专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1487981A2 GROWTH REGULATING PROTEINS 有权
标题翻译：生长调节基因
公开(公告)号：EP1487981A2
公开(公告)日：2004-12-22
申请号：EP03745382.6
申请日：2003-03-28
申请人： The Genetics Company Inc. , Universität Zürich
发明人： HAFEN, Ernst , STOCKER, Hugo , DARAM, Pierre , SCHINDELHOLZ, Benno , BREUER, Sebastian
IPC分类号： C12N15/11 , C07K14/47 , A61K48/00 , C12N15/12 , C07K16/18 , C07K14/435 , A61K38/17
CPC分类号： C07K14/43581 , C07K14/47
摘要： The application disloses a new family of proteins, namely the epsin like proteins (ELP). Said proteins comprise an ENTH domain (Epsin NH2 Terminal Homology domain) and have growth inhibiting activity. The disclosed proteins can be used for the diagnosis of hyperproliferative diseases as well as for gene therapy purposes.

2. 发明公开

EP2125751A1 AROMATIC 1,4-DI-CARBOXYLAMIDES AND THEIR USE 审中-公开
标题翻译：芳香1,4-二羧基酰胺及其用途
公开(公告)号：EP2125751A1
公开(公告)日：2009-12-02
申请号：EP07856577.7
申请日：2007-12-11
申请人： The Genetics Company, Inc.
发明人： GARCIA, Gabriel , DARAM, Pierre , FROESCH, Barbara , LEMAILLET, Guy , SCAPOZZA, Leonardo
IPC分类号： C07D233/96 , C07D401/14 , C07D407/12 , A61K31/444 , A61K31/505 , A61P35/00
CPC分类号： C07D401/14 , C07D233/96 , C07D407/12
摘要： The invention relates to novel compounds of formula (I) wherein X, Y, Z represent independently from one another C or N, n stands for 1, 2, 3, m is 0 or 1, p stands for 0 or an integer from 1 to 6, R1, R2 represent independently from one another hydrogen, a halogen atom, a hydroxyl group, a C1-C3 alkyl group and a C1-C3 alkoxy group, R3 represents, independently from one another if p is not 0, hydrogen, halogen, a C1-C5 linear or branched alkyl, a carboxylyl, a carbomethoxyl, carboethoxyl, a benzyl, an acyl, a hydroxyl, a C1-C4 linear or branched alkoxyl, a trifluoromethyl, a cyano, a morpholino, a 1,3-dioxolyl, an N-acetylamidyl or an amidoyl group, a saturated 5-8 membered ring, a heterocyclic ring, optionally substituted by a C1-C3 alkyl, a hydroxyl or a benzyl group, a C1-C6 alkylsulfonyl, a mono or disubstituted C1-C5 alkyl group, a branched or a cyclic amine, R6 is H or part of a alicyclic, heteroalicyclic ring system, if m is 0 then C represents CF3 or a branched or unbranched C1-C4 alkyl group, if m = 1 then C represents -CH2-O-, -CH2-, -CH2CH2-, -CH2CH2CH2-, -CH2(CH2)CH2- or denotes a chemical bond between N-C or C-C, the CONR6 group may be linked to C either via its carbon or via its nitrogen atom, CYC stands for a by R3 substituted or unsubstituted phenyl, pyridinyl, naphthyl, quinolinyl, isoquinolinyl, isoxaxolinyl, thiophenyl, 1,3,4-thiadiazazolidinyl, furanyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, morpholinyl, furanyl, cyclohexenyl, and chromen-2-on-yl and its use as a medicament for the treatment of cancer.

3. 发明公开

EP2125710A1 SULFONAMIDES AND THEIR USE AS A MEDICAMENT 审中-公开
标题翻译：磺胺类药物及其作为药物
公开(公告)号：EP2125710A1
公开(公告)日：2009-12-02
申请号：EP07856578.5
申请日：2007-12-11
申请人： The Genetics Company, Inc.
发明人： GARCIA, Gabriel , DARAM, Pierre , FROESCH, Barbara , FRANK, Jaschinski , LEMAILLET, Guy , MARTY-ERNST, Cornelia , MARZI, Elena , SCAPOZZA, Leonardo
IPC分类号： C07C311/37 , C07D211/26 , C07D231/12 , C07D295/08 , A61K31/18 , A61K31/415 , A61K31/435 , A61K31/535 , A61P35/00
CPC分类号： C07C311/38 , C07C311/21 , C07D207/335 , C07D209/40 , C07D213/24 , C07D213/53 , C07D215/12 , C07D217/12 , C07D231/12 , C07D233/64 , C07D271/12 , C07D295/096 , C07D295/135 , C07D295/155 , C07D333/58
摘要： The present invention relates to the use of a sulfonamide compound of formula (I): wherein R1 is selected from the group consisting of H, CN, halogen, trifluoromethyl, methyl, ethyl, hydroxy, methoxy, ethoxy, morpholino, R2 is selected from H, phenyl, substituted phenyl, CN, -SO2R, wherein R is phenyl or morpholino, -NC(O)Me, -NC(O)Et, - CH2C(O)OMe, CH2C(O)OEt, R3 is selected from the group consisting of H, NO2, NH2, halogen, -COOMe, -COOEt, RC(O)N-, morpholino, R4 is selected from the group consisting of H, a branched or unbranched methyl, ethyl, propyl, butyl, pentyl, methoxy, ethoxy, propoxy, butoxy, a substituted or unsubstituted phenyl, alkinyl, Me2SO2-, COOR, wherein R is a branched or unbranched methyl, ethyl, propyl, butyl, pentyl, - MeOC(O)-, a substituted or unsubstituted five or sixmembered aromatic or non-aromatic heterocyclic system with one, two or three heteroatoms, a hetaryl system, a condensed benzoheterocyclic system, X is a linker comprising 2 or 3 atoms, selected from the group consisting of -NH-NH-, -NH-NH-CH2-, ethinyl, -NH-C(O)-CH2-, - NH-NH-SO2-, -C(O)-NH-CH2-, -NH-N=CH-, -NH-N=C(Me)-, a -NH-N=CH- motif being part of a heterocyclic system, preferably a substituted or unsubstituted pyrazole or pyridazine system, and pharmaceutically active salts thereof. Further, the invention relates to the use of these compounds as a medicament, especially for the treatment of cancer.

4. 发明授权

EP1487981B1 GROWTH REGULATING PROTEINS 有权
标题翻译：生长调节基因
公开(公告)号：EP1487981B1
公开(公告)日：2007-05-16
申请号：EP03745382.6
申请日：2003-03-28
申请人： The Genetics Company Inc. , Universität Zürich
发明人： HAFEN, Ernst , STOCKER, Hugo , DARAM, Pierre , SCHINDELHOLZ, Benno , BREUER, Sebastian
IPC分类号： C12N15/11 , C07K14/47 , A61K48/00 , C12N15/12 , C07K16/18 , C07K14/435 , A61K38/17
CPC分类号： C07K14/43581 , C07K14/47
摘要： The application disloses a new family of proteins, namely the epsin like proteins (ELP). Said proteins comprise an ENTH domain (Epsin NH2 Terminal Homology domain) and have growth inhibiting activity. The disclosed proteins can be used for the diagnosis of hyperproliferative diseases as well as for gene therapy purposes.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式