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1. 发明授权

US06756048B1 Long time drug-sustained release preparation 有权
标题翻译：长时间药物缓释制剂
公开(公告)号：US06756048B1
公开(公告)日：2004-06-29
申请号：US09786746
申请日：2001-04-18
申请人： Akihiko Sano , Hiroo Maeda , Masako Kajihara , Shunsuke Tani , Toshihiko Sugie
发明人： Akihiko Sano , Hiroo Maeda , Masako Kajihara , Shunsuke Tani , Toshihiko Sugie
IPC分类号： A61F200
CPC分类号： A61K9/0087 , A61K31/00 , A61K47/30
摘要： The present invention relates to a sustained release preparation of a lipophilic drug, comprising a drug dispersion wherein the lipophilic drug and a water-soluble substance are dispersed, in a solid state at the body temperature of an animal or a human being to which the preparation is to be administered, in a water-impermeable and biocompatible material.
摘要翻译：本发明涉及亲脂性药物的持续释放制剂，其包含药物分散体，其中所述亲脂性药物和水溶性物质以固体状态分散在动物或人的体温，所述制剂将在不透水和生物相容的材料中施用。

2. 发明授权

US07101567B1 Controlled release preparations having multi-layer structure 有权
标题翻译：具有多层结构的控制释放制剂
公开(公告)号：US07101567B1
公开(公告)日：2006-09-05
申请号：US09701303
申请日：1999-05-19
申请人： Akihiko Sano , Masako Kajihara , Toshihiko Sugie
发明人： Akihiko Sano , Masako Kajihara , Toshihiko Sugie
IPC分类号： A61F2/00
CPC分类号： A61K9/209 , A61K9/0024
摘要： Preparations whereby two or more drugs can be released separately at appropriate speeds depending on the disease or the release behaviors of one or more drugs can be precisely controlled, which consist of an outer layer wherein a water-soluble drug is dispersed in a carrier made of a biologically non-degradable and hydrophobic polymer material, and one or more inner layers wherein a water-soluble drug, differing in kind or concentration from the one contained in the outer layer, is dispersed in a carrier made of a biologically non-degradable and hydrophobic polymer material, and in which the outer and inner layers are concentrically located in diametral direction of rod-like preparations and both or one of the ends in the axial direction are opened so as to directly come into contact with the environment.
摘要翻译：可以精确地控制两种或更多种药物以适当的速度单独释放的制剂，这取决于一种或多种药物的疾病或释放行为，其由外层组成，其中水溶性药物分散在由生物不可降解和疏水的聚合物材料，以及一种或多种内层，其中与外层中所含的不同种类或浓度的水溶性药物分散在由生物不可降解的载体制成的载体中，疏水性聚合物材料，并且其中外层和内层同心地位于棒状制剂的直径方向上，并且两个或一个端部沿轴向方向打开以直接与环境接触。

3. 发明授权

US07601363B2 Sustained-release drug formulations 失效
标题翻译：持续释放药物制剂
公开(公告)号：US07601363B2
公开(公告)日：2009-10-13
申请号：US11688082
申请日：2007-03-19
申请人： Akihiko Sano , Masako Kajihara , Hiroo Maeda
发明人： Akihiko Sano , Masako Kajihara , Hiroo Maeda
IPC分类号： A61K9/14 , A61F2/00 , A61F13/00
CPC分类号： A61K9/0024 , A61K47/02
摘要： The present invention relates to a formulation for implantation having a novel constitution, which accomplishes controlled releases of active ingredients. The formulation comprises one of combinations (a), (b) and (c), as well as a carrier comprising a hydrophobic polymer, wherein the particle combination is dispersed into the carrier: (a) particles comprising an active ingredient, particles comprising a carbonate, and particles comprising a substance which is reacted with the carbonate in an aqueous solution to generate carbon dioxide (substance such as an acid); (b) particles comprising an active ingredient and a carbonate, and particles comprising a substance such as an acid; and (c) particles comprising a carbonate, and particles comprising an active ingredient and a substance such as an acid.
摘要翻译：本发明涉及具有实现活性成分控制释放的新颖结构的植入制剂。制剂包含组合（a），（b）和（c）中的一种，以及包含疏水性聚合物的载体，其中所述颗粒组合分散在载体中：（a）包含活性成分的颗粒，碳酸盐和包含与碳酸盐在水溶液中反应产生二氧化碳（物质如酸）的物质的颗粒; （b）包含活性成分和碳酸酯的颗粒，以及包含物质如酸的颗粒; 和（c）包含碳酸盐的颗粒和包含活性成分和物质如酸的颗粒。

4. 发明授权

US07247312B1 Sustained-release drug formulations for implantation 失效
标题翻译：用于植入的持续释放药物制剂
公开(公告)号：US07247312B1
公开(公告)日：2007-07-24
申请号：US10089694
申请日：2000-10-31
申请人： Akihiko Sano , Masako Kajihara , Hiroo Maeda
发明人： Akihiko Sano , Masako Kajihara , Hiroo Maeda
IPC分类号： A61F13/00 , A61F2/00 , A61K9/14
CPC分类号： A61K9/0024 , A61K47/02
摘要： The present invention relates to a formulation for implantation having a novel constitution, which accomplishes controlled releases of active ingredients. The formulation comprises one of combinations (a), (b) and (c), as well as a carrier comprising a hydrophobic polymer, wherein the particle combination is dispersed into the carrier: (a) particles comprising an active ingredient, particles comprising a carbonate, and particles comprising a substance which is reacted with the carbonate in an aqueous solution to generate carbon dioxide (substance such as an acid); (b) particles comprising an active ingredient and a carbonate, and particles comprising a substance such as an acid; and (c) particles comprising a carbonate, and particles comprising an active ingredient and a substance such as an acid.
摘要翻译：本发明涉及具有实现活性成分控制释放的新颖结构的植入制剂。制剂包含组合（a），（b）和（c）中的一种，以及包含疏水性聚合物的载体，其中所述颗粒组合分散在载体中：（a）包含活性成分的颗粒，碳酸盐和包含与碳酸盐在水溶液中反应产生二氧化碳（物质如酸）的物质的颗粒; （b）包含活性成分和碳酸酯的颗粒，以及包含物质如酸的颗粒; 和（c）包含碳酸盐的颗粒和包含活性成分和物质如酸的颗粒。

5. 发明申请

US20070166377A1 SUSTAINED-RELEASE DRUG FORMULATIONS 失效
标题翻译：持续释放药物制剂
公开(公告)号：US20070166377A1
公开(公告)日：2007-07-19
申请号：US11688082
申请日：2007-03-19
申请人： Akihiko Sano , Masako Kajihara , Hiroo Maeda
发明人： Akihiko Sano , Masako Kajihara , Hiroo Maeda
IPC分类号： A61K39/00 , A61K9/46
CPC分类号： A61K9/0024 , A61K47/02
摘要： The present invention relates to a formulation for implantation having a novel constitution, which accomplishes controlled releases of active ingredients. The formulation comprises one of combinations (a), (b) and (c), as well as a carrier comprising a hydrophobic polymer, wherein the particle combination is dispersed into the carrier: (a) particles comprising an active ingredient, particles comprising a carbonate, and particles comprising a substance which is reacted with the carbonate in an aqueous solution to generate carbon dioxide (substance such as an acid); (b) particles comprising an active ingredient and a carbonate, and particles comprising a substance such as an acid; and (c) particles comprising a carbonate, and particles comprising an active ingredient and a substance such as an acid.
摘要翻译：本发明涉及具有实现活性成分控制释放的新颖结构的植入制剂。制剂包含组合（a），（b）和（c）中的一种，以及包含疏水性聚合物的载体，其中所述颗粒组合分散在载体中：（a）包含活性成分的颗粒，碳酸盐和包含与碳酸盐在水溶液中反应产生二氧化碳（物质如酸）的物质的颗粒; （b）包含活性成分和碳酸酯的颗粒，以及包含物质如酸的颗粒; 和（c）包含碳酸盐的颗粒和包含活性成分和物质如酸的颗粒。

6. 发明授权

US5851547A Controlled release drug formulation of open end cylindrical rod form 失效
标题翻译：开放式圆柱形杆形控释药物配方
公开(公告)号：US5851547A
公开(公告)日：1998-12-22
申请号：US762847
申请日：1996-12-10
申请人： Keiji Fujioka , Takeshi Hirasawa , Masako Kajihara , Akihiko Sano , Shuichi Sugawara , Yosuke Urabe
发明人： Keiji Fujioka , Takeshi Hirasawa , Masako Kajihara , Akihiko Sano , Shuichi Sugawara , Yosuke Urabe
IPC分类号： A61K9/00 , A61K9/22 , A61K9/24
CPC分类号： A61K9/0092
摘要： A drug formulation for producing sustained therapeutic efficacy, which releases at least one water-soluble drug over a prolonged period of time at a substantially constant rate wherein said drug formulation comprises (a) a nondisintegrating inner layer comprised of a biocompatible material that contains at least one uniformly dispersed water-soluble drug; and (b) an outer layer comprised of a biocompatible material that surrounds the circumference of the said inner layer, is impermeable to water, and is capable of controlling the swelling of the inner layer; wherein the ratio of the axial length of the drug formulation to the cross-sectional diameter of the inner layer is one or more and wherein one or both ends of the inner layer are open so as to come into direct contact with the external environment.
摘要翻译：一种用于产生持续治疗功效的药物制剂，其以基本恒定的速率在长时间内释放至少一种水溶性药物，其中所述药物制剂包含（a）由生物相容性材料组成的非整合内层，所述生物相容性材料至少包含一种均匀分散的水溶性药物; 和（b）由围绕所述内层的圆周的生物相容性材料构成的外层，不透水，并且能够控制内层的膨胀; 其中所述药物制剂的轴向长度与所述内层的横截面直径的比率是一个或多个，并且其中所述内层的一端或两端是敞开的，以便与外部环境直接接触。

7. 发明申请

US20140202838A1 ELECTRONIC COMPONENT 审中-公开
标题翻译：电子元件
公开(公告)号：US20140202838A1
公开(公告)日：2014-07-24
申请号：US14236639
申请日：2012-07-18
申请人： Akihiko Sano , Takeshi Fujiwara , Hidenori Maruyama , Tomonori Seki
发明人： Akihiko Sano , Takeshi Fujiwara , Hidenori Maruyama , Tomonori Seki
IPC分类号： H01H59/00
CPC分类号： H01H59/0009 , B81B2201/018 , B81B2207/012 , B81B2207/095 , B81C1/00238 , B81C2203/035 , H01H2001/0078
摘要： An electronic component has a first member in which an electrostatic actuator is provided, a second member in which a drive integrated circuit for driving the electrostatic actuator is provided, and join parts that joins the first member and the second member while a surface on which the electrostatic actuator is provided in the first member and a surface on which the drive integrated circuit is provided in the second member are opposed to each other. The electrostatic actuator and the drive integrated circuit are disposed in a space surrounded by the first member, the second member, and the join parts.
摘要翻译：电子部件具有设置有静电致动器的第一部件，设置有用于驱动静电致动器的驱动集成电路的第二部件和与第一部件和第二部件连接的接合部，静电致动器设置在第一构件中，并且在第二构件中设置有驱动集成电路的表面彼此相对。静电致动器和驱动集成电路设置在由第一构件，第二构件和接合部包围的空间中。

8. 发明授权

US08742091B2 Method of promoting nucleic acid transfer 有权
标题翻译：促进核酸转运的方法
公开(公告)号：US08742091B2
公开(公告)日：2014-06-03
申请号：US10481511
申请日：2002-06-20
申请人： Masaaki Terada , Takahiro Ochiya , Yu Aso , Kimi Honma , Akihiko Sano , Shunji Nagahara
发明人： Masaaki Terada , Takahiro Ochiya , Yu Aso , Kimi Honma , Akihiko Sano , Shunji Nagahara
IPC分类号： C07H21/02 , A61K38/17 , C12N15/11
CPC分类号： A61K48/0008 , A61K47/6435 , A61K48/00 , C12N15/87
摘要： Means for transferring efficiently a desired nucleic acid into a cell is provided.The present invention comprises using a complex comprising a collagen or a collagen derivative, and a desired nucleic acid.
摘要翻译：提供了将期望的核酸有效转移到细胞中的方法。本发明包括使用包含胶原蛋白或胶原衍生物和所需核酸的复合物。

9. 发明授权

US08696216B2 Optical module, method of producing optical module, optical transmission module, and electronic apparatus 失效
标题翻译：光模块，光模块生产方法，光传输模块和电子设备
公开(公告)号：US08696216B2
公开(公告)日：2014-04-15
申请号：US12296495
申请日：2007-04-12
申请人： Akihiko Sano , Hiroto Nozawa , Toshiaki Okuno , Junichi Tanaka , Naru Yasuda , Hayami Hosokawa
发明人： Akihiko Sano , Hiroto Nozawa , Toshiaki Okuno , Junichi Tanaka , Naru Yasuda , Hayami Hosokawa
IPC分类号： G02B6/36
CPC分类号： G02B6/4214 , G02B6/4253 , G02B6/4255
摘要： An optical module has a support board, an optical transmission path, and at least a single optical element having a light receiving function or a light emitting function provided on the support board. A light emission surface of the optical transmission path or a light incidence surface of the optical transmission path is arranged such that the optical element and the optical transmission path are optically coupled to each other, with respect to a light receiving surface or a light emitting surface of the optical element. The optical element is sealed by a sealing agent. A gap is provided between the optical transmission path and the surface of the sealing agent on the light receiving surface or the light emitting surface of the optical element.
摘要翻译：光学模块具有支撑板，光传输路径和至少一个光学元件，其具有设置在支撑板上的光接收功能或发光功能。光传输路径的光发射表面或光传输路径的光入射表面被布置成使得光学元件和光传输路径相对于光接收表面或发光表面彼此光学耦合的光学元件。光学元件由密封剂密封。在光传输路径和光学元件的光接收表面或发光表面上的密封剂的表面之间设置间隙。

10. 再颁专利

USRE43846E1 Bonding structures for containers and method of bonding same 有权
标题翻译：用于容器的粘合结构及其粘合方法
公开(公告)号：USRE43846E1
公开(公告)日：2012-12-11
申请号：US13506237
申请日：2012-04-05
申请人： Akihiko Sano , Yoshitaka Miura
发明人： Akihiko Sano , Yoshitaka Miura
IPC分类号： B23K20/12
CPC分类号： B23K20/126 , B23K20/1225 , B23K33/00 , F16H41/24 , F16H41/28 , F16H2041/243
摘要： A bonding structure for a container member is disclosed. The container member has an opening and a covering member for covering the opening. The container member and covering member are abutted with each other and bonded by a friction stir welding operation. The bonding structure for the container and covering members comprises a bonding portion and a backing member. The bonding portion of the container member and the covering member is formed by inserting a friction stir welding tool into an abutting portion of the container member and the covering member. The backing member is provided for obstructing a plastic flow of materials for the container member and the covering member when the friction stir welding operation is performed. The backing member is disposed adjacent to the bonding portion, at a side of the abutting portion that is opposite to an inserting side of the friction stir welding tool.
摘要翻译：公开了一种用于容器构件的接合结构。容器构件具有用于覆盖开口的开口和覆盖构件。容器构件和覆盖构件彼此抵接并通过摩擦搅拌焊接操作结合。用于容器和覆盖构件的接合结构包括接合部分和背衬构件。容器构件和覆盖构件的接合部分通过将摩擦搅拌焊接工具插入到容器构件和覆盖构件的邻接部分中而形成。背衬构件被设置用于当执行摩擦搅拌焊接操作时阻挡用于容器构件和覆盖构件的材料的塑性流动。背衬构件邻近结合部设置在与摩擦搅拌焊接工具的插入侧相对的抵接部的一侧。

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