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1. 发明专利

JP2007277249A Neutrokine-alpha and neutrokine-alpha splice variant 审中-公开
标题翻译： NEUTROKINE-ALPHA和NEUTROKINE-ALPHA SPLICE变体
公开(公告)号：JP2007277249A
公开(公告)日：2007-10-25
申请号：JP2007111070
申请日：2007-04-19
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： ROSEN CRAIG A , NI JIAN , EBNER REINHARD , YU GUO-LIANG
IPC分类号： C07K14/52 , C12N15/09 , A61K38/00 , A61K38/19 , A61P31/00 , A61P35/04 , A61P37/02 , A61P37/04 , A61P37/06 , C07K14/715 , C07K16/24 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/19 , C12P21/02
CPC分类号： C07K14/715 , A61K38/00 , C07K14/52 , C07K16/24 , C07K2317/34
摘要： PROBLEM TO BE SOLVED: To provide a cytokine similar to TNF involved in a pathological state. SOLUTION: The above protein is an isolated protein containing a Neutrokine-α protein fused to a toxin protein, wherein the Neutrokine-alpha protein contains an amino acid sequence chosen from the group consisting of (a) the amino acid sequence of particular amino acid residues, (b) an amino acid sequence that is at least 90% identical to the particular amino acid residues and (c) the amino acid sequence of a portion of the particular polypeptide, wherein the portion is at least 30 amino acids in length and is capable of stimulating B cell proliferation. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供与参与病理状态的TNF相似的细胞因子。解决方案：上述蛋白质是含有与毒素蛋白质融合的中和蛋白α蛋白质的分离蛋白质，其中中性粒细胞-β蛋白质含有选自（a）特定氨基酸序列的氨基酸序列氨基酸残基，（b）与特定氨基酸残基至少90％相同的氨基酸序列和（c）特定多肽的一部分的氨基酸序列，其中该部分至少具有30个氨基酸，长度，能够刺激B细胞增殖。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2010279364A 207 human secreted proteins 审中-公开
标题翻译： 207人类分泌蛋白
公开(公告)号：JP2010279364A
公开(公告)日：2010-12-16
申请号：JP2010152548
申请日：2010-07-02
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： PAUL YOUNG , JOHN M GREEN , FERRIE ANN M , RUBEN STEVEN M , ROSEN CRAIG A , HU JING-SHAN , OLSEN HENRIK S , EBNER REINHARD , BREWER LAURIE A , MOORE PAUL A , SHI YANGGU , FLORENCE CHARLES , FLORENCE KIMBERLY , LAFLEUR DAVID W , NI JIAN , FAN PIN , WEI IN-FEI , FISCHER CARRIE L , DANIEL R SOPETTO , LI YI , ZENG ZHIZHEN , KYAW HLA , YU GUO-LIANG , FENG PING , DILLON PATRICK J , ENDRESS GREGORY A , CARTER KENNETH C
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P1/04 , A61P35/00 , C07K14/47 , C07K16/18 , C12N5/10 , C12P21/08 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide secreted proteins or genes encoding such proteins, and methods for detecting, treating and preventing medical disorders using the proteins or genes. SOLUTION: There are disclosed 207 human secreted proteins and isolated nucleic acids comprising the coding regions of the genes encoding such proteins. There are also disclosed vectors, host cells, antibodies, and recombinant methods for producing the human secreted proteins. There are further disclosed diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these human secreted proteins. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供编码这种蛋白质的分泌蛋白质或基因，以及使用蛋白质或基因检测，治疗和预防医学病症的方法。解决方案：公开了207种人分泌蛋白质和分离的核酸，其包含编码这种蛋白质的基因的编码区。还公开了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。进一步公开了用于诊断和治疗与这些人分泌蛋白相关的疾病的诊断和治疗方法。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2008194038A HUMAN TUMOR NECROSIS FACTOR δ and ε 审中-公开
标题翻译：人肿瘤坏死因子三角洲和epsilon
公开(公告)号：JP2008194038A
公开(公告)日：2008-08-28
申请号：JP2008015655
申请日：2008-01-25
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： NI JIAN , YU GUO-LIANG , GENTZ REINER L , DILLON PATRICK J
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P35/00 , C07K16/24 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/577
CPC分类号： Y02A50/411 , Y02A50/58
摘要： PROBLEM TO BE SOLVED: To provide a human TNF δ and TNF ε polypeptides and a polynucleotide encoding the polypeptide and to provide a method for producing the polynucleotide. SOLUTION: The isolated polynucleotide includes a polynucleotide having at least 70% homology to a member selected from the following group of (a) a polynucleotide encoding a polypeptide including a specific amino acid sequence, (b) a polynucleotide encoding a polypeptide including a specific amino acid sequence, (c) a polynucleotide encoding a polypeptide including amino acid 39 to amino acid 233 of a specific sequence, (d) a polynucleotide complementary to the polynucleotide of (a), (b) or (c) and (e) a polynucleotide including at least 15 bases of the polynucleotide of (a), (b), (c) or (d). COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供人TNFδ和TNFε多肽和编码多肽的多核苷酸，并提供生产多核苷酸的方法。解决方案：分离的多核苷酸包括与选自以下组的成员具有至少70％同源性的多核苷酸，（a）编码包含特定氨基酸序列的多肽的多核苷酸，（b）编码多肽的多核苷酸，包括特定氨基酸序列，（c）编码包含特定序列的氨基酸39至氨基酸233的多肽的多核苷酸，（d）与（a），（b）或（c）和（ e）包含（a），（b），（c）或（d）的多核苷酸的至少15个碱基的多核苷酸。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2009165466A Vegi(vascular endothelial cell growth inhibitor) as inhibitor of neovascularization and tumor growth 审中-公开
标题翻译： VEGI（血管内皮细胞生长抑制剂）作为新生血管和肿瘤生长的抑制剂
公开(公告)号：JP2009165466A
公开(公告)日：2009-07-30
申请号：JP2008300188
申请日：2008-11-25
申请人： Georgetown Univ Medical Center , Human Genome Sciences Inc , ジョージタウンユニバーシティーメディカルセンター , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： LI LU-YUAN , ZHAI YIFAN , YU GUO-LIANG , NI JIAN , LIPPMAN MARC E , ROSEN CRAIG A
IPC分类号： C12N15/09 , A61K31/7088 , A61K31/711 , A61K38/00 , A61K48/00 , A61P1/00 , A61P9/00 , A61P9/10 , A61P9/14 , A61P17/00 , A61P17/02 , A61P17/06 , A61P27/02 , A61P27/06 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07K14/47 , C07K14/525 , C07K14/705 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/70575 , A61K38/00 , C12N2799/026
摘要： PROBLEM TO BE SOLVED: To provide a VEGI inhibiting neovascularization in cellular models and tumorigenesis in animal models, and to provide a method for using the same. SOLUTION: An isolated nucleic acid molecule is provided, comprising a polynucleotide selected from the group consisting of (a) a polypeptide comprising amino acids 1 to 174 of a specific amino acid sequence, (b) a polypeptide comprising amino acids 23-174 of a specific amino acid sequence, (c) a polypeptide comprising amino acids 39-174 of a specific amino acid sequence, (d) a polynucleotide encoding fragments having neovascularization-inhibitory activity of the polynucleotide (a), respectively, (e) a polynucleotide hybridizable with the complement of a polypeptide having neovascularization-inhibitory activity, (f) a polynucleotide encoding the allelic form of the polynucleotide (a), and (g) the complementary strand of (a), (b), (c), (d), (e) or (f). COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：在动物模型中提供VEGI抑制新生血管形成细胞模型和肿瘤发生，并提供使用该方法。解决方案：提供分离的核酸分子，其包含选自（a）包含特定氨基酸序列的氨基酸1至174的多肽的多核苷酸，（b）包含氨基酸23- （c）包含特定氨基酸序列的氨基酸39-174的多肽，（d）编码分别具有多核苷酸（a）的新血管形成抑制活性的片段的多核苷酸，（e）（f）编码多核苷酸（a）的等位基因形式的多核苷酸，和（g）（a），（b），（c）的互补链，可以与具有新血管形成抑制活性的多肽的补体杂交的多核苷酸，，（d），（e）或（f）。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2004129667A Neutrokine α 审中-公开
公开(公告)号：JP2004129667A
公开(公告)日：2004-04-30
申请号：JP2003362615
申请日：2003-10-22
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： YU GUO-LIANG , EBINER REINHARD , NI JIAN
IPC分类号： C12N15/09 , C07K14/52
CPC分类号： Y02A50/412
摘要： PROBLEM TO BE SOLVED: To provide an isolated nucleic acid molecule coding neutrokine-α protein. SOLUTION: The isolated nucleic acid molecule containing polynucleotide having at least 95% same sequence with following sequences is provided. (a) A sequence coding neutrokine-α polypeptide having a specific amino acid sequence. (b) A sequence coding neutrokine-α having a complete amino acid sequence corded by cDNA clone contained in ATCC deposit on 22 Oct. 1996. (c) A sequence coding neutrokine-α polypeptide extracellular domain. (d) A sequence coding neutrokine-α polypeptide transmembrane domain. (e) A sequence coding neutrokine-α polypeptide intercellular domain. (f) A sequence coding soluble neutrokine-α polypeptide defecting transmembrane domain. Or (g) a complementary sequence to an optional sequence of (a), (b), (c), (d), (e), or (f). COPYRIGHT: (C)2004,JPO

6. 发明专利

JP2004041216A Human endokine alpha 审中-公开
公开(公告)号：JP2004041216A
公开(公告)日：2004-02-12
申请号：JP2003288299
申请日：2003-08-06
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： YU GUO-LIANG , NI JIAN , ROSEN CRAIG A
IPC分类号： C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a cytokine analogous to a TNF relating to states of diseases. SOLUTION: An isolated nucleic acid molecule contains a polynucleotide having a nucleotide sequence of which at least 95% is identical to any one of sequences selected from a group comprising (a) to (e): (a) a nucleotide sequence which has a complete amino acid sequence of figure 1 or encodes a full-length endokine α polypeptide encoded by a cDNA clone contained in ATCC accession No.97640, (b) another nucleotide sequence which has about 44 to about 169 residues of the amino acid sequence of figure 1 or encodes an extracellular endokine α polypeptide encoded by the cDNA clone, (c) a third nucleotide sequence which has about 18 to about 43 residues of the amino acid sequence of figure 1 or encodes an endokine α membrane-penetrating domain encoded by the cDNA clone, (d) a fourth nucleotide sequence which has about 1 to about 18 residues of the amino acid sequence of the figure 1 or encodes an endokine α intracellular domain encoded by the cDNA clone, and (e) the other nucleotide sequence which is complementray to any one of the nucleotide sequences (a) to (d). COPYRIGHT: (C)2004,JPO

7. 发明专利

JP2013066468A HUMAN ENDOKINE α 审中-公开
标题翻译：人胃蛋白α
公开(公告)号：JP2013066468A
公开(公告)日：2013-04-18
申请号：JP2012221228
申请日：2012-10-03
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： YU GUO-LIANG , NI JIAN , ROSEN CRAIG A
IPC分类号： C12N15/09 , A61K39/395 , A61P7/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/06 , A61P39/02 , C07K14/52 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a cytokine analogous to TNF involved in a disease state.SOLUTION: There is provided an isolated nucleic acid molecule having a sequence at least 95% identical to a sequence selected from nucleotide sequences encoding: (a) a full length endokine α polypeptide having a specific amino acid sequence or encoded by a cDNA clone included in ATCC Accession No. 97640; (b) an extracellular endokine α polypeptide encoded by the cDNA clone; (c) an endokine α transmembrane domain encoded by the cDNA clone; (d) an endokine α intracellular domain encoded by the cDNA clone; and (e) a nucleotide sequence complementary to one of the items (a) to (d).
摘要翻译：待解决的问题：提供类似于参与疾病状态的TNF的细胞因子。提供了分离的核酸分子，其具有与选自以下核苷酸序列的序列至少95％相同的序列：编码：（a）具有特定氨基酸序列或由cDNA编码的全长内丝素α多肽包含在ATCC登录号97640中的克隆; （b）由cDNA克隆编码的胞外内丝素α多肽; （c）由cDNA克隆编码的内丝素α跨膜结构域; （d）由cDNA克隆编码的内丝素α细胞内结构域; 和（e）与（a）至（d）中任一项互补的核苷酸序列。版权所有（C）2013，JPO＆INPIT

8. 发明专利

JP2010252803A HUMAN ENDOKINE α AND METHOD OF USING THE SAME 审中-公开
标题翻译：人类内含子α及其使用方法
公开(公告)号：JP2010252803A
公开(公告)日：2010-11-11
申请号：JP2010144290
申请日：2010-06-24
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： YU GUO-LIANG , NI JIAN , ROSEN CRAIG A
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/10 , A61P7/04 , A61P7/06 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/04 , A61P21/02 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/18 , A61P33/00 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/52 , C07K14/525 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： C07K14/5255 , A61K38/00
摘要： PROBLEM TO BE SOLVED: To provide a new member of tumor necrosis factor (TNF) family of cytokines, concretely an isolated nucleic acid molecule encoding an endokine α protein. SOLUTION: There are provided a new member of the tumor necrosis factor (TNF) family of cytokines, in particular, isolated nucleic acid molecules encoding the endokine α protein. There are also provided endokine α polypeptides, vectors, host cells and recombinant methods for producing these substances. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders. The method includes a step to administer an individual with a therapeutically effective amount of the endokine α polypeptide or a step to administer an individual with a therapeutically effective amount of an endokine α antagonist. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为了提供细胞因子的肿瘤坏死因子（TNF）家族的新成员，具体地说是编码内丝素α蛋白的分离的核酸分子。解决方案：提供细胞因子的肿瘤坏死因子（TNF）家族的新成员，特别是编码内丝素α蛋白的分离的核酸分子。还提供了内含子α多肽，载体，宿主细胞和用于生产这些物质的重组方法。还提供了关于TNF家族相关疾病的诊断和治疗方法。该方法包括给予个体具有治疗有效量的内丝素α多肽的步骤或用治疗有效量的内丝素α拮抗剂给予个体的步骤。版权所有（C）2011，JPO＆INPIT

9. 发明专利

JP2009077723A HUMAN ENDOKINE α 审中-公开
标题翻译：人类内容
公开(公告)号：JP2009077723A
公开(公告)日：2009-04-16
申请号：JP2008269226
申请日：2008-10-17
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： YU GUO-LIANG , NI JIAN , ROSEN CRAIG A
IPC分类号： C12N15/09 , A61K39/395 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/06 , C07K14/525 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a cytokine analogous to TNF involved in a disease state. SOLUTION: An isolated nucleic acid molecule has an amino acid sequence at least 95% identical to a sequence selected from (a) a nucleotide sequence encoding a full length endokine α polypeptide having a specific amino acid sequence or encoding a cDNA clone contained in ATCC Deposit No. 97640, (b) a nucleotide sequence encoding an extracellular endokine α polypeptide having a specific amino acid sequence of about 44-169 residue or encoded by the cDNA clone, (c) a nucleotide sequence encoding an endokine α membrane-spanning domain having a specific amino acid sequence of about 18-43 residue or encoded by the cDNA clone, (d) a nucleotide sequence encoding an endokine α intracellular domain having a specific amino acid sequence of about 1-17 residue or encoded by the cDNA clone and (e) a nucleotide sequence which is complementary to either one of above items (a) to (d). COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供类似于参与疾病状态的TNF的细胞因子。解决方案：分离的核酸分子具有与选自以下的序列至少95％的氨基酸序列：（a）编码具有特定氨基酸序列的全长内丝素α多肽的核苷酸序列或编码包含的cDNA克隆在ATCC保藏号97640中，（b）编码具有大约44-169个残基的特定氨基酸序列或由cDNA克隆编码的细胞外内因素α多肽的核苷酸序列，（c）编码内丝素α膜 - 具有约18-43个残基的特定氨基酸序列或由cDNA克隆编码的跨越结构域，（d）编码具有约1-17个残基的特定氨基酸序列或由cDNA编码的内丝素α细胞内结构域的核苷酸序列克隆和（e）与上述（a）至（d）中任一项互补的核苷酸序列。版权所有（C）2009，JPO＆INPIT

10. 发明专利

JP2008081503A Death domain-containing receptor 5 审中-公开
标题翻译：死亡受体受体5
公开(公告)号：JP2008081503A
公开(公告)日：2008-04-10
申请号：JP2007260427
申请日：2007-10-03
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： NI JIAN , GENTZ REINER L , YU GUO-LIANG , SU JEFFREY Y , ROSEN CRAIG A
IPC分类号： C07K14/705 , C12N15/09 , A61K38/00 , A61K39/395 , A61P9/10 , A61P25/28 , A61P35/00 , A61P37/06 , C07K14/715 , C07K16/28 , C12N1/21 , C12N5/10 , C12N15/12
CPC分类号： C07K14/7151 , A61K38/00 , C07K2319/00
摘要： PROBLEM TO BE SOLVED: To provide a novel death domain-containing receptor 5 (DR5) protein. SOLUTION: The novel death domain-containing receptor 5 (DR5) proteins which are members of the tumor necrosis (TNF) receptor family and bind to TRAIL are provided. Precisely, isolated nucleic acid molecules encoding the human DR5 proteins are provided. The DR5 peptide is also provided and, in addition, vectors, host cells and recombinant methods for producing the same are provided. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种新型的含有死亡结构域的受体5（DR5）蛋白。解决方案：提供作为肿瘤坏死（TNF）受体家族成员并结合TRAIL的新型死亡结构域受体5（DR5）蛋白。正确地，提供了编码人类DR5蛋白质的分离的核酸分子。还提供了DR5肽，并且还提供了用于制备DR5肽的载体，宿主细胞和重组方法。本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。版权所有（C）2008，JPO＆INPIT

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