专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2008231120A Method for administering azithromycin 审中-公开
标题翻译：用于治疗AZITHROMYCIN的方法
公开(公告)号：JP2008231120A
公开(公告)日：2008-10-02
申请号：JP2008139689
申请日：2008-05-28
申请人： Pfizer Inc , ファイザー・インク
发明人： CURATOLO WILLIAM J , FOULDS GEORGE H , FRIEDMAN HYLAR L
IPC分类号： A61K31/7052 , C07H17/00 , A61K9/00 , A61K9/10 , A61K9/14 , A61K9/20 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61K47/02 , A61K47/04 , A61P31/00 , A61P31/04 , C07H17/08
CPC分类号： A61K31/70 , A61K9/0095 , Y10S514/96
摘要： PROBLEM TO BE SOLVED: To provide a dosage form of administering azithromycin to a patient which just took foods.
SOLUTION: The present invention provides an oral dosage form of azithromycin which can administer to mammals which took foods and contains azithromycin and substantially does not exhibit negative alimentary effect. Solubility of azithromycin is at least about 90% within about 30 min when dosage form in an amount corresponding to 250 mg azithromycin is tested by a method USP-711 in a USP-2 dissolution apparatus with a paddle rotating under the stringent conditions that correspond the following indices: 900 mL phosphoric acid buffer, pH 6.0, at 37°C and at 100 rpm, with the proviso that the dosage form is not a capsule and contains an alkaline earth metal oxide or hydroxide in an amount less than taste-blocking amount and does not exhibit adverse effect of foods.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供向刚刚服用食物的患者施用阿奇霉素的剂型。解决方案：本发明提供阿奇霉素的口服剂型，其可以施用于摄取食物并含有阿奇霉素的哺乳动物，并且基本上不显示消极的消化作用。阿奇霉素的溶解度在约30分钟内至少约90％，当剂量相当于250mg阿奇霉素的剂量在USP-2溶出装置中通过方法USP-711进行测试，其中桨在相应于以下指标：900ml磷酸缓冲液，pH6.0，在37℃和100rpm下，条件是剂型不是胶囊，并且含有少于味道阻断量的碱土金属氧化物或氢氧化物并不会对食品产生不良影响。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2005015466A Method for administering azithromycin 审中-公开
标题翻译：用于治疗AZITHROMYCIN的方法
公开(公告)号：JP2005015466A
公开(公告)日：2005-01-20
申请号：JP2004128641
申请日：2004-04-23
申请人： Pfizer Inc , ファイザー・インク
发明人： CURATOLO WILLIAM J , FOULDS GEORGE H , FRIEDMAN HYLAR L
IPC分类号： C07H17/00 , A61K9/00 , A61K9/10 , A61K9/14 , A61K9/20 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61K47/02 , A61P31/00 , A61P31/04 , C07H17/08
CPC分类号： A61K31/70 , A61K9/0095 , Y10S514/96
摘要： PROBLEM TO BE SOLVED: To provide a preparation capable of administering azithromycin to a patient just beginning to take a food. SOLUTION: This oral administration preparation of the azithromycin capable of being administered to a mammal capable of taking the food is provided by containing the azithromycin, without showing an disadvantageous effect of the food substantially, and achieving approximately 90 % dissolution of the azithromycin within 30 min in a USP-2 dissolution testing device under a strict condition similar to the below: a preparation corresponding to 250 mg azithromycin is tested in a phosphate buffer of 900 ml of pH6.0 at 37°C with a paddle rotating by 100 rpm, as indicated in the USP test . Provided that, the preparation is not a capsule preparation, but the oral preparation characterized by containing an alkaline earth metal oxide or hydroxide in an amount less than a taste-blocking amount and not exhibiting the bad effect of the food. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种能够将阿奇霉素施用于刚刚开始食用的患者的制剂。解决方案：能够给予能够摄取食物的哺乳动物的阿奇霉素的口服给药制剂通过含有阿奇霉素而提供，而不显示食物的不利影响，并且实现阿奇霉素约90％的溶解在USP-2溶出测试装置的30分钟内，在类似于以下条件的严格条件下，在37℃下，在900ml pH6.0的磷酸盐缓冲液中，用桨转动100 rpm，如USP测试<711>所示。前提是制剂不是胶囊制剂，而是口服制剂，其特征在于含有小于味道阻断量的碱土金属氧化物或氢氧化物，并且不显示食物的不良影响。版权所有（C）2005，JPO＆NCIPI

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式