基本信息:
- 专利标题： BCL6 저해제
- 申请号：KR20207032149 申请日：2019-04-12
- 公开(公告)号：KR20200144109A 公开(公告)日：2020-12-28
- 发明人： BELLENIE BENJAMIN RICHARD , CHEUNG KWAI MING JACK , DAVIS OWEN ALEXANDER , HOELDER SWEN , HUCKVALE ROSEMARY , COLLIE GAVIN , MENICONI MIRCO , BRENNAN ALFIE , LLOYD MATTHEW GARTH
- 申请人： CANCER RESEARCH TECH LTD , THE INSTITUTE OF CANCER RES ROYAL CANCER HOSPITAL
- 专利权人： CANCER RESEARCH TECH LTD,THE INSTITUTE OF CANCER RES ROYAL CANCER HOSPITAL
- 当前专利权人： CANCER RESEARCH TECH LTD,THE INSTITUTE OF CANCER RES ROYAL CANCER HOSPITAL
- 优先权： GB201806132 2018-04-13; GB201819136 2018-11-23
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; A61K31/5383 ; A61K31/542 ; A61K31/553 ; A61K31/554 ; A61P35/00 ; C07D471/04 ; C07D498/08 ; C07D498/14 ; C07D498/20 ; C07D513/04
摘要：
본발명은 BCL6(B-세포림프종 6) 활성의저해제로서기능하는하기화학식 I의화합물(식중 X1, X2, R1, R2, R30, R31 및고리 A는각각본 명세서에정의된바와같음)에관한것이다. 본발명은또한이러한화합물의제조방법, 이들을포함하는약제학적조성물, 및 BCL6 활성이연관된증식성장애, 예컨대, 암, 뿐만아니라다른질병또는질환의치료에서의이들의용도에관한것이다. [화학식 I] JPEGpct00220.jpg5555
摘要（英）：
The present invention relates to compounds of formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity:wherein X1, X2, R1, R2, R30, R31 and Ring A are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D498/00 | 杂环化合物，在稠环系中至少有1个杂环具有氮和氧原子作为仅有的杂环原子 |
| --------C07D498/02 | .在稠环系中含有两个杂环 |
| ----------C07D498/04 | ..邻位稠合系 |