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1. 外观设计

USD719666S1 Cell detection system with touchscreen 有权
标题翻译：带触摸屏的电池检测系统
公开(公告)号：USD719666S1
公开(公告)日：2014-12-16
申请号：US29449047
申请日：2013-03-14
申请人： Bala S. Manian
设计人： Bala S. Manian

2. 外观设计

USD717352S1 Chuck 有权
标题翻译：查克
公开(公告)号：USD717352S1
公开(公告)日：2014-11-11
申请号：US29449078
申请日：2013-03-14
申请人： Bala S. Manian
设计人： Bala S. Manian

3. 发明申请

US20120105842A1 METHODS FOR CALIBRATING A MEASUREMENT DEVICE, AND DEVICES THEREFROM 有权
标题翻译：用于校准测量装置的方法及其装置
公开(公告)号：US20120105842A1
公开(公告)日：2012-05-03
申请号：US13034380
申请日：2011-02-24
申请人： Bala S. Manian
发明人： Bala S. Manian
IPC分类号： G01J3/44 , G01N30/00
CPC分类号： G01N21/274 , G01N21/278 , G01N21/64 , G01N21/65
摘要： The invention provides a method of calibrating measurement device using a Raman-active composition, wherein the composition is active, in one embodiment, in a wavelength region that ranges from about 300 nm to about 1200 nm, and in another embodiment, from about 550 nm to about 650 nm. The method is especially useful in the calibration of fluorescent measurement devices. The method of the invention provides several advantages, such as, in facile identification of problems with the device when it occurs, in not having to tune and adjust the device very often, and neutralizing variations between different runs and different instruments. In another aspect, the invention also provides a device that is calibrated using the method of the invention. In one embodiment, the Raman-active composition useful in the invention is a derivative of 1,4-bis(2-methyl-styryl)-benzene.
摘要翻译：本发明提供了使用拉曼活性组合物校准测量装置的方法，其中在一个实施方案中，组合物在波长范围为约300nm至约1200nm，在另一个实施方案中为约550nm 至约650nm。该方法在荧光测量装置的校准中特别有用。本发明的方法提供了几个优点，例如在容易识别出现设备的问题时，不需要经常地调整和调整设备，并且中和不同的运行和不同的仪器之间的变化。在另一方面，本发明还提供了使用本发明的方法校准的装置。在一个实施方案中，可用于本发明的拉曼活性组合物是1,4-双（2-甲基 - 苯乙烯基） - 苯的衍生物。

4. 发明申请

US20120107950A1 MEASUREMENT SYSTEM FOR FLUORESCENT DETECTION, AND METHOD THEREFOR 审中-公开
标题翻译：用于荧光检测的测量系统及其方法
公开(公告)号：US20120107950A1
公开(公告)日：2012-05-03
申请号：US13034515
申请日：2011-02-24
申请人： Bala S. Manian
发明人： Bala S. Manian
IPC分类号： G01N21/64 , C12M1/34
CPC分类号： G01N21/6428 , G01N21/6452
摘要： In one aspect, the invention provides a measurement system, wherein the measurement system comprises a sample module to receive a sample, wherein the sample module comprises at least one fluorophore; an optics module to generate an incident beam to impinge on the sample to yield a laser spot; a detector module to detect fluorescence signals arising out of the sample; a processor module to process the fluorescence signals and provide relevant output; an output module; a control module to control the sample module, the optics module, the detector module and the output module. The measurement system of the invention is capable of measuring both bulk and event fluorescences of a sample containing at least one fluorophore. In another aspect, the invention provides a method for testing a fluid based on the measurement system of the invention.
摘要翻译：一方面，本发明提供了一种测量系统，其中测量系统包括用于接收样品的样品模块，其中样品模块包括至少一种荧光团; 光学模块，用于产生入射光束以撞击样品以产生激光光斑; 用于检测由样品产生的荧光信号的检测器模块; 处理器模块，用于处理荧光信号并提供相关输出; 输出模块; 用于控制样品模块，光学模块，检测器模块和输出模块的控制模块。本发明的测量系统能够测量含有至少一个荧光团的样品的体积和事件荧光。另一方面，本发明提供了一种基于本发明的测量系统测试流体的方法。

5. 发明授权

US07016087B2 Photon efficient scanner 有权
公开(公告)号：US07016087B2
公开(公告)日：2006-03-21
申请号：US09925124
申请日：2001-08-08
申请人： David M. Heffelfinger , Aram P. Schiffman , Bala S. Manian
发明人： David M. Heffelfinger , Aram P. Schiffman , Bala S. Manian
IPC分类号： H04N1/04
CPC分类号： G01N21/6452 , G01N21/6428 , G01N2021/6419 , G01N2021/6421
摘要： A system for optical interrogation of a sample adaptable for multiple wavelength illumination and multiple wavelength fluorescent or luminescent light collection, wherein the illumination wavelength profile and the light collection profile may overlap. In the system, coherent light from one or more lasers is focused onto a target layer on a sample to excite fluorescent or luminescent light from the target layer. Emitted light is collected from a selected depth by a reflective light collector that transmits the collected light to detection optics. The reflective light collector directs collected light at an angle to the optical axis of the illumination light, thereby separating collected emitted light from illumination light. The light collector may collect light from a focus, whereby the focused illumination light combined with the focused light collection aid in limitation of the depth of field to a selected depth. Additionally, a spatial filter positioned between the light collector and the detection optics may be used to confine the depth of field to a selected depth. This device may be incorporated into an optical scanner by scanning of illumination light in a first direction and translation of the sample in a tangent direction. Alternatively, the illumination and detection optics may remain stationary and the detectable targets moved past a scanning location (e.g. as in electrophoretic analysis).

6. 发明授权

US5932428A Method for preparing a sample in a scan capillary for immunofluorescent interrogation 失效
标题翻译：在扫描毛细管中制备免疫荧光询问的样品的方法
公开(公告)号：US5932428A
公开(公告)日：1999-08-03
申请号：US739131
申请日：1996-10-28
申请人： Robert S. Dubrow , Bala S. Manian
发明人： Robert S. Dubrow , Bala S. Manian
IPC分类号： G01N33/49 , G01N15/14 , G01N33/533 , G01N33/569 , G01N33/53
CPC分类号： G01N15/1468 , G01N33/569 , G01N33/56972 , Y10S435/962 , Y10S435/968 , Y10S436/805 , Y10S436/825 , Y10S436/826 , Y10T436/101666 , Y10T436/107497 , Y10T436/108331
摘要： An assay and sample mixture for the enumeration of fluorescently stained target components of a whole blood sample by an imaging instrument. The sample preparation method ensures that the amount of target components per unit of volume of the whole blood sample is preserved by elimination of certain non-quantitative preparation steps while producing an even hematocrit layer within a scan capillary. Typical target components include white blood cells that express certain surface antigens, such as CD-4 and CD-8 proteins. To inhibit aggregation of the red blood cells, a reagent is added to an aliquot of whole blood sample. The aliquot of whole blood is mixed and with a preselected amount of a fluorescent dye and ligand complex which tags the target components. The sample and fluorescent complex are allowed to incubate a sufficient amount of time to bind enough of the fluorescent complex to the target components to provide a fluorescent signal from the target components which will be distinguishable from the fluorescent signal from the unbound fluorescent complex in the sample. The resulting mixture allows the imaging instrument to detect peak intensities of fluorescence from the target components, thereby allowing the target components to be volumetrically enumerated with an improved level of accuracy and efficiency.
摘要翻译：用于通过成像仪计数全血样品的荧光染色的靶组分的测定和样品混合物。样品制备方法确保通过消除某些非定量制备步骤同时在扫描毛细管内产生均匀的血细胞比容层来保存全血样品每单位体积的目标成分的量。典型的靶组分包括表达某些表面抗原的白细胞，例如CD-4和CD-8蛋白。为了抑制红细胞的聚集，将试剂加入到全血样品的等分试样中。将全血的等分试样混合，并与预选量的荧光染料和配体复合物标记靶组分。允许样品和荧光复合物孵育足够的时间以将足够的荧光复合物与目标组分结合，以提供来自靶组分的荧光信号，其将与来自样品中未结合的荧光复合物的荧光信号区分开。所得到的混合物允许成像仪器检测来自目标组分的荧光的峰值强度，从而允许目标组分以精确度和效率提高的水平进行体积计数。

7. 发明授权

US5296341A Green light laser imaging method 失效
标题翻译：绿光激光成像方法
公开(公告)号：US5296341A
公开(公告)日：1994-03-22
申请号：US908575
申请日：1992-06-24
申请人： Bala S. Manian
发明人： Bala S. Manian
IPC分类号： G03C5/16 , H04N1/23 , G03C5/17
CPC分类号： G03C5/16 , H04N1/23 , Y10S430/146 , Y10S430/168
摘要： A method for digital imaging employing a green light laser. The method comprises obtaining a digitized picture image, modulating a green light laser beam in accord with the digitized picture image, and directing the modulated laser beam onto film that is sensitive to green-blue light. The film is then developed to create a gray-scale image useful in radiography and other imaging fields.
摘要翻译：一种使用绿光激光的数字成像方法。该方法包括获得数字化图像，根据数字化图像图像调制绿光激光束，并将调制的激光束引导到对绿蓝光敏感的膜上。然后，该电影被开发以产生用于放射照相和其它成像领域的灰度图像。

8. 发明授权

US5221454A Differential separation assay 失效
标题翻译：差示分离法
公开(公告)号：US5221454A
公开(公告)日：1993-06-22
申请号：US904854
申请日：1992-06-25
申请人： Bala S. Manian , Vartan Ghazarossian
发明人： Bala S. Manian , Vartan Ghazarossian
IPC分类号： G01N27/447
CPC分类号： G01N27/44721
摘要： An electrophoresis-based assay system for detection of one or more target substances, i.e. an analyte tagged with fluorescent binding agents. The analyte is reacted with an excess amount of fluorescently tagged binding agent. The reaction mixture is subjected to electrophoresis and the migration of bound and free fluorescent substances are timed at a location where there is a spatial and optical differentiation of the two substances. An optical detector supplies signals corresponding to fluorescent amplitudes of the two substances. The free fluorescent substance arrives at a time expected from calibration runs. This optical signal is a marker for a second time, either earlier or later, when the bound substance should have arrived. Recorded data is searched to establish the relation between free and bound dye among the recorded optical signals. An absence of a bound dye signal infers the absence of target analyte in a sample. The amounts of bound and unbound amounts of the same fluorescent substance may be related by ratio of amplitudes of the optical signals so that the amount of target analyte may be estimated.
摘要翻译：用于检测一种或多种靶物质的电泳测定系统，即用荧光结合剂标记的分析物。分析物与过量的荧光标记结合剂反应。将反应混合物进行电泳，并且结合的和游离的荧光物质的迁移在两种物质存在空间和光学分化的位置定时。光学检测器提供对应于两种物质的荧光幅度的信号。游离荧光物质在校准运行期间到达。这种光学信号是在结合的物质应该已经到达时，提前或稍后的标记物。搜索记录的数据以建立记录的光信号中自由和结合染料之间的关系。没有结合的染料信号推测样品中不存在目标分析物。相同荧光物质的结合量和未结合量的量可以通过光信号的幅度比来相关，以便可以估计目标分析物的量。

9. 发明授权

US5137609A Differential separation assay 失效
标题翻译：差示分离法
公开(公告)号：US5137609A
公开(公告)日：1992-08-11
申请号：US828407
申请日：1992-01-31
申请人： Bala S. Manian , Vartan Ghazarossian
发明人： Bala S. Manian , Vartan Ghazarossian
IPC分类号： G01N21/64 , B01D57/02 , G01N21/77 , G01N27/447
CPC分类号： G01N27/44721
摘要： An electrophoresis-based assay system for detection of one or more target substances, i.e. an analyte tagged with fluorescent binding agents. The analyte is reacted with an excess amount of fluroescently tagged binding agent. The reaction mixture is subjected to electrophoresis and the migration of bound and free fluorescent substances are timed at a location where there is a spatial and optical differentiation of the two substances. An optical detector supplies signals corresponding to fluorescent amplitudes of the two substances. The free fluorescent substance arrives at a time expected from calibration runs. This optical signal is a marker for a second time, either earlier or later, when the bound substance should have arrived. Recorded data is searched to establish the relation between free and bound dye among the recorded optical signals. An absence of a bound dye signal infers the absence of target analyte in a sample. The amounts of bound and unbound amounts of the same fluorescent substance may be related at ratio of amplitudes of the optical signals so that the amount of target analyte may be estimated.
摘要翻译：用于检测一种或多种靶物质的电泳测定系统，即用荧光结合剂标记的分析物。分析物与过量的荧光标记的结合剂反应。将反应混合物进行电泳，并且结合的和游离的荧光物质的迁移在两种物质存在空间和光学分化的位置定时。光学检测器提供对应于两种物质的荧光幅度的信号。游离荧光物质在校准运行期间到达。这种光学信号是在结合的物质应该已经到达时，提前或稍后的标记物。搜索记录的数据以建立记录的光信号中自由和结合染料之间的关系。没有结合的染料信号推测样品中不存在目标分析物。相同荧光物质的结合量和未结合量的量可以与光信号的幅度的比率相关，使得可以估计目标分析物的量。

10. 发明授权

US4725891A Film image digitizer 失效
标题翻译：电影图像数字化仪
公开(公告)号：US4725891A
公开(公告)日：1988-02-16
申请号：US7128
申请日：1987-01-27
申请人： Bala S. Manian
发明人： Bala S. Manian
IPC分类号： H04N1/06 , H04N1/191 , H04N1/18
CPC分类号： H04N1/0891 , H04N1/06 , H04N1/1912
摘要： An apparatus for digitizing an image on a film material using a plurality of movable equally spaced light detectors. Light sources direct light through a sheet of the material disposed on a transparent drum. The light which is transmitted is imaged onto light detectors through apertures in a mask. As the drum rotates, the mask and light detectors move in unison longitudinally at a rate of one pixel width per drum revolution. One embodiment of a scanning module comprises only light detectors and mask, while another embodiment also includes a pair of lens arrays that image the sheet onto the detectors. There are an integral number of pixel widths between adjacent detectors. A plurality of parallel lines on the mask and a scanner fixed relative to the drum sense the relative position between the mask and the drum for providing corrective feedback information to a motor moving the mask and light detectors. Color recording may be provided with a mask having three rows of apertures in which each row transmits a different one of red, green, and blue light. The film image is represented by a mosaic of pixels with each pixel mapping to an element of memory.
摘要翻译：一种用于使用多个可移动等间隔的光检测器对胶片材料上的图像进行数字化的设备。光源通过设置在透明鼓上的材料的片材引导光线。传输的光通过掩模中的孔成像到光检测器上。当滚筒旋转时，掩模和光检测器以每个转鼓一个像素宽度的速率纵向移动。扫描模块的一个实施例仅包括光检测器和掩模，而另一实施例还包括将片材成像到检测器上的一对透镜阵列。相邻检测器之间存在整数个像素宽度。掩模上的多条平行线和相对于滚筒固定的扫描仪感测掩模和滚筒之间的相对位置，以向移动掩模和光检测器的马达提供校正反馈信息。彩色记录可以设置有具有三排孔径的掩模，其中每行传输不同的红色，绿色和蓝色光。电影图像由像素的马赛克表示，每个像素映射到存储器的元素。

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