The method of this invention for the prevention and treatment of the novel azole of formula 1A and 1B, the novel antiviral active ingredient, the pharmaceutical composition, an antiviral drug, in particular viral diseases caused by the hepatitis C virus (HCV) in It relates.

Wherein: a solid line (---) accompanying the dotted line is one of them represents a single bond or a double bond, a single bond and the other is a double bond; X and Y are one of which is nitrogen (N), the other is oxygen (O), sulfur (S) or -NH group; R ¹ And R ² is 2- (R) - and (S) - substituted N- acyl pyrrolidine derivatives; N- methyl -N- [2- (R) and (S) - substituted 2,2-disubstituted acetamide; Methyl [2- (R) and (S) - substituted ((methyl) amino) - (1-oxo-butane-2-yl) -2- (R) -] and (S) - iso-propyl) carbazole It is optionally the same radical selected from formate. A is Dioxane, cycloalkyl-and bicyclo aliphatic, alkyloxy-alkyl, alkyloxy-alkylene-oxy-alkyl, alkenyloxy-alkyl, alkynyloxy-alkyl radical of bi and its thio analog; Acyl and thiophene-alkynyl cycloalkyl, alkynyl dioxane, alkynyl, aryl, alkyl-thiophene, alkenyl nilti thiophene and alkynyl nilti thiophene, alkyloxy aryl, alkenyloxy aryl, alkynyloxy aryl, alkylthio aryl, alkenyl thio aryl, alkynyl, aryl thio, cycloalkyl thiophene, an aliphatic C ₂ -C ₈ by a radical of aryl-dioxane and thiophenyl dioxane It shows a bi-radical. B is an acyl and thiophene, alkynyl, cycloalkyl, alkynyl dioxane, alkynyl, aryl, alkyl-thiophene, thiophene nilti alkenyl and alkynyl nilti thiophene, cycloalkyl benzene, 4-bi-phenyl-cycloalkyl, bicyclic cycloalkyl, benzene, 4- by bi-cycloalkyl, phenyl, cycloalkyl, thiophene, acyl dioxane and dioxane thiophenyl radical a single, double or triple bonds, including aliphatic C ₂ -C ₈ It represents a radical.