基本信息:
- 专利标题: AROMATIC SULFONE HYDROXAMATES AND THEIR USE AS PROTEASE INHIBITORS
- 专利标题(中):芳香磺酸羟肟酸酯及其作为蛋白酶抑制剂的用途
- 申请号:PCT/US0215257 申请日:2002-05-10
- 公开(公告)号:WO02092588A3 公开(公告)日:2003-02-27
- 发明人: BARTA THOMAS E , BECKER DANIEL P , BEDELL LOUIS J , BOEHM TERRI L , FOBIAN YVETTE M , FRESKOS JOHN N , HOCKERMAN SUSAN L , KASSAB DARREN J , KOLODZIEJ STEVE A , MCDONALD JOSEPH J , NORTON MONICA B , RICO JOSEPH G , TALLEY JOHN J , VILLAMIL CLARA I , WANG TIJUAN JANE
- 申请人: PHARMACIA CORP , BARTA THOMAS E , BECKER DANIEL P , BEDELL LOUIS J , BOEHM TERRI L , FOBIAN YVETTE M , FRESKOS JOHN N , HOCKERMAN SUSAN L , KASSAB DARREN J , KOLODZIEJ STEVE A , MCDONALD JOSEPH J , NORTON MONICA B , RICO JOSEPH G , TALLEY JOHN J , VILLAMIL CLARA I , WANG TIJUAN JANE
- 专利权人: PHARMACIA CORP,BARTA THOMAS E,BECKER DANIEL P,BEDELL LOUIS J,BOEHM TERRI L,FOBIAN YVETTE M,FRESKOS JOHN N,HOCKERMAN SUSAN L,KASSAB DARREN J,KOLODZIEJ STEVE A,MCDONALD JOSEPH J,NORTON MONICA B,RICO JOSEPH G,TALLEY JOHN J,VILLAMIL CLARA I,WANG TIJUAN JANE
- 当前专利权人: PHARMACIA CORP,BARTA THOMAS E,BECKER DANIEL P,BEDELL LOUIS J,BOEHM TERRI L,FOBIAN YVETTE M,FRESKOS JOHN N,HOCKERMAN SUSAN L,KASSAB DARREN J,KOLODZIEJ STEVE A,MCDONALD JOSEPH J,NORTON MONICA B,RICO JOSEPH G,TALLEY JOHN J,VILLAMIL CLARA I,WANG TIJUAN JANE
- 优先权: US29037501 2001-05-11
- 主分类号: C07D491/048
- IPC分类号: C07D491/048 ; A61K31/35 ; A61K31/351 ; A61K31/357 ; A61K31/381 ; A61K31/397 ; A61K31/4025 ; A61K31/404 ; A61K31/41 ; A61K31/4178 ; A61K31/4184 ; A61K31/42 ; A61K31/423 ; A61K31/4245 ; A61K31/427 ; A61K31/428 ; A61K31/4355 ; A61K31/4433 ; A61K31/445 ; A61K31/453 ; A61K31/454 ; A61K31/4545 ; A61K31/455 ; A61K31/4709 ; A61K31/4725 ; A61K31/506 ; A61K31/53 ; A61K31/5377 ; A61P1/02 ; A61P1/04 ; A61P1/16 ; A61P7/00 ; A61P7/02 ; A61P7/04 ; A61P9/00 ; A61P9/04 ; A61P9/10 ; A61P11/00 ; A61P13/12 ; A61P17/02 ; A61P17/06 ; A61P19/00 ; A61P19/02 ; A61P25/00 ; A61P25/18 ; A61P25/28 ; A61P27/02 ; A61P27/16 ; A61P29/00 ; A61P31/04 ; A61P35/00 ; A61P35/04 ; A61P37/02 ; A61P37/06 ; A61P39/00 ; A61P43/00 ; C07D211/66 ; C07D309/08 ; C07D309/12 ; C07D401/12 ; C07D405/12 ; C07D405/14 ; C07D407/12 ; C07D409/12 ; C07D409/14 ; C07D413/12 ; C07D413/14 ; C07D417/12 ; C07D417/14 ; C07D491/04
摘要:
This invention is directed to aromatic sulfone hydroxamates (also known as "aromatic sulfone hydroxamic acids") and salts thereof that, inter alia , inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.
摘要(中):
本发明涉及芳族砜异羟肟酸盐(也称为“芳族砜异羟肟酸”)及其盐,其特别是抑制基质金属蛋白酶(也称为“基质金属蛋白酶”或“MMP”)活性和/ 或聚集蛋白聚糖酶活性。 本发明还涉及一种预防或治疗方法,其包括将有效量的MMP抑制和/或聚集蛋白聚糖蛋白酶抑制剂的这种化合物或盐施用于动物,特别是哺乳动物,所述动物特别是哺乳动物具有(或设置为)具有相关的病理状态 具有MMP和/或蛋白聚糖蛋白聚糖酶活性。
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D491/00 | 杂环化合物,在稠环系中含有1个或多个有氧原子作为仅有的杂环原子的环,且含有1个或多个有氮原子作为仅有的杂环原子的环,不包含在C07D451/00至C07D459/00、C07D463/00、C07D477/00或C07D489/00组中 |
--------C07D491/02 | .在稠环系中含有两个杂环 |
----------C07D491/04 | ..邻位稠合系 |
------------C07D491/044 | ...在含氧环上仅有1个氧原子作为杂环原子 |
--------------C07D491/048 | ....含氧环是五元环 |