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1. 发明申请

WO2013049218A1 PROSTHETIC MITRAL VALVE WITH VENTRICULAR TETHERS AND METHODS FOR IMPLANTING SAME 审中-公开
标题翻译：具有胸腔三角形的前置麻醉阀及其植入方法
公开(公告)号：WO2013049218A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/057352
申请日：2012-09-26
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： MIGLIAZZA, John, F. , LAFRANCE, Hugues , CHEN, Harvey, H. , OBA, Travis, Zenyo
IPC分类号： A61F2/24 , A61M39/22 , A61F2/76
CPC分类号： A61F2/2412 , A61B17/0401 , A61B17/0487 , A61B2017/0417 , A61B2017/0437 , A61B2017/0441 , A61B2017/0464 , A61B2017/0496 , A61B2017/06176 , A61F2/2409 , A61F2/2418 , A61F2/2457 , A61F2250/0007
摘要： A prosthetic valve assembly and method of implanting same is disclosed. The prosthetic valve assembly includes a prosthetic valve formed by support frame and valve leaflets, with one or more tethers each having a first end secured to the support frame and the second end attached to, or configured for attachment to, to papillary muscles or other ventricular tissue. The tether is configured and positioned so as to avoid contact or other interference with movement of the valve leaflets, while at the same time providing a tethering action between the support frame and the ventricular tissue. The valve leaflets may be flexible (e.g., so-called tissue or synthetic leaflets) or mechanical.
摘要翻译：公开了一种人造瓣膜组件及其植入方法。假体瓣膜组件包括由支撑框架和瓣膜小叶形成的假体瓣，其中一个或多个系绳各自具有固定到支撑框架的第一端和附接到乳突肌或其它心室的第二端组织。系绳的构造和定位是为了避免接触或其他干扰瓣叶片的移动，同时在支撑框架和心室组织之间提供束缚作用。瓣膜小叶可以是柔性的（例如，所谓的组织或合成小叶）或机械的。

2. 发明申请

WO2011119754A2 METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE 审中-公开
标题翻译：调节片生物组织的方法
公开(公告)号：WO2011119754A2
公开(公告)日：2011-09-29
申请号：PCT/US2011/029654
申请日：2011-03-23
申请人： EDWARDS LIFESCIENCES CORPORATION , DOVE, Jeffrey, S. , TIAN, Bin , SCHNEIDER, Ralph , COHEN, Jeffrey, S. , JANKOVIC, Ivan , MIGLIAZZA, John, F. , WRIGHT, Gregory, A. , YOUNG, James, M. , CAMPBELL, Louis, A.
发明人： DOVE, Jeffrey, S. , TIAN, Bin , SCHNEIDER, Ralph , COHEN, Jeffrey, S. , JANKOVIC, Ivan , MIGLIAZZA, John, F. , WRIGHT, Gregory, A. , YOUNG, James, M. , CAMPBELL, Louis, A.
IPC分类号： A61F2/24 , A61L27/38 , D06M10/00 , D06M10/04
CPC分类号： A61F2/2415 , A61B18/20 , A61F2/02 , A61F2/24 , A61F2/2409 , A61F2/2418 , A61F2002/30324 , A61F2250/0036 , A61L27/3604 , A61L27/3625 , A61L27/3691 , A61L27/507 , A61L2300/60 , A61L2430/20 , B65B55/18 , B65B63/02
摘要： Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes. The finally thinned membrane may then be treated by capping of calcification nucleation sites and borohydride reduction. The leaflets may be formed to have more than one region of uniform thickness, such as a thicker peripheral sewing region.
摘要翻译：生物假体材料调理方法采用牛心包膜。指向膜的纤维表面并相对于其移动的激光将膜的厚度减小到特定的均匀厚度并平滑表面。选择激光器的波长，功率和脉冲速率，这将使纤维表面平滑，并将表面烧蚀到合适的厚度。或者，使用皮肤表面从膜的纤维表面去除一层材料。变薄也可能采用压缩。使用交联以稳定膜的逐步压缩来避免通过非弹性压缩损伤膜。相反，膜通过加成交联结合在弹性压缩状态。上述几种稀释技术可以一起使用以获得强的薄膜。然后可以通过封闭钙化成核位点和硼氢化钠还原来处理最终变薄的膜。传单可以形成为具有多于一个均匀厚度的区域，例如较厚的外围缝合区域。

3. 发明申请

WO2012027500A2 FLEXIBLE ANNULOPLASTY RING WITH SELECT CONTROL POINTS 审中-公开
标题翻译：具有选择控制点的灵活安氏环
公开(公告)号：WO2012027500A2
公开(公告)日：2012-03-01
申请号：PCT/US2011/049006
申请日：2011-08-24
申请人： EDWARDS LIFESCIENCES CORPORATION , MIGLIAZZA, John, F. , CROCKETT, Bob , ABRAM, Tim
发明人： MIGLIAZZA, John, F. , CROCKETT, Bob , ABRAM, Tim
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2448 , A61F2/2466 , A61F2230/0091 , A61F2250/0018
摘要： An annuloplasty repair segment for heart valve annulus repair. In one embodiment a multi- stranded cable replaces solid core wire for both the tricuspid and mitral valves. Cable allows for greater deployment flexibility for minimally-invasive surgical (MIS) implant, while still maintaining the required strength and similar tensile properties of solid-core wire. In addition, selective placement of point- welds or other such control points locally control other parameters such as the amount and direction of displacement as the ring undergoes external loading. Cable with well-placed control points result in a MIS annuloplasty ring with sufficient flexibility in the x-y plane to allow a surgeon to squeeze the ring into a small incision, such as for example 1cm x 1cm, while maintaining structural rigidity under forces exerted on the implanted ring by the cardiac cycle and allowing for asymmetrical deflection to be designed into the product.
摘要翻译：用于心脏瓣膜环修复的瓣环成形术修复部分。在一个实施例中，多股电缆替代用于三尖瓣和二尖瓣的实心芯线。电缆允许为微创手术（MIS）植入物提供更大的部署灵活性，同时仍然保持固体芯线所需的强度和类似的拉伸性能。此外，点焊或其他此类控制点的选择性放置可以局部地控制其他参数，如环经历外部负载时的位移量和方向。具有良好放置的控制点的电缆导致MIS瓣膜成形术环在xy平面上具有足够的灵活性，以允许外科医生将环挤压成小切口，例如1cm×1cm，同时在施加在通过心动周期植入环，并允许将非对称偏转设计到产品中。

4. 发明申请

WO2014158617A1 MULTI-STRANDED HEAT SET ANNULOPLASTY RINGS 审中-公开
标题翻译：多条热套安息圈
公开(公告)号：WO2014158617A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/018761
申请日：2014-02-26
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： MIGLIAZZA, John, F. , DE PAULIS, Ruggero
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2415 , A61F2/2448 , A61F2/2466 , A61F2210/0019 , A61F2230/0095 , A61F2240/001 , A61F2250/0042 , A61F2310/00005 , C22F1/10 , Y10T29/49826 , Y10T29/49844 , Y10T29/49865 , Y10T29/4989 , Y10T29/49908 , Y10T29/49948 , Y10T29/49968 , Y10T29/49986 , Y10T29/49998 , Y10T29/5353
摘要： An annuloplasty repair segment for heart valve annulus repair. In one embodiment a multi- stranded cable replaces solid core wire for both the tricuspid and mitral valves. Cable allows for greater deployment flexibility for minimally-invasive surgical (MIS) implant, while still maintaining the required strength and similar tensile properties of solid-core wire. Stranded cable provides a MIS annuloplasty ring with sufficient flexibility in the x-y plane to allow a surgeon to squeeze the ring into a small incision, such as being able to pass through an 18Fr or smaller catheter, while maintaining structural rigidity under forces exerted on the implanted ring by the cardiac cycle. The particular shape of the annuloplasty ring is fixed using a heat setting process.
摘要翻译：用于心脏瓣膜环修复的瓣环成形术修复部分。在一个实施例中，多股电缆替代用于三尖瓣和二尖瓣的实心芯线。电缆允许为微创手术（MIS）植入物提供更大的部署灵活性，同时仍然保持固体芯线所需的强度和类似的拉伸性能。绞线在XY平面上提供了具有足够灵活性的MIS瓣环成形术环，以允许外科医生将环挤压成小切口，例如能够通过18Fr或更小的导管，同时在施加在植入的力通过心动周期戒指。瓣环成形术环的特定形状使用热定形过程固定。

5. 发明申请

WO2012027384A2 COLOR-CODED PROSTHETIC VALVE SYSTEM AND METHODS FOR USING THE SAME 审中-公开
标题翻译：彩色假牙瓣膜系统及使用该系统的方法
公开(公告)号：WO2012027384A2
公开(公告)日：2012-03-01
申请号：PCT/US2011/048828
申请日：2011-08-23
申请人： EDWARDS LIFESCIENCES CORPORATION , LAU, Jackie , PETERSON, John , KIM, Grace , MIGLIAZZA, John, F. , OBA, Travis
发明人： LAU, Jackie , PETERSON, John , KIM, Grace , MIGLIAZZA, John, F. , OBA, Travis
IPC分类号： A61F2/24 , A61F2/82
CPC分类号： A61F2/2412 , A61F2/0095 , A61F2/2418 , A61F2/2427 , A61F2/2496 , A61F2250/0064 , A61F2250/0087 , A61F2250/0097
摘要： A color-coded bioprosthetic valve system having a valve with an annular sewing ring, and a valve holder system with a holder sutured to the ring of the valve, a post operatively connected to the holder, and an adapter sutured to the post and having a color associated with the valve model and/or size. For example, the adapter may be blue to indicate that the valve of the system is a mitral valve of a particular type and/or size. The system may also include a flex handle that is configured to engage with the adapter. The handle has a color associated with the adapter such that a user is able to visually determine that the handle color matches the valve model. For example, the handle may have a grip that is colored blue to match the blue color of the adapter. Accordingly, the color-coded system enables users to confirm easily that the correct accessories such as the sizer or flex handle are being used with the correct valve.
摘要翻译：一种颜色编码的生物人造瓣膜系统，其具有带环形缝合环的瓣膜，以及具有缝合到瓣膜环的保持器的瓣膜保持器系统，可操作地连接到保持器的柱，以及适配器缝合到柱上并具有与阀模型和/或尺寸相关的颜色。例如，适配器可以是蓝色的，以指示系统的瓣膜是特定类型和/或尺寸的二尖瓣。该系统还可以包括被配置为与适配器接合的柔性手柄。手柄具有与适配器相关联的颜色，使得用户能够可视地确定手柄颜色与阀模型匹配。例如，手柄可以具有蓝色的把手，以匹配适配器的蓝色。因此，颜色编码系统使用户能够轻松确认正确的配件，如尺寸测定仪或弹性手柄正在使用正确的阀门。

6. 发明申请

WO2011097355A2 DEVICES AND METHODS FOR TREATING A HEART 审中-公开
标题翻译：用于治疗心脏的装置和方法
公开(公告)号：WO2011097355A2
公开(公告)日：2011-08-11
申请号：PCT/US2011/023568
申请日：2011-02-03
申请人： EDWARDS LIFESCIENCES CORPORATION , BOBO, Donald, E. , BASH, Assaf , CAMPBELL, Louis, A. , CURTIS, Alison, S. , CHEUNG, Tak , MIGLIAZZA, John, F.
发明人： BOBO, Donald, E. , BASH, Assaf , CAMPBELL, Louis, A. , CURTIS, Alison, S. , CHEUNG, Tak , MIGLIAZZA, John, F.
IPC分类号： A61B17/12 , A61F2/24 , A61B5/02 , A61B5/107
CPC分类号： A61F2/2445 , A61B5/1076 , A61B6/503 , A61F2/2457 , A61F2/2487 , A61F2220/0008 , A61F2250/0004 , A61F2250/0007 , A61F2250/0012
摘要： Devices and related methods of use are provided for improving heart function. In one embodiment of the present disclosure, a device includes a ring-like structure configured to be secured to a heart valve; at least one elongate member extending from the ring-like structure, wherein an end of the elongate member is configured to be secured to heart geometry other than a heart valve; and an adjustment mechanism for simultaneously altering a dimension of the ring-like structure and a length of the elongate member.
摘要翻译：提供了用于改善心脏功能的装置和相关的使用方法。在本公开的一个实施例中，一种装置包括构造成固定到心脏瓣膜的环状结构; 至少一个细长构件，所述至少一个细长构件从所述环状结构延伸，其中所述细长构件的端部被构造成固定到除心脏瓣膜之外的心脏几何形状; 以及用于同时改变环状结构的尺寸和细长构件的长度的调节机构。

7. 发明授权

EP2608742B1 Color-coded prosthetic valve system 有权
标题翻译：彩色人工瓣膜系统
公开(公告)号：EP2608742B1
公开(公告)日：2017-07-12
申请号：EP11820533.5
申请日：2011-08-23
申请人： Edwards Lifesciences Corporation
发明人： LAU, Jackie , PETERSON, John , KIM, Grace , MIGLIAZZA, John, F. , OBA, Travis
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/0095 , A61F2/2418 , A61F2/2427 , A61F2/2496 , A61F2250/0064 , A61F2250/0087 , A61F2250/0097

8. 发明公开

EP2608743A2 FLEXIBLE ANNULOPLASTY RING WITH SELECT CONTROL POINTS 有权
标题翻译：柔性纤维蛋白酶抑制剂麻醉剂AUSWAHLKONTROLLPUNKTEN
公开(公告)号：EP2608743A2
公开(公告)日：2013-07-03
申请号：EP11820614.3
申请日：2011-08-24
申请人： Edwards Lifesciences Corporation
发明人： MIGLIAZZA, John, F. , CROCKETT, Bob , ABRAM, Tim
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2448 , A61F2/2466 , A61F2230/0091 , A61F2250/0018
摘要： An annuloplasty repair segment for heart valve annulus repair. In one embodiment a multi- stranded cable replaces solid core wire for both the tricuspid and mitral valves. Cable allows for greater deployment flexibility for minimally-invasive surgical (MIS) implant, while still maintaining the required strength and similar tensile properties of solid-core wire. In addition, selective placement of point- welds or other such control points locally control other parameters such as the amount and direction of displacement as the ring undergoes external loading. Cable with well-placed control points result in a MIS annuloplasty ring with sufficient flexibility in the x-y plane to allow a surgeon to squeeze the ring into a small incision, such as for example 1cm x 1cm, while maintaining structural rigidity under forces exerted on the implanted ring by the cardiac cycle and allowing for asymmetrical deflection to be designed into the product.
摘要翻译：用于心脏瓣膜环修复的瓣环成形术修复部分。在一个实施例中，多股电缆代替三尖瓣和二尖瓣两者的实心芯线。电缆允许为微创手术（MIS）植入物提供更大的部署灵活性，同时仍然保持固体芯线所需的强度和类似的拉伸性能。此外，点焊或其他此类控制点的选择性放置可以局部地控制其他参数，例如环经历外部负载时的位移量和方向。具有良好放置的控制点的电缆导致MIS瓣膜成形术环在xy平面上具有足够的灵活性，以允许外科医生将环挤压成小切口，例如1cm×1cm，同时在施加的力的同时保持结构刚度通过心脏周期在植入的环上，并允许将非对称偏转设计到产品中。

9. 发明公开

EP2608742A2 COLOR-CODED PROSTHETIC VALVE SYSTEM AND METHODS FOR USING THE SAME 有权
标题翻译： Farbkodiertes Herzklappenprothesensystem
公开(公告)号：EP2608742A2
公开(公告)日：2013-07-03
申请号：EP11820533.5
申请日：2011-08-23
申请人： Edwards Lifesciences Corporation
发明人： LAU, Jackie , PETERSON, John , KIM, Grace , MIGLIAZZA, John, F. , OBA, Travis
IPC分类号： A61F2/24 , A61F2/82
CPC分类号： A61F2/2412 , A61F2/0095 , A61F2/2418 , A61F2/2427 , A61F2/2496 , A61F2250/0064 , A61F2250/0087 , A61F2250/0097
摘要： A color-coded bioprosthetic valve system having a valve with an annular sewing ring, and a valve holder system with a holder sutured to the ring of the valve, a post operatively connected to the holder, and an adapter sutured to the post and having a color associated with the valve model and/or size. For example, the adapter may be blue to indicate that the valve of the system is a mitral valve of a particular type and/or size. The system may also include a flex handle that is configured to engage with the adapter. The handle has a color associated with the adapter such that a user is able to visually determine that the handle color matches the valve model. For example, the handle may have a grip that is colored blue to match the blue color of the adapter. Accordingly, the color-coded system enables users to confirm easily that the correct accessories such as the sizer or flex handle are being used with the correct valve.
摘要翻译：一种颜色编码的生物假体瓣膜系统，其具有带环形缝合环的阀，以及阀座系统，其具有固定在阀的环上的保持器，可操作地连接到保持器的柱，以及缝合到柱的适配器，与阀门模型和/或尺寸相关联的颜色。例如，适配器可以是蓝色的，以指示系统的阀是特定类型和/或尺寸的二尖瓣。该系统还可以包括配置成与适配器接合的柔性手柄。手柄具有与适配器相关联的颜色，使得用户能够在视觉上确定手柄颜色与阀模型匹配。例如，手柄可以具有蓝色的手柄以匹配适配器的蓝色。因此，颜色编码系统使用户能够容易地确认正确的配件如尺寸调节器或柔性手柄正在与正确的阀门一起使用。

10. 发明授权

EP2549957B1 METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE 有权
公开(公告)号：EP2549957B1
公开(公告)日：2019-01-30
申请号：EP11760162.5
申请日：2011-03-23
申请人： Edwards Lifesciences Corporation
发明人： DOVE, Jeffrey, S. , TIAN, Bin , SCHNEIDER, Ralph , COHEN, Jeffrey, S. , JANKOVIC, Ivan , MIGLIAZZA, John, F. , WRIGHT, Gregory, A. , YOUNG, James, M. , CAMPBELL, Louis, A.
IPC分类号： A61F2/24 , A61L27/36 , A61L27/50

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