • 公开了用于治疗诸如胰岛素抵抗综合征,糖尿病,高脂血症,脂肪肝疾病,恶病质,肥胖症,动脉粥样硬化和动脉硬化的各种代谢疾病的药剂。 其中n为1或2; m为0,1,2,4或5; q为0或1; t为0或1; R 2是具有1至3个碳原子的烷基; R 3是氢,卤素,具有1至3个碳原子的烷基或具有1至3个碳原子的烷氧基; A是未取代的或被1或2个选自:卤素,具有1或2个碳原子的烷基,全氟甲基,具有1或2个碳原子的烷氧基和全氟甲氧基取代的苯基; 或具有3至6个环碳原子的环烷基,其中环烷基是未取代的或一个或两个环碳独立地被甲基或乙基单取代; 或具有1或2个选自N,S和O的环杂原子的5或6元杂芳环,杂芳环通过环碳与式I化合物的其余部分共价结合; R 1是氢或具有1或2个碳原子的烷基。 或者,当R 1是氢时,生物活性剂可以是式I化合物的药学上可接受的盐。
    • 3. 发明申请
    • Compounds for the treatment of metabolic disorders
    • 用于治疗代谢紊乱的化合物
    • US20060247309A1
    • 2006-11-02
    • US10531630
    • 2004-02-09
    • Kevin HodgeShalini SharmaAlbert LeeReid von Borstel
    • Kevin HodgeShalini SharmaAlbert LeeReid von Borstel
    • A61K31/24A61K31/192
    • C07C69/734A61K31/192A61K31/24C07C59/68C07C65/24C07C69/76C07C69/92
    • Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, artherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; m is 0, 1, 2, 4 or 5; q is 0 or 1; t is 0 or 1; R2 is alkyl from 1 to 3 carbon atoms; R3 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by or 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloaldyl having from 3 to 6 ring carbon atoms wherein the cycloaldyl is unsubstitited or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compounds of formula (I) by a ring carbon; and R1 is hydrogen or alkyl having 1 or 2 carbon atoms. Alternatively, when R1 is hydrogen, the biologically active agent can be a pharmaceutically acceptable salt of the compound of Formula (I).
    • 公开了用于治疗各种代谢疾病如胰岛素抵抗综合征,糖尿病,高脂血症,脂肪肝疾病,恶病质,肥胖症,动脉粥样硬化和动脉硬化的药剂。 式(I)其中n为1或2; m为0,1,2,4或5; q为0或1; t为0或1; R 2是具有1至3个碳原子的烷基; R 3是氢,卤素,具有1至3个碳原子的烷基或具有1至3个碳原子的烷氧基; A是未取代或被1或2个选自以下的基团取代的苯基:卤素,具有1或2个碳原子的烷基,全氟甲基,具有1或2个碳原子的烷氧基和全氟甲氧基; 或具有3至6个环碳原子的环戊烯基,其中所述环烯基未被取代或一个或两个环碳独立地被甲基或乙基单取代; 或具有1或2个选自N,S和O的环杂原子的5或6元杂芳环,杂芳环通过环碳与其余的式(I)化合物共价结合; R 1是氢或具有1或2个碳原子的烷基。 或者,当R 1是氢时,生物活性剂可以是式(I)化合物的药学上可接受的盐。
    • 8. 发明授权
    • Backing strip for windshield wiper
    • 挡风玻璃刮水器背带
    • US08196256B2
    • 2012-06-12
    • US12715112
    • 2010-03-01
    • Albert Lee
    • Albert Lee
    • B60S1/38
    • B60S1/38B60S2001/382Y10S29/037Y10T29/49622Y10T29/49995Y10T29/49996
    • A backing strip for a windshield wiper assembly includes a pair of rails. Each of the pair of rails includes a body portion and a detent portion. The detent portion includes a cut-out on each side thereof. The cut-outs form at least a pair of hooks on each side of said detent portion. The cut-out on one side of the detent portion of each of said rails is for receiving a claw of the windshield wiper assembly and the hooks on the opposite side of the detent portion of each of the rails are for engaging a windshield wiper blade of the windshield wiper assembly.
    • 用于挡风玻璃刮水器组件的背衬条包括一对导轨。 一对轨道中的每一个包括主体部分和棘爪部分。 止动部分包括在其每一侧的切口。 所述切口在所述棘爪部分的每一侧形成至少一对钩。 每个所述轨道的止动部分的一侧上的切口用于容纳挡风玻璃刮水器组件的爪,并且每个轨道的止动部分的相对侧上的钩用于接合挡风玻璃刮水器组件的挡风玻璃刮水器 挡风玻璃刮水器组件。
    • 9. 发明授权
    • Windshield wiper arm bracket
    • 挡风玻璃刮水臂支架
    • US08166605B2
    • 2012-05-01
    • US11889845
    • 2007-08-16
    • Albert Lee
    • Albert Lee
    • B60S1/40
    • B60S1/4006B60S1/3851B60S1/3856B60S1/3867B60S1/4074Y10T24/44769Y10T24/44923Y10T29/49826Y10T29/49995Y10T403/32893Y10T403/32901Y10T403/583Y10T403/587
    • A windshield wiper arm bracket includes a pair of side walls. Each of said side walls include at least one centrally located pin arm receiving hole formed therein. The bracket also includes a post attaching the pair of side walls together. The post is for receiving a pin arm adaptor thereon. The bracket also includes an attachment arm formed on a bottom of each of the pair of side walls. The attachment arms are for connecting the bracket to a windshield wiper assembly. An adaptor for a windshield wiper arm bracket includes a top portion and a web portion. The web portion includes a central aperture formed therein. The central aperture includes a first portion for receiving a post of the windshield wiper arm bracket and a second aperture for receiving a pin arm of a windshield wiper arm.
    • 挡风玻璃刮水器支架包括一对侧壁。 每个所述侧壁包括形成在其中的至少一个位于中心的销臂接纳孔。 支架还包括将一对侧壁连接在一起的柱。 该柱用于在其上接收销臂适配器。 支架还包括形成在每对侧壁的底部上的连接臂。 连接臂用于将支架连接到挡风玻璃刮水器组件。 用于挡风玻璃刮水器臂支架的适配器包括顶部和腹板部分。 腹板部分包括形成在其中的中心孔。 中心孔包括用于接收挡风玻璃刮水器臂支架的柱的第一部分和用于接收挡风玻璃刮水器臂的销臂的第二孔。