PROBLEM TO BE SOLVED: To provide a preparation capable of administering azithromycin to a patient just beginning to take a food. SOLUTION: This oral administration preparation of the azithromycin capable of being administered to a mammal capable of taking the food is provided by containing the azithromycin, without showing an disadvantageous effect of the food substantially, and achieving approximately 90 % dissolution of the azithromycin within 30 min in a USP-2 dissolution testing device under a strict condition similar to the below: a preparation corresponding to 250 mg azithromycin is tested in a phosphate buffer of 900 ml of pH6.0 at 37°C with a paddle rotating by 100 rpm, as indicated in the USP test . Provided that, the preparation is not a capsule preparation, but the oral preparation characterized by containing an alkaline earth metal oxide or hydroxide in an amount less than a taste-blocking amount and not exhibiting the bad effect of the food. COPYRIGHT: (C)2005,JPO&NCIPI