基本信息:
- 专利标题: CNS 장애 치료용 2-이미다졸의 용도
- 专利标题(英):Use of 2-imidazoles for the treatment of cns disorders
- 专利标题(中):使用2-咪唑烷治疗CNS病症
- 申请号:KR1020087020948 申请日:2007-01-17
- 公开(公告)号:KR1020080090545A 公开(公告)日:2008-10-08
- 发明人: 갈레이귀도 , 그뢰브케즈빈덴카트린 , 노크로스로저 , 스탈더헨리
- 申请人: 에프. 호프만-라 로슈 아게
- 申请人地址: 스위스 체하-**** 바젤 그렌짜체스트라쎄 ***
- 专利权人: 에프. 호프만-라 로슈 아게
- 当前专利权人: 에프. 호프만-라 로슈 아게
- 当前专利权人地址: 스위스 체하-**** 바젤 그렌짜체스트라쎄 ***
- 代理人: 제일특허법인
- 优先权: EP061009510 2006-01-27
- 国际申请: PCT/EP2007/050444 2007-01-17
- 国际公布: WO2007085558 2007-08-02
- 主分类号: C07D233/54
- IPC分类号: C07D233/54 ; A61K31/4174 ; A61K31/4168 ; A61P25/00
摘要:
The present invention relates to the use of compounds of formula (I) R1 is hydrogen, tritium, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, amino or lower alkyl substituted by halogen; R2 is hydrogen, hydroxy or lower alkyl; X is N and Y is CH or CH2 or CH-lower alkyl or X is CH and Y is N; Q is CH2, O, NH, N-alkyl or N-SO2-alkyl or N-SO2-toluen-4-yl; W is CH2 or a bond are independently from one another 1, 2 or 3; when m is 2 or 3, R2 may m, n be the same or not; when n is 2 or 3, R1 may be the same or not; the dotted lines may each be independently from one another a bond or not; and to their pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers and tautomeric forms of compounds of formula (I) for the preparation of medicaments for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
摘要(中):
本发明涉及式(I)化合物的用途,R 1为氢,氚,羟基,低级烷基,低级烷氧基,卤素,硝基,氨基或被卤素取代的低级烷基; R2是氢,羟基或低级烷基; X是N,Y是CH或CH 2或CH-低级烷基或X是CH,Y是N; Q是CH 2,O,NH,N-烷基或N-SO 2 - 烷基或N-SO 2 - 甲苯-4-基; W是CH 2或键彼此独立地是1,2或3; 当m为2或3时,R 2可以m,n相同或不相同; 当n为2或3时,R 1可以相同或不相同; 虚线各自可以彼此独立地键合; 和其药物活性盐,外消旋混合物,对映异构体,光学异构体和互变异构形式的式(I)化合物用于制备用于治疗抑郁症,焦虑症,双相情感障碍,注意缺陷多动障碍,应激相关疾病的药物 精神分裂症如精神分裂症,神经系统疾病如帕金森病,神经退行性疾病如阿尔茨海默病,癫痫,偏头痛,高血压,药物滥用和代谢性疾病如进食障碍,糖尿病,糖尿病并发症,肥胖,血脂异常,能量消耗障碍 和体温平衡的同化,紊乱和功能障碍,睡眠和昼夜节律紊乱以及心血管疾病。
信息查询:
EspacenetIPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D233/00 | 杂环化合物,含1,3-二唑或氢化1,3-二唑环、不与其他环稠合 |
--------C07D233/54 | .环原子间或环原子与非环原子间有两个双键 |