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1. 发明申请

WO2020206032A1 DEVICE AND METHOD FOR WIRELESS MICROSTIMULATION 审中-公开
公开(公告)号：WO2020206032A1
公开(公告)日：2020-10-08
申请号：PCT/US2020/026260
申请日：2020-04-01
申请人： CAPARSO, Anthony V. , DAVIS, Richard J. , KAHOOK, Malik , MANDAVA, Naresh
发明人： CAPARSO, Anthony V. , DAVIS, Richard J. , KAHOOK, Malik , MANDAVA, Naresh
IPC分类号： A61N2/02 , A61N2/00 , A61N1/36 , A61N1/372 , A61N1/375 , A61N1/40
摘要： Systems and methods for wireless neural stimulation are presented. A microstimulator comprising a highly magnetic permeable material is implanted in the tissue of a living body. A wearable external controller creates a time-varying magnetic field that extends to the microstimulator in the tissue. The microstimulator re-shapes and boosts the time-varying magnetic field in the area surrounding the microstimulator, causing neural stimulation in the area around the microstimulator. A physician programmer device is also presented that allows a physician to program the wearable external controller.

2. 发明申请

WO2015038940A1 SHAPE MEMORY POLYMER INTRAOCULAR LENSES 审中-公开
标题翻译：形状记忆聚合物内窥镜
公开(公告)号：WO2015038940A1
公开(公告)日：2015-03-19
申请号：PCT/US2014/055459
申请日：2014-09-12
申请人： ABBOTT MEDICAL OPTICS INC. , KAHOOK, Malik, Y. , MANDAVA, Naresh , SHANDAS, Robin , RECH, Bryan , LOWERY, Michael, D. , URBANIAK, Daniel
发明人： KAHOOK, Malik, Y. , MANDAVA, Naresh , SHANDAS, Robin , RECH, Bryan , LOWERY, Michael, D. , URBANIAK, Daniel
IPC分类号： C08F220/18 , A61F2/16 , C08F2/48 , A61L27/16
CPC分类号： C08F220/18 , A61F2/14 , A61F2/16 , A61F2210/0014 , A61F2210/0019 , A61L27/16 , A61L2430/16 , C08F2/48 , C08K5/005 , C08F2220/1825 , C08F2222/108 , C08F226/02 , C08L33/14 , C08F2220/302
摘要： A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10°C and 60°C, inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45
摘要翻译：形状记忆聚合物（SMP）眼内透镜的折射率可以高于1.45，Tg在10℃至60℃之间，包括最小或不闪光，以及在可见光谱中的基本上100％的透射率。然后将眼内透镜在高于SMP材料的Tg的温度下滚动。将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。压缩的眼内透镜装置可以通过在角膜或巩膜或其他解剖结构中小于2mm宽的切口插入。透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值

3. 发明申请

WO2012122320A2 SHAPE MEMORY POLYMER INTRAOCULAR LENSES 审中-公开
标题翻译：形状记忆聚合物内窥镜
公开(公告)号：WO2012122320A2
公开(公告)日：2012-09-13
申请号：PCT/US2012/028150
申请日：2012-03-07
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , KAHOOK, Malik, Y. , MANDAVA, Naresh , SHANDAS, Robin , RECH, Bryan
发明人： KAHOOK, Malik, Y. , MANDAVA, Naresh , SHANDAS, Robin , RECH, Bryan
IPC分类号： C12N15/09
CPC分类号： B29D11/023 , A61F2/14 , A61F2/142 , A61F2/16 , A61F2002/16905 , A61F2210/0014 , A61F2210/0019 , A61F2210/0023 , A61L27/16 , A61L27/50 , A61L2400/16 , A61L2430/16 , B29C61/003 , B29C61/06 , B29C69/025 , B29L2011/0016 , C08L33/08 , C08L33/10 , C08F2220/1825 , C08F2222/108 , C08F226/02 , C08F2220/302
摘要： A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10 C and 60 C, inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.
摘要翻译：形状记忆聚合物（SMP）眼内透镜的折射率可以在1.45以上，Tg在10℃和60℃之间，包括最小或不闪光，以及在可见光谱中基本上100％的透光率。然后将眼内透镜在高于SMP材料的Tg的温度下滚动。将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。压缩的眼内透镜装置可以通过角膜或巩膜或其他解剖结构中的小于2mm宽的切口插入。透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。

4. 发明申请

WO2010107826A2 RELIABLY RETAINED SHAPE MEMORY OPHTHAL-MOLOGICAL IMPLANTS 审中-公开
标题翻译：可靠的保留形状记忆眼科植入物
公开(公告)号：WO2010107826A2
公开(公告)日：2010-09-23
申请号：PCT/US2010/027526
申请日：2010-03-16
申请人： ENDOSHAPE, INC. , LYONS, Michael, B. , TROMMETER, Julie, Marie , MANDAVA, Naresh , KAHOOK, Malik , SHANDAS, Robin , FOGELBERG, James , CASTLEBERRY, Jeffrey, Paul
发明人： LYONS, Michael, B. , TROMMETER, Julie, Marie , MANDAVA, Naresh , KAHOOK, Malik , SHANDAS, Robin , FOGELBERG, James , CASTLEBERRY, Jeffrey, Paul
IPC分类号： A61F9/00 , A61L27/14 , A61L27/04 , A61M31/00
CPC分类号： A61F9/00772 , A61F9/0017 , A61F2210/0014 , A61L27/04 , A61L27/14 , A61L27/50 , A61L2400/16 , A61L2430/16 , A61M25/00 , A61M25/01 , A61M25/04 , A61M31/002
摘要： An implantable ophthalmological device (10) in the form of a punctal plug or canalicular implant is configured for use at or near the nasolacrimal drainage system. In a deployed state, the device (10) may include an elongated body (25), an anchor (15) operably connected to the elongated body (25), a radially expanding occlusive feature disposed on an outer circumference of the elongated body (32), and a flange (30). The elongated body (25) may define a lumen (35) configured to receive a pharmacological treatment (55). The device (10) is made of a shape memory material such as a shape memory polymer.
摘要翻译：鼻泪管或小管植入物形式的可植入眼科装置（10）被配置用于在鼻泪管排出系统处或附近使用。在展开状态下，装置（10）可以包括细长主体（25），可操作地连接到细长主体（25）的锚固件（15），设置在细长主体（32）的外圆周上的径向扩张的闭塞特征）和凸缘（30）。细长主体（25）可以限定被配置为接受药物治疗（55）的管腔（35）。装置（10）由诸如形状记忆聚合物的形状记忆材料制成。

5. 发明申请

WO2012040380A1 AQUEOUS HUMOR MICRO BYPASS SHUNT 审中-公开
标题翻译： AQUEOUS HUMOR BYPASS SHUNT
公开(公告)号：WO2012040380A1
公开(公告)日：2012-03-29
申请号：PCT/US2011/052634
申请日：2011-09-21
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , KAHOOK, Malik , SHANDAS, Robin , MANDAVA, Naresh , RECH, Bryan Andrew
发明人： KAHOOK, Malik , SHANDAS, Robin , MANDAVA, Naresh , RECH, Bryan Andrew
IPC分类号： A61F2/02
CPC分类号： A61F9/00781 , B29C53/02
摘要： A small shunt can be placed within the eye to aid in drainage of aqueous humor from the anterior chamber of the eye to a pocket between the conjunctiva and the sclera to be absorbed, or to secrete through the cornea or the sclera external to the eye for glaucoma or ocular hypertension treatment. This drainage can decrease the pressure of the eye and potentially modify the course of advancing glaucomatous optic neuropathy as it relates to eye pressure. The shunt is formed of a shape memory polymer material and deformed into a smaller form factor to reduce trauma to the eye resulting from the insertion of the shunt through the sclera to the anterior chamber. Once in situ, the shunt deploys in response to body heat or other external stimulus and expands to its original, larger form factor to provide a secure friction fit of the shunt within the scleral tissue and to enlarge the lumen of the shunt to allow for aqueous flow.
摘要翻译：可以将小分流器放置在眼睛内，以帮助将房水从眼前房引流到结膜和巩膜之间的口袋中以被吸收，或者通过眼睛外部的角膜或巩膜分泌青光眼或高眼压症治疗。这种引流可以降低眼睛的压力，并可能改变与眼压有关的青光眼性视神经病变进展。分流器由形状记忆聚合物材料形成并变形成更小的形状因子，以减少由于将分流器穿过巩膜插入前房而引起的对眼睛的创伤。一旦就地，分流器响应于身体热量或其他外部刺激部署，并扩展到其原始的较大形状因子，以提供分流器在巩膜组织内的可靠的摩擦配合并且扩大分流器的内腔以允许水分流。

6. 发明申请

WO2012034126A1 MEDICAL FABRIC WITH INTEGRATED SHAPE MEMORY POLYMER 审中-公开
标题翻译：具有整体形状记忆聚合物的医用织物
公开(公告)号：WO2012034126A1
公开(公告)日：2012-03-15
申请号：PCT/US2011/051239
申请日：2011-09-12
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , SHANDAS, Robin , LANNING, Craig Joseph , GLANG, Robyn Grace Yeon , RECH, Bryan Andrew , MANDAVA, Nageswara Rao , MANDAVA, Naresh , KAHOOK, Malik
发明人： SHANDAS, Robin , LANNING, Craig Joseph , GLANG, Robyn Grace Yeon , RECH, Bryan Andrew , MANDAVA, Nageswara Rao , MANDAVA, Naresh , KAHOOK, Malik
IPC分类号： B32B27/00 , C08J5/04
CPC分类号： A61F2/0063 , C08J5/24 , C08J2300/12 , C08J2300/24
摘要： Formulations of shape memory polymer (SMP) are integrated with several existing clinically available medical fabrics. The SMP portion of a SMP integrated fabric can be fabricated in varying thicknesses with the minimum thickness determined by the thickness of the underlying fabric and up to almost any thickness. A large variety of patterns may be formed in SMP integrated fabrics based upon how the shape memory polymer is integrated into the base fabric. Integration of the SMP with the base fabrics does not alter the shape memory functionality of the SMP. The design tools for controlling activation rate for traditional SMP materials thus apply to SMP integrated fabrics. SMP integrated fabrics may also be steam sterilized without loss of shape memory functionality. By using multiple formulations of SMP on a single piece of fabric, a large combination of material properties may be provided within a single SMP integrated fabric device.
摘要翻译：形状记忆聚合物（SMP）的制剂与几种现有的临床医用织物相结合。 SMP集成织物的SMP部分可以以不同的厚度制造，最小厚度由下层织物的厚度确定并且几乎达到任何厚度。基于形状记忆聚合物如何整合到基底织物中，可以在SMP集成织物中形成各种图案。 SMP与基础结构的集成不会改变SMP的形状记忆功能。用于控制传统SMP材料激活速率的设计工具因此适用于SMP集成面料。 SMP集成织物也可以进行蒸汽灭菌，而不会损失形状记忆功能。通过在单个织物上使用多种配方的SMP，可以在单个SMP集成织物装置内提供大量材料性质的组合。

7. 发明申请

WO2011150431A1 MULTI-PHOTON TISSUE IMAGING 审中-公开
标题翻译：多光子组织成像
公开(公告)号：WO2011150431A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/038655
申请日：2011-05-31
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , AMMAR, David , KAHOOK, Malik , LEI, Tim , GIBSON, Emily , MASIHZADEH, Omid , MANDAVA, Naresh
发明人： AMMAR, David , KAHOOK, Malik , LEI, Tim , GIBSON, Emily , MASIHZADEH, Omid , MANDAVA, Naresh
IPC分类号： A61B6/00
CPC分类号： A61B3/0008 , A61B3/18 , A61B5/0066 , A61B5/0068 , G01N21/64 , G01N21/6408 , G01N21/6486 , G01N21/65 , G01N2021/653 , G01N2021/655
摘要： A multimodal method for imaging tissue comprising: aligning an excitation light source with at least a portion of the tissue; selecting at least two modalities of image acquisition; imaging the tissue portion with each of the modalities of image acquisition; and constructing a dual mode image using images from each of the modalities of image acquisition. A multimodal system for imaging tissue comprising: an excitation light source or light sources; an optical and alignment system for directing the excitation beam or beams to a sample and receiving an emission beam from the sample; at least one detector for receiving the emission beam from the sample; and a spectral filtering or dispersing device for providing at least two imaging modalities at the at least one detector; and a processor for analyzing the detected emission beam and constructing a dual mode image using images from each of the modalities of image acquisition.
摘要翻译：一种用于成像组织的多模式方法，包括：使激发光源与所述组织的至少一部分对准; 选择至少两种图像采集模式; 用图像采集的每种方式对组织部分进行成像; 以及使用来自每个图像采集模式的图像来构建双模式图像。一种用于成像组织的多模式系统，包括：激发光源或光源; 光学和对准系统，用于将激发光束或光束引导到样品并接收来自样品的发射光束; 用于从样品接收发射光束的至少一个检测器; 以及用于在所述至少一个检测器处提供至少两个成像模态的光谱滤波或分散装置; 以及处理器，用于分析检测到的发射光束并使用来自图像采集的每种方式的图像构建双模式图像。

8. 发明申请

WO2011046949A2 IMPLANTS FOR REDUCING INTRAOCULAR PRESSURE 审中-公开
标题翻译：减少眼内压的植入物
公开(公告)号：WO2011046949A2
公开(公告)日：2011-04-21
申请号：PCT/US2010/052350
申请日：2010-10-12
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , KAHOOK, Malik, Y. , MANDAVA, Naresh , SHANDAS, Robin , RECH, Bryan, Andrew
发明人： KAHOOK, Malik, Y. , MANDAVA, Naresh , SHANDAS, Robin , RECH, Bryan, Andrew
IPC分类号： A61F2/16 , A61L27/14 , A61L27/04 , A61F9/007
CPC分类号： A61F9/00781 , A61K9/0051 , A61L2400/16 , A61L2430/16 , C08L2201/12
摘要： The present invention provides ocular implants adapted to reside in Schlemm's canal for reducing intraocular pressure of an eye and methods for using the same. In some embodiments the ocular implants comprise a thin rod adapted and configured to extend in a curved volume in Schlemm's canal. The thin rod comprises a plurality of wave-shaped segments such that a sufficient number and amount of wave-shaped segments extend to the inner wall of the trabecular meshwork and to the outer wall of Schlemm's canal thereby keeping Schlemm's canal open.
摘要翻译：本发明提供了适合驻留在施累姆氏管中以降低眼睛眼内压的眼植入物及其使用方法。在一些实施例中，眼部植入物包括适于并构造成在施累姆氏管中以弯曲体积延伸的细杆。细杆包括多个波形段，使得足够数量和数量的波形段延伸至小梁网的内壁和施累姆氏管的外壁，从而保持施莱姆氏管开放。

9. 发明公开

EP2618777A1 AQUEOUS HUMOR MICRO BYPASS SHUNT 审中-公开
标题翻译：室内的水MICRO旁路分流
公开(公告)号：EP2618777A1
公开(公告)日：2013-07-31
申请号：EP11827479.4
申请日：2011-09-21
申请人： The Regents of the University of Colorado, a body corporate , Kahook, Malik , Shandas, Robin , Rech, Bryan Andrew
发明人： KAHOOK, Malik , SHANDAS, Robin , RECH, Bryan Andrew , MANDAVA, Naresh
IPC分类号： A61F2/02
CPC分类号： A61F9/00781 , B29C53/02
摘要： A small shunt can be placed within the eye to aid in drainage of aqueous humor from the anterior chamber of the eye to a pocket between the conjunctiva and the sclera to be absorbed, or to secrete through the cornea or the sclera external to the eye for glaucoma or ocular hypertension treatment. This drainage can decrease the pressure of the eye and potentially modify the course of advancing glaucomatous optic neuropathy as it relates to eye pressure. The shunt is formed of a shape memory polymer material and deformed into a smaller form factor to reduce trauma to the eye resulting from the insertion of the shunt through the sclera to the anterior chamber. Once in situ, the shunt deploys in response to body heat or other external stimulus and expands to its original, larger form factor to provide a secure friction fit of the shunt within the scleral tissue and to enlarge the lumen of the shunt to allow for aqueous flow.

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