专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010028458A1 PRODRUGS OF ISOXAZOLYL PENICILLINS AND USES THEREOF 审中-公开
标题翻译： ISOXAZOLYL PENICILLIN的产品及其用途
公开(公告)号：WO2010028458A1
公开(公告)日：2010-03-18
申请号：PCT/AU2009/001216
申请日：2009-09-14
申请人： PARNELL LABORATORIES (AUST) PTY LTD , STAJIC, Vladimir Marinko
发明人： STAJIC, Vladimir Marinko
IPC分类号： C07D499/21 , A61K31/431
CPC分类号： C07D499/897
摘要： The present invention relates to prodrugs of isoxazolyl penicillins, pharmaceutical compositions comprising same and their use in the treatment of microbial infections such as mastitis.
摘要翻译：本发明涉及异恶唑青霉素的前体药物，包含其的药物组合物及其在治疗微生物感染如乳腺炎中的用途。

2. 发明申请

WO2015012158A1 生物学的組織に血管系を付与する方法审中-公开
标题翻译：生物组织中提供血管系统的方法
公开(公告)号：WO2015012158A1
公开(公告)日：2015-01-29
申请号：PCT/JP2014/068808
申请日：2014-07-15
申请人：公立大学法人横浜市立大学
发明人：武部　貴則 , 谷口　英樹 , 高橋　禎暢
IPC分类号： C12N5/071 , A01K67/027 , A61L27/00 , C07D499/21 , G01N33/50
CPC分类号： C12N5/0691 , A01K67/0271 , A01K2207/12 , A01K2267/0325 , A01K2267/0331 , A01K2267/035 , A01K2267/0362 , A61K35/28 , A61K35/44 , A61K49/0008 , A61L27/3808 , A61L27/3834 , A61L27/3886 , C07D499/21 , C12N2502/13 , G01N33/5082
摘要：ｉｎｖｉｔｒｏにおいて、生物学的組織に血管系を付与する方法であって、生物学的組織を血管細胞及び間葉系細胞と共培養することを含む、前記方法。前記方法により、血管系が付与された生物学的組織。前記生物学的組織を非ヒト動物に移植し、血管網が構築された組織又は臓器に分化させることを含む、組織又は臓器の作製方法。前記生物学的組織をヒト又は非ヒト動物に移植し、血管網が構築された組織又は臓器に分化させることを含む、組織又は臓器の再生又は機能回復方法。前記生物学的組織を非ヒト動物に移植し、血管網が構築された組織又は臓器に分化させることを含む、非ヒトキメラ動物の作製方法。前記生物学的組織、前記方法で作製された組織及び臓器、並びに前記方法で作製された非ヒトキメラ動物からなる群より選択される少なくとも１つを用いて、薬剤を評価する方法。前記方法により、血管系を付与された生物学的組織を含む、再生医療用組成物。
摘要翻译：一种用于在体外在生物组织中提供血管系统的方法，所述方法包括将生物组织与血管细胞和间充质细胞共培养。通过所述方法提供血管系统的生物组织。一种用于产生组织或器官的方法，所述方法包括移植非人动物中的生物组织并诱导分化成其中构建血管网络的组织或器官。一种组织或器官再生或功能恢复方法，其包括在人或非人动物中移植所述生物组织并诱导分化成其中构建血管网络的组织或器官。一种用于生产非人嵌合体动物的方法，所述方法包括将生物组织移植到非人动物并诱导分化成已经构建血管网络的组织或器官。使用选自由所述方法产生的生物组织，组织和器官组成的组中的至少一种和通过所述方法产生的非人类嵌合体动物来评价药物的方法。一种再生治疗组合物，其包含通过所述方法提供血管系统的生物组织。

3. 发明申请

WO2012000421A1 棉酚衍生物在制备抗肿瘤药物中的应用审中-公开
公开(公告)号：WO2012000421A1
公开(公告)日：2012-01-05
申请号：PCT/CN2011/076482
申请日：2011-06-28
申请人：中国科学院上海生命科学研究院 , 上海中科高等研究院 , 郭方 , 姜标
发明人：郭方 , 姜标
IPC分类号： C07D499/21 , C07C251/24 , C07D209/20 , A61K31/431 , A61K31/195 , A61K31/405 , A61K31/04 , A61K31/513 , A61P35/00 , C07D499/16 , C07D499/10 , C07C249/02
CPC分类号： A61K31/04 , A61K31/195 , A61K31/405 , A61K31/431 , A61K31/513 , C07C251/24 , C07D209/20 , C07D499/10 , C07D499/16 , C07D499/21

4. 发明申请

WO99003859A1 NOVEL SPIROAZABICYCLIC HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：新型螺旋化合物杂环化合物
公开(公告)号：WO99003859A1
公开(公告)日：1999-01-28
申请号：PCT/SE1998/001364
申请日：1998-07-10
IPC分类号： C07D491/22 , A61K20060101 , A61K31/395 , A61K31/435 , A61K31/4353 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/438 , A61K31/439 , A61K31/44 , A61K31/444 , A61K31/4738 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K31/695 , A61P20060101 , A61P1/00 , A61P1/04 , A61P25/00 , A61P25/04 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/34 , A61P43/00 , C07D20060101 , C07D491/12 , C07D491/20 , C07D495/12 , C07D499/21 , C07F5/02 , C07F7/18
CPC分类号： C07D491/22
摘要： A compound of formula (I) wherein n is 0 or 1; m is 0 or 1; p is 0 or 1; X is oxygen or sulfur; Y is CH, N or NO; W is oxygen, H2 or F2; A is N or C(R ); G is N or C(R ); D is N or C(R ); with the proviso that no more than one of A, G, and D is nitrogen, but at least one of Y, A, G, and D is nitrogen or NO; R is hydrogen or C1 to C4 alkyl; R , R , and R are independently hydrogen, halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, aryl, heteroaryl, OH, OC1-C4 alkyl, CO2R , -CN, -NO2, -NR R , -CF3, -OSO2CF3 or R and R , or R and R , respectively, may together form another six membered aromatic or heteroaromatic ring sharing A and G, or G and D, respectively, containing between zero and two nitrogen atoms, and substituted with one to two of the following substituents: independently hydrogen, halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, aryl, heteroaryl, OH, OC1-C4 alkyl, CO2R , -CN, -NO2, -NR R , -CF3, -OSO2CF3; R and R are independently hydrogen, C1-C4 alkyl, C(O)R , C(O)NHR , C(O)OR , SO2R or may together be (CH2)jQ(CH2)k where Q is O, S, NR , or a bond; j is 2 to 7, k is 0 to 2; R , R , R , R , and R are independently C1-C4 alkyl, aryl, or heteroaryl, or an enantiomer thereof, and the pharmaceutically acceptable salts thereof, processes for preparing them, composition containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders.
摘要翻译：式（I）的化合物，其中n为0或1; m为0或1; p为0或1; X是氧或硫; Y为CH，N或NO; W是氧，H2或F2; A是N或C（R 2）; G是N或C（R 3）; D是N或C（R 4）; 条件是A，G和D中不超过一个为氮，但Y，A，G和D中的至少一个为氮或NO; R 1是氢或C 1至C 4烷基; R 2，R 3和R 4独立地是氢，卤素，C 1 -C 4烷基，C 2 -C 4烯基，C 2 -C 4炔基，芳基，杂芳基，OH，OC 1 -C 4烷基，CO 2 R 1 ，-CN，-NO 2，-NR 5 R 6，-CF 3，-OSO 2 CF 3或R 2和R 3，或R 3和R 4分别可一起形成分别分别含有0和2个氮原子的A和G或G和D的六元芳族或杂芳族环，并被一至两个以下取代基取代：独立地是氢，卤素，C 1 -C 4烷基， C 4链烯基，C 2 -C 4炔基，芳基，杂芳基，OH，OC 1 -C 4烷基，CO 2 R 1，-CN，-NO 2，-NR 5 R 6，-CF 3，-OSO 2 CF 3; R 5和R 6独立地是氢，C 1 -C 4烷基，C（O）R 7，C（O）NHR 8，C（O）OR 9，SO 2 R 10或可以一起为（CH 2）j Q（CH 2）k，其中Q为O，S，NR 11或键; j为2〜7，k为0〜2; R 7，R 8，R 9，R 10和R 11独立地为C 1 -C 4烷基，芳基或杂芳基，或其对映异构体及其药学上可接受的盐，方法用于制备它们，含有它们的组合物及其在治疗中的用途，特别是治疗或预防精神病和智力障碍障碍。

5. 发明申请

WO2021211969A2 FLUORESCENCE QUENCHING IMMUNOSSAY 审中-公开
公开(公告)号：WO2021211969A2
公开(公告)日：2021-10-21
申请号：PCT/US2021/027684
申请日：2021-04-16
申请人： IDEXX LABORATORIES, INC.
发明人： GAGNER, Jennifer, E. , HAJIZADEH, Kiamars , PECK, Evan, M. , SALTER, James, R. , TRAVERS, Paul, James , CHRISTOPHER, Turmel, P. , WU, Yingzi , XIE, Hongzhi , YERRAMILLI, Murthy, V.S.N.
IPC分类号： C08J3/215 , G03G9/00 , G03G9/087 , C07D311/82 , C07D405/12 , C07D495/04 , C07D499/21 , C07D499/883
摘要： The present invention relates to a method and reagents for determining the presence of or the amount of an analyte in a sample.

6. 发明申请

WO2008010048A3 NOVEL 2-SUBSTITUTED METHYL PENAM DERIVATIVES 审中-公开
公开(公告)号：WO2008010048A3
公开(公告)日：2008-01-24
申请号：PCT/IB2007/001941
申请日：2007-07-11
申请人： ORCHID CHEMICALS & PHARMACEUTICALS LIMITED , UDAYAMPALAYAM, Palanisamy, Senthilkumar , GNANAPRAKASAM, Andrew , GANAPATHY, Panchapakesan , MUKUT, Gohain , VENKATASUBRAMANIAN, Hariharan , SRIRAM, Rajagopal , PAUL-SATYASEELA, Maneesh , SOLANKI, Shakti, Singh , DEVARAJAN, Sathishkumar
发明人： UDAYAMPALAYAM, Palanisamy, Senthilkumar , GNANAPRAKASAM, Andrew , GANAPATHY, Panchapakesan , MUKUT, Gohain , VENKATASUBRAMANIAN, Hariharan , SRIRAM, Rajagopal , PAUL-SATYASEELA, Maneesh , SOLANKI, Shakti, Singh , DEVARAJAN, Sathishkumar
IPC分类号： C07D499/87 , C07D499/21 , C07D499/28 , C07D499/32
摘要： Novel 2-substituted methyl penam derivatives include the formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their solvates, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them; wherein A = C or N; Het is a three- to seven-membered heterocyclic ring; R 1 represents carboxylate anion, or -COOR 4 where R 4 represents hydrogen, carboxylic acid protecting group or a pharmaceutically acceptable salt; R 2 and R 3 may be same or different and independently represent hydrogen, halogen, amino, alkyl, protected amino, optionally substituted alkyl, alkenyl, alkynyl and the like; R represents substituted or unsubstituted alkyl, alkenyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heterocyclylalkyl.

7. 发明申请

WO01098518A3 BIOTRANSFORMATION OF BIOLOGICALLY ACTIVE COMPOUNDS MADE OF VARIOUS CLASSES OF CHEMICAL SUBSTANCES BY MEANS OF LACCASE AND MANGANESE PEROXIDASE ENZYMES 审中-公开
标题翻译：生物活性化合物从不同的化学物质种类的酶法和手段漆酶锰过氧化物酶的生物转化
公开(公告)号：WO01098518A3
公开(公告)日：2002-06-20
申请号：PCT/EP2001/007152
申请日：2001-06-23
IPC分类号： A01N43/90 , A61K31/43 , A61K45/00 , A61P31/04 , A61P43/00 , C07D499/21 , C07D499/68 , C12P11/00 , C12P13/00 , C12P17/12 , C12P17/14 , C12P35/00 , C12P37/00 , C07C235/60 , C07D501/18
CPC分类号： C12P13/001 , C12P11/00 , C12P17/12 , C12P17/14 , C12P35/00 , C12P37/00
摘要： The invention relates to a method for producing biologically active ingredients. Active ingredients comprising additional functional groups, a modified spectrum of activity and modified application properties can be obtained from medicaments or plant protection agents in the form of substrates which, as functional groups, carry at least one amino or hydroxyl group. Said active ingredients can be obtained by means of a one-electron reaction which is catalysed using enzymes or mixtures exhibiting enzymatic activity with a broad substrate spectrum. The method is characterised in that radical-forming enzymes are used as enzymes, and/or supernatants of ligninolytic mushrooms in an aqueous solution are used as mixtures exhibiting enzymatic activity. The following can be introduced in the form of additional functional groups: A) polyfunctional synthones which give the active ingredient a different solution behaviour in aqueous and lipophile systems, and high interfacial activity, B) aromatic molecules and heteroaromatic compounds, C) heterocyclic compounds, D) active ingredients with independent biological efficacy, and E) active ingredients which bring together independent activity and surfactant properties in one molecule. Together, said additional functional groups and the starting products produce covalently linked coupling products exhibiting modified distribution behaviour, by means of which polyfunctional interaction with the target organism is made possible.
摘要翻译：一种制备生物活性剂的，过程，借此，从药物和植物保护产品开始作为携带的官能团的至少一个氨基或羟基，与由一个被酶或它们的混合物具有酶活性的装置具有广泛的底物范围单电子反应剂催化的底物是在水溶液中作为酶的酶形成自由基的和/或作为混合物具有酶活性的上清液木质素真菌，其中，作为另外的官能团可用另外的官能团和活性的变形频谱，和修改的应用程序的属性，其特征在于A）多官能性合成子的活性成分的提供在水溶液中和亲油系统的改性溶解行为和高的表面活性，B）的芳族分子，杂芳族化合物，C）杂环，D）无线与自身的生物活性，E）的活性，其在分子中结合了独立的效果，表面活性剂可被引入与所述起始材料共价连接的偶合产物与经修饰的分发的行为，通过与靶生物的多官能性的相互作用使能导致物质rkstoffe。

8. 发明申请

WO2014171971A1 ANTI-BACTERIAL SIDEROPHORE-AMINOPENICILLIN CONJUGATES 审中-公开
标题翻译：抗细菌性外源性氨基宁霉素结合蛋白
公开(公告)号：WO2014171971A1
公开(公告)日：2014-10-23
申请号：PCT/US2013/066408
申请日：2013-10-23
申请人： UNIVERSITY OF NOTRE DAME DU LAC
发明人： MILLER, Marvin, J. , JI, Cheng , MILLER, Patricia, A.
IPC分类号： C07D499/21 , C07D499/68 , A61K31/43 , A61P31/04
CPC分类号： A61K47/48023 , A61K31/133 , A61K31/165 , A61K31/167 , A61K31/235 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/42 , A61K31/427 , A61K31/43 , A61K31/439 , A61K31/4409 , A61K31/4439 , A61K31/496 , A61K31/545 , A61K31/63 , A61K31/635 , A61K31/65 , A61K31/702 , A61K31/7024 , A61K31/7036 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K47/547 , Y02A50/473 , Y02A50/481 , Y02A50/483
摘要： An artificial tris -catecolate siderophore with a tripodal backbone and its conjugates with ampicillin and amoxicillin were synthesized. Both conjugates exhibited significantly enhanced in vitro antibacterial activities against Gram-negative species compared to the parent drugs, especially against P. aeruginosa . The conjugates appear to be assimilated by an induced bacterial iron transport process as their activities were inversely related to iron concentration. The easily synthesized tris -catecolate siderophores can be used with a variety of drugs as conjugates to target antibiotic-resistant Gram-negative bacteria.
摘要翻译：合成了具有三节体骨架的人造三邻苯二甲酸铁载体及其与氨苄青霉素和阿莫西林的缀合物。与母体药物相比，两种缀合物对革兰氏阴性物质的体外抗菌活性显示出显着增加，特别是对于铜绿假单胞菌。由于它们的活性与铁浓度呈负相关，所以共轭物似乎被诱导的细菌铁运输过程所吸收。容易合成的三碳酸酯铁载体可用于各种药物作为缀合物以靶向抗生素抗性革兰氏阴性细菌。

9. 发明申请

WO2008010048A2 NOVEL 2-SUBSTITUTED METHYL PENAM DERIVATIVES 审中-公开
标题翻译：新型2-取代甲基熊果酸衍生物
公开(公告)号：WO2008010048A2
公开(公告)日：2008-01-24
申请号：PCT/IB2007001941
申请日：2007-07-11
申请人： ORCHID CHEMICALS & PHARM LTD , UDAYAMPALAYAM PALANISAMY SENTH , GNANAPRAKASAM ANDREW , GANAPATHY PANCHAPAKESAN , MUKUT GOHAIN , VENKATASUBRAMANIAN HARIHARAN , SRIRAM RAJAGOPAL , PAUL-SATYASEELA MANEESH , SOLANKI SHAKTI SINGH , DEVARAJAN SATHISHKUMAR
发明人： UDAYAMPALAYAM PALANISAMY SENTH , GNANAPRAKASAM ANDREW , GANAPATHY PANCHAPAKESAN , MUKUT GOHAIN , VENKATASUBRAMANIAN HARIHARAN , SRIRAM RAJAGOPAL , PAUL-SATYASEELA MANEESH , SOLANKI SHAKTI SINGH , DEVARAJAN SATHISHKUMAR
IPC分类号： C07D499/87 , C07D499/21 , C07D499/28
CPC分类号： C07D499/86 , Y02P20/55
摘要： Novel 2-substituted methyl penam derivatives include the formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their solvates, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them; wherein A = C or N; Het is a three- to seven-membered heterocyclic ring; R 1 represents carboxylate anion, or -COOR 4 where R 4 represents hydrogen, carboxylic acid protecting group or a pharmaceutically acceptable salt; R 2 and R 3 may be same or different and independently represent hydrogen, halogen, amino, alkyl, protected amino, optionally substituted alkyl, alkenyl, alkynyl and the like; R represents substituted or unsubstituted alkyl, alkenyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heterocyclylalkyl.
摘要翻译：新的2-取代的甲基青霉胺衍生物包括式（I），它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，它们的溶剂化物，它们的药学上可接受的盐和含有它们的药物组合物; 其中A = C或N; Het是三至七元杂环; R 1代表羧酸根阴离子或-COOR 4其中R 4代表氢，羧酸保护基或其药学上可接受的盐; R 2和R 3可以相同或不同，并且独立地表示氢，卤素，氨基，烷基，保护的氨基，任选取代的烷基，烯基，炔基等; R代表取代或未取代的烷基，烯基，芳基，芳烷基，环烷基，杂环基或杂环基烷基。

10. 发明申请

WO0198518A2 BIOTRANSFORMATION OF BIOLOGICALLY ACTIVE COMPOUNDS MADE OF VARIOUS CLASSES OF CHEMICAL SUBSTANCES BY MEANS OF LACCASE AND MANGANESE PEROXIDASE ENZYMES 审中-公开
标题翻译：生物活性化合物从不同的化学物质种类的酶法和手段漆酶锰过氧化物酶的生物转化
公开(公告)号：WO0198518A2
公开(公告)日：2001-12-27
申请号：PCT/EP0107152
申请日：2001-06-23
申请人： GANOMYCIN GMBH , JUELICH WOLF DIETER , SCHAUER FRIEDER , LINDEQUIST ULRIKE , HAMMER ELKE , SCHAEFER ANNETT , JONAS ULRIKE
发明人： JUELICH WOLF-DIETER , SCHAUER FRIEDER , LINDEQUIST ULRIKE , HAMMER ELKE , SCHAEFER ANNETT , JONAS ULRIKE
IPC分类号： A01N43/90 , A61K31/43 , A61K45/00 , A61P31/04 , A61P43/00 , C07D499/21 , C07D499/68 , C12P11/00 , C12P13/00 , C12P17/12 , C12P17/14 , C12P35/00 , C12P37/00 , C12P
CPC分类号： C12P13/001 , C12P11/00 , C12P17/12 , C12P17/14 , C12P35/00 , C12P37/00
摘要： The invention relates to a method for producing biologically active ingredients. Active ingredients comprising additional functional groups, a modified spectrum of activity and modified application properties can be obtained from medicaments or plant protection agents in the form of substrates which, as functional groups, carry at least one amino or hydroxyl group. Said active ingredients can be obtained by means of a one-electron reaction which is catalysed using enzymes or mixtures exhibiting enzymatic activity with a broad substrate spectrum. The method is characterised in that radical-forming enzymes are used as enzymes, and/or supernatants of ligninolytic mushrooms in an aqueous solution are used as mixtures exhibiting enzymatic activity. The following can be introduced in the form of additional functional groups: A) polyfunctional synthones which give the active ingredient a different solution behaviour in aqueous and lipophile systems, and high interfacial activity, B) aromatic molecules and heteroaromatic compounds, C) heterocyclic compounds, D) active ingredients with independent biological efficacy, and E) active ingredients which bring together independent activity and surfactant properties in one molecule. Together, said additional functional groups and the starting products produce covalently linked coupling products exhibiting modified distribution behaviour, by means of which polyfunctional interaction with the target organism is made possible.
摘要翻译：一种制备生物活性剂的，过程，借此，从药物和植物保护产品开始作为携带的官能团的至少一个氨基或羟基，与由一个被酶或它们的混合物具有酶活性的装置具有广泛的底物范围单电子反应剂催化的底物是在水溶液中作为酶的酶形成自由基的和/或作为混合物具有酶活性的上清液木质素真菌，其中，作为另外的官能团可用另外的官能团和活性的变形频谱，和修改的应用程序的属性，其特征在于A）多官能性合成子的活性成分的提供在水溶液中和亲油系统的改性溶解行为和高的表面活性，B）的芳族分子，杂芳族化合物，C）杂环，D）无线与自身的生物活性，E）的活性，其在分子中结合了独立的效果，表面活性剂可被引入与所述起始材料共价连接的偶合产物与经修饰的分发的行为，通过与靶生物的多官能性的相互作用使能导致物质rkstoffe。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式