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1. 外观设计

USD719666S1 Cell detection system with touchscreen 有权
标题翻译：带触摸屏的电池检测系统
公开(公告)号：USD719666S1
公开(公告)日：2014-12-16
申请号：US29449047
申请日：2013-03-14
申请人： Bala S. Manian
设计人： Bala S. Manian

2. 外观设计

USD717352S1 Chuck 有权
标题翻译：查克
公开(公告)号：USD717352S1
公开(公告)日：2014-11-11
申请号：US29449078
申请日：2013-03-14
申请人： Bala S. Manian
设计人： Bala S. Manian

3. 发明申请

US20120105842A1 METHODS FOR CALIBRATING A MEASUREMENT DEVICE, AND DEVICES THEREFROM 有权
标题翻译：用于校准测量装置的方法及其装置
公开(公告)号：US20120105842A1
公开(公告)日：2012-05-03
申请号：US13034380
申请日：2011-02-24
申请人： Bala S. Manian
发明人： Bala S. Manian
IPC分类号： G01J3/44 , G01N30/00
CPC分类号： G01N21/274 , G01N21/278 , G01N21/64 , G01N21/65
摘要： The invention provides a method of calibrating measurement device using a Raman-active composition, wherein the composition is active, in one embodiment, in a wavelength region that ranges from about 300 nm to about 1200 nm, and in another embodiment, from about 550 nm to about 650 nm. The method is especially useful in the calibration of fluorescent measurement devices. The method of the invention provides several advantages, such as, in facile identification of problems with the device when it occurs, in not having to tune and adjust the device very often, and neutralizing variations between different runs and different instruments. In another aspect, the invention also provides a device that is calibrated using the method of the invention. In one embodiment, the Raman-active composition useful in the invention is a derivative of 1,4-bis(2-methyl-styryl)-benzene.
摘要翻译：本发明提供了使用拉曼活性组合物校准测量装置的方法，其中在一个实施方案中，组合物在波长范围为约300nm至约1200nm，在另一个实施方案中为约550nm 至约650nm。该方法在荧光测量装置的校准中特别有用。本发明的方法提供了几个优点，例如在容易识别出现设备的问题时，不需要经常地调整和调整设备，并且中和不同的运行和不同的仪器之间的变化。在另一方面，本发明还提供了使用本发明的方法校准的装置。在一个实施方案中，可用于本发明的拉曼活性组合物是1,4-双（2-甲基 - 苯乙烯基） - 苯的衍生物。

4. 发明授权

US08441634B2 Methods for calibrating a measurement device, and devices therefrom 有权
标题翻译：用于校准测量装置的方法及其装置
公开(公告)号：US08441634B2
公开(公告)日：2013-05-14
申请号：US13034380
申请日：2011-02-24
申请人： Bala S. Manian
发明人： Bala S. Manian
IPC分类号： G01J3/44
CPC分类号： G01N21/274 , G01N21/278 , G01N21/64 , G01N21/65
摘要： The invention provides a method of calibrating measurement device using a Raman-active composition, wherein the composition is active, in one embodiment, in a wavelength region that ranges from about 300 nm to about 1200 nm, and in another embodiment, from about 550 nm to about 650 nm. The method is especially useful in the calibration of fluorescent measurement devices. The method of the invention provides several advantages, such as, in facile identification of problems with the device when it occurs, in not having to tune and adjust the device very often, and neutralizing variations between different runs and different instruments. In another aspect, the invention also provides a device that is calibrated using the method of the invention. In one embodiment, the Raman-active composition useful in the invention is a derivative of 1,4-bis(2-methyl-styryl)-benzene.
摘要翻译：本发明提供了使用拉曼活性组合物校准测量装置的方法，其中在一个实施方案中，组合物在波长范围为约300nm至约1200nm，在另一个实施方案中为约550nm 至约650nm。该方法在荧光测量装置的校准中特别有用。本发明的方法提供了几个优点，例如，在容易识别出现该装置的问题时，不需要经常调整和调整装置，并且中和不同运行和不同仪器之间的变化。在另一方面，本发明还提供了使用本发明的方法校准的装置。在一个实施方案中，可用于本发明的拉曼活性组合物是1,4-双（2-甲基苯乙烯基） - 苯的衍生物。

5. 发明授权

US06750457B2 System for high throughput analysis 失效
标题翻译：高通量分析系统
公开(公告)号：US06750457B2
公开(公告)日：2004-06-15
申请号：US09942472
申请日：2001-08-29
申请人： David M. Heffelfinger , Aram P. Schiffman , Bala S. Manian
发明人： David M. Heffelfinger , Aram P. Schiffman , Bala S. Manian
IPC分类号： G01N2100
CPC分类号： G01N21/6452 , G01J3/10 , G01J3/14 , G01J3/36 , G01J3/4406 , G01N27/44721 , G01N2021/6463
摘要： An apparatus and method in which illumination light and collected emitted light share a pathway and subsequently are physically separated. The optical configuration is designed such that at the point of separation, the illumination light is at has a smaller cross sectional area than the collected light. Collected light is directed away from the pathway of the illumination light and to detection optics. This configuration is adaptable to illumination and light collection across a broad wavelength spectrum. This configuration is adaptable to scanning in a limited depth of field to allow high throughput optical analysis of samples.
摘要翻译：照明光和收集的发射光共享通路并随后物理分离的装置和方法。光学构造被设计成使得在分离点处，照明光具有比收集的光更小的横截面面积。收集的光被引导离开照明光的路径和检测光学器件。该配置适用于宽波长光谱下的照明和光采集。该配置适用于在有限的景深中的扫描，以允许样品的高通量光学分析。

6. 发明授权

US06238874B1 Cell motility assay 有权
标题翻译：细胞运动性测定
公开(公告)号：US06238874B1
公开(公告)日：2001-05-29
申请号：US09363247
申请日：1999-07-28
申请人： Kurt R. Jarnagin , Steven T. Kunitake , Bala S. Manian
发明人： Kurt R. Jarnagin , Steven T. Kunitake , Bala S. Manian
IPC分类号： G01N33533
CPC分类号： C12M41/46 , Y10S436/809
摘要： An apparatus and method of use for assaying cellular motility in response to a concentration gradient of a chemotactic agent. Generally, the apparatus includes a chamber having a region for receiving a biological sample containing cells of interest and, spaced apart from such region, another region for receiving a chemotactic agent. Between these regions, a concentration gradient of chemotactic agent is established. The apparatus further includes an optical system for detecting and mapping the positions of individual cells responsive to such concentration gradient. Means for processing and analyzing the collected data are also provided. Motility determinations may be made on purified or unpurified samples. Single-site assay devices and multi-site, high-throughput assay devices are disclosed.
摘要翻译：用于响应于趋化剂的浓度梯度来测定细胞运动性的装置和方法。通常，该装置包括具有用于接收含有感兴趣的细胞的生物样品并与该区域间隔的区域的腔室，用于接收趋化剂的另一区域。在这些区域之间，建立了趋化剂的浓度梯度。该装置还包括用于响应于这种浓度梯度来检测和映射各个单元的位置的光学系统。还提供了处理和分析收集的数据的手段。可以对纯化或未纯化的样品进行运动测定。公开了单位点测定装置和多位点，高通量测定装置。

7. 发明授权

US6130745A Optical autofocus for use with microtiter plates 有权
公开(公告)号：US6130745A
公开(公告)日：2000-10-10
申请号：US245782
申请日：1999-02-05
申请人： Bala S. Manian , David M. Heffelfinger , Edward M. Goldberg
发明人： Bala S. Manian , David M. Heffelfinger , Edward M. Goldberg
IPC分类号： G01B11/00 , G01J1/00 , G01N21/03 , G01N21/55 , G01N21/64 , G01N33/483 , G02B7/28 , G02B21/24 , G02B21/34
CPC分类号： G02B21/34 , G01N21/6452 , G02B21/241
摘要： A method and apparatus for autofocus on a target layer contained within a microplate well is provided. The instrument is capable of optically sensing a reference point on the underside of a microplate. This reference point is then used to focus light onto a target layer within the microplate well, the target layer having a location that is in defined relation to the reference point. The reference point is either a surface of the bottom of the microplate well or is an optically detectable mark on the underside of the microplate. In an alternate embodiment, a light position sensitive detector is used to enable deterministic autofocus for a plurality of wells on a microplate.

8. 发明授权

US5843680A Differential separation assay methods and test kits 失效
标题翻译：差示分离法和检测试剂盒
公开(公告)号：US5843680A
公开(公告)日：1998-12-01
申请号：US425718
申请日：1995-04-19
申请人： Bala S. Manian , Vartan E. Ghazarossian , Paul G. Hayter
发明人： Bala S. Manian , Vartan E. Ghazarossian , Paul G. Hayter
IPC分类号： G01N27/447 , G01N33/538 , G01N33/561 , G01N33/558 , G01N33/573
CPC分类号： G01N27/44726 , G01N33/538 , G01N33/561
摘要： Analytes can be detected from among closely related substances by reacting the analyte in a test sample with a labeled binding agent which specifically binds to the analyte to form a complex. The labeled binding agent is supplied in excess, and the complex is identified through a time window relative to the detection of the excess unbound agent. The complex and labeled binding agent are isolated on a separation media and identified by the differential rate of migration.
摘要翻译：通过将测试样品中的分析物与特异性结合分析物的标记结合剂反应以形成复合物，可以从紧密相关的物质中检测分析物。标记的结合剂被过量供应，并且通过相对于过量未结合剂的检测的时间窗口来鉴定复合物。复合物和标记的结合剂在分离介质上分离并通过不同的迁移速率鉴定。

9. 发明授权

US5585246A Method for preparing a sample in a scan capillary for immunofluorescent interrogation 失效
公开(公告)号：US5585246A
公开(公告)日：1996-12-17
申请号：US328241
申请日：1994-10-24
申请人： Robert S. Dubrow , Bala S. Manian
发明人： Robert S. Dubrow , Bala S. Manian
IPC分类号： G01N33/49 , G01N15/14 , G01N33/533 , G01N33/569 , G01N33/53
CPC分类号： G01N15/1468 , G01N33/569 , G01N33/56972 , Y10S435/962 , Y10S435/968 , Y10S436/805 , Y10S436/825 , Y10S436/826 , Y10T436/101666 , Y10T436/107497 , Y10T436/108331
摘要： An assay and sample mixture for the enumeration of fluorescently stained target components of a whole blood sample by an imaging instrument. The sample preparation method ensures that the amount of target components per unit of volume of the whole blood sample is preserved by elimination of certain non-quantitative preparation steps while producing an even hematocrit layer within a scan capillary. Typical target components include white blood cells that express certain surface antigens, such as CD-4 and CD-8 proteins. To inhibit aggregation of the red blood cells, a reagent is added to an aliquot of whole blood sample. The aliquot of whole blood is mixed and with a preselected amount of a fluorescent dye and ligand complex which tags the target components. The sample and fluorescent complex are allowed to incubate a sufficient amount of time to bind enough of the fluorescent complex to the target components to provide a fluorescent signal from the target components which will be distinguishable from the fluorescent signal from the unbound fluorescent complex in the sample. The resulting mixture allows the imaging instrument to detect peak intensities of fluorescence from the target components, thereby allowing the target components to be volumetrically enumerated with an improved level of accuracy and efficiency.

10. 发明授权

US5547849A Apparatus and method for volumetric capillary cytometry 失效
标题翻译：用于体积毛细血管细胞计数的装置和方法
公开(公告)号：US5547849A
公开(公告)日：1996-08-20
申请号：US236342
申请日：1994-05-02
申请人： Thomas M. Baer , Louis J. Dietz , Robert S. Dubrow , Paul G. Hayter , Michael Hodges , Bala S. Manian , Robert J. Shartle
发明人： Thomas M. Baer , Louis J. Dietz , Robert S. Dubrow , Paul G. Hayter , Michael Hodges , Bala S. Manian , Robert J. Shartle
IPC分类号： G01N33/49 , G01N15/14 , G01N21/78 , G01N33/543 , G01N33/554 , G06K9/00 , G01N33/536
CPC分类号： G06K9/00127 , G01N15/1468
摘要： The apparatus and method of the present invention disclose a scanning imaging cytometer wherein an unprocessed biological fluid sample is reacted with a fluorescently-labeled binding agent. The reacted sample undergoes minimal processing before it is placed into a capillary tube. The sample is optically scanned and fluorescence excitation is recorded from a plurality of columnar regions of the capillary tube, each columnar region generally defined by the spot size of the excitation beam and the depth dimension of the capillary tube. A spatial filter of a sufficient pinhole diameter is selected to allow simultaneous volumetric detection of all fluorescent targets in each columnar region.
摘要翻译：本发明的装置和方法公开了一种扫描成像细胞仪，其中未处理的生物流体样品与荧光标记的结合剂反应。反应的样品在放入毛细管之前经历最少的处理。样品被光学扫描，并且从毛细管的多个柱状区域记录荧光激发，每个柱状区域通常由激发光束的光斑尺寸和毛细管的深度尺寸限定。选择足够的针孔直径的空间滤波器以允许对每个柱状区域中的所有荧光目标的同时体积检测。

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