基本信息:
- 专利标题: 인돌린-2-온 또는 피롤로-피리딘-2-온 유도체
- 专利标题(英):Indolin-2-one or pyrrolo-pyridin-2-one derivatives
- 专利标题(中):-2- - 2-吲哚-2-酮或吡咯并吡啶-2-酮衍生物
- 申请号:KR1020177002270 申请日:2015-06-23
- 公开(公告)号:KR1020170020522A 公开(公告)日:2017-02-22
- 发明人: 힐페르트한스 , 콜체브스키사비네 , 훔롤란드 , 스톨테오도르 , 뮤저토르스텐 , 플랑셰장-마르크 , 가우프레투델핀느
- 申请人: 에프. 호프만-라 로슈 아게
- 申请人地址: 스위스 체하-**** 바젤 그렌짜체스트라쎄 ***
- 专利权人: 에프. 호프만-라 로슈 아게
- 当前专利权人: 에프. 호프만-라 로슈 아게
- 当前专利权人地址: 스위스 체하-**** 바젤 그렌짜체스트라쎄 ***
- 代理人: 제일특허법인
- 优先权: EP141745596 2014-06-26
- 国际申请: PCT/EP2015/064016 2015-06-23
- 国际公布: WO2015197567 2015-12-30
- 主分类号: C07D401/14
- IPC分类号: C07D401/14 ; A61K31/404 ; A61K31/506 ; A61K31/437 ; C07D403/14 ; C07D471/04 ; C07D409/14 ; C07D413/14 ; C07D417/14
The present invention relates to 2-oxo-2,3 of formula I - indole, or a pharmaceutically acceptable salt, racemic mixture, or their corresponding enantiomers and / or optical isomers and / or stereoisomers that It relates:
[Formula I]
Wherein
In Ar
1 is phenyl, or N, being 5-or 6-membered heteroaryl odd containing one, two or three heteroatoms selected from S or O, N- heteroaryl group within a heteroatom is N
+
- - (O) It can be oxidized and;
R
1 is lower alkyl, halogen, cyano or cycloalkyl;
Ar
2 is oxidized to N, are 5-or 6-membered heteroaryl odd containing 1, 2, 3 or 4 heteroatoms selected from S or O, N- heteroaryl group within a heteroatom is N
+
- - (O) may be, Ar
2 is a benzo [b] thiophenyl and phenyl;
R
2 is hydrogen, lower alkyl, halogen, cyano, hydroxyl lower alkyl substituted by hydroxy, lower alkyl substituted by halogen, lower alkyl substituted by amino, lower alkyl substituted by alkoxycarbonyl, a lower alkyl substituted amide, or cycloalkyl;
X is CH or N;
n is 1 or 2;
m is 1 or 2.
The compound is the amount of schizophrenia sexual symptoms (psychosis) and negative symptoms, drug abuse, alcohol and drug addiction, obsessive-compulsive disorder, cognitive impairment, bipolar disorder, mood disorders, major depressive disorder, treatment resistant depression, anxiety disorders, Alzheimer's disease, autism, Parkinson's disease, chronic pain, borderline personality disorders, neurodegenerative diseases, sleep disorders, chronic fatigue syndrome, spasticity, inflammatory diseases, asthma, Huntington's disease, ADHD, amyotrophic lateral sclerosis, epilepsy, effect on arthritis, autoimmune diseases It can be used in the treatment of viral and fungal infections in the CNS related diseases, cardiovascular diseases, and inflammatory ophthalmic diseases of the retina or balance disorders.
公开/授权文献:
- KR101819433B1 인돌린-2-온 또는 피롤로-피리딘-2-온 유도체 公开/授权日:2018-01-16
信息查询:
EspacenetIPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D401/00 | 杂环化合物,含有两个或更多个杂环,以氮原子作为仅有的杂环原子,至少有1个环是仅含有1个氮原子的六元环 |
--------C07D401/14 | .含有3个或更多个杂环 |