发明申请
WO2003074718A1 ENZYMATIC PROCESS FOR PREPARING ORGANOSILICON GROUP CONTAINING PHOTOINITIATORS
审中-公开
基本信息:
- 专利标题： ENZYMATIC PROCESS FOR PREPARING ORGANOSILICON GROUP CONTAINING PHOTOINITIATORS
- 专利标题（中）：用于制备含有光敏剂的有机硅基团的酶法
- 申请号：PCT/EP2003/001896 申请日：2003-02-25
- 公开(公告)号：WO2003074718A1 公开(公告)日：2003-09-12
- 发明人： ÖHRLEIN, Reinhold , SCHÖNING, Kai-Uwe , BAISCH, Gabriele , HARTWIG, Jemima , BAUDIN, Gisèle , JUNG, Tunja
- 申请人： CIBA SPECIALTY CHEMICALS HOLDING INC. , ÖHRLEIN, Reinhold , SCHÖNING, Kai-Uwe , BAISCH, Gabriele , HARTWIG, Jemima , BAUDIN, Gisèle , JUNG, Tunja
- 申请人地址： Klybeckstrasse 141, CH-4057 Basel CH
- 专利权人： CIBA SPECIALTY CHEMICALS HOLDING INC.,ÖHRLEIN, Reinhold,SCHÖNING, Kai-Uwe,BAISCH, Gabriele,HARTWIG, Jemima,BAUDIN, Gisèle,JUNG, Tunja
- 当前专利权人： CIBA SPECIALTY CHEMICALS HOLDING INC.,ÖHRLEIN, Reinhold,SCHÖNING, Kai-Uwe,BAISCH, Gabriele,HARTWIG, Jemima,BAUDIN, Gisèle,JUNG, Tunja
- 当前专利权人地址： Klybeckstrasse 141, CH-4057 Basel CH
- 代理机构： CIBA SPECIALTY CHEMICALS HOLDING INC.
- 优先权： EP02405171.6 20020306
- 主分类号： C12P9/00
- IPC分类号： C12P9/00
摘要：
The invention relates to a process for preparing organosilicon group containing photoinitiators of the formula (I), wherein m is a number from 1 to 200; q is 0 or 1; A is IN-C(O)-O-CHR 3 -Y- or IN-C(O)-NH-CHR 3 -Y-; A’ is A or R 1 ’; R 1 and R 1 ’, R 2 and R 2 ’ are C 1 -C 18 alkyl or phenyl, or -(O) q -SiR 1 R 1 ’R2; R 3 is hydrogen or C 1 -C 6 alkyl, Y is a divalent group selected from C 1 -C 10 alkeylene, C 2 -C 10 alkenylene or -(CH 2 ) b -O-(CH 2 ) a -; and b are each independently of the other a number of 1 to 6; IN is a photolabile functional moiety of the formula (II) or (III), wherein R 4 is hydrogen or -C(O)-C(O)-OH or -C(O)-C(O)-OC 1 -C 6 alkyl and n is 1-3; R 5 and R 6 are C 1 -C 12 alkyl or together are cycloC 5 -C 7 alkyl; R 7 is hydroxy, C 1 -C 6 alkoxy or morpholinyl; X is -(CH 2 ) a -, -(CH 2 ) b -O-(CH 2 ) a - or -(CH 2 ) b -O-CO-(CH 2 ) a -; a and b are each independently of the other a number of 1 to 6; whereby the process is characterized in that a photolabile functional moiety containing a carboxy group (IN-COOH) or an alkoxycarbonyl group (IN-CO-OC 1 -C 6 alkyl) is reacted with a carbinol- or amino terminated organosilicon compound of the formula (IV), wherein m, R 1 and R 1 ’, R 2 and R 2 ’ are as defined above and B is -Y-CHR 3 -OH or -Y-CHR 3 -NH 2 ; B’ is B or R 1 ’, in the presence of an enzyme which catalyzes the esterification, transesterification or amidation reaction.
摘要（中）：
本发明涉及一种制备含有式（I）的光引发剂的有机硅基团的方法，其中m为1至200的数; q为0或1; A是IN-C（O）-O-CHR 3 -Y-或IN-C（O）-NH-CHR 3 -Y-; A'是A或R1'; R1和R1'，R2和R2'是C1-C18烷基或苯基，或 - （O）q-SiR1R1'R2; R 3是氢或C 1 -C 6烷基，Y是选自C 1 -C 10亚乙烯基，C 2 -C 10亚烯基或 - （CH 2）b -O-（CH 2）a - 的二价基团。 和b各自独立地为1至6的数; IN是式（II）或（III）的光不稳定官能部分，其中R4是氢或-C（O）-C（O）-OH或-C（O）-C（O）-OC1-C6烷基， n为1-3; R5和R6是C1-C12烷基或一起是环C 5 -C 7烷基; R7是羟基，C1-C6烷氧基或吗啉基; X是 - （CH 2）a - ， - （CH 2）b -O-（CH 2）a-或 - （CH 2）b -O-CO-（CH 2）a-; a和b各自独立地为1至6的数; 其特征在于含有羧基（IN-COOH）或烷氧基羰基（IN-CO-OC1-C6烷基）的光不稳定官能部分与式（IV）的甲醇或氨基封端的有机硅化合物反应， 其中m，R1和R1'，R2和R2'如上所定义，B是-Y-CHR 3 -OH或-Y-CHR 3 -NH 2; 在催化酯化，酯交换反应或酰胺化反应的酶存在下，B'是B或R1'。