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1. 发明授权

US07070940B2 Method for determining the ability of a compound to modify the interaction between parkin and the p38 protein 有权
标题翻译：确定化合物修饰parkin和p38蛋白之间相互作用的能力的方法
公开(公告)号：US07070940B2
公开(公告)日：2006-07-04
申请号：US10622817
申请日：2003-07-18
申请人： Olga Corti , Cornelia Hampe , Alexis Brice , Laurent Pradier , Thomas Rooney , Alain Fournier
发明人： Olga Corti , Cornelia Hampe , Alexis Brice , Laurent Pradier , Thomas Rooney , Alain Fournier
IPC分类号： G01N33/53 , C07K14/00
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/47
摘要： The present invention relates to a method for determining the ability of a compound to modify the interaction between parkin and the p38 protein, and in particular to a method for screening for or detecting compounds intended for the prevention and/or treatment of neurodegenerative pathological conditions. The present inventions also relates to compounds identified in the above screening method.
摘要翻译：本发明涉及一种测定化合物修饰parkin和p38蛋白之间相互作用的能力的方法，特别涉及用于筛选或检测旨在预防和/或治疗神经变性病理状况的化合物的方法。本发明还涉及上述筛选方法鉴定的化合物。

2. 发明授权

US07629374B2 Use of aminoindazole derivatives for the inhibition of tau phosphorylation 失效
标题翻译：氨基吲唑衍生物用于抑制tau磷酸化
公开(公告)号：US07629374B2
公开(公告)日：2009-12-08
申请号：US12143070
申请日：2008-06-20
申请人： Dominique Lesuisse , Gilles Dutruc-Rosset , Franck Halley , Didier Babin , Thomas Rooney , Gilles Tiraboschi
发明人： Dominique Lesuisse , Gilles Dutruc-Rosset , Franck Halley , Didier Babin , Thomas Rooney , Gilles Tiraboschi
IPC分类号： A61K31/415
CPC分类号： C07D231/56 , A61K31/416 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D403/12 , C07D405/12
摘要： The present invention relates to the use of novel derivatives of general formula (I) in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO2R1, C(═NH)R1 or C(═NH)NR1 radical; R5, R6 and R7 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH2, OH, OR8, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, —O—SO2R8, —SO2—O—R8, trifluoromethyl, trifluoromethoxy, (1-6C)alkyl, (1-6C)alkoxy, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl, to treat a disease selected from the group consisting of: neurodegenerative diseases, strokes, cranial and spinal traumas and peripheral neuropathies, obesity, metabolic diseases, type II diabetes, essential hypertension, atherosclerotic cardiovascular diseases, polycystic ovaries syndrome, syndrome X, immunodeficiency and cancer.
摘要翻译：本发明涉及通式（I）的新型衍生物，其中R3是（1-6C）烷基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，芳基或与（1-10C）环烷基，杂环，杂环烷基，环烷基，金刚烷基，多环烷基，烯基，炔基，CONR1R2，COOR1，SO2R1，C（-NH）R1或C（-NH）NR1基团稠合的杂芳基） R 5，R 6和R 7彼此独立地选自以下基团：卤素，CN，NO 2，NH 2，OH，OR 8，COOH，C（O）OR 8，-OC（O）R 8，NR 8 R 9，NHC ）R8，C（O）NR8R9，NHC（S）R8，C（S）NR8R9，SR8，S（O）R8，SO2R8，NHSO2R8，SO2NR8R9，-O-SO2R8，-SO2-O-R8，三氟甲基，三氟甲氧基，（1-6C）烷基，（1-6C）烷氧基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，杂环，环烷基，烯基，炔基，金刚烷基或多环烷基，选自以下的疾病：神经变性疾病，中风，颅脑和脊髓创伤和周围神经病变，肥胖症，代谢疾病，II型糖尿病，原发性高血压，动脉粥样硬化性心血管疾病，多囊卵巢综合征，综合征X，免疫缺陷和癌症。

3. 发明申请

US20120257955A1 OFFSHORE HYDROELECTRIC TURBINE ASSEMBLY AND METHOD 失效
标题翻译：海洋水电涡轮组件及方法
公开(公告)号：US20120257955A1
公开(公告)日：2012-10-11
申请号：US13444113
申请日：2012-04-11
申请人： Thomas Rooney
发明人： Thomas Rooney
IPC分类号： F01D25/28
CPC分类号： F03B13/10 , F03B17/061 , F05B2240/13 , F05B2240/40 , F05B2250/232 , F05B2270/18 , Y02E10/22 , Y02E10/28
摘要： The invention is directed to a single moored offshore marine turbine assembly having a central control vessel which includes a main vessel tethered to a control buoy. The main vessel having a first cap, a corresponding second cap and a tubular shell positioned between both the first cap and second cap. The tubular shell contains one or more vertical partitions to assist in ballasting. The control buoy includes a compressor and an air conduit which forces air into the main vessel through a manifold. A hollow suction caisson affixes the central control vessel to the ocean floor. A taut line mooring secures the suction caisson to the main vessel. Electricity is generated via a turbine shroud assembly having a conical shroud and a hydro-turbine. By attaching a plurality of turbine shroud assemblies in series via cables, a horizontal turbine array is formed resulting in a simple, economical and safe layout.
摘要翻译：本发明涉及一种具有中央控制容器的单个系泊海上涡轮机组件，该中央控制容器包括连接到控制浮标的主船。主容器具有第一盖，相应的第二盖和位于第一盖和第二盖之间的管状壳。管状壳体包含一个或多个垂直隔板以辅助压载。控制浮标包括压缩机和通过歧管迫使空气进入主容器的空气管道。空心抽吸沉箱将中央控制船舶固定在海底。拉紧系泊系统将吸力沉箱固定在主船上。通过具有锥形护罩和水轮机的涡轮机护罩组件产生电力。通过经由电缆将多个涡轮机护罩组件串联连接，形成水平涡轮机阵列，从而形成简单，经济和安全的布局。

4. 发明授权

US07582669B2 Aminoindazole derivatives as medicaments and pharmaceutical compositions including them 有权
标题翻译：氨基吲唑衍生物作为药物和药物组合物，包括它们
公开(公告)号：US07582669B2
公开(公告)日：2009-09-01
申请号：US11567442
申请日：2006-12-06
申请人： Dominique Lesuisse , Gilles Dutruc-Rosset , Franck Halley , Didier Babin , Thomas Rooney
发明人： Dominique Lesuisse , Gilles Dutruc-Rosset , Franck Halley , Didier Babin , Thomas Rooney
IPC分类号： A61K31/416
CPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to novel derivatives of general formula (I) in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO2R1, C(═NH)R1 or C(═NH)NR1 radical; R5 and R6 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH2, OH, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, —O—SO2R8, —SO2—O—R8, trifluoromethyl, trifluoromethoxy, (1-6C)alkyl, (1-6C)alkoxy, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl.
摘要翻译：本发明涉及通式（I）的新型衍生物，其中R3是（1-6C）烷基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，芳基或杂芳基（1-10C）环烷基，杂环，杂环烷基，环烷基，金刚烷基，多环烷基，烯基，炔基，CONR1R2，COOR1，SO2R1，C（-NH）R1或C（-NH）NR1基; R 5和R 6彼此独立地选自以下基团：卤素，CN，NO 2，NH 2，OH，COOH，C（O）OR 8，-OC（O）R 8，NR 8 R 9，NHC（O）（O）NR8R9，NHC（S）R8，C（S）NR8R9，SR8，S（O）R8，SO2R8，NHSO2R8，SO2NR8R9，-O-SO2R8，-SO2-O-R8，三氟甲基，三氟甲氧基，（1- 6C）烷基，（1-6C）烷氧基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，杂环，环烷基，烯基，炔基，金刚烷基或多环烷基。

5. 发明申请

US20070093479A1 NOVEL AMINOINDAZOLE DERIVATIVES AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM 有权
标题翻译：作为药物和药物组合物的新型氨基咔唑衍生物包括它们
公开(公告)号：US20070093479A1
公开(公告)日：2007-04-26
申请号：US11567442
申请日：2006-12-06
申请人： Dominique Lesuisse , Gilles Dutruc-Rosset , Franck Halley , Didier Babin , Thomas Rooney
发明人： Dominique Lesuisse , Gilles Dutruc-Rosset , Franck Halley , Didier Babin , Thomas Rooney
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/427 , A61K31/416
CPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to novel derivatives of general formula (I) in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO2R1, C(═NH)R1 or C(═NH)NR1 radical; R5 and R6 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH2, OH, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, —O—SO2R8, —SO2—O—R8, trifluoromethyl, trifluoromethoxy, (1-6C)alkyl, (1-6C)alkoxy, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl.
摘要翻译：本发明涉及通式（I）的新型衍生物，其中R3是（1-6C）烷基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，芳基或杂芳基（1-10C）环烷基，杂环，杂环烷基，环烷基，金刚烷基，多环烷基，烯基，炔基，CONR1R2，COOR1，SO2R1，C（-NH）R1或C（-NH）NR1 激进; R 5和R 6彼此独立地选自以下基团：卤素，CN，NO 2，NH 2，OH，COOH，C（O）OR 8， -OC（O）R8，NR8R9，NHC（O）R8，C（O）NR8R9，NHC（S）R8，C（S）NR8R9，SR8，S（O） R 8，NHSO 2 R 8，SO 2 NR 8 R 9，-O-SO 2 R 8，-SO 2 -O （1-6C）烷氧基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，杂环，环烷基，链烯基，炔基，金刚烷基或多环烷基。

6. 发明申请

US20050056953A1 Deformable molds and methods for their use in the manufacture of ophthalmic lenses 失效
标题翻译：可变形的模具及其用于制造眼镜的方法
公开(公告)号：US20050056953A1
公开(公告)日：2005-03-17
申请号：US10881773
申请日：2004-06-29
申请人： Gregory Hofmann , Thomas Rooney , David Pearson , Zaffir Chaudhry , Jacqueline Roche , Jeffrey Roffman , Larry Jones , Mark Ealey
发明人： Gregory Hofmann , Thomas Rooney , David Pearson , Zaffir Chaudhry , Jacqueline Roche , Jeffrey Roffman , Larry Jones , Mark Ealey
IPC分类号： B29D11/00 , B29D11/02
CPC分类号： B29D11/00557 , B29D11/00125 , B29D11/00432 , B29D11/023 , Y10S425/808 , Y10T74/165 , Y10T74/20582
摘要： The present provides deformable molds and methods for manufacturing ophthalmic lenses using deformable molds. The molds of the invention may be used in the custom manufacture of ophthalmic lenses.
摘要翻译：本发明提供了使用可变形模具制造眼科镜片的可变形模具和方法。本发明的模具可用于眼科镜片的定制制造。

7. 发明授权

US07309701B2 Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them 有权
标题翻译：哒嗪酮衍生物作为药物和含有它们的药物组合物
公开(公告)号：US07309701B2
公开(公告)日：2007-12-18
申请号：US10715358
申请日：2003-11-19
申请人： Swen Hölder , Thorsten Naumann , Karl Schönafinger , David William Will , Hans Matter , Günther Müller , Dominique Le Suisse , Bernard Baudoin , Thomas Rooney , Franck Halley , Gilles Tiraboschi
发明人： Swen Hölder , Thorsten Naumann , Karl Schönafinger , David William Will , Hans Matter , Günther Müller , Dominique Le Suisse , Bernard Baudoin , Thomas Rooney , Franck Halley , Gilles Tiraboschi
IPC分类号： C07D413/12 , C07D403/12 , C07D237/04 , A61K31/501 , A61K31/50
CPC分类号： C07D401/04 , C07D237/14 , C07D237/24 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/14 , C07D513/04
摘要： The present invention relates to novel pyridazinone derivatives of the general formula (I) wherein A is A1 or A2; R is unsubstituted or at least monosubstituted C1-C10-alkyl, aryl, aryl-(C1-C10-alkyl)-, heteroaryl, heteroaryl-(C1-C10-alkyl)-, heterocyclyl, heterocyclyl-(C1-C10-alkyl)-, C3-C10-cycloalkyl, polycycloalkyl, C2-C10-alkenyl or C2-C10-alkinyl and Ar is unsubstituted or at least monosubstituted aryl or heteroaryl.
摘要翻译：本发明涉及通式（I）的新的哒嗪酮衍生物，其中A为A 1或A 2; R是未取代的或至少单取代的C 1 -C 10 - 烷基，芳基，芳基 - （C 1 -C 10 - 烷基） - ，杂芳基，杂芳基 - （C 1 -C 10 - 烷基） - ，杂环基，杂环基 - （C 1 -C 12 - C 1 -C 10 - 烷基） - ，C 3 -C 10 - 环烷基，多环烷基，C 2 - C 10 - 链烯基或C 2 -C 10 - 炔基，Ar是未取代的或至少单取代的芳基或杂芳基。

8. 发明申请

US20070084550A1 Method to increase the fusion of radio-frequency welds between dissimilar materials 审中-公开
标题翻译：增加不同材料之间射频焊接融合的方法
公开(公告)号：US20070084550A1
公开(公告)日：2007-04-19
申请号：US11545630
申请日：2006-10-10
申请人： Adam Epstein , Thomas Rooney , Stephen Wiater
发明人： Adam Epstein , Thomas Rooney , Stephen Wiater
IPC分类号： B29C65/04 , B29C65/06
CPC分类号： B29C65/04 , B29C65/16 , B29C65/38 , B29C65/4815 , B29C65/482 , B29C65/523 , B29C66/026 , B29C66/1122 , B29C66/5344 , B29C66/612 , B29C66/71 , B29C66/712 , B29C66/73921 , B29K2027/06 , B29K2069/00 , B29K2075/00
摘要： A practical method to increase the fusion of radio-frequency welds between two structures made of dissimilar materials by introduction of a bonding layer between the two structures. The bonding layer must be an RF-weldable material that welds or bonds well to both of the materials from which the respective structures are made. The bonding layer may be introduced by coating one of the structures with the bonding material or by forming the bonding material into a sleeve which is placed over one of the structures.
摘要翻译：通过在两个结构之间引入结合层，增加由异种材料制成的两个结构之间的射频焊接的融合的实用方法。接合层必须是RF可焊接材料，其可以与制造相应结构的材料两者焊接或粘合良好。可以通过用结合材料涂覆结构之一或通过将结合材料形成为放置在结构之一上的套筒中来引入粘结层。

9. 发明授权

US07166629B2 Aminoindazole derivatives as medicaments and pharmaceutical compositions including them 有权
标题翻译：氨基吲唑衍生物作为药物和药物组合物，包括它们
公开(公告)号：US07166629B2
公开(公告)日：2007-01-23
申请号：US10654703
申请日：2003-09-04
申请人： Dominique Lesuisse , Gilles Dutruc-Rosset , Franck Halley , Didier Babin , Thomas Rooney
发明人： Dominique Lesuisse , Gilles Dutruc-Rosset , Franck Halley , Didier Babin , Thomas Rooney
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to novel derivatives of general formula (I) in which R3 is a (1–6C)alkyl, aryl, aryl(1–6C)alkyl, heteroaryl, heteroaryl(1–6C)alkyl, aryl or heteroaryl fused to a (1–10C)cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO2R1, C(═NH)R1 or C(═NH)NR1 radical; R5 and R6 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH2, OH, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, —O—SO2R8, —SO2—O—R8, trifluoromethyl, trifluoromethoxy, (1–6C)alkyl, (1–6C)alkoxy, aryl, aryl(1–6C)alkyl, heteroaryl, heteroaryl(1–6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl.
摘要翻译：本发明涉及通式（I）的新型衍生物，其中R3是（1-6C）烷基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，芳基或杂芳基（1-10C）环烷基，杂环，杂环烷基，环烷基，金刚烷基，多环烷基，烯基，炔基，CONR1R2，COOR1，SO2R1，C（-NH）R1或C（-NH）NR1 激进; R 5和R 6彼此独立地选自以下基团：卤素，CN，NO 2，NH 2，OH，COOH，C（O）OR 8， -OC（O）R8，NR8R9，NHC（O）R8，C（O）NR8R9，NHC（S）R8，C（S）NR8R9，SR8，S（O） R 8，NHSO 2 R 8，SO 2 NR 8 R 9，-O-SO 2 R 8，-SO 2 -O （1-6C）烷氧基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，杂环，环烷基，链烯基，炔基，金刚烷基或多环烷基。

10. 发明申请

US20060100408A1 Method for forming contact lenses comprising therapeutic agents 审中-公开
标题翻译：形成包含治疗剂的隐形眼镜的方法
公开(公告)号：US20060100408A1
公开(公告)日：2006-05-11
申请号：US11246771
申请日：2005-10-07
申请人： P. Powell , Frank Molock , W. Martin , Thomas Rooney , Ranganath Raja , Holly Grammer , Osman Rathore , Shivkumar Mahadevan , Ram Bhat
发明人： P. Powell , Frank Molock , W. Martin , Thomas Rooney , Ranganath Raja , Holly Grammer , Osman Rathore , Shivkumar Mahadevan , Ram Bhat
IPC分类号： C08F118/00
CPC分类号： A61K9/0051 , A61L31/16 , A61L2300/00 , B29D11/00038 , C08F220/18 , G02B1/043
摘要： The present invention relates to a process comprising (a) dosing a reactive mixture comprising at least one crosslinkable prepolymer into a mold; (b) curing said reactive mixture to form a medical device; (c) contacting, said medical device with no more than about 500 mL of solution per medical device; and (d) incorporating, prior to or during said contacting step (c), at least one therapeutic agent.
摘要翻译：本发明涉及一种方法，其包括（a）将包含至少一种可交联预聚物的反应性混合物投料到模具中; （b）固化所述反应混合物以形成医疗装置; （c）使所述医疗装置与每个医疗装置不超过约500mL溶液接触; 和（d）在所述接触步骤（c）之前或期间掺入至少一种治疗剂。

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