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1. 发明申请

US20200087625A1 METHODS FOR ISOLATING, EXPANDING AND ADMINISTERING CANCER SPECIFIC CD8+ T CELLS 审中-公开
公开(公告)号：US20200087625A1
公开(公告)日：2020-03-19
申请号：US16495083
申请日：2018-03-30
申请人： Dennis A. Carson , Tomoko Hayashi , Kun-Liang Guan , Toshiro Moroishi
发明人： Dennis A. Carson , Tomoko Hayashi , Kun-Liang Guan , Toshiro Moroishi
IPC分类号： C12N5/0783 , A61K35/17 , A61P35/04
摘要： Methods to isolate and expand tumor specific CD8+ T cells, and the use thereof, are provided. Also provided are method of using TLR7 agonists.

2. 发明申请

US20080188461A1 Compositions and methods for detecting, preventing and treating seizures and seizure related disorders 审中-公开
标题翻译：用于检测，预防和治疗癫痫发作和癫痫发作相关疾病的组合物和方法
公开(公告)号：US20080188461A1
公开(公告)日：2008-08-07
申请号：US11823971
申请日：2007-06-29
申请人： Kun-Liang Guan , David Franz
发明人： Kun-Liang Guan , David Franz
IPC分类号： A61K31/55 , A61K31/335 , A61P25/08
CPC分类号： A61K45/06 , A61K31/436 , A61K2300/00
摘要： The present invention relates to compositions and methods for the detecting, preventing, treating, and empirically investigating seizures and seizure related disorders (e.g., West syndrome, TSC, childhood absence epilepsy, benign focal epilepsies of childhood, juvenile myoclonic epilepsy (JME), temperol lobe epilepsy, frontal lobe epilepsy, Lennox-Gastaut syndrome, occipital lobe epilepsy). In particular, the present invention provides compositions and methods for detecting, treating, preventing and empirical investigating seizures and seizure related disorders through inhibition of mTOR function. In addition, the present invention provides methods and compositions that utilize mTOR inhibiting agents (e.g., rapamycin) in the detecting, preventing, treating, and empirical investigating of seizures and seizure related disorders.
摘要翻译：本发明涉及用于检测，预防，治疗和经验调查癫痫发作和癫痫发作相关疾病的组合物和方法（例如，西综合征，TSC，儿童期不存在癫痫，儿童良性发作性癫痫，青少年肌阵挛性癫痫（JME）叶片性癫痫，额叶癫痫，Lennox-Gastaut综合征，枕叶性癫痫）。特别地，本发明提供了通过抑制mTOR功能来检测，治疗，预防和经验性研究癫痫发作和发作相关疾病的组合物和方法。此外，本发明提供了利用mTOR抑制剂（例如雷帕霉素）检测，预防，治疗和经验性研究癫痫发作和发作相关疾病的方法和组合物。

3. 发明申请

US20080207671A1 Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway 审中-公开
标题翻译：诊断和治疗结节性硬化症途径缺陷引起的疾病
公开(公告)号：US20080207671A1
公开(公告)日：2008-08-28
申请号：US11888184
申请日：2007-07-31
申请人： Kun-Liang Guan , Ken Inoki , Hiroyuki Mori
发明人： Kun-Liang Guan , Ken Inoki , Hiroyuki Mori
IPC分类号： A61K31/436 , A61P3/10
CPC分类号： A61K31/436 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compositions, methods for identifying, and methods for treating abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing, treating and preventing disorders caused by defects in the TSC signaling pathway (e.g., TSC-1, TSC-2, TSC-1/TSC-2, Rheb, mTOR, S6K, and 4EBP-1) such as tuberous sclerosis, diabetes, and complications related to diabetes (e.g., insulin resistance, obesity, nephropathy). The present invention further relates to compositions for treating and preventing disorders such as tuberous sclerosis, diabetes, and complications related to diabetes (e.g., insulin resistance, obesity, nephropathy).
摘要翻译：本发明涉及组合物，鉴定方法和治疗TSC信号通路异常的方法。特别地，本发明涉及诊断，治疗和预防由TSC信号通路缺陷引起的疾病（例如，TSC-1，TSC-2，TSC-1 / TSC-2，Rheb，mTOR，S6K和 4EBP-1）如结节性硬化症，糖尿病以及与糖尿病有关的并发症（例如胰岛素抵抗，肥胖症，肾病）。本发明还涉及用于治疗和预防诸如结节性硬化症，糖尿病和与糖尿病相关并发症（例如胰岛素抵抗，肥胖，肾病）的疾病的组合物。

4. 发明授权

US07169594B2 Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway 有权
标题翻译：诊断和治疗结节性硬化症途径缺陷引起的疾病
公开(公告)号：US07169594B2
公开(公告)日：2007-01-30
申请号：US10639263
申请日：2003-08-12
申请人： Kun-Liang Guan
发明人： Kun-Liang Guan
IPC分类号： C12N9/12
CPC分类号： G01N33/5041 , C12Q1/485
摘要： The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.
摘要翻译：本发明涉及鉴定TSC信号通路异常的组合物和方法。特别地，本发明涉及诊断和治疗由TSC基因突变引起的结节性硬化症等疾病的方法。本发明还涉及用于治疗由TSC信号传导疾病介导的癌症的方法和组合物。

5. 发明申请

US20080199896A1 Diagnosis and Treatment of Diseases Arising from Defects in the Tuberous Sclerosis Pathway 审中-公开
标题翻译：结节性硬化症缺陷引起的疾病诊断与治疗
公开(公告)号：US20080199896A1
公开(公告)日：2008-08-21
申请号：US11927222
申请日：2007-10-29
申请人： Kun-Liang Guan
发明人： Kun-Liang Guan
IPC分类号： A61K31/436 , C12Q1/42 , A61P43/00
CPC分类号： A61K31/00 , A61K31/352 , A61K31/436 , A61K31/7004 , A61K31/7056 , C12Q1/485 , G01N33/6893 , G01N33/6896
摘要： The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.
摘要翻译：本发明涉及鉴定TSC信号通路异常的组合物和方法。特别地，本发明涉及诊断和治疗由TSC基因突变引起的结节性硬化症等疾病的方法。本发明还涉及用于治疗由TSC信号传导疾病介导的癌症的方法和组合物。

6. 发明申请

US20070122860A1 Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway 有权
公开(公告)号：US20070122860A1
公开(公告)日：2007-05-31
申请号：US11643443
申请日：2006-12-21
申请人： Kun-Liang Guan
发明人： Kun-Liang Guan
IPC分类号： C12Q1/48 , A61K31/70 , A61K31/4745 , A61K31/353
CPC分类号： G01N33/5041 , C12Q1/485
摘要： The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.

7. 发明申请

US20050070567A1 Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway 审中-公开
标题翻译：诊断和治疗结节性硬化症途径缺陷引起的疾病
公开(公告)号：US20050070567A1
公开(公告)日：2005-03-31
申请号：US10720417
申请日：2003-11-24
申请人： Kun-Liang Guan
发明人： Kun-Liang Guan
IPC分类号： A61K31/4745 , C12Q1/48 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/68
CPC分类号： A61K31/00 , A61K31/352 , A61K31/436 , A61K31/7004 , A61K31/7056 , C12Q1/485 , G01N33/6893 , G01N33/6896
摘要： The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.
摘要翻译：本发明涉及鉴定TSC信号通路异常的组合物和方法。特别地，本发明涉及诊断和治疗由TSC基因突变引起的结节性硬化症等疾病的方法。本发明还涉及用于治疗由TSC信号传导疾病介导的癌症的方法和组合物。

8. 发明申请

US20080312267A1 Diagnosis and Treatment of Diseases Arising from Defects in the Tuberous Sclerosis Pathway 审中-公开
公开(公告)号：US20080312267A1
公开(公告)日：2008-12-18
申请号：US12118224
申请日：2008-05-09
申请人： Kun-Liang Guan
发明人： Kun-Liang Guan
IPC分类号： A61K31/436 , A61P9/10
CPC分类号： G01N33/5041 , C12Q1/485
摘要： The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.

9. 发明授权

US07416724B2 Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway 有权
标题翻译：诊断和治疗结节性硬化症途径缺陷引起的疾病
公开(公告)号：US07416724B2
公开(公告)日：2008-08-26
申请号：US11643443
申请日：2006-12-21
申请人： Kun-Liang Guan
发明人： Kun-Liang Guan
IPC分类号： A01N37/18 , A61K38/00
CPC分类号： G01N33/5041 , C12Q1/485
摘要： The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.
摘要翻译：本发明涉及鉴定TSC信号通路异常的组合物和方法。特别地，本发明涉及诊断和治疗由TSC基因突变引起的结节性硬化症等疾病的方法。本发明还涉及用于治疗由TSC信号传导障碍介导的癌症的方法和组合物。

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