
基本信息:
- 专利标题: AROMATIC 1,4-DI-CARBOXYLAMIDES AND THEIR USE
- 专利标题(中):芳香1,4-二羧基酰胺及其用途
- 申请号:EP07856577.7 申请日:2007-12-11
- 公开(公告)号:EP2125751A1 公开(公告)日:2009-12-02
- 发明人: GARCIA, Gabriel , DARAM, Pierre , FROESCH, Barbara , LEMAILLET, Guy , SCAPOZZA, Leonardo
- 申请人: The Genetics Company, Inc.
- 申请人地址: Wagistrasse 27 8952 Schlieren CH
- 专利权人: The Genetics Company, Inc.
- 当前专利权人: The Genetics Company, Inc.
- 当前专利权人地址: Wagistrasse 27 8952 Schlieren CH
- 代理机构: Stolmár, Matthias
- 优先权: EP06025620 20061211
- 国际公布: WO2008071397 20080619
- 主分类号: C07D233/96
- IPC分类号: C07D233/96 ; C07D401/14 ; C07D407/12 ; A61K31/444 ; A61K31/505 ; A61P35/00
摘要:
The invention relates to novel compounds of formula (I) wherein X, Y, Z represent independently from one another C or N, n stands for 1, 2, 3, m is 0 or 1, p stands for 0 or an integer from 1 to 6, R1, R2 represent independently from one another hydrogen, a halogen atom, a hydroxyl group, a C1-C3 alkyl group and a C1-C3 alkoxy group, R3 represents, independently from one another if p is not 0, hydrogen, halogen, a C1-C5 linear or branched alkyl, a carboxylyl, a carbomethoxyl, carboethoxyl, a benzyl, an acyl, a hydroxyl, a C1-C4 linear or branched alkoxyl, a trifluoromethyl, a cyano, a morpholino, a 1,3-dioxolyl, an N-acetylamidyl or an amidoyl group, a saturated 5-8 membered ring, a heterocyclic ring, optionally substituted by a C1-C3 alkyl, a hydroxyl or a benzyl group, a C1-C6 alkylsulfonyl, a mono or disubstituted C1-C5 alkyl group, a branched or a cyclic amine, R6 is H or part of a alicyclic, heteroalicyclic ring system, if m is 0 then C represents CF3 or a branched or unbranched C1-C4 alkyl group, if m = 1 then C represents -CH2-O-, -CH2-, -CH2CH2-, -CH2CH2CH2-, -CH2(CH2)CH2- or denotes a chemical bond between N-C or C-C, the CONR6 group may be linked to C either via its carbon or via its nitrogen atom, CYC stands for a by R3 substituted or unsubstituted phenyl, pyridinyl, naphthyl, quinolinyl, isoquinolinyl, isoxaxolinyl, thiophenyl, 1,3,4-thiadiazazolidinyl, furanyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, morpholinyl, furanyl, cyclohexenyl, and chromen-2-on-yl and its use as a medicament for the treatment of cancer.
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D233/00 | 杂环化合物,含1,3-二唑或氢化1,3-二唑环、不与其他环稠合 |
--------C07D233/96 | .环原子间或环原子与非环原子间有3个双键 |