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1. 发明申请

US20090270704A1 PATCHES, SYSTEMS, AND METHODS FOR NON-INVASIVE GLUCOSE MEASUREMENT 审中-公开
标题翻译：用于非入侵葡萄糖测量的配件，系统和方法
公开(公告)号：US20090270704A1
公开(公告)日：2009-10-29
申请号：US12435300
申请日：2009-05-04
申请人： Thomas A. PEYSER , Russell O. Potts , Herbert L. Berman , James W. Moyer , Mikhail A. Kouchnir , Robert N. Blair
发明人： Thomas A. PEYSER , Russell O. Potts , Herbert L. Berman , James W. Moyer , Mikhail A. Kouchnir , Robert N. Blair
IPC分类号： A61B5/1477
CPC分类号： G01N33/66 , A61B5/14521 , A61B5/14532 , A61B5/1486 , A61B5/6833 , A61B10/0064 , A61B2560/0412 , A61B2562/0295
摘要： Described here are patches, systems, and methods for measuring glucose. In general, the patches comprise a microfluidic collection layer and a detector, and the systems comprise a patch and a measurement device. Some methods for measuring glucose comprise cleaning the skin surface, collecting sweat from the skin surface using a microfluidic collection device, and measuring the collected glucose. Other methods comprise cleaning the skin surface, collecting sweat in a patch comprising a microfludic collection layer, and measuring glucose collected in the patch. Still other methods comprise cleaning the skin surface, collecting a first sweat sample from the skin surface in a patch comprising a microfludic collection layer and a detector layer, transferring the first sweat sample from the collection layer to the detector layer, measuring glucose in the first sweat sample, and repeating the collection, transferring, and measuring steps at least once.
摘要翻译：这里描述了用于测量葡萄糖的补丁，系统和方法。通常，贴片包括微流体收集层和检测器，并且系统包括贴片和测量装置。用于测量葡萄糖的一些方法包括清洁皮肤表面，使用微流体收集装置从皮肤表面收集汗液，以及测量收集的葡萄糖。其他方法包括清洁皮肤表面，在包含微量收集层的贴片中收集汗液，以及测量在贴片中收集的葡萄糖。还有其它方法包括清洁皮肤表面，在包括微量收集层和检测器层的贴片中从皮肤表面收集第一汗液样品，将第一汗液样品从收集层转移到检测器层，测量第一汗液样品中的葡萄糖汗液样品，并重复收集，转移和测量步骤至少一次。

2. 发明授权

US06748250B1 Method and system of monitoring a patient 失效
标题翻译：监测病人的方法和系统
公开(公告)号：US06748250B1
公开(公告)日：2004-06-08
申请号：US09844687
申请日：2001-04-27
申请人： Herbert L. Berman , Robert N. Blair , James W. Moyer
发明人： Herbert L. Berman , Robert N. Blair , James W. Moyer
IPC分类号： A61K922
CPC分类号： A61B5/002 , A61B5/0022 , A61B5/14532 , G01N21/552 , G06F19/00 , G16H40/67 , Y10S128/903 , Y10S128/92
摘要： A patient monitor system implemented by a service provider for users via recording a patient's analytes measurements by an attenuated total reflection (ATR) infrared total spectroscopy method. The system comprises an input module that provides a non-invasive method in measuring analytes in a patient, such as a measurement of the glucose level and other blood analytes. The measurement is shared among a plurality of output devices such as computers, personal digital assistants (PDAs), cellular phones, and pagers that are stationed or held by various users, such as doctors, patients, researchers, pharmacies, labs, and health insurers. In addition, behavioral attributes are recorded and correlated with the analytes measurements to generate a profile. The profile is selectively sent to output devices based on the user profile corresponding to the output device. Also, access to the profile is monitored by a security module that encrypts the profile to prevent access by un-authorized users.
摘要翻译：由用户通过衰减的全反射（ATR）红外全光谱法记录患者的分析物测量来实现由用户提供服务的患者监护系统。该系统包括输入模块，其提供测量患者中的分析物的非侵入性方法，例如葡萄糖水平和其他血液分析物的测量。诸如医生，病人，研究人员，药房，实验室和健康保险公司等各种用户所驻扎或持有的多个输出设备如计算机，个人数字助理（PDA），蜂窝电话和寻呼机共享测量。。此外，记录行为属性并与分析物测量相关联以生成轮廓。基于与输出设备相对应的用户简档，该配置文件被选择性地发送到输出设备。此外，对配置文件的访问由加密配置文件以防止未授权用户访问的安全模块来监视。

3. 发明授权

US07725149B2 Devices, methods, and kits for non-invasive glucose measurement 失效
标题翻译：用于非侵入性葡萄糖测量的装置，方法和试剂盒
公开(公告)号：US07725149B2
公开(公告)日：2010-05-25
申请号：US11159587
申请日：2005-06-22
申请人： Thomas A. Peyser , Russell O. Potts , Herbert L. Berman , James W. Moyer , Mikhail A. Kouchnir
发明人： Thomas A. Peyser , Russell O. Potts , Herbert L. Berman , James W. Moyer , Mikhail A. Kouchnir
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/1455 , A61B5/14521 , A61B5/14532 , A61B2562/0295 , G01N33/66 , G06F19/00
摘要： Described are devices, methods, and kits for non-invasively measuring glucose. In general, the devices comprise skin patches for placement on a skin surface and measurement devices for measuring glucose collected in the patches. The patches may include an adhesive material, a collection layer, an interface layer, and a sweat-permeable membrane. The sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion. In this way, non-correlatable skin surface glucose will not be measured. The patches may further include components to induce a local sweat response. The measurement device typically includes a display, a processor, and a measurement mechanism. The methods typically include the steps of wiping the skin surface with a wipe containing at least one solvent for removing glucose, placing a patch on a skin surface, and measuring glucose collected in the patch. Kits comprising the patch and measurement device are also described.
摘要翻译：描述了用于非侵入性测量葡萄糖的装置，方法和试剂盒。通常，这些装置包括用于放置在皮肤表面上的皮肤贴片和用于测量在贴片中收集的葡萄糖的测量装置。贴剂可以包括粘合剂材料，收集层，界面层和汗液渗透膜。透汗膜被配置为作为通过扩散带到皮肤表面的表皮污染物和葡萄糖的屏障。以这种方式，不能测量不相关的皮肤表面葡萄糖。补片还可以包括诱发局部汗水反应的组件。测量装置通常包括显示器，处理器和测量机构。所述方法通常包括以下步骤：用含有至少一种用于除去葡萄糖的溶剂的擦拭物擦拭皮肤表面，将贴片放置在皮肤表面上，以及测量在贴剂中收集的葡萄糖。还描述了包括贴剂和测量装置的试剂盒。

4. 发明申请

US20120165626A1 DEVICES, METHODS, AND KITS FOR DETERMINING ANALYTE CONCENTRATIONS 审中-公开
标题翻译：用于确定分析浓度的装置，方法和试剂盒
公开(公告)号：US20120165626A1
公开(公告)日：2012-06-28
申请号：US13383809
申请日：2010-07-01
申请人： Finkelshtein V. Irina , James W. Moyer , Russell O. Potts , Burton H. Sage , Robert J. Shartie , Donald R. Wilson , Bruce D. Wong
发明人： Finkelshtein V. Irina , James W. Moyer , Russell O. Potts , Burton H. Sage , Robert J. Shartie , Donald R. Wilson , Bruce D. Wong
IPC分类号： A61B5/1455 , A61B5/145
CPC分类号： C12Q1/006 , A61B5/14517 , A61B5/14532 , A61B5/1455 , A61B10/0064 , G01N21/78 , G01N21/8483 , G01N33/52 , G01N2021/7786
摘要： Devices, methods, and kits for measuring or otherwise evaluating the concentration of one or more analytes in a body fluid are described. The devices, methods, and/or kits may be non-invasive. In some variations, a method for measuring the concentration of an analyte in sweat of a subject may comprise contacting a colorimetric membrane with a skin surface of the subject so that the membrane collects a volume of sweat from the skin surface, and analyzing the colorimetric membrane to determine the concentration of the analyte in the collected volume of sweat.
摘要翻译：描述了用于测量或以其它方式评价体液中一种或多种分析物的浓度的装置，方法和试剂盒。装置，方法和/或试剂盒可以是非侵入性的。在一些变型中，用于测量受试者汗液中分析物浓度的方法可以包括使比色膜与受试者的皮肤表面接触，使得膜从皮肤表面收集体积的汗液，并分析比色膜以确定所收集体积的汗液中分析物的浓度。

5. 发明申请

US20100063372A1 SWEAT COLLECTION DEVICES FOR GLUCOSE MEASUREMENT 审中-公开
标题翻译：用于葡萄糖测量的SWEAT收集装置
公开(公告)号：US20100063372A1
公开(公告)日：2010-03-11
申请号：US12555718
申请日：2009-09-08
申请人： Russell O. POTTS , James W. Moyer , Hiroshi Yanazawa , Irina Finkelshtein , Shuying Ye
发明人： Russell O. POTTS , James W. Moyer , Hiroshi Yanazawa , Irina Finkelshtein , Shuying Ye
IPC分类号： A61B5/1468
CPC分类号： A61B5/6833 , A61B5/14521 , A61B5/14532 , A61B5/14865
摘要： Devices, methods, and kits for collecting sweat that has come to the surface of the skin are provided. The sweat may be collected for measuring sweat glucose levels. Because sweat glucose levels correlate to blood glucose levels, the provided devices, methods, and kits may be used by diabetic patients to non-invasively monitor blood glucose levels. Sweat collection devices may be attachable to the surface of the skin and may collect about one microliter or less of sweat. Because only a small, fixed volume of sweat may be collected, the sweat glucose level may be measured in a matter of minutes. Further, as a fixed volume of sweat is tested, inaccuracies due to estimates of the sweat volume being tested are less likely to cause an inaccurate glucose measurement.
摘要翻译：提供了收集到皮肤表面的汗液的装置，方法和试剂盒。可以收集汗液来测量汗水葡萄糖水平。由于汗葡萄糖水平与血糖水平相关，糖尿病患者可使用所提供的装置，方法和试剂盒非侵入性地监测血糖水平。汗液收集装置可以附着到皮肤表面，并且可以收集大约一微升或更少的汗液。因为只能收集少量固定量的汗液，所以可以在几分钟内测量出汗糖水平。此外，当测试固定体积的汗液时，由于测试的汗液体积的估计导致的不准确度不太可能导致不准确的葡萄糖测量。

6. 发明授权

US07695901B2 Identification of poinsettia cultivars 失效
标题翻译：鉴定一品红品种
公开(公告)号：US07695901B2
公开(公告)日：2010-04-13
申请号：US09912072
申请日：2001-07-24
申请人： James W. Moyer , Elizabeth Parks
发明人： James W. Moyer , Elizabeth Parks
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6895 , C12Q2600/156
摘要： Methods of determining whether a plant is a member of a known cultivar utilize DNA fingerprinting techniques and the discovery of 41 polymorphic fragments that correlate with cultivar identity. These methods are useful in determining whether a plant is a member of a particular breeding family and potentially whether plants are genetically similar to each other.
摘要翻译：确定植物是否是已知品种的成员的方法利用DNA指纹技术和发现与品种鉴定相关的41个多态性片段。这些方法可用于确定植物是否是特定育种家族的成员，并且潜在地是否植物在遗传上彼此相似。

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