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1. 发明申请

WO2002079853A1 ELECTROSTATICALLY ACTUATED MICRO-ELECTRO-MECHANICAL DEVICES AND METHOD OF MANUFACTURE 审中-公开
标题翻译：静电致动微电子机械装置及其制造方法
公开(公告)号：WO2002079853A1
公开(公告)日：2002-10-10
申请号：PCT/US2002/007670
申请日：2002-03-15
申请人： CORNING INTELLISENSE CORPORATION , KUDRLE, Thomas, David , MASTRANGELO, Carlos, Horacio , WAELTI, Marc , WANG, ChanChe , SHEDD, Gordon, M. , KIRKOS, Gregory, A. , BANCU, Mirela, Gabriela , HSIAO, James, Ching-Ming
发明人： KUDRLE, Thomas, David , MASTRANGELO, Carlos, Horacio , WAELTI, Marc , WANG, ChanChe , SHEDD, Gordon, M. , KIRKOS, Gregory, A. , BANCU, Mirela, Gabriela , HSIAO, James, Ching-Ming
IPC分类号： G02B26/08
CPC分类号： G02B6/357 , B81B3/0062 , G02B6/3518 , G02B6/3556 , G02B6/3584 , G02B26/0841 , H01L2924/19107 , Y10S359/904
摘要： One embodiment is directed to a gimbal mechanism for a MEMS mirror device having folded flexure hinges (40, 42). Another embodiment is directed to a gimbal mechanism having a frame with through-holes or recesses (72) distributed thereabout to reduce weight of said frame. Other embodiments are directed to improved electrode structues for electrostatically actuated MEMS devices. Other embodiments are directed to methods for fabricating electrodes electrostatically acutated MEMS devices. Other embodiments are directed to methods of fabricating through-wafer interconnect devices. Other embodiments are directed MEMS mirror array packaging. Other embodiments are directed to electrostatically acutated MEMS devices having driver circuits integrated therewith. Other embodiments are directed to methods of patterning wafers with a plurality of through-holes. Other embodiments are directed to methods of forming moveable structues in MEMS devices. Other embodiments are directed to methods of depositing a thin film an the back of MEMS device.
摘要翻译：一个实施例涉及一种具有折叠的弯曲铰链（40,42）的MEMS反射镜装置的万向架机构。另一个实施例涉及一种万向节机构，其具有框架，该框架具有分布在其周围的通孔或凹槽（72），以减轻所述框架的重量。其他实施例涉及用于静电致动MEMS器件的改进的电极结构。其他实施例涉及用于制造静电极性MEMS器件的电极的方法。其他实施例涉及制造跨晶片互连器件的方法。其他实施例是定向的MEMS镜阵列封装。其他实施例涉及具有与其集成的驱动电路的静电适应MEMS器件。其他实施例涉及用多个通孔图案化晶片的方法。其他实施例涉及在MEMS器件中形成可移动结构的方法。其他实施例涉及在MEMS器件背面沉积薄膜的方法。

2. 发明申请

WO2011066071A1 RESONANT-WAVELENGTH MEASUREMENT METHOD FOR LABEL-INDEPENDENT SCANNING OPTICAL READER 审中-公开
标题翻译：用于标签独立扫描光学读取器的共振波长测量方法
公开(公告)号：WO2011066071A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/055260
申请日：2010-11-03
申请人： CORNING INCORPORATED , GOLLIER, Jacques , SHEDD, Gordon M
发明人： GOLLIER, Jacques , SHEDD, Gordon M
IPC分类号： G01N21/77 , G01N21/25 , B01L99/00
CPC分类号： G01N21/774 , G01N21/253
摘要： A method of measuring a resonant wavelength of a resonant waveguide (RWG) biosensor in an array of RWG biosensors supported by a microplate in a label-independent optical reader is disclosed. An exemplary method includes scanning a light spot over the RWG biosensor to obtain a plurality of spectra from both a central portion and at least one edge portion of the RWG biosensor. The method includes calculating a weighted-average spectrum for the biosensor by averaging the plurality of spectra while applying greater weight to the central portion than to the at least one edge portion. The method includes determining the resonant wavelength from the weighted-average spectrum. The resulting resonant wavelength measurement has substantially reduced noise and provides improved performance for label-independent scanning optical reader systems that use scanned optical beams.
摘要翻译：公开了一种在标签无关的光学读取器中测量由微孔板支持的RWG生物传感器阵列中的谐振波导（RWG）生物传感器的谐振波长的方法。一种示例性方法包括在RWG生物传感器上扫描光点以从RWG生物传感器的中心部分和至少一个边缘部分获得多个光谱。该方法包括通过对多个光谱进行平均来计算生物传感器的加权平均光谱，同时对中心部分施加更大的权重而不是至少一个边缘部分。该方法包括从加权平均光谱确定谐振波长。所得到的谐振波长测量具有显着降低的噪声，并且为使用扫描光束的标签无关扫描光学读取器系统提供改进的性能。

3. 发明申请

WO2007106306A2 REFERENCE MICROPLATES AND METHODS FOR MAKING AND USING THE REFERENCE MICROPLATES 审中-公开
标题翻译：参考微量元素和制备和使用参考微量的方法
公开(公告)号：WO2007106306A2
公开(公告)日：2007-09-20
申请号：PCT/US2007004537
申请日：2007-02-20
申请人： CORNING INC , PASTEL DAVID A , PIECH GARRETT A , SHEDD GORDON M , SHELTON BRETT C , ZAINUL MOHAMED A
发明人： PASTEL DAVID A , PIECH GARRETT A , SHEDD GORDON M , SHELTON BRETT C , ZAINUL MOHAMED A
IPC分类号： G01N21/25 , B01L3/00 , G01N21/27
CPC分类号： G01N21/0332 , B01L3/5085 , B01L3/50851 , B01L2200/148 , B01L2300/0636 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/1827 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/31 , G01N35/00594 , G01N35/028 , G01N2001/2893 , G01N2021/0325
摘要： A reference microplate is described herein which can be used to help calibrate and troubleshoot an optical interrogation system. In one embodiment, the reference microplate has a frame with an array of wells each of which contains an optical biosensor and each optical biosensor is at least partially coated with a substance (e.g., elastomer, optical epoxy). In another embodiment, the reference microplate in addition to having its optical biosensors at least partially covered with a substance (e.g., elastomer, optical epoxy) also has a controllable heating device attached thereto which is used to heat the optical biosensors.
摘要翻译：本文描述了参考微孔板，其可用于帮助校准和诊断光学询问系统。在一个实施方案中，参考微量培养板具有一个具有孔阵列的框架，每个孔包含光学生物传感器，并且每个光学生物传感器至少部分涂覆有物质（例如弹性体，光学环氧树脂）。在另一个实施方案中，参考微板除了使其光学生物传感器至少部分被物质（例如弹性体，光学环氧树脂）覆盖之外，还具有连接到其上的可控加热装置，其用于加热光学生物传感器。

4. 发明申请

WO2008033311A1 OPTICAL INTERROGATION SYSTEM AND MICROPLATE POSITION CORRECTION METHOD 审中-公开
标题翻译：光学系统与微波位置校正方法
公开(公告)号：WO2008033311A1
公开(公告)日：2008-03-20
申请号：PCT/US2007/019680
申请日：2007-09-11
申请人： CORNING INCORPORATED , DAILEY, Michael, J, Jr. , PIECH, Garrett A , SHEDD, Gordon M , WEBB, Michael B , ZAMBRANO, Elvis A
发明人： DAILEY, Michael, J, Jr. , PIECH, Garrett A , SHEDD, Gordon M , WEBB, Michael B , ZAMBRANO, Elvis A
IPC分类号： G01N21/25 , G01N21/64
CPC分类号： G01N21/253 , B01L3/5085 , B01L9/50 , B01L2300/0636 , G01N35/028
摘要： An optical interrogation system and method are described herein that are capable of detecting and correcting a positional misalignment of a label independent detection (LID) microplate so that the LID microplate can be properly interrogated after being removed from and then re-inserted back into a microplate holder/XY translation stage.
摘要翻译：本文描述了能够检测和校正标签无关检测（LID）微孔板的位置不对准的光学询问系统和方法，使得LID微孔板在被移除之后被重新插入微孔板之后被适当询问持有人/ XY翻译阶段。

5. 发明申请

WO2007106306A3 REFERENCE MICROPLATES AND METHODS FOR MAKING AND USING THE REFERENCE MICROPLATES 审中-公开
公开(公告)号：WO2007106306A3
公开(公告)日：2007-09-20
申请号：PCT/US2007/004537
申请日：2007-02-20
申请人： CORNING INCORPORATED , PASTEL, David, A. , PIECH, Garrett, A. , SHEDD, Gordon, M. , SHELTON, Brett, C. , ZAINUL, Mohamed, A.
发明人： PASTEL, David, A. , PIECH, Garrett, A. , SHEDD, Gordon, M. , SHELTON, Brett, C. , ZAINUL, Mohamed, A.
IPC分类号： G01N21/25 , G01N21/27 , B01L3/00
摘要： A reference microplate is described herein which can be used to help calibrate and troubleshoot an optical interrogation system. In one embodiment, the reference microplate has a frame with an array of wells each of which contains an optical biosensor and each optical biosensor is at least partially coated with a substance (e.g., elastomer, optical epoxy). In another embodiment, the reference microplate in addition to having its optical biosensors at least partially covered with a substance (e.g., elastomer, optical epoxy) also has a controllable heating device attached thereto which is used to heat the optical biosensors.

6. 发明申请

WO1996032741A1 METHOD FOR WATER VAPOR ENHANCED CHARGED-PARTICLE-BEAM MACHINING 审中-公开
标题翻译：用于水蒸汽增强的粒子束加工方法
公开(公告)号：WO1996032741A1
公开(公告)日：1996-10-17
申请号：PCT/US1996004769
申请日：1996-04-08
申请人： NORTH CAROLINA STATE UNIVERSITY , RUSSELL, Phillip, E. , GRIFFIS, Dieter, P. , SHEDD, Gordon, M. , STARK, Terrence, J. , VITARELLI, James
发明人： NORTH CAROLINA STATE UNIVERSITY
IPC分类号： H01L21/306
CPC分类号： H01L21/31127 , H01J37/3056 , H01J2237/31744 , H01L21/3065 , H01L21/31138 , H01L21/32131
摘要： Water vapor enhanced focused particle-beam-machining speeds up the removal of polymer-based dielectric materials from areas surrounding metallic interconnects on integrated circuits while at the same time decreasing the rate of removal of aluminum. Selective material removal protects metal interconnects from machining damage and greatly reduces the time that protective material is exposed to the particle beam.
摘要翻译：水蒸气增强的聚焦粒子束加工加速了从集成电路上的金属互连周围的区域去除基于聚合物的电介质材料，同时降低了铝的去除速率。选择性材料去除保护金属互连免受加工损伤，并大大减少保护材料暴露于粒子束的时间。

7. 发明申请

WO2007018872A1 LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD 审中-公开
标题翻译：无标签的高通量生物分子筛选系统和方法
公开(公告)号：WO2007018872A1
公开(公告)日：2007-02-15
申请号：PCT/US2006/026504
申请日：2006-07-06
申请人： CORNING INCORPORATED , CARRACCI, Stephen, J. , ECKELT, Volker, H. , FRUTOS, Anthony, G. , KROL, Mark, F. , MOORE, Thomas, C. , PASTEL, David, A. , SHEDD, Gordon, M.
发明人： CARRACCI, Stephen, J. , ECKELT, Volker, H. , FRUTOS, Anthony, G. , KROL, Mark, F. , MOORE, Thomas, C. , PASTEL, David, A. , SHEDD, Gordon, M.
IPC分类号： G01N35/02 , G01N33/53
CPC分类号： G01N35/028 , G01N2035/00158 , G01N2035/00356 , G01N2035/0097
摘要： A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occurr in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate-handling devices to help perform automated HTS assays.
摘要翻译：本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。筛选系统还包括流体处理和板处理装置，以帮助执行自动化的HTS测定。

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