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1. 发明授权

US09738604B2 Ethynylbenzene derivatives 有权
公开(公告)号：US09738604B2
公开(公告)日：2017-08-22
申请号：US13820404
申请日：2011-09-06
申请人： Pei Zhou , Eric J. Toone
发明人： Pei Zhou , Eric J. Toone
IPC分类号： C07C237/34 , C07C259/06 , C07D207/273 , C07C275/14 , C07C275/24 , C07C275/28 , C07C311/19 , C07C311/39 , C07D205/085 , C07D231/12 , C07D249/04 , C07D257/04 , C07D261/08 , C07D263/16 , C07D265/30 , C07D275/03 , C07D277/22 , C07D295/155 , C07D307/36 , C07D333/06 , C07C311/37 , C07D209/20 , C07D213/73 , C07D233/64
CPC分类号： C07D207/273 , A61P31/04 , C07C237/34 , C07C259/06 , C07C275/14 , C07C275/24 , C07C275/28 , C07C311/19 , C07C311/37 , C07C311/39 , C07D205/085 , C07D209/20 , C07D213/73 , C07D231/12 , C07D233/64 , C07D249/04 , C07D257/04 , C07D261/08 , C07D263/16 , C07D265/30 , C07D275/03 , C07D277/22 , C07D295/155 , C07D307/36 , C07D333/06
摘要： Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.

2. 发明申请

US20120020991A1 PRODOMAIN MODULATORS OF ADAM 10 审中-公开
标题翻译： ADAM 10的PRODOMAIN调制器
公开(公告)号：US20120020991A1
公开(公告)日：2012-01-26
申请号：US13268282
申请日：2011-10-07
申请人： Marcia Moss , Pei Zhou
发明人： Marcia Moss , Pei Zhou
IPC分类号： A61K38/17 , A61P25/28 , A61P35/00 , A61P37/08 , A61P29/00 , A61P11/06
CPC分类号： C12N9/6489 , A61K38/00
摘要： The presently disclosed subject matter discloses isolated ADAM 10 modulating peptides and related compounds useful for studying the biological functions of ADAM 10 and for the treatment of diseases such as cancer, neurological disorders, asthma, and allergic responses, and disorders characterized at least in part by the presence of one or more of inflammation, excess cell proliferation, angiogenesis, and excess soluble CD23. In one aspect, the presently disclosed subject matter provides isolated mouse and human ADAM 10 prodomain comprising the sequence set forth in SEQ ID NOs 1-8, or a sequence having at least 95% homology to any of SEQ ID NOs 1-8 and having the functionality of modulating ADAM 10 activity.
摘要翻译：目前公开的主题公开了分离的ADAM10调节肽和相关化合物，其可用于研究ADAM10的生物学功能和用于治疗疾病如癌症，神经障碍，哮喘和过敏反应，以及至少部分地由存在一种或多种炎症，过量细胞增殖，血管生成和过量可溶性CD23。一方面，本公开的主题提供分离的小鼠和人ADAM10前结构域，其包含SEQ ID NO 1-8中所示的序列，或与SEQ ID NO 1-8中任一个具有至少95％同源性的序列，并具有调节ADAM 10活性的功能。

3. 发明申请

US20080096820A1 Prodomain modulators of ADAM 10 失效
标题翻译： ADAM 10的前域调制器
公开(公告)号：US20080096820A1
公开(公告)日：2008-04-24
申请号：US11897018
申请日：2007-08-28
申请人： Marcia Moss , Pei Zhou
发明人： Marcia Moss , Pei Zhou
IPC分类号： A61K38/17 , A61P35/00 , C07K14/47 , C12N15/12 , C12N15/85 , C12N5/10 , C12P21/00 , A61P11/06 , A61P37/08
CPC分类号： C12N9/6489 , A61K38/00
摘要： The presently disclosed subject matter discloses isolated ADAM 10 modulating peptides and related compounds useful for studying the biological functions of ADAM 10 and for the treatment of diseases such as cancer, neurological disorders, asthma, and allergic responses, and disorders characterized at least in part by the presence of one or more of inflammation, excess cell proliferation, angiogenesis, and excess soluble CD23. In one aspect, the presently disclosed subject matter provides isolated mouse and human ADAM 10 prodomain comprising the sequence set forth in SEQ ID NOs 1-8, or a sequence having at least 95% homology to any of SEQ ID NOs 1-8 and having the functionality of modulating ADAM 10 activity.
摘要翻译：目前公开的主题公开了分离的ADAM10调节肽和相关化合物，其可用于研究ADAM10的生物学功能和用于治疗疾病如癌症，神经障碍，哮喘和过敏反应，以及至少部分地由存在一种或多种炎症，过量细胞增殖，血管生成和过量可溶性CD23。一方面，本公开的主题提供分离的小鼠和人ADAM10前结构域，其包含SEQ ID NO 1-8中所示的序列，或与SEQ ID NO 1-8中任一个具有至少95％同源性的序列，并具有调节ADAM 10活性的功能。

4. 外观设计

USD970618S1 Marker 有权
公开(公告)号：USD970618S1
公开(公告)日：2022-11-22
申请号：US29749322
申请日：2020-09-04
申请人： Pei Zhou
设计人： Pei Zhou

5. 发明授权

US08034783B2 Prodomain modulators of ADAM 10 失效
标题翻译： ADAM 10的前域调制器
公开(公告)号：US08034783B2
公开(公告)日：2011-10-11
申请号：US12580682
申请日：2009-10-16
申请人： Marcia Moss , Pei Zhou
发明人： Marcia Moss , Pei Zhou
IPC分类号： A61K38/16 , C07K1/00 , C07K14/00
CPC分类号： C12N9/6489 , A61K38/00
摘要： The presently disclosed subject matter discloses isolated ADAM 10 modulating peptides and related compounds useful for studying the biological functions of ADAM 10 and for the treatment of diseases such as cancer, neurological disorders, asthma, and allergic responses, and disorders characterized at least in part by the presence of one or more of inflammation, excess cell proliferation, angiogenesis, and excess soluble CD23. In one aspect, the presently disclosed subject matter provides isolated mouse and human ADAM 10 prodomain comprising the sequence set forth in SEQ ID NOs 1-8, or a sequence having at least 95% homology to any of SEQ ID NOs 1-8 and having the functionality of modulating ADAM 10 activity.
摘要翻译：目前公开的主题公开了分离的ADAM10调节肽和相关化合物，其可用于研究ADAM10的生物学功能和用于治疗疾病如癌症，神经障碍，哮喘和过敏反应，以及至少部分地由存在一种或多种炎症，过量细胞增殖，血管生成和过量可溶性CD23。一方面，本公开的主题提供分离的小鼠和人ADAM10前结构域，其包含SEQ ID NO 1-8中所示的序列，或与SEQ ID NO 1-8中任一个具有至少95％同源性的序列，并具有调节ADAM 10活性的功能。

6. 发明授权

US07638301B2 Prodomain modulators of ADAM 10 失效
标题翻译： ADAM 10的前域调制器
公开(公告)号：US07638301B2
公开(公告)日：2009-12-29
申请号：US11897018
申请日：2007-08-28
申请人： Marcia Moss , Pei Zhou
发明人： Marcia Moss , Pei Zhou
IPC分类号： C12P21/06 , C12N5/00 , G01N33/53 , C07K14/00 , C08H1/00
CPC分类号： C12N9/6489 , A61K38/00
摘要： The presently disclosed subject matter discloses isolated ADAM 10 modulating peptides and related compounds useful for studying the biological functions of ADAM 10 and for the treatment of diseases such as cancer, neurological disorders, asthma, and allergic responses, and disorders characterized at least in part by the presence of one or more of inflammation, excess cell proliferation, angiogenesis, and excess soluble CD23. In one aspect, the presently disclosed subject matter provides isolated mouse and human ADAM 10 prodomain comprising the sequence set forth in SEQ ID NOs 1-8, or a sequence having at least 95% homology to any of SEQ ID NOs 1-8 and having the functionality of modulating ADAM 10 activity.
摘要翻译：目前公开的主题公开了分离的ADAM10调节肽和相关化合物，其可用于研究ADAM10的生物学功能和用于治疗疾病如癌症，神经障碍，哮喘和过敏反应，以及至少部分地由存在一种或多种炎症，过量细胞增殖，血管生成和过量可溶性CD23。一方面，本公开的主题提供分离的小鼠和人ADAM10前结构域，其包含SEQ ID NO 1-8中所示的序列，或与SEQ ID NO 1-8中任一个具有至少95％同源性的序列，并具有调节ADAM 10活性的功能。

7. 发明申请

US20090281049A1 New use of ginsenoside compound-k in manufacturing medicaments 审中-公开
标题翻译：人参皂甙化合物在制造药物中的新用途
公开(公告)号：US20090281049A1
公开(公告)日：2009-11-12
申请号：US12311081
申请日：2007-08-06
申请人： Quanhai Liu , Pei Zhou , Hua Bai , Wei Zhou , Jingjing Li , Meiqing Feng , Moli Hua , Jingyue Xu
发明人： Quanhai Liu , Pei Zhou , Hua Bai , Wei Zhou , Jingjing Li , Meiqing Feng , Moli Hua , Jingyue Xu
IPC分类号： A61K31/7032 , A61P19/02
CPC分类号： A61K31/704
摘要： Use of ginsenoside Compound-K, which structural formula is the following: in manufacturing medicaments for prevention or treatment of arthritis.
摘要翻译：使用人参皂甙化合物K，其结构式如下：制备用于预防或治疗关节炎的药物。

8. 发明申请

US20130231323A1 ETHYNYLBENZENE DERIVATIVES 有权
标题翻译：乙烯苯衍生物
公开(公告)号：US20130231323A1
公开(公告)日：2013-09-05
申请号：US13820404
申请日：2011-09-06
申请人： Pei Zhou , Eric J. Toone
发明人： Pei Zhou , Eric J. Toone
IPC分类号： C07D207/273 , C07D205/085 , C07D213/73 , C07D249/04 , C07D209/20 , C07D233/64 , C07D265/30 , C07C237/34 , C07C311/37
CPC分类号： C07D207/273 , A61P31/04 , C07C237/34 , C07C259/06 , C07C275/14 , C07C275/24 , C07C275/28 , C07C311/19 , C07C311/37 , C07C311/39 , C07D205/085 , C07D209/20 , C07D213/73 , C07D231/12 , C07D233/64 , C07D249/04 , C07D257/04 , C07D261/08 , C07D263/16 , C07D265/30 , C07D275/03 , C07D277/22 , C07D295/155 , C07D307/36 , C07D333/06
摘要： Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.
摘要翻译：公开了式（I），（II）和（II）I的化合物及其药学上可接受的盐，其中R，R 1，R 2，R 3，R 101，L，D，Q，Y，X和 Z在本文中定义。这些化合物可用于治疗革兰氏阴性菌感染。

9. 外观设计

USD969912S1 Paint marker 有权
公开(公告)号：USD969912S1
公开(公告)日：2022-11-15
申请号：US29749327
申请日：2020-09-04
申请人： Pei Zhou
设计人： Pei Zhou

10. 发明申请

US20100081620A1 PRODOMAIN MODULATORS OF ADAM 10 失效
标题翻译： ADAM 10的PRODOMAIN调制器
公开(公告)号：US20100081620A1
公开(公告)日：2010-04-01
申请号：US12580682
申请日：2009-10-16
申请人： Marcia Moss , Pei Zhou
发明人： Marcia Moss , Pei Zhou
IPC分类号： A61K38/16 , C12N9/48 , A61K38/02 , A61P29/00 , A61P35/00
CPC分类号： C12N9/6489 , A61K38/00
摘要： The presently disclosed subject matter discloses isolated ADAM 10 modulating peptides and related compounds useful for studying the biological functions of ADAM 10 and for the treatment of diseases such as cancer, neurological disorders, asthma, and allergic responses, and disorders characterized at least in part by the presence of one or more of inflammation, excess cell proliferation, angiogenesis, and excess soluble CD23. In one aspect, the presently disclosed subject matter provides isolated mouse and human ADAM 10 prodomain comprising the sequence set forth in SEQ ID NOs 1-8, or a sequence having at least 95% homology to any of SEQ ID NOs 1-8 and having the functionality of modulating ADAM 10 activity.
摘要翻译：目前公开的主题公开了分离的ADAM10调节肽和相关化合物，其可用于研究ADAM10的生物学功能和用于治疗疾病如癌症，神经障碍，哮喘和过敏反应，以及至少部分地由存在一种或多种炎症，过量细胞增殖，血管生成和过量可溶性CD23。一方面，本公开的主题提供分离的小鼠和人ADAM10前结构域，其包含SEQ ID NO 1-8中所示的序列，或与SEQ ID NO 1-8中任一个具有至少95％同源性的序列，并具有调节ADAM 10活性的功能。

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