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1. 发明授权

US06251944B1 Para-substituted phenylene derivatives 失效
标题翻译：对位取代亚苯衍生物
公开(公告)号：US06251944B1
公开(公告)日：2001-06-26
申请号：US09288742
申请日：1999-04-08
申请人： Barbara B. Chen , Helen Y. Chen , Glen J. Gesicki , Richard A. Haack , James W. Malecha , Thomas D. Penning , Joseph G. Rico , Thomas E. Rogers , Peter G. Ruminski , Mark A. Russell , Stella S. Yu
发明人： Barbara B. Chen , Helen Y. Chen , Glen J. Gesicki , Richard A. Haack , James W. Malecha , Thomas D. Penning , Joseph G. Rico , Thomas E. Rogers , Peter G. Ruminski , Mark A. Russell , Stella S. Yu
IPC分类号： A61K3119
CPC分类号： C07D271/07 , A61K31/155 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07C279/28 , C07C311/06 , C07C311/13 , C07C311/19 , C07C311/64 , C07C317/44 , C07C323/52 , C07D223/12 , C07D231/12 , C07D233/50 , C07D233/56 , C07D233/88 , C07D239/14 , C07D249/08 , C07D249/14 , C07D295/215
摘要： The present invention relates to a class of compounds represented by Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗α-角蛋白3整联蛋白的方法。

2. 发明授权

US5952381A Para-substituted phenylene derivatives 失效
标题翻译：对位取代亚苯衍生物
公开(公告)号：US5952381A
公开(公告)日：1999-09-14
申请号：US826244
申请日：1997-03-27
申请人： Barbara B. Chen , Helen Y. Chen , Glen J. Gesicki , Richard A. Haack , James W. Malecha , Thomas D. Penning , Joseph G. Rico , Thomas E. Rogers , Peter G. Ruminski , Mark A. Russell , Stella S. Yu
发明人： Barbara B. Chen , Helen Y. Chen , Glen J. Gesicki , Richard A. Haack , James W. Malecha , Thomas D. Penning , Joseph G. Rico , Thomas E. Rogers , Peter G. Ruminski , Mark A. Russell , Stella S. Yu
IPC分类号： A61K31/155 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/216 , A61K31/4168 , A61K31/4192 , A61K31/4453 , A61K31/505 , A61K31/5375 , A61P9/14 , A61P19/08 , A61P19/10 , A61P27/02 , A61P35/00 , C07C257/18 , C07C259/18 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07C279/28 , C07C311/06 , C07C311/13 , C07C311/19 , C07C311/47 , C07C311/64 , C07C317/44 , C07C323/52 , C07D223/12 , C07D233/50 , C07D233/88 , C07D239/14 , C07D249/14 , C07D271/06 , C07D271/07 , C07D295/20 , C07D295/215 , C07D521/00 , C07C229/00 , A61K31/19 , C07C205/00
CPC分类号： C07D271/07 , A61K31/155 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07C279/28 , C07C311/06 , C07C311/13 , C07C311/19 , C07C311/64 , C07C317/44 , C07C323/52 , C07D223/12 , C07D231/12 , C07D233/50 , C07D233/56 , C07D233/88 , C07D239/14 , C07D249/08 , C07D249/14 , C07D295/215
摘要： The present invention relates to a class of compounds represented by Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗αvβ3整联蛋白的方法。

3. 发明授权

US5852210A Cinnamic acid derivatives 失效
标题翻译：肉桂酸衍生物
公开(公告)号：US5852210A
公开(公告)日：1998-12-22
申请号：US825080
申请日：1997-03-27
申请人： Barbara B. Chen , Helen Y. Chen , Michael Clare , Stephen H. Docter , Ish Kumar Khanna , Francis Jan Koszyk , James W. Malecha , Julie Marion Miyashiro , Thomas D. Penning , Joseph G. Rico , Peter G. Ruminski , Mark A. Russell , Richard Mathias Weier , Xiangdong Xu , Stella S. Yu , Yi Yu
发明人： Barbara B. Chen , Helen Y. Chen , Michael Clare , Stephen H. Docter , Ish Kumar Khanna , Francis Jan Koszyk , James W. Malecha , Julie Marion Miyashiro , Thomas D. Penning , Joseph G. Rico , Peter G. Ruminski , Mark A. Russell , Richard Mathias Weier , Xiangdong Xu , Stella S. Yu , Yi Yu
IPC分类号： A61K31/00 , A61K31/195 , A61K31/215 , A61K31/216 , A61K31/275 , A61K31/277 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/505 , A61K31/506 , A61K31/54 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/14 , A61P19/00 , A61P19/10 , A61P35/00 , A61P35/04 , C07C205/34 , C07C205/35 , C07C205/37 , C07C205/44 , C07C205/45 , C07C205/56 , C07C205/57 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07D231/06 , C07D233/50 , C07D233/54 , C07D233/64 , C07D239/14 , C07D239/42 , C07D263/32 , C07D279/06 , C07D401/12 , C07D403/12 , C07C241/00 , C07C205/00 , C07D233/44 , C07D239/02
CPC分类号： C07D231/06 , C07C205/34 , C07C205/35 , C07C205/37 , C07C205/44 , C07C205/45 , C07C205/56 , C07C205/57 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07D233/50 , C07D233/64 , C07D239/14 , C07D239/42 , C07D263/32 , C07D279/06 , C07D401/12 , C07D403/12
摘要： The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗αvβ3整联蛋白的方法。

4. 发明授权

US5773646A Meta-substituted phenylene derivatives 失效
标题翻译：元取代亚苯衍生物
公开(公告)号：US5773646A
公开(公告)日：1998-06-30
申请号：US825086
申请日：1997-03-27
申请人： Nizal Chandrakumar , Barbara B. Chen , Helen Y. Chen , Michael Clare , Alan F. Gasiecki , Richard A. Haack , James W. Malecha , Peter G. Ruminski , Mark A. Russell
发明人： Nizal Chandrakumar , Barbara B. Chen , Helen Y. Chen , Michael Clare , Alan F. Gasiecki , Richard A. Haack , James W. Malecha , Peter G. Ruminski , Mark A. Russell
IPC分类号： A61K31/00 , A61K31/195 , A61K31/196 , A61K31/215 , A61K31/216 , A61K31/415 , A61K31/4164 , A61K31/4168 , A61K31/4184 , A61K31/496 , A61K31/505 , A61P1/00 , A61P1/02 , A61P19/00 , A61P19/08 , A61P19/10 , A61P27/00 , A61P27/02 , A61P35/00 , A61P43/00 , C07C45/67 , C07C49/796 , C07C205/35 , C07C205/45 , C07C205/56 , C07C205/57 , C07C257/16 , C07C257/18 , C07C259/18 , C07C275/42 , C07C279/18 , C07C279/24 , C07C279/28 , C07C311/46 , C07C311/47 , C07C317/42 , C07C317/44 , C07C323/44 , C07C323/56 , C07C335/16 , C07C335/22 , C07C335/32 , C07D223/06 , C07D233/50 , C07D233/88 , C07D235/30 , C07D239/14 , C07D311/18 , C07D311/20 , C07D405/12 , C07C241/00 , C07C205/00 , C07C229/00 , C07C321/00
CPC分类号： C07C45/673 , C07C205/35 , C07C205/45 , C07C205/56 , C07C205/57 , C07C257/16 , C07C259/18 , C07C275/42 , C07C279/18 , C07C279/24 , C07C279/28 , C07C311/46 , C07C311/47 , C07C317/42 , C07C323/44 , C07C335/16 , C07C335/22 , C07C335/32 , C07C49/796 , C07D223/06 , C07D233/50 , C07D233/88 , C07D235/30 , C07D239/14 , C07D311/18 , C07D311/20 , C07D405/12
摘要： The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗αvβ3整联蛋白的方法。

5. 发明授权

US06531494B1 Gem-substituted &agr;v&bgr;3 antagonists 失效
标题翻译：宝石取代的alphavbeta3拮抗剂
公开(公告)号：US06531494B1
公开(公告)日：2003-03-11
申请号：US09942214
申请日：2001-08-29
申请人： Ish Kumar Khanna , Yi Yu , Balekudru Devadas , Hwang-Fun Lu , Nizal S Chandrakumar , Renee M. Huff , Bipinchandra N. Desai , Srinivasan Raj Nagarajan , Alan F. Gasiecki , Thomas D. Penning , Mark A. Russell , Mark L. Boys , Lori A. Schretzman , Barbara B. Chen , Thomas Rogers , John Adam Wendt , Albert Khilevich , Yaping Wang
发明人： Ish Kumar Khanna , Yi Yu , Balekudru Devadas , Hwang-Fun Lu , Nizal S Chandrakumar , Renee M. Huff , Bipinchandra N. Desai , Srinivasan Raj Nagarajan , Alan F. Gasiecki , Thomas D. Penning , Mark A. Russell , Mark L. Boys , Lori A. Schretzman , Barbara B. Chen , Thomas Rogers , John Adam Wendt , Albert Khilevich , Yaping Wang
IPC分类号： A61K3144
CPC分类号： C07D213/74 , C07D213/73 , C07D401/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;V&bgr;3 and/or the &agr;V&bgr;5 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗αVβ3和/或αVβ5整联蛋白的方法。

6. 发明授权

US5773644A Cyclopropyl alkanoic acid derivatives 失效
标题翻译：环丙基链烷酸衍生物
公开(公告)号：US5773644A
公开(公告)日：1998-06-30
申请号：US825040
申请日：1997-03-27
申请人： Barbara B. Chen , Helen Y. Chen , Michael Clare , Shashidhar N. Rao , Mark A. Russell
发明人： Barbara B. Chen , Helen Y. Chen , Michael Clare , Shashidhar N. Rao , Mark A. Russell
IPC分类号： C07D239/14 , A61K31/00 , A61K31/195 , A61K31/196 , A61K31/215 , A61K31/216 , A61K31/505 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/10 , A61P35/00 , A61P35/04 , A61P43/00 , C07C279/18 , C07C279/24 , C07D239/42 , C07C241/00 , C07C229/00 , C07D239/00
CPC分类号： C07D239/42 , C07C279/18 , C07C279/24 , C07C2101/02
摘要： The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗αvβ3整联蛋白的方法。

7. 发明授权

US07352857B2 Method and apparatus for spectral containment over telephone service lines 失效
标题翻译：用于通过电话服务线路进行频谱抑制的方法和装置
公开(公告)号：US07352857B2
公开(公告)日：2008-04-01
申请号：US11262818
申请日：2005-11-01
申请人： Mark A. Russell , Stephen Weinert
发明人： Mark A. Russell , Stephen Weinert
IPC分类号： H04M1/00 , H04M9/00
CPC分类号： H04M11/062 , H04M3/007
摘要： A method for providing spectral containment over telecommunications service lines is provided. The method includes selecting a filter having spectral characteristics corresponding to a predetermined passband. The method also includes connecting the filter in series to at least one loop used to provide at least one telecommunications service to a customer. The method further includes activating service over the at least one loop. The filter attenuates signals transmitted on frequencies outside of the predetermined passband over the at least one loop.
摘要翻译：提供了一种通过电信业务线路提供频谱抑制的方法。该方法包括选择具有对应于预定通带的频谱特性的滤波器。该方法还包括将滤波器串联连接到用于向客户提供至少一个电信服务的至少一个回路。该方法还包括通过至少一个循环激活服务。滤波器衰减在至少一个环路上在预定通带以外的频率上传输的信号。

8. 发明授权

US5843906A Meta-substituted phenylene sulphonamide derivatives 失效
标题翻译：元取代亚苯基磺酰胺衍生物
公开(公告)号：US5843906A
公开(公告)日：1998-12-01
申请号：US824626
申请日：1997-03-27
申请人： Nizal Chandrakumar , Michael Clare , Wendell Doubleday , Alan F. Gasiecki , Mark A. Russell
发明人： Nizal Chandrakumar , Michael Clare , Wendell Doubleday , Alan F. Gasiecki , Mark A. Russell
IPC分类号： A61K31/00 , A61K31/195 , A61K31/415 , A61K31/4164 , A61K31/4168 , A61K31/44 , A61K31/445 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/10 , A61P35/00 , A61P35/04 , A61P43/00 , C07C311/42 , C07C311/46 , C07C311/47 , C07D211/96 , C07D213/55 , C07D233/50 , C07D295/26 , A61K38/00
CPC分类号： C07D295/26 , C07C311/42 , C07C311/46 , C07C311/47 , C07D211/96 , C07D213/55 , C07D233/50
摘要： The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗αvβ3整联蛋白的方法。

9. 发明授权

US5594792A Methods and apparatus for modeling and emulating devices in a network of telecommunication systems 失效
标题翻译：用于建模和仿真电信系统网络中的设备的方法和装置
公开(公告)号：US5594792A
公开(公告)日：1997-01-14
申请号：US188473
申请日：1994-01-28
申请人： Philippe J. Chouraki , Simon F. Moloney , Mark A. Russell , David R. Preston
发明人： Philippe J. Chouraki , Simon F. Moloney , Mark A. Russell , David R. Preston
IPC分类号： G06F13/10 , H04Q3/00 , H04M1/57 , H04M1/64
CPC分类号： G06F13/105 , H04Q3/0083 , H04Q2213/13504 , H04Q2213/13544 , H04Q2213/13547
摘要： A compiler is provided to a network element management subsystem for compiling rules and behaviors of device types into nested meta data structures of model databases. The rules and behaviors of the device types are specified via definitions describing controls of the device types, and features assignable to the device types. In one embodiment, the compiler is a two phase compiler comprising a parsing and list building phase and a database building phase. The device type model databases are loaded into memory to allow fast access and traversal. Each of the model databases comprises a plurality of nested meta data structures. Data are conditionally retrieved by selectively traversing the model databases using navigation sequences. An array of evaluation functions is further provided to evaluate predicates embedded in the nested meta data structures in view of operational data. During operation, user and system actions are interpreted through device emulation accessing the appropriate model databases.
摘要翻译：向网元管理子系统提供编译器，用于将设备类型的规则和行为编入模型数据库的嵌套元数据结构中。设备类型的规则和行为通过描述设备类型控制的定义和可指定到设备类型的功能来指定。在一个实施例中，编译器是包括分析和列表构建阶段和数据库构建阶段的两阶段编译器。设备类型模型数据库被加载到内存中以允许快速访问和遍历。每个模型数据库包括多个嵌套元数据结构。通过使用导航序列选择性地遍历模型数据库来有条件地检索数据。还提供了一系列评估函数，用于根据操作数据来评估嵌入在元数据结构中的谓词。在操作期间，通过访问相应模型数据库的设备仿真来解释用户和系统操作。

10. 发明授权

US06677308B1 Meta-substituted phenylene sulphonamide derivatives 失效
标题翻译：元取代亚苯基磺酰胺衍生物
公开(公告)号：US06677308B1
公开(公告)日：2004-01-13
申请号：US09141547
申请日：1998-08-28
申请人： Nizal Chandrakumar , Michael Clare , Wendell Doubleday , Alan F. Gasiecki , Mark A. Russell
发明人： Nizal Chandrakumar , Michael Clare , Wendell Doubleday , Alan F. Gasiecki , Mark A. Russell
IPC分类号： A61K3800
CPC分类号： C07D295/26 , C07C311/42 , C07C311/46 , C07C311/47 , C07D211/96 , C07D213/55 , C07D233/50
摘要： The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗阿尔茨海因3整联蛋白的方法。

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