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1. 发明申请

WO2023088287A1 FUSION PROTEINS COMPRISING AI-073 CORE PEPTIDE AND USE THEREOF 审中-公开
公开(公告)号：WO2023088287A1
公开(公告)日：2023-05-25
申请号：PCT/CN2022/132188
申请日：2022-11-16
申请人： ACROIMMUNE GUANGZHOU BIOTECH LTD
发明人： ZHOU, Qunmin , FANG, Xianfeng , LI, Dongling , MU, Libing , ZHOU, JianYing
IPC分类号： C07K16/28 , C07K16/32 , C12N15/63 , A61P15/00 , G01N33/566
摘要： The compositions of a glycosylated and/or sialylated core peptide (073 core) and compositions of proteins based on fusion of one or more copy of the peptide to the Fc fragment of human immunoglobulin and their use in treating diseases propagated by inflammation associated with tissue injuries or invading pathogens.

2. 发明申请

WO2023063717A1 피부 노화 진단을 위한 후각 수용체 유전자 및 이들의 용도 审中-公开
公开(公告)号：WO2023063717A1
公开(公告)日：2023-04-20
申请号：PCT/KR2022/015394
申请日：2022-10-12
申请人： 연세대학교 산학협력단
发明人： 박태선 , 강위석
IPC分类号： G01N33/566 , C12Q1/6883
摘要： 본 발명은 피부 노화의 진단용 조성물에 관한 것으로, 본 발명의 조성물은 내인성 요인으로 인한 현재의 피부 노화 정도를 평가할 뿐 아니라, 향후 이러한 피부 노화가 진행될 유전적 위험성을 높은 신뢰도로 예측함으로써 피부 노화에 대한 개인별 맞춤 치료 전략을 조기에 수립하는 데에 유용하게 이용될 수 있다. 본 발명은 또한 피부 노화 개선제의 스크리닝 방법에 관한 것으로, 본 발명의 스크리닝 방법은 피부 진피(dermis)의 노화에 따라 감소된 진피 섬유아세포의 콜라겐 생성을 복원하여 피부 조직의 결합력 저하, 탄력 감소, 수분 상실 및 장벽기능 손상을 가역적으로 회복시킴으로써 수분 공급과 같은 대증적 요법을 넘어서는 근원적인 피부 노화 억제제를 정확하고 신속하게 탐색할 수 있다.

3. 发明申请

WO2022271264A1 REAL-TIME G-PROTEIN COUPLED RECEPTOR (GPCR) LINKED BIOLUMINESCENT SENSING OF BIOLOGICAL TARGETS AND PROCESSES 审中-公开
公开(公告)号：WO2022271264A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/025761
申请日：2022-04-21
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： NARGI, Frances , WICK, Scott, Thomas , MISHRA, Deepak
IPC分类号： G01N33/74 , C07K14/705 , C07K14/72 , G01N33/566 , C07K14/66 , C07K14/721 , C07K14/723 , C07K2319/03 , C07K2319/09 , C07K2319/50 , C12N15/625 , C12N9/0071 , C12Y114/14003 , G01N2333/726 , G01N33/5023
摘要： The invention relates to compositions and methods for making and use of a real-time cellular sensor. Components of a multipart enzyme are sequestered in different cellular compartments and only come together after receptor activation; a pool of substrate is made available in the cell to ensure real- time enzymatic output.

4. 发明申请

WO2022165576A1 BIOSSENSOR SEM MARCAÇÃO BASEADO EM ESTRUTURA DE IMIDAZOLATO ZEOLÍTICO, PROCESSO DE FABRICAÇÃO DO MESMO E PROCESSO DE DETECÇÃO DE INTERAÇÕES PROTEÍNA-PROTEÍNA 审中-公开
公开(公告)号：WO2022165576A1
公开(公告)日：2022-08-11
申请号：PCT/BR2022/050033
申请日：2022-02-03
申请人： CNPEM - CENTRO NACIONAL DE PESQUISA EM ENERGIA E MATERIAIS
发明人： TRINO ALBANO, Luciana Daniele , SIMÃO ALBANO, Luiz Gustavo , CAMPOS GRANATO, Daniela , GUIMARÃES SANTANA, Aline , STARNINI DE CAMARGO, Davi Henrique , CRISPILHO CORRÊA, Cátia , BOF BUFON, Carlos Cesar , PAES LEME, Adriana Franco
IPC分类号： G01N27/02 , G01N33/566 , G01N27/327
摘要： A presente descrição se refere a um biossensor sem marcação ( label-free ) com eletrodos interdigitados baseados em ZIF-8 para detecção de interações proteína-proteína. O processo de detecção com o referido biossensor se dá por medições de espectroscopia de impedância eletroquímica dos eletrodos. Também é descrito o processo de fabricação de tais biossensores, incluindo etapas de fabricação do eletrodo interdigitado (4), modificação do eletrodo com ZIF-8 (5), imobilização de uma proteína no eletrodo (6) e exposição do eletrodo a uma concentração de uma outra proteína, que é parceiro de interação da primeira, para detecção da interação entre as mesmas.

5. 发明申请

WO2022150834A2 MOLECULAR TARGET IN CANCER 审中-公开
公开(公告)号：WO2022150834A2
公开(公告)日：2022-07-14
申请号：PCT/US2022/070081
申请日：2022-01-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： REYA, Tannishtha
IPC分类号： G01N33/58 , A61P35/02 , C07K14/36 , C07K2319/21 , C12Q1/6876 , G01N21/6428 , G01N33/542 , G01N33/566 , G01N33/582
摘要： Disclosed are methods for identifying small molecule modulators of protein-RNA interactions that could potentially function as therapeutic agents in cancer treatment. Methods of identifying inhibitors of the RNA-binding functions of MSI2, as well as inhibitors identified thereof, are also disclosed.

6. 发明申请

WO2022133107A1 METHODS FOR DIAGNOSING ALZHEIMER'S DISEASE AND OTHER NEUROLOGICAL DISORDERS 审中-公开
公开(公告)号：WO2022133107A1
公开(公告)日：2022-06-23
申请号：PCT/US2021/063843
申请日：2021-12-16
申请人： COGNEXT DIAGNOSTICS LLC , THE JOHNS HOPKINS UNIVERSITY
发明人： WORLEY, Paul, F. , XIAO, Meifang , XU, Desheng
IPC分类号： G01N33/68 , C07K16/18 , G01N33/566 , G01N33/53
摘要： Disclosed herein are methods for diagnosing a subject as having a neurological disorder, such as Alzheimer's disease, using proximity-based detection assays capable of detecting complexes containing two or more synaptic proteins, such as neuronal pentraxins, from a blood, cerebrospinal fluid, or other fluid sample of the subject. Also disclosed are methods of evaluating and monitoring subjects having or at risk of developing a neurological disorder using the aforementioned assays.

7. 发明申请

WO2022117978A1 DIAGNOSTIC TESTING 审中-公开
公开(公告)号：WO2022117978A1
公开(公告)日：2022-06-09
申请号：PCT/GB2021/050083
申请日：2021-01-14
申请人： PARAYTEC LTD
发明人： SMYTHE, Carl Glenton Weymouth , GOODALL, David Murray
IPC分类号： G01N33/533 , G01N33/543 , G01N33/566 , G01N33/569 , G01N33/574
摘要： The present invention concerns the field of diagnostic testing to confirm the presence of target pathogens in a test sample, typically obtained from a human or animal. The test has particular application in testing for viruses, but could include cancer cells or other particulate pathogens, including bacteria. The disclosure provides a method for facilitating the detection of target pathogen particles in a test sample, the method comprising: providing one or more supports defining a support surface, the support surface being provided with a coating of a first set of macromolecular assemblies, the assemblies each being capable of selectively binding with the target pathogen particles, providing a second set of macromolecular assemblies, the assemblies also each being capable of binding selectively with the target pathogen particles, and wherein each of the second set of macromolecular assemblies is provided with at least one fluorophore moiety, obtaining or providing the test sample to be assayed for the presence of the target pathogen therein, exposing the macromolecular assemblies to the test sample so that target pathogen particles present in the test sample bind to the macromolecular assemblies, thereby producing a multitude of target pathogen particles distributed over and anchored to said support surface by members of the first set of macromolecular assemblies, with a plurality of fluorophore moieties being bound to each pathogen particle by members of the second set of macromolecular assemblies, so as to produce a fluorophore coating on anchored pathogen particles on the support. The invention provides assemblies of pathogen particles produced by this method. The methods may include a detection step for detecting fluorescence from bound fluorophores.

8. 发明申请

WO2022046728A2 COMPOSITIONS AND METHODS FOR EARLY DETECTION OF OSTEOPOROSIS 审中-公开
公开(公告)号：WO2022046728A2
公开(公告)日：2022-03-03
申请号：PCT/US2021/047283
申请日：2021-08-24
申请人： NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY
发明人： PARK-MIN, Kyung-Hyun
IPC分类号： G01N33/53 , G01N33/566 , G01N33/68 , C12Q1/00
摘要： Provided herein are methods of diagnosing and treating a skeletal disease in a subject. The method includes (i) identifying the presence of osteoclast-enhancing cells (OECs) in the subject; (ii) quantifying the number of circulating OECs in a sample from the subject; and (iii) diagnosing a skeletal disease in the subject when an increase in OECs is detected as compared to a control.

9. 发明申请

WO2022035989A1 METHODS OF IDENTIFYING INTERACTIONS OF A COMPOUND AND A CONDENSATE, OR A COMPONENT THEREOF, AND USES THEREOF 审中-公开
公开(公告)号：WO2022035989A1
公开(公告)日：2022-02-17
申请号：PCT/US2021/045592
申请日：2021-08-11
申请人： DEWPOINT THERAPEUTICS, INC.
发明人： MITREA, Diana Maria , MITTASCH, Matthäus , DANDLIKER, Peter Jeffrey , BEUTEL, Bruce Aaron , BOCZEK, Edgar Erik
IPC分类号： G01N33/566 , G01N33/58 , G01N33/50 , G01N33/68 , G01N21/17
摘要： In some aspects, provided herein are methods of identifying interactions of a compound and a condensate, or a component thereof, and uses thereof. In other aspects, provided herein are methods of identifying (or screening for or designing) compounds, or portions thereof, having a desired interaction with a condensate, or a component thereof. In yet other aspects, provided herein are applications of the methods described herein, e.g., libraries of compounds having known or predicted characteristics, and methods of identifying compounds useful for treatment of a disease.

10. 发明申请

WO2022020435A1 SAVORY TASTE ENHANCEMENT VIA TRANSMEMBRANE REGION BINDING 审中-公开
公开(公告)号：WO2022020435A1
公开(公告)日：2022-01-27
申请号：PCT/US2021/042523
申请日：2021-07-21
申请人： FIRMENICH INCORPORATED
发明人： SERVANT, Guy
IPC分类号： G01N33/566 , A23L27/00 , C12Q1/6804
摘要： The present disclosure generally provides methods for imparting or enhancing an umami taste of a flavored article by introducing a compound that modulates a transmembrane (TM) region of a T1R taste receptor, such as the TM region of a T1r1 taste receptor. In some other aspects, the disclosure provides methods of identifying compounds that modulate a transmembrane (TM) region of a T1R taste receptor, and which thereby imparts or enhances an umami taste in a flavored article. In some other aspects, the disclosure provides compounds that modulate a transmembrane (TM) region of a T1R taste receptor, and their use in food or beverage products, in some cases, in combination with other compounds known to impart or enhance umami taste, such as glutamates, aspartates, and purinic ribonucleotides, such as inosine monophosphate (IMP) and guanosine monophosphate (GMP). In some aspects, the inclusion of such TM-region modulators in flavored products may allow one to reduce or eliminate the concentration of glutamate and aspartate in certain food and beverage products.

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