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    • 2. 发明申请
    • PRODOMAIN MODULATORS OF ADAM 10
    • ADAM 10的PRODOMAIN调制器
    • US20100081620A1
    • 2010-04-01
    • US12580682
    • 2009-10-16
    • Marcia MossPei Zhou
    • Marcia MossPei Zhou
    • A61K38/16C12N9/48A61K38/02A61P29/00A61P35/00
    • C12N9/6489A61K38/00
    • The presently disclosed subject matter discloses isolated ADAM 10 modulating peptides and related compounds useful for studying the biological functions of ADAM 10 and for the treatment of diseases such as cancer, neurological disorders, asthma, and allergic responses, and disorders characterized at least in part by the presence of one or more of inflammation, excess cell proliferation, angiogenesis, and excess soluble CD23. In one aspect, the presently disclosed subject matter provides isolated mouse and human ADAM 10 prodomain comprising the sequence set forth in SEQ ID NOs 1-8, or a sequence having at least 95% homology to any of SEQ ID NOs 1-8 and having the functionality of modulating ADAM 10 activity.
    • 目前公开的主题公开了分离的ADAM10调节肽和相关化合物,其可用于研究ADAM10的生物学功能和用于治疗疾病如癌症,神经障碍,哮喘和过敏反应,以及至少部分地由 存在一种或多种炎症,过量细胞增殖,血管生成和过量可溶性CD23。 一方面,本公开的主题提供分离的小鼠和人ADAM10前结构域,其包含SEQ ID NO 1-8中所示的序列,或与SEQ ID NO 1-8中任一个具有至少95%同源性的序列,并具有 调节ADAM 10活性的功能。
    • 4. 发明申请
    • PRODOMAIN MODULATORS OF ADAM 10
    • ADAM 10的PRODOMAIN调制器
    • US20120020991A1
    • 2012-01-26
    • US13268282
    • 2011-10-07
    • Marcia MossPei Zhou
    • Marcia MossPei Zhou
    • A61K38/17A61P25/28A61P35/00A61P37/08A61P29/00A61P11/06
    • C12N9/6489A61K38/00
    • The presently disclosed subject matter discloses isolated ADAM 10 modulating peptides and related compounds useful for studying the biological functions of ADAM 10 and for the treatment of diseases such as cancer, neurological disorders, asthma, and allergic responses, and disorders characterized at least in part by the presence of one or more of inflammation, excess cell proliferation, angiogenesis, and excess soluble CD23. In one aspect, the presently disclosed subject matter provides isolated mouse and human ADAM 10 prodomain comprising the sequence set forth in SEQ ID NOs 1-8, or a sequence having at least 95% homology to any of SEQ ID NOs 1-8 and having the functionality of modulating ADAM 10 activity.
    • 目前公开的主题公开了分离的ADAM10调节肽和相关化合物,其可用于研究ADAM10的生物学功能和用于治疗疾病如癌症,神经障碍,哮喘和过敏反应,以及至少部分地由 存在一种或多种炎症,过量细胞增殖,血管生成和过量可溶性CD23。 一方面,本公开的主题提供分离的小鼠和人ADAM10前结构域,其包含SEQ ID NO 1-8中所示的序列,或与SEQ ID NO 1-8中任一个具有至少95%同源性的序列,并具有 调节ADAM 10活性的功能。
    • 5. 发明申请
    • Prodomain modulators of ADAM 10
    • ADAM 10的前域调制器
    • US20080096820A1
    • 2008-04-24
    • US11897018
    • 2007-08-28
    • Marcia MossPei Zhou
    • Marcia MossPei Zhou
    • A61K38/17A61P35/00C07K14/47C12N15/12C12N15/85C12N5/10C12P21/00A61P11/06A61P37/08
    • C12N9/6489A61K38/00
    • The presently disclosed subject matter discloses isolated ADAM 10 modulating peptides and related compounds useful for studying the biological functions of ADAM 10 and for the treatment of diseases such as cancer, neurological disorders, asthma, and allergic responses, and disorders characterized at least in part by the presence of one or more of inflammation, excess cell proliferation, angiogenesis, and excess soluble CD23. In one aspect, the presently disclosed subject matter provides isolated mouse and human ADAM 10 prodomain comprising the sequence set forth in SEQ ID NOs 1-8, or a sequence having at least 95% homology to any of SEQ ID NOs 1-8 and having the functionality of modulating ADAM 10 activity.
    • 目前公开的主题公开了分离的ADAM10调节肽和相关化合物,其可用于研究ADAM10的生物学功能和用于治疗疾病如癌症,神经障碍,哮喘和过敏反应,以及至少部分地由 存在一种或多种炎症,过量细胞增殖,血管生成和过量可溶性CD23。 一方面,本公开的主题提供分离的小鼠和人ADAM10前结构域,其包含SEQ ID NO 1-8中所示的序列,或与SEQ ID NO 1-8中任一个具有至少95%同源性的序列,并具有 调节ADAM 10活性的功能。
    • 6. 发明授权
    • Rotary film calciner
    • 旋转膜煅烧炉
    • US5906483A
    • 1999-05-25
    • US71396
    • 1998-05-01
    • Jun Pei Zhou
    • Jun Pei Zhou
    • F26B13/18F26B17/28F27B7/00F27B7/08F27B7/32
    • F26B17/284F26B13/186F27B7/00F27B7/08
    • An apparatus for drying/calcining comprises a horizontally extending rotatable drum and a center tube, concentrically positioned within the rotatable drum to provide an annular combustion chamber between the outer wall of the center tube and the inner wall of the rotatable drum. One or more gas jet burners are positioned to inject gas fuel and combustion air into the annular combustion chamber in a tangential direction to create a vortex flow of combustion gases through the annular combustion chamber. The flue gas is discharged through the center tube. In operation, a material to be dried and/or calcined is applied to the external wall of the rotatable drum as it rotates toward a scraper or doctor blade where the dried or calcined product is removed by scraping.
    • 用于干燥/煅烧的装置包括水平延伸的可旋转鼓和中心管,同心地位于可旋转滚筒内,以在中心管的外壁和可旋转滚筒的内壁之间提供环形燃烧室。 定位一个或多个气体喷射燃烧器以将气体燃料和燃烧空气沿切线方向喷射到环形燃烧室中,以产生通过环形燃烧室的燃烧气体的涡流。 烟气通过中心管排出。 在操作中,将待干燥和/或煅烧的材料施加到可旋转滚筒的外壁上,当其朝向刮刀或刮刀转动时,通过刮擦将干燥或煅烧产品除去。
    • 8. 发明授权
    • Prodomain modulators of ADAM 10
    • ADAM 10的前域调制器
    • US07638301B2
    • 2009-12-29
    • US11897018
    • 2007-08-28
    • Marcia MossPei Zhou
    • Marcia MossPei Zhou
    • C12P21/06C12N5/00G01N33/53C07K14/00C08H1/00
    • C12N9/6489A61K38/00
    • The presently disclosed subject matter discloses isolated ADAM 10 modulating peptides and related compounds useful for studying the biological functions of ADAM 10 and for the treatment of diseases such as cancer, neurological disorders, asthma, and allergic responses, and disorders characterized at least in part by the presence of one or more of inflammation, excess cell proliferation, angiogenesis, and excess soluble CD23. In one aspect, the presently disclosed subject matter provides isolated mouse and human ADAM 10 prodomain comprising the sequence set forth in SEQ ID NOs 1-8, or a sequence having at least 95% homology to any of SEQ ID NOs 1-8 and having the functionality of modulating ADAM 10 activity.
    • 目前公开的主题公开了分离的ADAM10调节肽和相关化合物,其可用于研究ADAM10的生物学功能和用于治疗疾病如癌症,神经障碍,哮喘和过敏反应,以及至少部分地由 存在一种或多种炎症,过量细胞增殖,血管生成和过量可溶性CD23。 一方面,本公开的主题提供分离的小鼠和人ADAM10前结构域,其包含SEQ ID NO 1-8中所示的序列,或与SEQ ID NO 1-8中任一个具有至少95%同源性的序列,并具有 调节ADAM 10活性的功能。