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1. 发明申请

US20050217750A1 Method and apparatus for gradient generation 有权
标题翻译：用于梯度产生的方法和装置
公开(公告)号：US20050217750A1
公开(公告)日：2005-10-06
申请号：US11037459
申请日：2005-01-18
申请人： Noo Jeon , Stephan Dertinger , Daniel Chiu , Insung Choi , George Whitesides
发明人： Noo Jeon , Stephan Dertinger , Daniel Chiu , Insung Choi , George Whitesides
IPC分类号： G01N33/53 , B01D3/00 , B01F5/06 , B01F13/00 , B01F15/04 , B01J4/00 , B01J19/00 , B01J19/24 , B01L20060101 , B01L1/00 , B01L3/00 , B65B3/00 , B65B3/04 , C12M1/34 , C23G1/00 , G01F11/28 , G01N1/28 , G01N1/38 , G01N33/543 , G01N37/00
CPC分类号： B01F5/0601 , B01F5/064 , B01F13/0059 , B01F15/0404 , B01J4/001 , B01J19/0093 , B01J2219/0086 , B01J2219/00889 , B01L3/5027 , G01N1/2813 , G01N1/38
摘要： A method and apparatus for treating a fluid. A method for treating a fluid may include combining two or more separate streams into a common stream and then splitting the common stream into a new set of separate streams wherein the separate streams may possess different properties. The separate streams may be combined to produce a gradient, such as a concentration gradient or shear gradient. The apparatus of the invention may provide a network of fluidic channels that may be used to manipulate a fluid to produce, for example, a gradient or a series of solutions containing a substance at varying concentrations.
摘要翻译：一种用于处理流体的方法和装置。用于处理流体的方法可以包括将两个或更多个分离的流组合成共同物流，然后将共同物流分成新的一组独立的流，其中分离的流可具有不同的性质。可以将单独的流组合以产生梯度，例如浓度梯度或剪切梯度。本发明的装置可以提供流体通道网络，其可以用于操纵流体以产生例如含有不同浓度物质的梯度或一系列溶液。

2. 发明申请

US20060039980A1 Process of preparing a biodegradable polymer using an enzyme catalyst and a biodegradable polymer prepared through the process 失效
标题翻译：使用酶催化剂和通过该方法制备的可生物降解的聚合物制备可生物降解的聚合物的方法
公开(公告)号：US20060039980A1
公开(公告)日：2006-02-23
申请号：US10974118
申请日：2004-10-27
申请人： Insung Choi , Kuk Yoon
发明人： Insung Choi , Kuk Yoon
IPC分类号： A61K9/14 , C12P7/62
CPC分类号： C12P7/625 , A61K47/34
摘要： Disclosed is a process of preparing a biodegradable polymer using an enzyme catalyst and a biodegradable polymer prepared through the process. The process includes polycondensing a polyhydric alcohol monomer having a secondary hydroxyl functional group and an acid monomer having a dicarboxylic group in the presence of the enzyme catalyst. Since the biodegradable polymer according to the present invention is polymerized using an enzyme in the course of the polycondensation, it is easily prepared and friendly to nature, and it is possible to control the molecular weight by varying the reaction time in the course of the polymerization. Thus, the biodegradable polymer is usefully applied to control the dose of a drug in a drug release system and is useful as a supporter for regenerating a desired biological tissue of a patient in tissue engineering.
摘要翻译：公开了使用酶催化剂和通过该方法制备的可生物降解的聚合物来制备可生物降解的聚合物的方法。该方法包括在酶催化剂存在下使具有仲羟基官能团的多元醇单体和具有二羧基的酸单体缩聚。由于本发明的生物降解性聚合物在缩聚过程中使用酶进行聚合，所以易于制备和对自然的友好，并且可以通过改变聚合过程中的反应时间来控制分子量。因此，可生物降解的聚合物有效地用于控制药物释放系统中的药物的剂量，并且可用作在组织工程中再生患者的期望的生物组织的支持物。

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