专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08273548B2 Nucleic acids encoding a human PAP1 polypeptide 失效
标题翻译：编码人PAP1多肽的核酸
公开(公告)号：US08273548B2
公开(公告)日：2012-09-25
申请号：US11390195
申请日：2006-03-28
申请人： Han Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Françoise Rosier-Montus , Olga Corti
发明人： Han Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Françoise Rosier-Montus , Olga Corti
IPC分类号： C12N15/12 , C12N15/63 , C12N15/85 , C12N1/21
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention relates to novel compounds and their uses, in particular their pharmaceutical or diagnostic uses or their use as pharmacological targets. More particularly, the present invention relates to a novel protein, referred to as PAP1, as well as to novel peptides and compounds which are capable of modulating, at least partially, the activity of parkin.
摘要翻译：本发明涉及新化合物及其用途，特别是其药物或诊断用途或其作为药理学靶标的用途。更具体地，本发明涉及一种称为PAP1的新型蛋白质，以及能够至少部分调节帕金蛋白酶活性的新型肽和化合物。

2. 发明授权

US07132396B2 Compositions which can be used for regulating the activity of parkin 有权
公开(公告)号：US07132396B2
公开(公告)日：2006-11-07
申请号：US09785548
申请日：2001-02-20
申请人： Hana Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Françoise Rosier-Montus , Olga Corti
发明人： Hana Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Françoise Rosier-Montus , Olga Corti
IPC分类号： A61K38/17 , C07K14/435
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention relates to novel compounds and their uses, in particular their pharmaceutical or diagnostic uses or their use as pharmacological targets. More particularly, the present invention relates to a novel protein, referred to as PAP1, as well as to novel peptides and compounds which are capable of modulating, at least partially, the activity of parkin.

3. 发明申请

US20060287230A1 Compositions which can be used for regulating the activity of parkin 失效
公开(公告)号：US20060287230A1
公开(公告)日：2006-12-21
申请号：US11390195
申请日：2006-03-28
申请人： Hana Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Francoise Rosier-Montus , Olga Corti
发明人： Hana Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Francoise Rosier-Montus , Olga Corti
IPC分类号： A61K38/17 , A61K39/395 , C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention relates to novel compounds and their uses, in particular their pharmaceutical or diagnostic uses or their use as pharmacological targets. More particularly, the present invention relates to a novel protein, referred to as PAP1, as well as to novel peptides and compounds which are capable of modulating, at least partially, the activity of parkin.

4. 发明授权

US07070940B2 Method for determining the ability of a compound to modify the interaction between parkin and the p38 protein 有权
标题翻译：确定化合物修饰parkin和p38蛋白之间相互作用的能力的方法
公开(公告)号：US07070940B2
公开(公告)日：2006-07-04
申请号：US10622817
申请日：2003-07-18
申请人： Olga Corti , Cornelia Hampe , Alexis Brice , Laurent Pradier , Thomas Rooney , Alain Fournier
发明人： Olga Corti , Cornelia Hampe , Alexis Brice , Laurent Pradier , Thomas Rooney , Alain Fournier
IPC分类号： G01N33/53 , C07K14/00
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/47
摘要： The present invention relates to a method for determining the ability of a compound to modify the interaction between parkin and the p38 protein, and in particular to a method for screening for or detecting compounds intended for the prevention and/or treatment of neurodegenerative pathological conditions. The present inventions also relates to compounds identified in the above screening method.
摘要翻译：本发明涉及一种测定化合物修饰parkin和p38蛋白之间相互作用的能力的方法，特别涉及用于筛选或检测旨在预防和/或治疗神经变性病理状况的化合物的方法。本发明还涉及上述筛选方法鉴定的化合物。

5. 发明申请

US20090176276A1 Fusion Polypeptides of Human Serum Albumin and a Therapeutically Active Polypeptide 失效
标题翻译：人血清白蛋白和治疗活性多肽的融合多肽
公开(公告)号：US20090176276A1
公开(公告)日：2009-07-09
申请号：US11927628
申请日：2007-10-29
申请人： Reinhard Fleer , Alain Fournier , Jean-Dominique Guitton , Gerard Jung , Patrice Yeh
发明人： Reinhard Fleer , Alain Fournier , Jean-Dominique Guitton , Gerard Jung , Patrice Yeh
IPC分类号： C12P21/00 , C07K14/76 , C07H21/04 , C12N15/63 , C12N1/19
CPC分类号： B65B69/00 , A61K38/21 , A61K38/38 , A61K47/642 , A61K47/643 , C07K14/575 , C07K14/755 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/02 , C07K2319/31 , C07K2319/33 , C12N9/6456 , A61K2300/00
摘要： Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.
摘要翻译：包含与人血清白蛋白或其变体融合的治疗活性多肽的生物活性多肽，其制备方法，编码这种融合多肽的核苷酸序列，包含该核苷酸序列的表达盒，含有该表达盒的自体复制质粒和药物组合物含有所述融合多肽。

6. 发明申请

US20090028790A1 Labelled adrenomedullin derivatives and their use for imaging and therapy 有权
标题翻译：标记的肾上腺髓质素衍生物及其用于成像和治疗
公开(公告)号：US20090028790A1
公开(公告)日：2009-01-29
申请号：US12149989
申请日：2008-05-12
申请人： Jocelyn Dupuis , Alain Fournier
发明人： Jocelyn Dupuis , Alain Fournier
IPC分类号： A61K51/00 , C07K14/00 , A61K49/00
CPC分类号： A61K51/088 , C07K14/575
摘要： The present invention relates to an adrenomedullin derivative including an adrenomedullin peptide, or a fragment thereof chelated or otherwise bound to at least one active agent. Examples of active agents include a paramagnetic element, a radioactive element and a fibrinolytic agent, among others. Paramagnetic agents have a distribution that is relatively easily shown through Magnetic Resonance Imaging (MRI). Radioactive agents have applications in imaging and delivery of radiations, depending on the specific element included in the active agent. Delivery of fibrinolytic agents mainly to a specific organ, such as for example to the lungs, allows to substantially improve the specificity and efficacy of thrombolytic therapy by allowing local delivery of the fibrinolytic agent, thereby reducing the risks of major bleeding in the therapy of the organ. If the organ is the lungs, a non-limiting example of pathology treatable with the fibrinolytic agent is pulmonary embolus.
摘要翻译：本发明涉及包含与至少一种活性剂螯合或以其它方式结合的肾上腺髓质素肽或其片段的肾上腺髓质素衍生物。活性剂的实例包括顺磁元件，放射性元素和纤维蛋白溶解剂等。顺磁剂具有通过磁共振成像（MRI）相对容易地显示的分布。取决于活性剂中包含的特定元素，放射性剂可用于成像和辐射辐射。纤维蛋白溶解剂主要递送到特定器官，例如肺，允许通过允许局部输送纤维蛋白溶解剂来大大改善溶栓治疗的特异性和功效，从而降低治疗中的大出血的风险器官。如果器官是肺，则可用纤维蛋白溶解剂治疗的病理学的非限制性实例是肺栓塞。

7. 发明授权

US07081354B2 Interleukin and albumin fusion protein 失效
标题翻译：白介素和白蛋白融合蛋白
公开(公告)号：US07081354B2
公开(公告)日：2006-07-25
申请号：US10237708
申请日：2002-09-10
申请人： Reinhard Fleer , Alain Fournier , Jean-Dominique Guitton , Gérard Jung , Patrice Yeh
发明人： Reinhard Fleer , Alain Fournier , Jean-Dominique Guitton , Gérard Jung , Patrice Yeh
IPC分类号： C12N15/00 , C12N15/12 , C12N15/63 , C07K14/00 , C07H21/04
CPC分类号： B65B69/00 , A61K38/21 , A61K38/38 , A61K47/642 , A61K47/643 , C07K14/575 , C07K14/755 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/02 , C07K2319/31 , C07K2319/33 , C12N9/6456 , A61K2300/00
摘要： Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.
摘要翻译：包含与人血清白蛋白或其变体融合的治疗活性多肽的生物活性多肽，其制备方法，编码这种融合多肽的核苷酸序列，包含该核苷酸序列的表达盒，含有该表达盒的自体复制质粒和药物组合物含有所述融合多肽。

8. 发明授权

US07056701B2 Hormone and albumin fusion protein 失效
标题翻译：激素和白蛋白融合蛋白
公开(公告)号：US07056701B2
公开(公告)日：2006-06-06
申请号：US10237624
申请日：2002-09-10
申请人： Reinhard Fleer , Alain Fournier , Jean-Dominique Guitton , Gérard Jung , Patrice Yeh
发明人： Reinhard Fleer , Alain Fournier , Jean-Dominique Guitton , Gérard Jung , Patrice Yeh
IPC分类号： C12N15/00 , C12N15/12 , C12N15/63 , C07K14/00 , C07H21/04
CPC分类号： B65B69/00 , A61K38/21 , A61K38/38 , A61K47/642 , A61K47/643 , C07K14/575 , C07K14/755 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/02 , C07K2319/31 , C07K2319/33 , C12N9/6456 , A61K2300/00
摘要： Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.
摘要翻译：包含与人血清白蛋白或其变体融合的治疗活性多肽的生物活性多肽，其制备方法，编码这种融合多肽的核苷酸序列，包含该核苷酸序列的表达盒，含有该表达盒的自体复制质粒和药物组合物含有所述融合多肽。

9. 发明授权

US06790531B2 Process for the protection of flexible silicone membranes, particularly in the case of molding by resin transfer 有权
标题翻译：用于保护柔性硅氧烷膜的方法，特别是在通过树脂转移成型的情况下
公开(公告)号：US06790531B2
公开(公告)日：2004-09-14
申请号：US10095082
申请日：2002-03-12
申请人： Alain Fournier
发明人： Alain Fournier
IPC分类号： B32B2520
CPC分类号： C08J7/047 , B29C33/64 , B29C43/3642 , B29K2083/00 , B29K2995/0067 , B29K2995/0069 , B32B25/20 , C08J2383/04 , C08J2483/00 , Y10S528/901 , Y10T428/31663
摘要： Process for treating a flexible bi-constituent self-demolding silicone membrane used as a counterform particularly for resin transfer molding. The membrane is coated with a thin layer of at least one monoconstituent silicone which is a polysiloxane cross-linkable at ambient temperature in the presence of the moisture in air. The polysiloxane corresponds to the formula (I): in which: the substituents R3, R4, and R5 are selected from alkyl or aryl radicals, R6 represents an alkyloxy group, an alkenyloxy group, an alcanoyloxy group, an amino group, a ketiminoxy group, an amido group, an aminoxy group.
摘要翻译：用于处理柔性双组分自脱模硅酮膜的方法，其特别用于树脂传递模塑。膜上涂有薄层的至少一种单成分硅酮，它是在空气中存在湿气的情况下可在环境温度下交联的聚硅氧烷。聚硅氧烷对应于式（I）：其中：取代基R 3，R 4和R 5选自烷基或芳基，R 6表示烷氧基，链烯氧基氨基酰氧基，氨基，酮亚氨氧基，酰氨基，氨氧基。

10. 发明授权

US06696273B2 FEBP1 Protein: vector, host cells and method for making FEBP1 protein 失效
标题翻译： FEBP1蛋白：载体，宿主细胞和制备FEBP1蛋白的方法
公开(公告)号：US06696273B2
公开(公告)日：2004-02-24
申请号：US09780996
申请日：2001-02-09
申请人： Isabelle Maury , Luc Mercken , Alain Fournier
发明人： Isabelle Maury , Luc Mercken , Alain Fournier
IPC分类号： C12N1511
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to novel compounds and their pharmaceutical or diagnostic use, or use as a pharmacological target. More particularly, the present invention describes the identification of partners of the FE65 protein and the use of these partners, or of any compound which is capable of modulating, at least partially, their interaction with FE65, for regulating the activity of FE65, and in particular the phenomenon of intracellular transport or of endocytosis of the APP.
摘要翻译：本发明涉及新化合物及其药物或诊断用途，或用作药理学靶标。更具体地，本发明描述了鉴定FE65蛋白的配偶体以及这些配偶体或任何能够至少部分调节其与FE65的相互作用以调节FE65活性的化合物的使用，以及特别是APP的细胞内运输或内吞现象。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式