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1. 发明申请

WO2005123710A8 SUBSTITUTED BENZOYLCYCLOHEXANDIONES FOR USE AS HERBICIDES 审中-公开
标题翻译：取代benzoylcyclohexanediones作为除草剂
公开(公告)号：WO2005123710A8
公开(公告)日：2006-02-16
申请号：PCT/EP2005006018
申请日：2005-06-04
申请人： BAYER CROPSCIENCE GMBH , VAN ALMSICK ANDREAS , WILLMS LOTHAR , AULER THOMAS , ROSINGER CHRISTOPHER , KEHNE HEINZ , HILLS MARTIN , FEUCHT DIETER
发明人： VAN ALMSICK ANDREAS , WILLMS LOTHAR , AULER THOMAS , ROSINGER CHRISTOPHER , KEHNE HEINZ , HILLS MARTIN , FEUCHT DIETER
IPC分类号： C07D317/22 , A01N35/06 , A01N43/08 , A01N43/16 , A01N43/28 , A01N43/32 , A01N43/50 , C07D319/00 , C07D319/12 , C07D493/10
CPC分类号： A01N43/28 , A01N43/32 , C07D317/22 , C07D319/12 , C07D493/10
摘要： The invention relates to the derivatives of the benzoylcyclohexandiones of formula (I), wherein R
摘要翻译：还有被描述为式（I）的除草剂benzoylcyclohexanediones衍生物及其用途。在该通式（I）R

2. 发明申请

WO0153325A3 METHOD OF AFFINITY PURIFYING PROTEINS USING MODIFIED BIS-ARSENICAL FLUORESCEIN 审中-公开
标题翻译：使用修饰的双相荧光素的亲和素纯化蛋白质的方法
公开(公告)号：WO0153325A3
公开(公告)日：2002-03-07
申请号：PCT/US0102214
申请日：2001-01-22
申请人： UNIV CALIFORNIA
发明人： VALE RONALD D , THORN KURT , COOKE ROGER , MATUSKA MARIJA , NABER NARIMAN
IPC分类号： C07F9/80 , C07K1/22 , C07K19/00 , C07D305/00 , C07C49/213 , C07C49/225 , C07C49/563 , C07C49/76 , C07D307/00 , C07D309/00 , C07D313/00 , C07D315/00 , C07D317/00 , C07D319/00 , C07D323/00 , C07D325/00 , C07D329/00 , C07D407/00 , C07D493/00 , C07F213/00
CPC分类号： C07F9/80 , C07K1/22 , C07K19/00
摘要： The present invention features methods for purifying polypeptides of interest using a modified Fluorescein arsenical helix binder (F1AsH) compound immobilized on a solid support. An exemplary F1AsH target sequence motif is also presented. Examples of modification of the F1AsH compound which allow immobilization to a solid support are also provided. The present invention also provides DNA constructs for producing a dual affinity tagged polypeptide and methods for purification thereof.
摘要翻译：本发明的特征在于使用固定在固体支持物上的修饰的荧光素砷螺旋粘合剂（F1AsH）化合物来纯化目的多肽的方法。还提供了示例性的F1AsH靶序列基序。还提供了允许固定化成固体支持物的F1AsH化合物的改性实例。本发明还提供了用于产生双重亲和标记的多肽的DNA构建体及其纯化方法。

3. 发明申请

WO99058530A1 WATER SOLUBLE AZOLES AS BROAD-SPECTRUM ANTIFUNGALS 审中-公开
标题翻译：水溶性AZOLES作为广播光谱抗体
公开(公告)号：WO99058530A1
公开(公告)日：1999-11-18
申请号：PCT/EP1999/003243
申请日：1999-05-06
IPC分类号： A61K31/495 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61P31/04 , A61P31/10 , C07D249/00 , C07D249/12 , C07D295/00 , C07D319/00 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D521/00
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D249/12
摘要： The present invention concerns novel compounds of formula (I); the N-oxide forms, the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein L represents a radical of formula (a); (b); (c); (d); (e); or (f); wherein each Alk independently represents an optionally substituted C1-6alkanediyl; n is 1, 2 or 3; Y is O, S or NR ; R represents hydrogen, aryl, Het , or an optionally substituted C1-6alkyl; each R independently represents hydrogen or C1-6alkyl; or in case R and R are attached to the same nitrogen atom, they may be taken together to form a heterocyclic radical; or they may be taken together to form an azido radical; each R independently represents hydrogen, hydroxy or C1-4alkyloxy; aryl represents phenyl, naphthalenyl, 1,2,3,4-tetrahydro-naphthalenyl, indenyl or indanyl; each of said aryl groups may optionally be substituted; Het represents an optionally substituted monocyclic or bicyclic heterocyclic radical; Het is the same as Het and may also be piperazinyl, homopiperazinyl, 1,4-dioxanyl, morpholinyl, thiomorpholinyl; R represents hydrogen or C1-4alkyl; R represents hydrogen or C1-4alkyl; or R and R taken together form a bivalent radical of formula -N=CH- (i), -CH=N- (ii), -CH=CH- (iii), -CH2-CH2 (iv), wherein one hydrogen atom in the radicals (i) and (ii) may be replaced with a C1-4alkyl radical and one or more hydrogen atoms in radicals (iii) and (iv) may be replaced by a C1-4alkyl radical; D represents a trisubstituted 1,3-dioxolane derivative; as antifungals; their processes for preparation, compositions containing them and their use as a medicine.
摘要翻译：本发明涉及新的式（I）化合物; N-氧化物形式，其药学上可接受的加成盐和立体化学异构形式，其中L表示式（a）的基团; （B）; （C）; （D）; （E）; 或（f）; 其中每个Alk独立地表示任选取代的C 1-6烷二基; n为1,2或3; Y是O，S或NR 2; R 1表示氢，芳基，Het 1或任选取代的C 1-6烷基; 每个R 2独立地表示氢或C 1-6烷基; 或者在R 1和R 2连接到相同的氮原子的情况下，它们可以一起形成杂环基; 或者它们可以一起形成叠氮基; 每个R 3独立地表示氢，羟基或C 1-4烷氧基; 芳基表示苯基，萘基，1,2,3,4-四氢 - 萘基，茚基或茚满基; 每个所述芳基可任选被取代; Het 1表示任选取代的单环或双环杂环基; Het <2>与Het <1>相同，也可以是哌嗪基，高哌嗪基，1,4-二氧杂环己基，吗啉基，硫代吗啉基; R 6表示氢或C 1-4烷基; R 7表示氢或C 1-4烷基; 或者R 6和R 7一起形成式-N = CH-（i），-CH = N-（ⅱ），-CH = CH-（ⅲ），-CH 2 -CH 2（ iv），其中基团（i）和（ii）中的一个氢原子可以被C 1-4烷基取代，并且基团（iii）和（iv）中的一个或多个氢原子可以被C 1-4烷基取代 ; D表示三取代的1,3-二氧戊环衍生物; 作为抗真菌剂; 其制备方法，含有它们的组合物及其作为药物的用途。

4. 发明申请

WO2014074365A1 NOVEL BENZYL SULFONAMIDE COMPOUNDS USEFUL AS MOGAT-2 INHIBITORS 审中-公开
标题翻译：新型苄基磺酰胺化合物可用作MOGAT-2抑制剂
公开(公告)号：WO2014074365A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/067466
申请日：2013-10-30
申请人： ELI LILLY AND COMPANY
发明人： AGEJAS-CHICHARRO, Francisco Javier , DIAZ BUEZO, Nuria , GRUBER, Joseph Michael , STACK, Douglas Richard
IPC分类号： C07D309/00 , C07D311/00 , C07D217/00 , C07D319/00 , C07D263/00 , C07D207/00 , C07D273/00 , C07D307/00
CPC分类号： C07D491/056 , C07D207/00 , C07D207/14 , C07D217/00 , C07D217/24 , C07D263/00 , C07D263/58 , C07D265/30 , C07D265/36 , C07D273/00 , C07D307/00 , C07D307/22 , C07D307/79 , C07D307/87 , C07D309/00 , C07D309/04 , C07D311/00 , C07D311/58 , C07D311/76 , C07D319/00 , C07D319/12 , C07D319/20 , C07D491/052
摘要： The present invention provides compounds of Formula I. Wherein Rl, L, and A are as described herein, or a pharmaceutical salt thereof, processes for preparing the compounds, and methods of treating a condition, such as hypertriglyceridemia, using the compounds.
摘要翻译：本发明提供式I化合物。其中R1，L和A如本文所述，或其药学盐，制备化合物的方法，以及使用该化合物治疗诸如高甘油三酯血症的病症的方法。

5. 发明申请

WO2013010488A1 AN INTERMEDIATE OF STATIN DRUGS AND PREPARATION THEREOF 审中-公开
标题翻译：药物的中间体及其制备
公开(公告)号：WO2013010488A1
公开(公告)日：2013-01-24
申请号：PCT/CN2012/078862
申请日：2012-07-19
申请人： SUNSHINE LAKE PHARMA CO., LTD. , YICHANG CHANGJIANG PHARMACEUTICAL CO., LTD. , ZHANG, Shouhua , WANG, Zhongqing , LUO, Zhonghua
发明人： ZHANG, Shouhua , WANG, Zhongqing , LUO, Zhonghua
IPC分类号： C07D319/00 , C07D257/04 , C07D405/12
CPC分类号： C07D257/04 , C07B53/00 , C07D319/06 , C07D405/12 , C07F7/1852
摘要： The present invention relates to the field of pharmaceutical chemistry, specifically relates to a statin intermediate having formula (I) and preparation thereof. The advantages of the method used to prepare the chiral sulfone intermediate having formula (I) are that a fluorophore is introduced at the beginning of the synthesis, and the intermediates are mostly solid, which enables quality control to be easily carried out.
摘要翻译：本发明涉及药物化学领域，具体涉及具有式（I）的他汀类中间体及其制备方法。用于制备具有式（I）的手性砜中间体的方法的优点是在合成开始时引入荧光团，并且中间体主要是固体，这使得能够容易地进行质量控制。

6. 发明申请

WO01002463A1 CATALYST COMPOSITION AND USE THEREOF 审中-公开
标题翻译：催化剂组合物及其用途
公开(公告)号：WO01002463A1
公开(公告)日：2001-01-11
申请号：PCT/EP2000/006402
申请日：2000-07-05
IPC分类号： B01J31/24 , B01J31/18 , B01J31/28 , C07D319/00 , C07D319/08 , C07F9/50 , C07F9/655 , C07F15/00 , C08G67/02
CPC分类号： C08G67/02 , B01J31/1895 , B01J31/2409 , B01J31/28 , B01J2531/80 , B01J2531/824 , C07D319/08 , C07F9/65522 , C07F15/0066
摘要： Catalyst composition based on (a) a Group VIII metal compound, (b) an anion, and (c) a ligand of the formula R R M -R -M R R , wherein R , R , R and R represent similar or different hydrocarbyl groups, which may optionally be substituted, M and M represent similar or different elements selected from arsenic, antimony, phosphorus and nitrogen and R represents a bivalent bridging group in which the bridge consists of three atoms, the outer two of which are carbon atoms and the middle one (X) of which forms part of a group (I) wherein: X represents carbon or silicon; Y may represent a variety of groups and structures. The catalyst composition is particularly useful in the preparation of linear alternating polyketone polymers.
摘要翻译：基于（a）VIII族金属化合物，（b）阴离子和（c）式R 1 R 2 M 1 -R 5 -M 2的配体的催化剂组合物， R 3 R 4，其中R 1，R 2，R 3和R 4表示相似或不同的烃基，其可任选被取代，M 1和M 2 >表示从砷，锑，磷和氮中选择的相似或不同的元素，R 5表示桥接由三个原子组成的二价桥连基团，其中外部两个为碳原子，中间为（X）其形成组（I）的一部分，其中：X表示碳或硅; Y可以代表各种组织和结构。催化剂组合物特别可用于制备线性交替聚酮聚合物。

7. 发明申请

WO00066556A1 INDOLINE DERIVATIVES AS PROGESTERONE ANTAGONISTS 审中-公开
标题翻译：吲哚衍生物作为孕激素拮抗剂
公开(公告)号：WO00066556A1
公开(公告)日：2000-11-09
申请号：PCT/US2000/011847
申请日：2000-05-01
IPC分类号： A61K20060101 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/404 , A61K31/407 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4747 , A61K31/506 , A61P20060101 , A61P5/00 , A61P13/08 , A61P15/00 , A61P15/18 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/00 , C07D209/02 , C07D209/34 , C07D209/96 , C07D311/00 , C07D317/00 , C07D319/00 , C07D401/02 , C07D401/04 , C07D403/02 , C07D403/04 , C07D405/04 , C07D409/02 , C07D409/04 , C07D471/10 , C07D487/10 , C07D491/04 , C07D491/10 , C07D491/107 , C07D491/113
CPC分类号： C07D209/34 , C07D209/96 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D491/10
摘要： This invention comprises compounds of formula (I), which are antagonists of the progesterone receptor, their preparation and utility.
摘要翻译：本发明包括式（I）化合物，其为孕酮受体的拮抗剂，其制备和用途。

8. 发明申请

WO00042080A1 PHOTOPOLYMERIZABLE VINYL ETHER BASED MONOMERIC FORMULATIONS AND POLYMERIZABLE COMPOSITIONS WHICH MAY INCLUDE CERTAIN NOVEL SPIROORTHOCARBONATES 审中-公开
标题翻译：可光聚合的乙烯基单体制剂和可以包含某些新型螺旋体的聚合物组合物
公开(公告)号：WO00042080A1
公开(公告)日：2000-07-20
申请号：PCT/US1999/020002
申请日：1999-09-01
IPC分类号： G03F7/027 , A61K6/00 , A61K6/087 , C07D493/10 , C07D493/20 , C07D493/22 , C08F2/46 , C08F2/50 , C08F16/12 , C08G59/20 , G03F7/028 , C07D319/00 , C08G2/24 , A16C5/00 , A16C5/04 , A16C5/08
CPC分类号： C07D493/10 , C08F2/50 , C08F16/12 , Y10S522/908
摘要： Photopolymerizable compositions are provided which are the reaction products of a vinyl ether, a photoinitiator system comprising an iodonium salt, a visible light sensitizer and an electron donor compound. These monomeric/oligomeric compositions may also include epoxides, polyols, spiroorthocarbonates. One embodiment of the present invention is a polymerizable composition comprised of a vinyl ether, a spiroorthocarbonate, and a photoinitiator system. Another embodiment of the present invention is a polymerizable composition comprised of a vinyl ether, an epoxide, a polyol, and a photoinitiator system. Still another embodiment of the present invention is a polymerizable composition comprised of a vinyl ether, an epoxide, a polyol, a spiroorthocarbonate, and a photoinitiator system. Still further, another embodiment of the present invention is certain novel spiroorthocarbonate compounds. Each of these novel spiroorthocarbonate compounds include at least one epoxy group as a substituent.
摘要翻译：提供了可光聚合的组合物，其是乙烯基醚，包含碘鎓盐，可见光增感剂和电子给体化合物的光引发剂体系的反应产物。这些单体/低聚组合物还可以包括环氧化物，多元醇，螺原碳酸酯。本发明的一个实施方案是由乙烯基醚，螺状碳酸酯和光引发剂体系组成的可聚合组合物。本发明的另一个实施方案是由乙烯基醚，环氧化物，多元醇和光引发剂体系组成的可聚合组合物。本发明的另一个实施方案是由乙烯基醚，环氧化物，多元醇，螺状碳酸酯和光引发剂体系组成的可聚合组合物。此外，本发明的另一个实施方案是某些新的螺状碳酸酯化合物。这些新型螺状原碳酸酯化合物中的每一种都包括至少一个环氧基作为取代基。

9. 发明申请

WO2022258792A1 NOVEL ANTI-FIBROTIC DRUGS 审中-公开
公开(公告)号：WO2022258792A1
公开(公告)日：2022-12-15
申请号：PCT/EP2022/065773
申请日：2022-06-09
申请人： HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)
发明人： BURGSTALLER, Gerald , GERCKENS, Michael , PLETTENBURG, Oliver , YILDIRIM, Ali Önder , HUILONG, Ma
IPC分类号： A61K31/167 , A61K31/42 , A61P9/00 , A61P11/00 , A61P13/12 , A61P17/00 , A61P35/00 , C07C233/00 , C07D213/00 , C07D249/00 , C07D311/00 , C07D319/00 , A61K31/357 , A61K31/36 , A61K31/4192 , A61P29/00 , C07C235/38 , C07D213/643 , C07D213/75 , C07D231/20 , C07D307/81 , C07D311/14 , C07D317/60
摘要： The present invention relates to new cinnamic add amides which may be used for treatment of fibrosis and neoplasia and to cinnamic acid amides for use in the treatment of fibrosis, neoplasia, arthrolithiasis, familiar mediterranean fever and pericarditis. Further, the invention relates to a pharmaceutical composition comprising said cinnamic acid amides and to a screening essay for identifying compounds suitable for the treatment of fibrosis.

10. 发明申请

WO2018026545A1 INTEGRAL 3D HUMIC ACID-CARBON HYBRID FOAM AND DEVICES CONTAINING SAME 审中-公开
标题翻译：整体三维腐殖酸 - 碳混合泡沫及含有该装置的装置
公开(公告)号：WO2018026545A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/043284
申请日：2017-07-21
申请人： NANOTEK INSTRUMENTS, INC.
发明人： ZHAMU, Aruna , JANG, Bor Z.
IPC分类号： C07D319/00 , B01D53/14
CPC分类号： B01J20/20 , B01J20/205 , B01J20/24 , B01J20/28045 , B01J20/28083 , B01J20/3007 , B01J20/3078 , C02F1/283 , C02F1/286
摘要： Provided is an integral 3D humic acid-carbon hybrid foam composed of multiple pores and pore walls, wherein pore walls contain single-layer or few-layer humic acid sheets chemically bonded by a carbon material at their edges and have a carbon material-to-humic acid weight ratio from 1/200 to 1/2, wherein the few-layer humic acid sheets have 2-10 layers of stacked substantially hexagonal carbon planes having an inter-plane spacing d 002 from 0.3354 nm to 0.40 nm as measured by X-ray diffraction and the single-layer or few-layer humic acid sheets contain 0.01% to 25% by weight of non-carbon elements wherein said humic acid is selected from oxidized humic acid, reduced humic acid, fluorinated humic acid, chlorinated humic acid, brominated humic acid, iodized humic acid, hydrogenated humic acid, nitrogenated humic acid, doped humic acid, chemically functionalized humic acid, or a combination thereof.
摘要翻译：提供一种由多个孔和孔壁组成的整体3D腐殖酸 - 碳混合泡沫体，其中孔壁包含在其边缘通过碳材料化学键合的单层或几层腐殖酸片并且具有1/200至1/2的碳材料与腐殖酸的重量比，其中所述几层腐植酸层具有2-10层堆叠的基本上六角形的碳平面，其具有平面间间距d' 通过X射线衍射测量，所述单层或几层腐殖酸片含有0.01-25重量％的非碳元素，其中所述腐殖酸选自于从0.3354nm至0.40nm的所述腐殖酸氧化的腐殖酸，还原的腐植酸，氟化的腐殖酸，氯化的腐殖酸，溴化的腐殖酸，碘化的腐殖酸，氢化的腐殖酸，氮化的腐殖酸，掺杂的腐殖酸，化学官能化的腐殖酸或其组合。

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