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1. 发明公开

EP2618777A1 AQUEOUS HUMOR MICRO BYPASS SHUNT 审中-公开
标题翻译：室内的水MICRO旁路分流
公开(公告)号：EP2618777A1
公开(公告)日：2013-07-31
申请号：EP11827479.4
申请日：2011-09-21
申请人： The Regents of the University of Colorado, a body corporate , Kahook, Malik , Shandas, Robin , Rech, Bryan Andrew
发明人： KAHOOK, Malik , SHANDAS, Robin , RECH, Bryan Andrew , MANDAVA, Naresh
IPC分类号： A61F2/02
CPC分类号： A61F9/00781 , B29C53/02
摘要： A small shunt can be placed within the eye to aid in drainage of aqueous humor from the anterior chamber of the eye to a pocket between the conjunctiva and the sclera to be absorbed, or to secrete through the cornea or the sclera external to the eye for glaucoma or ocular hypertension treatment. This drainage can decrease the pressure of the eye and potentially modify the course of advancing glaucomatous optic neuropathy as it relates to eye pressure. The shunt is formed of a shape memory polymer material and deformed into a smaller form factor to reduce trauma to the eye resulting from the insertion of the shunt through the sclera to the anterior chamber. Once in situ, the shunt deploys in response to body heat or other external stimulus and expands to its original, larger form factor to provide a secure friction fit of the shunt within the scleral tissue and to enlarge the lumen of the shunt to allow for aqueous flow.

2. 发明申请

WO2012040380A1 AQUEOUS HUMOR MICRO BYPASS SHUNT 审中-公开
标题翻译： AQUEOUS HUMOR BYPASS SHUNT
公开(公告)号：WO2012040380A1
公开(公告)日：2012-03-29
申请号：PCT/US2011/052634
申请日：2011-09-21
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , KAHOOK, Malik , SHANDAS, Robin , MANDAVA, Naresh , RECH, Bryan Andrew
发明人： KAHOOK, Malik , SHANDAS, Robin , MANDAVA, Naresh , RECH, Bryan Andrew
IPC分类号： A61F2/02
CPC分类号： A61F9/00781 , B29C53/02
摘要： A small shunt can be placed within the eye to aid in drainage of aqueous humor from the anterior chamber of the eye to a pocket between the conjunctiva and the sclera to be absorbed, or to secrete through the cornea or the sclera external to the eye for glaucoma or ocular hypertension treatment. This drainage can decrease the pressure of the eye and potentially modify the course of advancing glaucomatous optic neuropathy as it relates to eye pressure. The shunt is formed of a shape memory polymer material and deformed into a smaller form factor to reduce trauma to the eye resulting from the insertion of the shunt through the sclera to the anterior chamber. Once in situ, the shunt deploys in response to body heat or other external stimulus and expands to its original, larger form factor to provide a secure friction fit of the shunt within the scleral tissue and to enlarge the lumen of the shunt to allow for aqueous flow.
摘要翻译：可以将小分流器放置在眼睛内，以帮助将房水从眼前房引流到结膜和巩膜之间的口袋中以被吸收，或者通过眼睛外部的角膜或巩膜分泌青光眼或高眼压症治疗。这种引流可以降低眼睛的压力，并可能改变与眼压有关的青光眼性视神经病变进展。分流器由形状记忆聚合物材料形成并变形成更小的形状因子，以减少由于将分流器穿过巩膜插入前房而引起的对眼睛的创伤。一旦就地，分流器响应于身体热量或其他外部刺激部署，并扩展到其原始的较大形状因子，以提供分流器在巩膜组织内的可靠的摩擦配合并且扩大分流器的内腔以允许水分流。

3. 发明申请

WO2012034126A1 MEDICAL FABRIC WITH INTEGRATED SHAPE MEMORY POLYMER 审中-公开
标题翻译：具有整体形状记忆聚合物的医用织物
公开(公告)号：WO2012034126A1
公开(公告)日：2012-03-15
申请号：PCT/US2011/051239
申请日：2011-09-12
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , SHANDAS, Robin , LANNING, Craig Joseph , GLANG, Robyn Grace Yeon , RECH, Bryan Andrew , MANDAVA, Nageswara Rao , MANDAVA, Naresh , KAHOOK, Malik
发明人： SHANDAS, Robin , LANNING, Craig Joseph , GLANG, Robyn Grace Yeon , RECH, Bryan Andrew , MANDAVA, Nageswara Rao , MANDAVA, Naresh , KAHOOK, Malik
IPC分类号： B32B27/00 , C08J5/04
CPC分类号： A61F2/0063 , C08J5/24 , C08J2300/12 , C08J2300/24
摘要： Formulations of shape memory polymer (SMP) are integrated with several existing clinically available medical fabrics. The SMP portion of a SMP integrated fabric can be fabricated in varying thicknesses with the minimum thickness determined by the thickness of the underlying fabric and up to almost any thickness. A large variety of patterns may be formed in SMP integrated fabrics based upon how the shape memory polymer is integrated into the base fabric. Integration of the SMP with the base fabrics does not alter the shape memory functionality of the SMP. The design tools for controlling activation rate for traditional SMP materials thus apply to SMP integrated fabrics. SMP integrated fabrics may also be steam sterilized without loss of shape memory functionality. By using multiple formulations of SMP on a single piece of fabric, a large combination of material properties may be provided within a single SMP integrated fabric device.
摘要翻译：形状记忆聚合物（SMP）的制剂与几种现有的临床医用织物相结合。 SMP集成织物的SMP部分可以以不同的厚度制造，最小厚度由下层织物的厚度确定并且几乎达到任何厚度。基于形状记忆聚合物如何整合到基底织物中，可以在SMP集成织物中形成各种图案。 SMP与基础结构的集成不会改变SMP的形状记忆功能。用于控制传统SMP材料激活速率的设计工具因此适用于SMP集成面料。 SMP集成织物也可以进行蒸汽灭菌，而不会损失形状记忆功能。通过在单个织物上使用多种配方的SMP，可以在单个SMP集成织物装置内提供大量材料性质的组合。

4. 发明申请

WO2011046949A3 IMPLANTS FOR REDUCING INTRAOCULAR PRESSURE 审中-公开
标题翻译：用于减少内压的植入物
公开(公告)号：WO2011046949A3
公开(公告)日：2011-08-18
申请号：PCT/US2010052350
申请日：2010-10-12
申请人： UNIV COLORADO REGENTS , KAHOOK MALIK Y , MANDAVA NARESH , SHANDAS ROBIN , RECH BRYAN ANDREW
发明人： KAHOOK MALIK Y , MANDAVA NARESH , SHANDAS ROBIN , RECH BRYAN ANDREW
IPC分类号： A61F2/16 , A61F9/007 , A61L27/04 , A61L27/14
CPC分类号： A61F9/00781 , A61K9/0051 , A61L2400/16 , A61L2430/16 , C08L2201/12
摘要： The present invention provides ocular implants adapted to reside in Schlemm's canal for reducing intraocular pressure of an eye and methods for using the same. In some embodiments the ocular implants comprise a thin rod adapted and configured to extend in a curved volume in Schlemm's canal. The thin rod comprises a plurality of wave-shaped segments such that a sufficient number and amount of wave-shaped segments extend to the inner wall of the trabecular meshwork and to the outer wall of Schlemm's canal thereby keeping Schlemm's canal open.
摘要翻译：本发明提供适于驻留在施莱姆氏管中以减少眼睛眼内压的眼部植入物及其使用方法。在一些实施例中，眼部植入物包括适于和构造成在Schlemm管中以弯曲体积延伸的细杆。细杆包括多个波形段，使得足够数量的波形段延伸到小梁网的内壁和Schlemm管的外壁，从而保持施莱姆管的开放。

5. 发明申请

WO2011046949A2 IMPLANTS FOR REDUCING INTRAOCULAR PRESSURE 审中-公开
标题翻译：减少眼内压的植入物
公开(公告)号：WO2011046949A2
公开(公告)日：2011-04-21
申请号：PCT/US2010/052350
申请日：2010-10-12
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , KAHOOK, Malik, Y. , MANDAVA, Naresh , SHANDAS, Robin , RECH, Bryan, Andrew
发明人： KAHOOK, Malik, Y. , MANDAVA, Naresh , SHANDAS, Robin , RECH, Bryan, Andrew
IPC分类号： A61F2/16 , A61L27/14 , A61L27/04 , A61F9/007
CPC分类号： A61F9/00781 , A61K9/0051 , A61L2400/16 , A61L2430/16 , C08L2201/12
摘要： The present invention provides ocular implants adapted to reside in Schlemm's canal for reducing intraocular pressure of an eye and methods for using the same. In some embodiments the ocular implants comprise a thin rod adapted and configured to extend in a curved volume in Schlemm's canal. The thin rod comprises a plurality of wave-shaped segments such that a sufficient number and amount of wave-shaped segments extend to the inner wall of the trabecular meshwork and to the outer wall of Schlemm's canal thereby keeping Schlemm's canal open.
摘要翻译：本发明提供了适合驻留在施累姆氏管中以降低眼睛眼内压的眼植入物及其使用方法。在一些实施例中，眼部植入物包括适于并构造成在施累姆氏管中以弯曲体积延伸的细杆。细杆包括多个波形段，使得足够数量和数量的波形段延伸至小梁网的内壁和施累姆氏管的外壁，从而保持施莱姆氏管开放。

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