基本信息:
- 专利标题： CLONED NON-HUMAN MAMMALS FROM CONTACT INHIBITED DONOR CELLS
- 专利标题（中）：从接触抑制的细胞中克隆非人类哺乳动物
- 申请号：PCT/US0221680 申请日：2002-07-09
- 公开(公告)号：WO03005810A9 公开(公告)日：2004-02-26
- 发明人： FODOR WILLIAM , RAMPSOONDAR JAGDEECE , BONDIOLI KENNETH R
- 申请人： ALEXION PHARMA INC
- 专利权人： ALEXION PHARMA INC
- 当前专利权人： ALEXION PHARMA INC
- 优先权： US30443101 2001-07-09
- 主分类号： C12N15/873
- IPC分类号： C12N15/873 ; C12N15/877 ; G01N33/00 ; A01K67/00 ; C12N15/00
摘要：
Cloned non-human mammalian nuclear transfer units, embryos and animals are provided by introducing a contact-inhibited non-cycling mammalian donor cell in the G1 state or a nucleus thereof into an enucleated oocyte from a non-human mammal of the same species as the donor to form a nuclear transfer unit, implanting the nuclear transfer unit into the uterus of a surrogate mother, permitting the nuclear transfer unit to develop into the cloned non-human mammalian embryo and allowing the embryo to come to term.
摘要（中）：
克隆的非人哺乳动物核转移单位，胚胎和动物通过将G1状态或其核中的接触抑制非循环哺乳动物供体细胞引入与来自相同种类的非人哺乳动物的去核卵母细胞 供体形成核转移单元，将核转移单元植入代孕母亲的子宫，允许核转移单位发育成克隆的非人哺乳动物胚胎并允许胚胎进入期限。