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1. 发明申请

US20050153360A1 Diagnostic method for stroke 审中-公开
标题翻译：中风诊断方法
公开(公告)号：US20050153360A1
公开(公告)日：2005-07-14
申请号：US10909761
申请日：2004-08-02
申请人： Denis Hochstrasser , Jean-Charles Sanchez , Elisabeth Guillaume , Laure Allard
发明人： Denis Hochstrasser , Jean-Charles Sanchez , Elisabeth Guillaume , Laure Allard
IPC分类号： G01N33/00 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6893 , G01N33/6848 , G01N2800/2871
摘要： The present invention provides a method of diagnosis of stroke or the possibility thereof in a subject suspected of suffering from stroke, comprising subjecting a sample of body fluid taken from the subject to mass spectrometry to determine a test amount of a polypeptide in the sample, wherein the polypeptide is differentially contained in the body fluid of stroke-affected subjects and non-stroke-affected subjects, and has a molecular weight in the range of from 3000 to 30000 Da; and determining whether the test amount is consistent with a diagnosis of stroke. The test amount can also be used to determine the type of stroke that is diagnosed, in particular whether it is of the ischemic or hemorrhagic type. The invention also provides use of the polypeptides for diagnostic, prognostic and therapeutic applications. The invention further provides a kit for use in diagnosis of stroke, comprising a probe for receiving a sample of body fluid, and for placement in a mass spectrometer, thereby to determine a test amount of a polypeptide in the sample, wherein the polypeptide is differentially contained in the body fluid of stroke-affected subjects and non-stroke-affected subjects, and has a molecular weight in the range of from 3000 to 30000 Da.
摘要翻译：本发明提供了一种诊断中风的方法或其在怀疑患有中风的受试者中的可能性，包括使得自受试者取得的体液样品进行质谱以确定样品中多肽的检测量，其中该多肽差异包含在中风受影响的受试者和非中风受试者的体液中，分子量在3000至30000Da的范围内; 并确定测试量是否与中风的诊断一致。测试量也可用于确定被诊断的中风的类型，特别是是否是缺血性或出血型。本发明还提供了多肽用于诊断，预后和治疗应用的用途。本发明还提供了一种用于卒中诊断的试剂盒，其包括用于接收体液样品的探针，并用于放置在质谱仪中，由此确定样品中多肽的检测量，其中多肽是差异的包含在中风影响的受试者和非中风受试者的体液中，分子量在3000至30000Da的范围内。

2. 发明申请

US20080220013A1 Diagnostic Method for Brain Damage-Related Disorders 有权
标题翻译：脑损伤相关疾病的诊断方法
公开(公告)号：US20080220013A1
公开(公告)日：2008-09-11
申请号：US11995501
申请日：2006-07-14
申请人： Denis Hochstrasser , Jean-Charles Sanchez
发明人： Denis Hochstrasser , Jean-Charles Sanchez
IPC分类号： G01N33/68 , C12Q1/26 , C12Q1/32 , C12Q1/48 , C12Q1/40 , C12Q1/00 , C12Q1/44 , G01N33/573 , A61K38/44 , A61K38/45 , A61K38/46 , A61K39/00 , A61K38/02 , A61K38/16 , A61K38/17 , C40B40/10 , A61P25/00
CPC分类号： G01N33/6896 , G01N33/6893 , G01N2800/28 , G01N2800/30
摘要： A brain damage-related disorder is diagnosed in a subject by detecting at least one polypeptide, or a variant or mutant thereof, in a sample of body fluid taken from the subject, wherein the polypeptide is one for which the level is either increased or decreased in cerebrospinal fluid from deceased patients compared to cerebrospinal fluid from healthy donors.
摘要翻译：通过检测取自受试者的体液样品中的至少一种多肽或其变体或突变体，在受试者中诊断脑损伤相关疾病，其中所述多肽是水平增加或减少的多肽来自死亡患者的脑脊液与来自健康供体的脑脊液相比。

3. 发明申请

US20070166758A1 Diagnostic method for stroke 有权
标题翻译：中风诊断方法
公开(公告)号：US20070166758A1
公开(公告)日：2007-07-19
申请号：US10568093
申请日：2004-08-16
申请人： Pierre Lescuyer , Denis Hochstrasser , Jean-Charles Sanchez , Laure Allard , Elisabeth Guillaume
发明人： Pierre Lescuyer , Denis Hochstrasser , Jean-Charles Sanchez , Laure Allard , Elisabeth Guillaume
IPC分类号： G01N33/53 , C12M3/00
CPC分类号： G01N33/6893 , G01N2333/4709 , G01N2333/775 , G01N2333/8128 , G01N2800/2871
摘要： Stroke is diagnosed in a subject by determining the concentration of at least one polypeptide selected from Apo C-III, Serum Amyloid A, Apo C-I, Antithrombin III fragment and Apo A-I in a sample of body fluid taken from the subject.
摘要翻译：通过从取自受试者的体液样品中测定至少一种选自Apo C-III，血清淀粉样蛋白A，Apo C-I，抗凝血酶III片段和Apo A-I的多肽的浓度，在受试者中诊断中风。

4. 发明申请

US20070042425A1 Diagnostic method for brain damage-related disorders 有权
标题翻译：脑损伤相关疾病的诊断方法
公开(公告)号：US20070042425A1
公开(公告)日：2007-02-22
申请号：US11154911
申请日：2005-06-16
申请人： Denis Hochstrasser , Jean-Charles Sanchez , Pierre Lescuyer , Laure Allard
发明人： Denis Hochstrasser , Jean-Charles Sanchez , Pierre Lescuyer , Laure Allard
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/6896 , C07K14/005 , C12N2730/10122 , C12N2740/16222 , G01N2333/705 , G01N2333/912 , G01N2333/948 , G01N2800/28
摘要： A brain damage-related disorder is diagnosed in a subject by detecting at least one polypeptide, or a variant or mutant thereof, selected from A-FABP, E-FABP, PGP 9.5, GFAP, Prostaglandin D synthase, Neuromodulin, Neurofilament L, Calcyphosine, RNA binding regulatory subunit, Ubiquitin fusion degradation protein 1 homolog, Nucleoside diphosphate kinase A, Glutathione S tranferase P, Cathepsin D, DJ-1 protein, Peroxiredoxin 5 and Peptidyl-prolyl cis-trans isomerase A (Cyclophilin A) in a sample of body fluid taken from the subject.
摘要翻译：通过检测至少一种选自A-FABP，E-FABP，PGP 9.5，GFAP，前列腺素D合成酶，神经调制蛋白，神经丝L，Calcyphosine的多肽或其变体或突变体，在受试者中诊断脑损伤相关疾病，RNA结合调控亚基，泛素融合降解蛋白1同系物，核苷二磷酸激酶A，谷胱甘肽S转移酶P，组织蛋白酶D，DJ-1蛋白，过氧化还原毒素5和肽基脯氨酰顺式反式异构酶A（Cyclophilin A）取自受试者的体液。

5. 发明申请

US20080008696A1 MARKERS FOR DIFFERENTIAL DIAGNOSIS AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于差异诊断的标记及其使用方法
公开(公告)号：US20080008696A1
公开(公告)日：2008-01-10
申请号：US11737621
申请日：2007-04-19
申请人： Denis Hochstrasser , Jean-Charles Sanchez , Pierre Lescuyer , Laure Allard , Kenneth Buechler
发明人： Denis Hochstrasser , Jean-Charles Sanchez , Pierre Lescuyer , Laure Allard , Kenneth Buechler
IPC分类号： A61K38/43
CPC分类号： A61B5/14546 , A61B5/4076 , A61B5/412 , G01N33/6896 , G01N2800/2871 , G01N2800/324 , G01N2800/60
摘要： The present invention provides methods for the identification and use of diagnostic markers for differential diagnosis of diseases. In various aspects, the invention relates to methods and compositions able to determine the presence or absence of one, and preferably a plurality, of diseases that exhibit one or more similar or identical symptoms. Such methods and compositions can be used to provide assays and assay devices for use in determining the disease underlying one or more non-specific symptoms exhibited in a clinical setting.
摘要翻译：本发明提供用于识别和使用用于疾病鉴别诊断的诊断标记物的方法。在各个方面，本发明涉及能够确定呈现一种或多种类似或相同症状的一种，优选多种疾病的存在或不存在的方法和组合物。这样的方法和组合物可用于提供用于确定临床环境中显示的一种或多种非特异性症状的疾病的测定和测定装置。

6. 发明申请

US20070134726A1 DIAGNOSTIC ASSAY FOR STROKE 有权
标题翻译：诊断诊断测试
公开(公告)号：US20070134726A1
公开(公告)日：2007-06-14
申请号：US11536283
申请日：2006-09-28
申请人： Denis Hochstrasser , Jean-Charles Sanchez , Catherine Zimmerman
发明人： Denis Hochstrasser , Jean-Charles Sanchez , Catherine Zimmerman
IPC分类号： G01N33/53 , G01N33/92
CPC分类号： G01N33/6893 , G01N2800/2871 , G01N2800/324 , Y10S435/97 , Y10S435/973 , Y10S436/811 , Y10T436/104165 , Y10T436/105831 , Y10T436/106664
摘要： Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for stroke. The invention provides a diagnostic assay for either of these markers, preferably by ELISA using a anti-H-FABP or B-FABP antibody. Since H-FABP is also a marker for acute myocardial infarction (AMI), to distinguish stroke from AMI requires an assay specific to AMI, e.g. using troponin-1 or CK-MB as a marker, also to be carried out.
摘要翻译：心脏和脑脂肪酸结合蛋白（H-FABP，B-FABP）是中风的标志物。本发明提供了用于这些标记之一的诊断测定法，优选通过使用抗H-FABP或B-FABP抗体的ELISA进行。由于H-FABP也是急性心肌梗塞（AMI）的标志物，因此要区分中风与AMI需要AMI特异性检测。使用肌钙蛋白-1或CK-MB作为标记，也要进行。

7. 发明申请

US20060240561A1 Biomarkers for diagnosing alzheimer's disease 审中-公开
标题翻译：用于诊断阿尔茨海默病的生物标志物
公开(公告)号：US20060240561A1
公开(公告)日：2006-10-26
申请号：US10525633
申请日：2003-08-11
申请人： Ozkan Yalkinoglu , Gerhard Konig , Denis Hochstrasser , Jean-Charles Sanchez , Odile Carrette
发明人： Ozkan Yalkinoglu , Gerhard Konig , Denis Hochstrasser , Jean-Charles Sanchez , Odile Carrette
IPC分类号： G01N33/50
CPC分类号： G01N33/6896 , C07K7/08 , C07K14/70539 , C07K14/805 , C07K14/8139 , G01N2800/2821
摘要： A method for assessing the state of Alzheimer's disease in patients is disclosed. A method for monitoring the progression of Alzheimer's disease in patients is also disclosed. The method applies detection of specific peptide markers, e.g., using mass spectrometric analysis.
摘要翻译：公开了一种评估患者阿尔茨海默病状态的方法。还公开了一种用于监测患者中阿尔茨海默病进展的方法。该方法应用特异性肽标志物的检测，例如使用质谱分析。

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