专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060040276A1 Molecular recognition at surfaces derivatized with self-assembled monolayers 审中-公开
公开(公告)号：US20060040276A1
公开(公告)日：2006-02-23
申请号：US10969222
申请日：2004-10-20
申请人： Cynthia Bamdad , George Sigal , Jack Strominger , George Whitesides
发明人： Cynthia Bamdad , George Sigal , Jack Strominger , George Whitesides
IPC分类号： C12Q1/68 , C07H21/04 , C12M1/34
CPC分类号： B82Y30/00 , B82Y15/00 , B82Y40/00 , C07H21/04 , C12Q1/6837 , G01N33/54353 , G01N33/54373 , G01N33/553 , G01N2610/00
摘要： An article suitable for use as a biosensor includes a molecule of a formula X—R-Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the chelating agent, and a polyamino acid-tagged biological binding partner of a target biological molecule coordinated to the metal ion. A method of the invention involves bringing the article into contact with a medium containing or suspected of containing the target biological molecule and allowing the biological molecule to biologically bind to the binding partner. The article is useful particularly as a surface plasmon resonance chip.

2. 发明申请

US20100239833A9 Elastomeric mask and use in fabrication of devices 审中-公开
标题翻译：弹性面膜和用于制造器件
公开(公告)号：US20100239833A9
公开(公告)日：2010-09-23
申请号：US11890326
申请日：2007-08-06
申请人： Rebecca Jackman , David Duffy , George Whitesides , Kathleen Vaeth , Klavs Jensen
发明人： Rebecca Jackman , David Duffy , George Whitesides , Kathleen Vaeth , Klavs Jensen
IPC分类号： B32B27/32
CPC分类号： C23C14/042 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F1/00 , G03F7/0002 , G03F7/0007 , G03F7/12 , H01L27/3211 , H01L27/3244 , H01L27/3281 , H01L51/0011 , H01L51/56
摘要： An elastomeric mask is provided that allows deposition of a variety of materials through mask openings. The mask seals effectively against substrate surfaces, allowing simple deposition from fluid phase, gas phase, and the like or removal of material using gaseous or liquid etchants. The mask then can be simply peeled from the surface of the substrate leaving the patterned material behind. Multi-layered mask techniques are described in which openings in an upper mask allow selected openings of a lower mask to remain un-shielded, while other openings of the lower mask are shielded. A first deposition step, following by re-orientation of the upper mask to expose a different set of lower mask openings, allows selective deposition of different materials in different openings of the lower mask. Pixelated organic electroluminescent devices are provided via the described technique.
摘要翻译：提供了一种弹性体掩模，其允许通过掩模开口沉积各种材料。掩模有效地密封衬底表面，允许从流体相，气相等简单沉积或使用气体或液体蚀刻剂去除材料。然后可以从掩模的表面简单地剥离掩模，留下图案化材料。描述了多层掩模技术，其中上掩模中的开口允许下掩模的选定开口保持未屏蔽，而下掩模的其它开口被屏蔽。第一沉积步骤，随后通过上掩模的重新定向以暴露不同的一组下掩模开口，允许不同材料在下掩模的不同开口中的选择性沉积。通过所述技术提供像素化的有机电致发光器件。

3. 发明申请

US20080063851A1 Elastomeric mask and use in fabrication of devices 审中-公开
标题翻译：弹性面膜和用于制造器件
公开(公告)号：US20080063851A1
公开(公告)日：2008-03-13
申请号：US11890326
申请日：2007-08-06
申请人： Rebecca Jackman , David Duffy , George Whitesides , Kathleen Vaeth , Klavs Jensen
发明人： Rebecca Jackman , David Duffy , George Whitesides , Kathleen Vaeth , Klavs Jensen
IPC分类号： B32B27/32
CPC分类号： C23C14/042 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F1/00 , G03F7/0002 , G03F7/0007 , G03F7/12 , H01L27/3211 , H01L27/3244 , H01L27/3281 , H01L51/0011 , H01L51/56
摘要： An elastomeric mask is provided that allows deposition of a variety of materials through mask openings. The mask seals effectively against substrate surfaces, allowing simple deposition from fluid phase, gas phase, and the like or removal of material using gaseous or liquid etchants. The mask then can be simply peeled from the surface of the substrate leaving the patterned material behind. Multi-layered mask techniques are described in which openings in an upper mask allow selected openings of a lower mask to remain un-shielded, while other openings of the lower mask are shielded. A first deposition step, following by re-orientation of the upper mask to expose a different set of lower mask openings, allows selective deposition of different materials in different openings of the lower mask. Pixelated organic electroluminescent devices are provided via the described technique.
摘要翻译：提供了一种弹性体掩模，其允许通过掩模开口沉积各种材料。掩模有效地密封衬底表面，允许从流体相，气相等简单沉积或使用气体或液体蚀刻剂去除材料。然后可以从掩模的表面简单地剥离掩模，留下图案化材料。描述了多层掩模技术，其中上掩模中的开口允许下掩模的选定开口保持未屏蔽，而下掩模的其它开口被屏蔽。第一沉积步骤，随后通过上掩模的重新定向以暴露不同的一组下掩模开口，允许不同材料在下掩模的不同开口中的选择性沉积。通过所述技术提供像素化的有机电致发光器件。

4. 发明申请

US20060210595A1 Device containing cytophilic islands that adhere cells separated by cytophobic regions 失效
公开(公告)号：US20060210595A1
公开(公告)日：2006-09-21
申请号：US11331849
申请日：2006-01-13
申请人： Rahul Singhvi , Amit Kumar , George Whitesides , Donald Ingber , Gabriel Lopez , Daniel Wang , Gregory Stephanopoulos
发明人： Rahul Singhvi , Amit Kumar , George Whitesides , Donald Ingber , Gabriel Lopez , Daniel Wang , Gregory Stephanopoulos
IPC分类号： A61F2/06 , A61F13/00
CPC分类号： C12N1/00 , B01J19/0046 , B01J2219/00382 , B01J2219/00385 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B81B2201/0214 , B81C1/00206 , B81C2201/034 , B82Y5/00 , B82Y30/00 , C12N5/0068 , C12N5/067 , C12N2535/10 , C12Q1/02 , C40B60/14
摘要： The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).

5. 发明授权

US06228248B1 Biomimetic pathways for assembling inorganic thin films and oriented mesoscopic silicate patterns through guided growth 失效
公开(公告)号：US06228248B1
公开(公告)日：2001-05-08
申请号：US09291549
申请日：1999-04-14
申请人： Ilhan A. Aksay , Mathias Trau , Srinivas Manne , Itaru Honma , George Whitesides
发明人： Ilhan A. Aksay , Mathias Trau , Srinivas Manne , Itaru Honma , George Whitesides
IPC分类号： C25D100
CPC分类号： C01B33/12 , Y10T428/31598
摘要： A process directed to preparing surfactant-polycrystalline inorganic nanostructured materials having designed microscopic patterns. The process includes forming a polycrystalline inorganic substrate having a flat surface and placing in contact with the flat surface of the substrate a surface having a predetermined microscopic pattern. An acidified aqueous reacting solution is then placed in contact with an edge of the surface having the predetermined microscopic pattern. The solution wicks into the microscopic pattern by capillary action. The reacting solution has an effective amount of a silica source and an effective amount of a surfactant to produce a mesoscopic silica film upon contact of the reacting solution with the flat surface of the polycrystalline inorganic substrate and absorption of the surfactant into the surface. Subsequently an electric field is applied tangentially directed to the surface within the microscopic pattern. The electric field is sufficient to cause electro-osmotic fluid motion and enhanced rates of fossilization by localized Joule heating.

6. 发明授权

US09682856B2 MEMS force sensors fabricated using paper substrates 有权
公开(公告)号：US09682856B2
公开(公告)日：2017-06-20
申请号：US13557861
申请日：2012-07-25
申请人： George Whitesides , Xinyu Liu , XiuJun Li , Martin M. Thuo , Michael O'Brien , Yu Sun
发明人： George Whitesides , Xinyu Liu , XiuJun Li , Martin M. Thuo , Michael O'Brien , Yu Sun
IPC分类号： G01P15/12 , B81B7/02 , G01P15/08 , G01P15/18 , G01L1/18 , B81C1/00 , G01G3/13
CPC分类号： B81B7/02 , B81C1/0015 , G01G3/13 , G01L1/18 , G01P15/0802 , G01P15/123 , G01P15/18 , G01P2015/0862
摘要： MEMS devices fabricated using inexpensive substrate materials such as paper or fabric, are provided. Using paper as a substrate, low cost, simple to prepare, lightweight, disposable piezoresistive sensors, including accelerometers are prepared. Signal-processing circuitry can also be patterned on the substrate material.The sensors can be utilized as two-dimensional sensors, or the paper substrate material can be folded to arrange the sensors in a three dimensional conformation. For example, three sensors can be patterned on a paper substrate and folded into a cube such that the three sensors are orthogonally positioned on the faces of a cube, permitting simultaneous measurement of accelerations along three orthogonal directions (x-y-z). These paper-based sensors can be mass produced by incorporating highly developed technologies for automatic paper cutting, folding, and screen-printing.Also provided are methods of modifying paper for use as a substrate material in MEMS devices.

7. 发明申请

US20080116608A1 Molded waveguides 审中-公开
标题翻译：模制波导
公开(公告)号：US20080116608A1
公开(公告)日：2008-05-22
申请号：US12001564
申请日：2007-12-12
申请人： Enoch Kim , Younan Xia , Milan Mrksich , Rebecca Jackman , Xiao-Mei Zhao , Stephen Smith , Mara Prentiss , George Whitesides , Christian Marzolin
发明人： Enoch Kim , Younan Xia , Milan Mrksich , Rebecca Jackman , Xiao-Mei Zhao , Stephen Smith , Mara Prentiss , George Whitesides , Christian Marzolin
IPC分类号： B29C45/16
CPC分类号： B81C1/00206 , A61K47/6957 , B01J19/0046 , B01J2219/00382 , B01J2219/00416 , B01J2219/0043 , B01J2219/00466 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00713 , B29C31/04 , B29C33/42 , B29C37/0053 , B29C39/24 , B29C43/021 , B29C67/246 , B29D11/00346 , B29D11/00663 , B29K2105/0002 , B29L2011/0016 , B81B2201/0214 , B81C1/00031 , B81C99/0085 , B81C2201/034 , B82Y30/00 , C40B60/14 , G01N21/7703 , G01N2021/7776 , G02B6/138 , H05K3/0079 , H05K3/061
摘要： Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of identical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors.
摘要翻译：化学或生物化学活性剂或其它物质通过提供具有轮廓表面的微胶体并在基底表面上形成结构的化学或生物化学活性剂或流体前体而在基底表面上图案化。化学或生物化学活性剂或流体前体也可以从敷料器中的凹陷转移到基底表面。衬底表面可以是平面的或非平面的。聚合物结构，无机陶瓷和盐等的流体前体可用于在表面形成图案化聚合物制品，无机盐和陶瓷，反应离子蚀刻掩模等。制品可以形成为包括横向尺寸小于约1毫米或更小的部分的图案。涂抹器的压痕图案可以用于将单独的，不同的化学或生物化学活性剂或流体前体转移到基底表面的分离的，分离的区域。可以制作波导阵列，组合化学或生化图谱等。可以通过将由相同的预聚物材料制成的波导和包层进行不同的聚合或交联条件来产生波导和包层的折射率差异。干涉仪通过耦合波导阵列来定义，其中可以通过改变阵列的任何所需位置处的包层和波导之间的折射率差来控制耦合。改变和折射率可以通过光化学，化学等方式产生。还公开了传感器，包括生化传感器。

8. 发明申请

US20060063276A1 Alteration of surface affinities 有权
标题翻译：表面亲和力的改变
公开(公告)号：US20060063276A1
公开(公告)日：2006-03-23
申请号：US11181371
申请日：2005-07-14
申请人： Xingyu Jiang , Rosaria Ferrigno , George Whitesides
发明人： Xingyu Jiang , Rosaria Ferrigno , George Whitesides
IPC分类号： G01N1/28 , G01N33/543
CPC分类号： B82Y30/00 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3225 , B01J20/3227 , B01J20/3248 , B01J20/3251 , B01J20/3274 , B01J20/3285 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B05D3/14 , B05D3/207 , G01N33/54353 , G01N2610/00 , Y10S436/823 , Y10T436/118339
摘要： The present invention provides a series of methods, compositions, and articles for altering a property of a surface (for example, the cytophilicity and/or the hydrophilicity), by exposing at least a portion of the surface to a non-chemical, force-creating field and/or force, such as an electric field. The field/force may be created by any suitable technique. For instance, the field can be created by applying a voltage across the surface, by electrical induction, etc. In certain embodiments, the surface includes molecules attached thereto that can be detached when exposed to non-chemical, force-creating fields and/or forces, thereby altering the chemical composition of at least a portion of the surface. In one set of embodiments, the molecules attached to the surface may include molecules forming a self-assembled monolayer on the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in an alkanethiol), by which the molecule can become attached to the surface. In certain cases, the molecules may be terminated at the unattached end with one or more hydrophilic groups, for example, unmodified ethylene glycol moieties. In some cases, the molecules attached to the surface may include one or more moieties that can bind to various entities such as proteins, peptides, nucleic acids, drugs, cells, etc. In certain embodiments, the techniques are used to enable novel assays for cell motility and/or spreading and screening tests for determining drugs and/or treatments effective in increasing or decreasing cell shape changes and/or motility on surfaces.
摘要翻译：本发明提供了一系列用于改变表面性质（例如，细胞毒性和/或亲水性）的方法，组合物和制品，通过将至少一部分表面暴露于非化学，产生场和/或力，例如电场。场/力可以通过任何合适的技术来产生。例如，可以通过在表面上施加电压，通过电感应等来产生该场。在某些实施例中，表面包括附着于其上的分子，当暴露于非化学，力产生场和/或从而改变表面的至少一部分的化学成分。在一组实施方案中，连接到表面的分子可以包括在表面上形成自组装单层的分子。在一些实施方案中，附着于表面的分子可以包括硫醇部分（例如，如在链烷硫醇中），通过该分子可以使分子附着于表面。在某些情况下，分子可以在一个或多个亲水基团例如未改性的乙二醇部分的非附着端封端。在一些情况下，附着于表面的分子可以包括可结合各种实体的一个或多个部分，例如蛋白质，肽，核酸，药物，细胞等。在某些实施方案中，该技术用于使新的测定方法用于确定有效增加或减少细胞形状变化和/或表面活力的药物和/或治疗的细胞运动性和/或扩散和筛选试验。

9. 发明申请

US20050217750A1 Method and apparatus for gradient generation 有权
标题翻译：用于梯度产生的方法和装置
公开(公告)号：US20050217750A1
公开(公告)日：2005-10-06
申请号：US11037459
申请日：2005-01-18
申请人： Noo Jeon , Stephan Dertinger , Daniel Chiu , Insung Choi , George Whitesides
发明人： Noo Jeon , Stephan Dertinger , Daniel Chiu , Insung Choi , George Whitesides
IPC分类号： G01N33/53 , B01D3/00 , B01F5/06 , B01F13/00 , B01F15/04 , B01J4/00 , B01J19/00 , B01J19/24 , B01L20060101 , B01L1/00 , B01L3/00 , B65B3/00 , B65B3/04 , C12M1/34 , C23G1/00 , G01F11/28 , G01N1/28 , G01N1/38 , G01N33/543 , G01N37/00
CPC分类号： B01F5/0601 , B01F5/064 , B01F13/0059 , B01F15/0404 , B01J4/001 , B01J19/0093 , B01J2219/0086 , B01J2219/00889 , B01L3/5027 , G01N1/2813 , G01N1/38
摘要： A method and apparatus for treating a fluid. A method for treating a fluid may include combining two or more separate streams into a common stream and then splitting the common stream into a new set of separate streams wherein the separate streams may possess different properties. The separate streams may be combined to produce a gradient, such as a concentration gradient or shear gradient. The apparatus of the invention may provide a network of fluidic channels that may be used to manipulate a fluid to produce, for example, a gradient or a series of solutions containing a substance at varying concentrations.
摘要翻译：一种用于处理流体的方法和装置。用于处理流体的方法可以包括将两个或更多个分离的流组合成共同物流，然后将共同物流分成新的一组独立的流，其中分离的流可具有不同的性质。可以将单独的流组合以产生梯度，例如浓度梯度或剪切梯度。本发明的装置可以提供流体通道网络，其可以用于操纵流体以产生例如含有不同浓度物质的梯度或一系列溶液。

10. 发明申请

US20050172476A1 Method and apparatus for fluid dispersion 有权
标题翻译：流体分散方法和装置
公开(公告)号：US20050172476A1
公开(公告)日：2005-08-11
申请号：US11024228
申请日：2004-12-28
申请人： Howard Stone , Shelley Anna , Nathalie Bontoux , Darren Link , David Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow Diluzio , George Whitesides
发明人： Howard Stone , Shelley Anna , Nathalie Bontoux , Darren Link , David Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow Diluzio , George Whitesides
IPC分类号： B01F3/08 , B01F5/06 , B01F13/00 , B01L3/00 , B05B7/04 , B01D61/42
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式