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1. 发明授权

US08722919B2 Process for production of mono-substituted alkylated compound using aldimine or derivative thereof 有权
标题翻译：使用醛亚胺或其衍生物生产单取代烷基化化合物的方法
公开(公告)号：US08722919B2
公开(公告)日：2014-05-13
申请号：US11997168
申请日：2006-07-28
申请人： Keiji Maruoka , Toru Inoue , Jun Matsumoto
发明人： Keiji Maruoka , Toru Inoue , Jun Matsumoto
IPC分类号： C07C251/24
CPC分类号： C07B53/00 , B01J31/0239 , B01J31/0244 , B01J2231/46 , B01J2531/98 , C07C227/32 , C07C231/18 , C07C249/02 , C07C229/36 , C07C237/20 , C07C251/24
摘要： The present invention provides a method for producing asymmetrical mono-substituted alkylated compounds of α-amino acids that are represented by a specific formula, using an aldimine-type Schiff base. In the method of the present invention, the process of alkylating an aldimine-type Schiff base in a medium in the presence of an optically-active quaternary ammonium salt phase-transfer catalyst and an inorganic base is initiated, and subsequently the reaction is quenched at a time earlier than a time for completion of the stoichiometric reaction of the alkylation reaction, so that a mono-substituted alkylated product with high optical purity can be obtained.
摘要翻译：本发明提供了使用醛亚胺型席夫碱制备由特定的式表示的α-氨基酸的不对称单取代烷基化化合物的方法。在本发明的方法中，开始在光学活性季铵盐相转移催化剂和无机碱的存在下在介质中烷基化醛亚胺型希夫碱的方法，随后将反应在比完成烷基化反应的化学计量反应的时间早，从而可以获得具有高光学纯度的单取代的烷基化产物。

2. 发明申请

US20090054679A1 PROCESS FOR PRODUCTION OF MONO-SUBSTITUTED ALKYLATED COMPOUND USING ALDIMINE OR DERIVATIVE THEREOF 有权
标题翻译：使用其衍生物或其衍生物生产单取代的烷基化合物的方法
公开(公告)号：US20090054679A1
公开(公告)日：2009-02-26
申请号：US11997168
申请日：2006-07-28
申请人： Keiji Maruoka , Toru Inoue , Jun Matsumoto
发明人： Keiji Maruoka , Toru Inoue , Jun Matsumoto
IPC分类号： C07C227/34
CPC分类号： C07B53/00 , B01J31/0239 , B01J31/0244 , B01J2231/46 , B01J2531/98 , C07C227/32 , C07C231/18 , C07C249/02 , C07C229/36 , C07C237/20 , C07C251/24
摘要： The present invention provides a method for producing asymmetrical mono-substituted alkylated compounds of α-amino acids that are represented by a specific formula, using an aldimine-type Schiff base. In the method of the present invention, the process of alkylating an aldimine-type Schiff base in a medium in the presence of an optically-active quaternary ammonium salt phase-transfer catalyst and an inorganic base is initiated, and subsequently the reaction is quenched at a time earlier than a time for completion of the stoichiometric reaction of the alkylation reaction, so that a mono-substituted alkylated product with high optical purity can be obtained.
摘要翻译：本发明提供了使用醛亚胺型席夫碱制备由特定的式表示的α-氨基酸的不对称单取代烷基化化合物的方法。在本发明的方法中，开始在光学活性季铵盐相转移催化剂和无机碱的存在下在介质中烷基化醛亚胺型希夫碱的方法，随后将反应在比完成烷基化反应的化学计量反应的时间早，从而可以获得具有高光学纯度的单取代的烷基化产物。

3. 发明授权

US08242303B2 Method of producing optically active N-(halopropyl) amino acid derivative 有权
标题翻译：光学活性N-（卤代丙基）氨基酸衍生物的制造方法
公开(公告)号：US08242303B2
公开(公告)日：2012-08-14
申请号：US12671565
申请日：2008-05-19
申请人： Jun Matsumoto , Toru Inoue
发明人： Jun Matsumoto , Toru Inoue
IPC分类号： C07C229/00
CPC分类号： C07B53/00 , C07B2200/07 , C07C229/12 , C07C233/83 , C07C271/22 , Y02P20/55
摘要： The present invention provides a method for producing an optically active N-(halopropyl)amino acid derivative, wherein the method comprises the steps of obtaining a compound represented by formula (III) by reacting an optically active alanine ester represented by formula (I) or a salt thereof (hereinafter sometimes simply referred to as an “alanine ester”) with a halogenated propane represented by formula (II); and obtaining an optically active N-(halopropyl)amino acid derivative represented by formula (IV) by introducing a protecting group onto the nitrogen atom of the compound represented by formula (III). The present invention provides a method for efficiently producing an optically active N-(halopropyl)amino acid derivative.
摘要翻译：本发明提供了一种光学活性N-（卤代丙基）氨基酸衍生物的制备方法，其中该方法包括以下步骤：通过使式（I）表示的光学活性丙氨酸酯或式其盐（以下有时简称为“丙氨酸酯”）与式（II）表示的卤代丙烷; 通过在式（III）表示的化合物的氮原子上引入保护基，得到由式（Ⅳ）表示的光学活性的N-（卤代丙基）氨基酸衍生物。本发明提供了有效制备光学活性N-（卤代丙基）氨基酸衍生物的方法。

4. 发明申请

US20110190527A1 METHOD OF PRODUCING OPTICALLY ACTIVE N-(HALOPROPYL) AMINO ACID DERIVATIVE 有权
标题翻译：制备光学活性N-（羟基丙酸）氨基酸衍生物的方法
公开(公告)号：US20110190527A1
公开(公告)日：2011-08-04
申请号：US12671565
申请日：2008-05-19
申请人： Jun Matsumoto , Toru Inoue
发明人： Jun Matsumoto , Toru Inoue
IPC分类号： C07C69/96 , C07C67/307 , C07C67/313 , C07C271/54
CPC分类号： C07B53/00 , C07B2200/07 , C07C229/12 , C07C233/83 , C07C271/22 , Y02P20/55
摘要： The present invention provides a method for producing an optically active N-(halopropyl)amino acid derivative, wherein the method comprises the steps of obtaining a compound represented by formula (III) by reacting an optically active alanine ester represented by formula (I) or a salt thereof (hereinafter sometimes simply referred to as an “alanine ester”) with a halogenated propane represented by formula (II); and obtaining an optically active N-(halopropyl)amino acid derivative represented by formula (IV) by introducing a protecting group onto the nitrogen atom of the compound represented by formula (III). The present invention provides a method for efficiently producing an optically active N-(halopropyl)amino acid derivative.
摘要翻译：本发明提供了一种光学活性N-（卤代丙基）氨基酸衍生物的制备方法，其中该方法包括以下步骤：通过使式（I）表示的光学活性丙氨酸酯或式其盐（以下有时简称为“丙氨酸酯”）与式（II）表示的卤代丙烷; 通过在式（III）表示的化合物的氮原子上引入保护基，得到由式（Ⅳ）表示的光学活性的N-（卤代丙基）氨基酸衍生物。本发明提供了有效制备光学活性N-（卤代丙基）氨基酸衍生物的方法。

5. 发明授权

US09134313B2 Method of detecting colorectal cancer of stages 0 to I 有权
标题翻译：检测0〜I期结直肠癌的方法
公开(公告)号：US09134313B2
公开(公告)日：2015-09-15
申请号：US12480983
申请日：2009-06-09
申请人： Masao Kawakita , Kyoko Hiramatsu , Keiichi Takahashi , Naotaka Hamasaki , Koji Yamaguchi , Tsunehisa Kaku , Koichiro Muta , Munechika Enjoji , Seiji Naito , Jun Hayashi , Shoshu Mitsuyama , Hiroyuki Yamashita , Toru Inoue , Masato Kato
发明人： Masao Kawakita , Kyoko Hiramatsu , Keiichi Takahashi , Naotaka Hamasaki , Koji Yamaguchi , Tsunehisa Kaku , Koichiro Muta , Munechika Enjoji , Seiji Naito , Jun Hayashi , Shoshu Mitsuyama , Hiroyuki Yamashita , Toru Inoue , Masato Kato
IPC分类号： G01N33/574 , C07K16/30
CPC分类号： G01N33/574 , C07K16/30
摘要： A tumor marker comprising diacetylspermine, and a method of evaluating the state of a tumor, comprising reacting an antibody to diacetylspermine with a biological sample to thereby detect diacetylspermine and evaluating the state of the tumor using the obtained detection results as an indicator.
摘要翻译：包含二乙酰精胺的肿瘤标志物和评价肿瘤状态的方法，包括使抗体与二乙酰精胺与生物样品反应，从而检测二乙酰精胺，并使用所获得的检测结果作为指标来评价肿瘤的状态。

6. 发明申请

US20110190986A1 WORKING FLUID MEDIUM TEMPERATURE CONTROL SYSTEM AND METHOD 有权
标题翻译：工作流体介质温度控制系统及方法
公开(公告)号：US20110190986A1
公开(公告)日：2011-08-04
申请号：US13017868
申请日：2011-01-31
申请人： Takayuki Bitou , Koh Uchida , Katsuhiro Suda , Taisuke Ueda , Toru Inoue , Yoshikazu Takahashi , Hideyuki Kita , Yohei Koike , Nariaki Tazawa
发明人： Takayuki Bitou , Koh Uchida , Katsuhiro Suda , Taisuke Ueda , Toru Inoue , Yoshikazu Takahashi , Hideyuki Kita , Yohei Koike , Nariaki Tazawa
IPC分类号： B62D6/00 , B62D5/06 , B62D5/04 , F04C15/00
CPC分类号： B62D5/065 , B62D5/0463 , B62D5/062 , B62D5/064 , F15B21/042 , Y10T74/20018
摘要： A working fluid medium temperature control system comprises an actuator operable on a working fluid medium, a pump for the working fluid medium, a fluid passage structure for the working fluid medium, an electric motor drivingly connected to the pump, and a control unit for the electric motor, the control unit including an inverter and an inverter controller. The inverter and the electric motor are integrated in such a way that the inverter is in heat transfer communication with the electric motor. The fluid passage structure is in heat transfer communication with the inverter.
摘要翻译：工作流体介质温度控制系统包括可在工作流体介质上操作的致动器，用于工作流体介质的泵，用于工作流体介质的流体通道结构，驱动地连接到泵的电动马达，以及用于电动机，控制单元包括逆变器和逆变器控制器。逆变器和电动机的集成方式使得逆变器与电动机进行热传递通信。流体通道结构与逆变器进行热传递通信。

7. 发明申请

US20070053729A1 Fixing device 有权
标题翻译：固定装置
公开(公告)号：US20070053729A1
公开(公告)日：2007-03-08
申请号：US11354002
申请日：2006-02-15
申请人： Tetsuo Yamada , Atsumi Kurita , Toru Inoue , Yasuyuki Kobayashi , Yasushi Nagata , Aya Kakishima , Tatsunori Izawa
发明人： Tetsuo Yamada , Atsumi Kurita , Toru Inoue , Yasuyuki Kobayashi , Yasushi Nagata , Aya Kakishima , Tatsunori Izawa
IPC分类号： G03G15/20
CPC分类号： G03G15/2025 , G03G15/2028
摘要： A fixing device for heating and pressing a recording medium carrying an unfixed toner image or an unfixed ink image to fix the unfixed toner image or the unfixed ink image on the recording medium, includes a heating roller which has a heating source and has an endless peripheral surface moves around an axis, a pressure roller which is pressed onto the peripheral surface of the heating roller, and presses the recording medium passing between the pressure roller and the heating roller onto the peripheral surface of the heating roller, and plural cleaning sections which are provided to make contact with the heating roller. At least one of the cleaning sections is set, at a portion making contact with the heating roller, to have a relatively negative potential with respect to a surface potential of the heating roller.
摘要翻译：用于加热和压制携带未定影调色剂图像的记录介质或未定影油墨图像以将未定影调色剂图像或未定影油墨图像固定在记录介质上的定影装置包括：加热辊，其具有加热源并具有环形周边表面沿着轴线移动，压辊被压在加热辊的外周表面上，并将通过加压辊和加热辊的记录介质按压到加热辊的周面上，并且多个清洁部分被设置成与加热辊接触。在与加热辊接触的部分处设置至少一个清洁部分相对于加热辊的表面电位具有相对负的电位。

8. 发明申请

US20060201741A1 Ultralight soundproof material 有权
标题翻译：超轻型隔音材料
公开(公告)号：US20060201741A1
公开(公告)日：2006-09-14
申请号：US10551124
申请日：2004-03-23
申请人： Toru Inoue , Masaki Ishikawa , Youhei Ishikawa , Sohei Matsuyama , Hideyuki Mori
发明人： Toru Inoue , Masaki Ishikawa , Youhei Ishikawa , Sohei Matsuyama , Hideyuki Mori
IPC分类号： F02B77/13
CPC分类号： G10K11/16 , B60R13/0815 , G10K11/168 , Y10T428/249953 , Y10T428/249982 , Y10T428/249987
摘要： A sound insulator of the invention includes a sound absorption layer 202 and an air-impermeable resonance layer 203, which are bonded to each other via an adhesive layer 204. The sound absorption layer 202 has a thickness in a range of 5 to 50 mm and an area-weight of not greater than 2000 g/m2. The sound absorption layer 202 has a two-layer structure of a high-density sound absorption layer 202a and a low-density sound absorption layer 202b, which have different densities. The high-density sound absorption layer 202a is bonded to the air-impermeable resonance layer 203 via the adhesive layer 204 and has a density in a range of 0.05 to 0.20 g/cm3 and a thickness in a range of 2 to 30 mm. The low-density sound absorption layer 202b is bonded to the other face of the high-density sound absorption layer 202a, which is opposite to the air-impermeable resonance layer 203, via an adhesive layer 202c and has a density in a range of 0.01 to 0.10 g/cm3 and a thickness in a range of 2 to 30 mm. The structure of this sound insulator effectively reduces a noise level in a voice-tone frequency band, especially in a high frequency domain, thereby efficiently enhancing the clarity of conversion in a vehicle interior.
摘要翻译：本发明的隔音器包括通过粘合剂层204彼此结合的吸声层202和不透气的共振层203。吸音层202的厚度为5〜50mm，面积重量为2000g / m 2以下。吸音层202具有密度不同的高密度吸声层202a和低密度吸声层202b的两层结构。高密度吸声层202a经由粘合剂层204与不透气性共振层203接合，密度为0.05〜0.20g / cm 3，厚度为范围为2至30 mm。低密度吸声层202b经由粘合层202c与不透气性共振层203相对的高密度吸声层202a的另一面粘接，密度为范围为0.01〜0.10g / cm 3，厚度范围为2〜30mm。该隔音器的结构有效地降低了语音频带中的噪声水平，特别是在高频域，从而有效地提高了车辆内部的转换清晰度。

9. 发明授权

US06721621B1 Numerical controller for wire electrical discharge machine 失效
标题翻译：电线放电机数控机
公开(公告)号：US06721621B1
公开(公告)日：2004-04-13
申请号：US09462672
申请日：2002-10-18
申请人： Shigeaki Naka , Toru Inoue
发明人： Shigeaki Naka , Toru Inoue
IPC分类号： G06F1900
CPC分类号： B23H7/20 , B23H7/04 , B23H7/065 , B23H2600/12
摘要： In wire electrical discharge machining, to make it possible to determine the state of rough machining or finishing in various stages, the machining speed, the working voltage, and execution portion information are stored as a set for each movement of a fixed distance in the process of execution of a plurality of times of machining in which rough machining through finish machining are consecutively executed, and are displayed in a two-dimensional graph.
摘要翻译：在电线放电加工中，为了能够以各种阶段确定粗加工或精加工的状态，加工速度，工作电压和执行部分信息作为一组固定距离存储在该过程中执行通过精加工的粗加工的多次加工的执行，并且以二维图形显示。

10. 发明授权

US06414825B1 Thin film device, thin film magnetic head and magnetoresistive element 有权
标题翻译：薄膜器件，薄膜磁头和磁阻元件
公开(公告)号：US06414825B1
公开(公告)日：2002-07-02
申请号：US09409382
申请日：1999-09-30
申请人： Toru Inoue , Koichi Terunuma
发明人： Toru Inoue , Koichi Terunuma
IPC分类号： G11B539
CPC分类号： G11B5/3903 , G11B5/235 , G11B5/3133 , G11B5/40
摘要： An object of the invention is to improve the thermal conductivity and the hardness of a first shield gap film and a second shield gap film. Another object is to improve the thermal conductivity while decreasing the stress. The first shield gap film and the second shield gap film are formed of an insulating film which includes at least one of BN, SiN or CN as the main component, a little Ar and oxygen. Higher thermal conductivity can be obtained by using the insulating film which includes at least one of BN, SiN, or CN so that the heat generated in an MR element can be effectively dissipated. In addition, including Ar improves the hardness so that excessive polishing can be suppressed at the time of forming the air bearing surface. Moreover, including oxygen decreases the stress and exfoliation of the first and the second shield gap films can be avoided.
摘要翻译：本发明的目的是提高第一屏蔽间隙膜和第二屏蔽间隙膜的热导率和硬度。另一个目的是提高导热性同时降低应力。第一屏蔽间隙膜和第二屏蔽间隙膜由包括BN，SiN或CN中的至少一种作为主要成分，少量Ar和氧的绝缘膜形成。通过使用包括BN，SiN或CN中的至少一种的绝缘膜可以获得更高的导热性，使得可以有效地消散在MR元件中产生的热量。此外，包括Ar提高硬度，从而在形成空气轴承表面时可以抑制过多的抛光。此外，包括氧减少了应力，并且可以避免第一和第二屏蔽间隙膜的剥离。

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