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1. 发明申请

US20200087625A1 METHODS FOR ISOLATING, EXPANDING AND ADMINISTERING CANCER SPECIFIC CD8+ T CELLS 审中-公开
公开(公告)号：US20200087625A1
公开(公告)日：2020-03-19
申请号：US16495083
申请日：2018-03-30
申请人： Dennis A. Carson , Tomoko Hayashi , Kun-Liang Guan , Toshiro Moroishi
发明人： Dennis A. Carson , Tomoko Hayashi , Kun-Liang Guan , Toshiro Moroishi
IPC分类号： C12N5/0783 , A61K35/17 , A61P35/04
摘要： Methods to isolate and expand tumor specific CD8+ T cells, and the use thereof, are provided. Also provided are method of using TLR7 agonists.

2. 发明申请

US20130202629A1 USES OF PHOSPHOLIPID CONJUGATES OF SYNTHETIC TLR7 AGONISTS 审中-公开
标题翻译：使用合成TLR7激动剂的磷脂结合
公开(公告)号：US20130202629A1
公开(公告)日：2013-08-08
申请号：US13695385
申请日：2011-04-29
申请人： Dennis A. Carson , Howard B. Cottam , Tomoko Hayashi , Michael Chan , Christina C.N. Wu
发明人： Dennis A. Carson , Howard B. Cottam , Tomoko Hayashi , Michael Chan , Christina C.N. Wu
IPC分类号： A61K39/39 , C07F9/6561
CPC分类号： A61K39/39 , A61K31/52 , A61K31/66 , A61K39/07 , A61K47/544 , A61K2039/543 , A61K2039/55511 , A61K2039/55555 , C07F9/65616 , Y02A50/414
摘要： The invention provides uses for phospholipid conjugates of TLR agonists, for instance in vaccines, and to prevent, inhibit or treat a variety of disorders including inflammation, cancer and pathogen, e.g., microbe, infection.
摘要翻译：本发明提供了用于例如疫苗中TLR激动剂的磷脂缀合物的用途，并且用于预防，抑制或治疗各种疾病，包括炎症，癌症和病原体，例如微生物感染。

3. 发明授权

US08729088B2 Toll-like receptor modulators and treatment of diseases 有权
标题翻译： Toll样受体调节剂和治疗疾病
公开(公告)号：US08729088B2
公开(公告)日：2014-05-20
申请号：US12704343
申请日：2010-02-11
申请人： Dennis A. Carson , Howard B. Cottam , Tomoko Hayashi , Michael Chan
发明人： Dennis A. Carson , Howard B. Cottam , Tomoko Hayashi , Michael Chan
IPC分类号： A61K31/52 , C07D473/00
CPC分类号： C07D473/18 , C07D471/04 , C07D473/16 , C07D473/24 , C07D519/00
摘要： Provided herein are small molecule conjugates that are agonists or antagonists of one or more toll-like receptors. For example, such conjugates include a structure according to Formula I:
摘要翻译：本文提供作为一种或多种toll样受体的激动剂或拮抗剂的小分子缀合物。例如，这种缀合物包括根据式I的结构：

4. 发明申请

US20100210598A1 TOLL-LIKE RECEPTOR MODULATORS AND TREATMENT OF DISEASES 有权
标题翻译： TOLL-LIKE受体调节剂和治疗疾病
公开(公告)号：US20100210598A1
公开(公告)日：2010-08-19
申请号：US12704343
申请日：2010-02-11
申请人： Dennis A. Carson , Howard B. Cottam , Tomoko Hayashi , Michael Chan
发明人： Dennis A. Carson , Howard B. Cottam , Tomoko Hayashi , Michael Chan
IPC分类号： A61K31/522 , C07D473/04 , C07F9/6558 , A61K31/688 , C07F9/6524 , A61K31/685 , A61K31/52 , A61P29/00 , A61P37/06
CPC分类号： C07D473/18 , C07D471/04 , C07D473/16 , C07D473/24 , C07D519/00
摘要： Provided herein are small molecule conjugates that are agonists or antagonists of one or more toll-like receptors.
摘要翻译：本文提供作为一种或多种toll样受体的激动剂或拮抗剂的小分子缀合物。

5. 发明申请

US20210038742A1 CONJUGATION OF TLR7 AGONIST TO NANO-MATERIALS ENHANCES THE AGONISTIC ACTIVITY 有权
公开(公告)号：US20210038742A1
公开(公告)日：2021-02-11
申请号：US16906933
申请日：2020-06-19
申请人： Ching-Hsin Huang , Natalie Mendez , James Wang , Tomoko Hayashi , Joi Weeks , Oscar Hernandez Echeagaray , Andrew Kummel , William C. Trogler , Natalie A. Gude
发明人： Ching-Hsin Huang , Natalie Mendez , James Wang , Tomoko Hayashi , Joi Weeks , Oscar Hernandez Echeagaray , Andrew Kummel , William C. Trogler , Natalie A. Gude
IPC分类号： A61K47/69 , A61K31/522 , A61K31/437 , A61P35/04
摘要： A composition comprising silica shells conjugated to a TLR7 agonist and methods of using the composition are provided.

6. 发明授权

US07271291B2 1,3,5-tris (arylamino) benzenes 失效
标题翻译： 1,3,5-三（芳基氨基）苯
公开(公告)号：US07271291B2
公开(公告)日：2007-09-18
申请号：US10549166
申请日：2004-03-15
申请人： Hiroshi Inada , Nobutaka Akashi , Tomoko Hayashi
发明人： Hiroshi Inada , Nobutaka Akashi , Tomoko Hayashi
IPC分类号： C07C211/54 , H01L35/24
CPC分类号： C07C211/58 , H01L51/0059 , H01L51/006 , H01L51/5048
摘要： The invention provides 1,3,5-tris(arylamino)benzenes represented by the general formula (I) wherein A is naphthyl, anthryl or phenanthryl group, and R is hydrogen atom or diarylamino group. These 1,3,5-tris(arylamino)benzenes have oxidation potentials in the range of about 0.5-0.6V, excellent reversibility in oxidation-reduction process, high glass transition temperatures and high heat resistance, so that they can form practicable organic semiconductor film readily by a coating method or a vacuum deposition method. In addition, they are capable of forming stable and durable amorphous film useful as high performance organic semiconductors at normal temperatures or higher with no aid of binder resins, that is, by themselves.
摘要翻译：本发明提供由通式（I）表示的1,3,5-三（芳氨基）苯，其中A为萘基，蒽基或菲基，R为氢原子或二芳基氨基。这些1,3,5-三（芳基氨基）苯具有在约0.5-0.6V的范围内的氧化电位，氧化还原过程的优异可逆性，高玻璃化转变温度和高耐热性，使得它们可以形成可行的有机半导体通过涂布方法或真空沉积方法容易地制备薄膜。此外，它们能够在常温或更高温度下形成稳定且耐用的无定形薄膜，无需粘合剂树脂，即本身就可以使用。

7. 发明申请

US20050090692A1 Novel 1,3,5-tris(arylamino)benzene 失效
标题翻译：新的1,3,5-三（芳基氨基）苯
公开(公告)号：US20050090692A1
公开(公告)日：2005-04-28
申请号：US10508910
申请日：2003-03-26
申请人： Nobutaka Akashi , Hideki Norisada , Tomoko Hayashi , Yasuhiko Shirota
发明人： Nobutaka Akashi , Hideki Norisada , Tomoko Hayashi , Yasuhiko Shirota
IPC分类号： C07C211/54 , C07C211/58 , C07C211/61 , G03G5/06 , C07C211/00
CPC分类号： C07C211/54 , C07C211/58 , C07C211/61 , G03G5/0614 , Y10S428/917
摘要： The invention provides 1,3,5-tris(arylamino)benzenes represented by the general formula (I) wherein A is naphthyl, anthryl, phenanthryl, biphenylyl or terphenylyl group, and R is alkyl having 1-6 carbon atoms or cycloalkyl group having five or six carbon atoms. The 1,3,5-tris(arylamino)benzenes have oxidation potentials in the range of about 0.5-0.6V, excellent reversibility in oxidation-reduction process and high glass transition temperatures and in addition, they are capable of forming stable and durable amorphous film useful as high performance organic semiconductors at normal temperatures or higher with no aid of binder resins, that is, by themselves.
摘要翻译：本发明提供由通式（I）表示的1,3,5-三（芳氨基）苯，其中A为萘基，蒽基，菲基，联苯基或三联苯基，R为具有1-6个碳原子的烷基或具有五或六个碳原子。 1,3,5-三（芳基氨基）苯具有在约0.5-0.6V的范围内的氧化电位，氧化还原过程的优异的可逆性和高的玻璃化转变温度，此外，它们能够形成稳定和耐用的无定形膜在正常温度或更高温度下作为高性能有机半导体，无助于粘合剂树脂，也就是本身。

8. 发明授权

US09867811B2 Method of treating atherosclerosis in high triglyceride subjects 有权
公开(公告)号：US09867811B2
公开(公告)日：2018-01-16
申请号：US14128877
申请日：2012-07-06
申请人： Yoshie Arai , Margaret Elizabeth Brousseau , Jessie Gu , Tomoko Hayashi , Hironobu Mitani , Muneto Mogi , Kazuhiko Nonomura , Ken Yamada
发明人： Yoshie Arai , Margaret Elizabeth Brousseau , Jessie Gu , Tomoko Hayashi , Hironobu Mitani , Muneto Mogi , Kazuhiko Nonomura , Ken Yamada
IPC分类号： A61K31/421 , A61K31/41 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/506 , A61K31/55 , A61K31/505 , A61K31/5377 , A61K45/06
CPC分类号： A61K31/421 , A61K31/41 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06
摘要： The present invention provides a compound of Formula I: for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP activity, such as atherosclerosis and dyslipidemia, in a subject with high triglyceride level; wherein R1, X1, R7, R5, C, L and p are defined herein. The present invention further provides a combination of pharmacologically active agents for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP activity, such as atherosclerosis and dyslipidemia, in a subject with high triglyceride levels.

9. 发明申请

US20060173216A1 Novel 1, 3, 5 tris (arylamino) benzenes 失效
标题翻译：新的1,3,5-三（芳基氨基）苯
公开(公告)号：US20060173216A1
公开(公告)日：2006-08-03
申请号：US10549166
申请日：2004-03-15
申请人： Hiroshi Inada , Nobutaka Akashi , Tomoko Hayashi
发明人： Hiroshi Inada , Nobutaka Akashi , Tomoko Hayashi
IPC分类号： C07C211/50
CPC分类号： C07C211/58 , H01L51/0059 , H01L51/006 , H01L51/5048
摘要： The invention provides 1,3,5-tris(arylamino)benzenes represented by the general formula (I) wherein A is naphthyl, anthryl or phenanthryl group, and R is hydrogen atom or diarylamino group. These 1,3,5-tris(arylamino)benzenes have oxidation potentials in the range of about 0.5-0.6V, excellent reversibility in oxidation-reduction process, high glass transition temperatures and high heat resistance, so that they can form practicable organic semiconductor film readily by a coating method or a vacuum deposition method. In addition, they are capable of forming stable and durable amorphous film useful as high performance organic semiconductors at normal temperatures or higher with no aid of binder resins, that is, by themselves.
摘要翻译：本发明提供由通式（I）表示的1,3,5-三（芳氨基）苯，其中A为萘基，蒽基或菲基，R为氢原子或二芳基氨基。这些1,3,5-三（芳基氨基）苯具有在约0.5-0.6V的范围内的氧化电位，氧化还原过程的优异可逆性，高玻璃化转变温度和高耐热性，使得它们可以形成可行的有机半导体通过涂布方法或真空沉积方法容易地制备薄膜。此外，它们能够在常温或更高温度下形成稳定且耐用的无定形薄膜，无需粘合剂树脂，即本身就可以使用。

10. 发明授权

US07196224B2 1,3,5-tris(arylamino)benzenes 失效
标题翻译： 1,3,5-三（芳基氨基）苯
公开(公告)号：US07196224B2
公开(公告)日：2007-03-27
申请号：US10508910
申请日：2003-03-26
申请人： Nobutaka Akashi , Hideki Norisada , Tomoko Hayashi , Yasuhiko Shirota
发明人： Nobutaka Akashi , Hideki Norisada , Tomoko Hayashi , Yasuhiko Shirota
IPC分类号： C07C211/61 , C07C211/58 , C07C211/55 , G03G15/06
CPC分类号： C07C211/54 , C07C211/58 , C07C211/61 , G03G5/0614 , Y10S428/917
摘要： The invention provides 1,3,5-tris(arylamino)benzenes represented by the general formula (I) wherein A is naphthyl, anthryl, phenanthryl, biphenylyl or terphenylyl group, and R is alkyl having 1–6 carbon atoms or cycloalkyl group having five or six carbon atoms. The 1,3,5-tris(arylamino)benzenes have oxidation potentials in the range of about 0.5–0.6V, excellent reversibility in oxidation-reduction process and high glass transition temperatures and in addition, they are capable of forming stable and durable amorphous film useful as high performance organic semiconductors at normal temperatures or higher with no aid of binder resins, that is, by themselves.
摘要翻译：本发明提供由通式（I）表示的1,3,5-三（芳基氨基）苯，

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